S P Mooijaart

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study
    S P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Intern Med 274:77-85. 2013
  2. ncbi request reprint Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, C 2 R Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Exp Gerontol 42:1116-22. 2007
  3. ncbi request reprint Plasma levels of apolipoprotein E and cognitive function in old age
    Simon P Mooijaart
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ann N Y Acad Sci 1100:148-61. 2007
  4. ncbi request reprint Liver X receptor alpha associates with human life span
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:343-9. 2007
  5. pmc ApoE plasma levels and risk of cardiovascular mortality in old age
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e176. 2006
  6. pmc Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, The Netherlands
    Aging (Albany NY) 3:55-62. 2011
  7. ncbi request reprint C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age
    S P Mooijaart
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ageing Res Rev 4:351-71. 2005
  8. pmc C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e23890. 2011
  9. doi request reprint APOE genotype modulates the effect of serum calcium levels on cognitive function in old age
    P Van Vliet
    Leiden University Medical Center, Department of Gerontology and Geriatrics C2 R, Leiden, The Netherlands
    Neurology 72:821-8. 2009
  10. doi request reprint Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity
    C A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Am J Physiol Endocrinol Metab 302:E344-8. 2012

Detail Information

Publications25

  1. doi request reprint Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study
    S P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Intern Med 274:77-85. 2013
    ..The objective of this study was to investigate the associations between both high concentration of IL-6 and the -174 promoter polymorphism, and increased cognitive decline in old age...
  2. ncbi request reprint Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, C 2 R Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Exp Gerontol 42:1116-22. 2007
    ..Visual impairment identifies elderly with an increased risk of cardiovascular disease...
  3. ncbi request reprint Plasma levels of apolipoprotein E and cognitive function in old age
    Simon P Mooijaart
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ann N Y Acad Sci 1100:148-61. 2007
    ..We conclude that in old age, in non-epsilon2-allele carriers, high plasma apoE levels are associated with cognitive impairments, independent of genotype, cardiovascular risk factors, and stroke...
  4. ncbi request reprint Liver X receptor alpha associates with human life span
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:343-9. 2007
    ..018), and higher levels of triglycerides (p =.041). Genetic variation in the gene coding for the LXRalpha (NR1H3) associates with human life span...
  5. pmc ApoE plasma levels and risk of cardiovascular mortality in old age
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e176. 2006
    ..Whereas the isoforms have been associated with cardiovascular disease, the relation between plasma apoE levels and cardiovascular disease is unknown...
  6. pmc Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, The Netherlands
    Aging (Albany NY) 3:55-62. 2011
    ..523). The better glucose tolerance of the "offspring" is not explained by a lower burden of type 2 diabetes risk alleles, suggesting that specific mechanisms determining longevity exist...
  7. ncbi request reprint C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age
    S P Mooijaart
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ageing Res Rev 4:351-71. 2005
    ..Genomic variations in these NHRs or their target genes are prime candidates for the regulation of human lifespan and disease at old age...
  8. pmc C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e23890. 2011
    ..Plasma concentrations of C-reactive protein (CRP), a marker of chronic inflammation, have been associated with cognitive impairment in old age. However, it is unknown whether CRP is causally linked to cognitive decline...
  9. doi request reprint APOE genotype modulates the effect of serum calcium levels on cognitive function in old age
    P Van Vliet
    Leiden University Medical Center, Department of Gerontology and Geriatrics C2 R, Leiden, The Netherlands
    Neurology 72:821-8. 2009
    ..Here, we studied whether the APOE genotype modulates the association between serum calcium levels and cognition...
  10. doi request reprint Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity
    C A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Am J Physiol Endocrinol Metab 302:E344-8. 2012
    ..Future research should focus on assessing what mechanisms may explain the lower IMCL levels in familial longevity...
  11. ncbi request reprint Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center LUMC, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Biogerontology 7:231-8. 2006
    ..We conclude that, in spite the effect of the ER22/23EK and N363S SNPs on metabolism, these polymorphisms together with the BclI SNP, do not affect the risks of cardiovascular disease and survival at old age...
  12. pmc Genomics of human longevity
    P E Slagboom
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 366:35-42. 2011
    ..By the integration of research in different study cohorts, and with research in animal models, biological research into human longevity is thus making considerable progress...
  13. pmc Human insulin/IGF-1 and familial longevity at middle age
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Aging (Albany NY) 1:714-22. 2009
    ....
  14. doi request reprint Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    ....
  15. ncbi request reprint Plasma apolipoprotein CI protects against mortality from infection in old age
    Jimmy F P Berbee
    Department of Biomedical Research, TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:122-6. 2008
    ..63; 95% CI, 0.44-0.90; p =.013), whereas for HDL cholesterol significance was lost. We conclude that high apoCI levels are associated with reduced mortality from infection, in line with experimental evidence in rodents...
  16. ncbi request reprint Reduced insulin/IGF-1 signalling and human longevity
    Diana van Heemst
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 4:79-85. 2005
    ..This effect was stronger for the GH1 SNP than for variation in the conserved IIS genes that were found to affect longevity in model organisms...
  17. ncbi request reprint Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study
    Simon P Mooijaart
    Departments of Gerontology and Geriatrics and Clinical Chemistry, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 82:866-71. 2005
    ..High concentrations of homocysteine and low concentrations of vitamin B-12 and folic acid are frequently observed in subjects with dementia...
  18. ncbi request reprint Plasma levels of apolipoprotein E and risk of stroke in old age
    Peter van Vliet
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Ann N Y Acad Sci 1100:140-7. 2007
    ..440). In conclusion, in old age, except for epsilon2-allele carriers, high plasma apoE levels are associated with a higher risk of stroke, independent of APOE genotype, plasma levels of lipids, and other cardiovascular risk factors...
  19. ncbi request reprint VDR gene variants associate with cognitive function and depressive symptoms in old age
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neurobiol Aging 30:466-73. 2009
    ..In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms...
  20. doi request reprint Genes encoding longevity: from model organisms to humans
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Aging Cell 7:270-80. 2008
    ..In conclusion, although the study of model organisms has revealed potential candidate genetic mechanisms determining aging and lifespan, to what extent they explain variation in human populations is still uncertain...
  21. pmc Homocysteine and familial longevity: the Leiden Longevity Study
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e17543. 2011
    ..63). The results suggest that homocysteine metabolism is not likely to predict familial longevity...
  22. ncbi request reprint Variation in the SHC1 gene and longevity in humans
    Simon P Mooijaart
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9503, RC Leiden 2300, The Netherlands
    Exp Gerontol 39:263-8. 2004
    ..Low valine allele frequency resulted, however, in low power to detect statistical significance. These data suggest that an association between the Met(410)Val polymorphism and longevity in humans may exist...
  23. doi request reprint Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study
    Maarten P Rozing
    Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Am Geriatr Soc 58:564-9. 2010
    ..To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity...
  24. doi request reprint Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:365-8. 2010
    ..In human populations, an association was observed between low thyroid function and longevity at old age, but the beneficial effects of low thyroid hormone metabolism at middle age remain elusive...
  25. ncbi request reprint Variation in the human TP53 gene affects old age survival and cancer mortality
    Diana van Heemst
    Exp Gerontol 40:11-5. 2005
    ..032) despite a 2.54 fold increased (p = 0.007) proportional mortality from cancer. It is suggested that human p53 protect against cancer but at a cost of longevity...