Stephan Michel

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Mechanism of bilateral communication in the suprachiasmatic nucleus
    Stephan Michel
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, LUMC PZ S5 P, PO 9600, 2300 RC, Leiden, The Netherlands
    Eur J Neurosci 37:964-71. 2013
  2. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
  3. doi request reprint Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock
    Sahar Farajnia
    Department of Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurosci 32:5891-9. 2012
  4. doi request reprint Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice
    Floor van Oosterhout
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Neurol 64:315-24. 2008
  5. ncbi request reprint Seasonal encoding by the circadian pacemaker of the SCN
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Lab for Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Curr Biol 17:468-73. 2007
  6. doi request reprint Dynamic neuronal network organization of the circadian clock and possible deterioration in disease
    Johanna H Meijer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Prog Brain Res 199:143-62. 2012
  7. pmc Phase shifting capacity of the circadian pacemaker determined by the SCN neuronal network organization
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e4976. 2009
  8. doi request reprint Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
    Johanna H Meijer
    Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Neurosci 32:2143-51. 2010
  9. doi request reprint Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock
    Eliane A Lucassen
    Laboratory of Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Neurosci 35:1466-74. 2012
  10. doi request reprint Phase of the electrical activity rhythm in the SCN in vitro not influenced by preparation time
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands
    Chronobiol Int 26:1075-89. 2009

Collaborators

  • J H Meijer
  • Tom Deboer
  • William J Schwartz
  • CHRISTOPHER SCOTT COLWELL
  • NANCY WAYNE
  • Wayne S Sossin
  • Henk Tjebbe VanderLeest
  • Mariska J Vansteensel
  • Jos H T Rohling
  • Sahar Farajnia
  • Thijs Houben
  • Ashna Ramkisoensing
  • Henk Albus
  • Eliane A Lucassen
  • Floor van Oosterhout
  • Gene D Block
  • Jason N Itri
  • Jason Itri
  • John R Dyer
  • Heleen M D van Engeldorp Gastelaars
  • Changgui Gu
  • Hester C van Diepen
  • Roman Yasenkov
  • Hans Duindam
  • Arn M J M van den Maagdenberg
  • Joost Westerhout
  • Rob C G van de Ven
  • Michel D Ferrari
  • James A Waschek
  • Vincent F Castellucci
  • Wenjau Lee

Detail Information

Publications26

  1. doi request reprint Mechanism of bilateral communication in the suprachiasmatic nucleus
    Stephan Michel
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, LUMC PZ S5 P, PO 9600, 2300 RC, Leiden, The Netherlands
    Eur J Neurosci 37:964-71. 2013
    ..These phase shifts were blocked by a glutamate receptor antagonist. Taken together, these results implicate glutamate as a transmitter required for communication between the left and right SCN...
  2. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
    ....
  3. doi request reprint Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock
    Sahar Farajnia
    Department of Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurosci 32:5891-9. 2012
    ..We propose that aberrant SCN rhythmicity in old animals--with electrophysiological arrhythmia at the single-cell level and phase desynchronization at the network level--can account for defective circadian function with aging...
  4. doi request reprint Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice
    Floor van Oosterhout
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Neurol 64:315-24. 2008
    ..1 calcium channels, causing increased presynaptic calcium influx and neurotransmitter release. We investigated whether these mice have an abnormal adjustment to phase advance shifts...
  5. ncbi request reprint Seasonal encoding by the circadian pacemaker of the SCN
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Lab for Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Curr Biol 17:468-73. 2007
    ..48 and 3.85 hr, respectively). The data indicate that coding for day length involves plasticity within SCN neuronal networks in which the phase distribution of oscillating neurons carries information on the photoperiod's duration...
  6. doi request reprint Dynamic neuronal network organization of the circadian clock and possible deterioration in disease
    Johanna H Meijer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Prog Brain Res 199:143-62. 2012
    ..Whether the decrease in amplitude is caused by a loss of synchronization or by a loss of single-cell rhythmicity remains to be determined and is important for the development of strategies to ameliorate circadian disorders...
  7. pmc Phase shifting capacity of the circadian pacemaker determined by the SCN neuronal network organization
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e4976. 2009
    ..The effects of light on the circadian system are strongly dependent on the photoperiod to which animals are exposed. An explanation for this phenomenon is currently lacking...
  8. doi request reprint Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
    Johanna H Meijer
    Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Neurosci 32:2143-51. 2010
    ..While both photic entrainment and seasonal adaptation arise from a redistribution of SCN oscillatory activity patterns, different neuronal coupling mechanisms are employed, which are reviewed in the present paper...
  9. doi request reprint Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock
    Eliane A Lucassen
    Laboratory of Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Neurosci 35:1466-74. 2012
    ..The data indicate that the intact circadian system can compensate for some of the consequences of the loss of VIP, whereas this peptide is indispensable for endogenous encoding of seasonal information...
  10. doi request reprint Phase of the electrical activity rhythm in the SCN in vitro not influenced by preparation time
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands
    Chronobiol Int 26:1075-89. 2009
    ....
  11. pmc Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons
    Jos H T Rohling
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e25437. 2011
    ..The large desynchronization observed following advances may contribute to the relative difficulty of the circadian system to respond to advanced light cycles...
  12. ncbi request reprint Processing of daily and seasonal light information in the mammalian circadian clock
    Johanna H Meijer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Postal zone S5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Gen Comp Endocrinol 152:159-64. 2007
    ..Encoding of day-length is manifested in SCN neuronal activity patterns and may be the product of network interactions rather than being based on the single cell...
  13. doi request reprint Enhanced phase resetting in the synchronized suprachiasmatic nucleus network
    Ashna Ramkisoensing
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Rhythms 29:4-15. 2014
    ..On the basis of the phase shifts observed in vitro, we conclude that highly synchronized SCN networks with high-amplitude rhythms show a larger phase-shifting capacity than desynchronized networks of low amplitude. ..
  14. doi request reprint Aging of the suprachiasmatic clock
    Sahar Farajnia
    1Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Neuroscientist 20:44-55. 2014
    ..Understanding the mechanisms underlying age-related deficits in circadian clock function will therefore not only benefit rhythm disorders but also alleviate age-associated diseases aggravated by clock dysfunction. ..
  15. ncbi request reprint Organization of cell and tissue circadian pacemakers: a comparison among species
    Mariska J Vansteensel
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Postal zone S5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Brain Res Rev 58:18-47. 2008
    ....
  16. ncbi request reprint A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock
    Henk Albus
    Department of Neurophysiology, Leiden University Medical Center, Wassenaarseweg 62, Post Office Box 9604, 2300 RC Leiden, The Netherlands
    Curr Biol 15:886-93. 2005
    ..In order to understand synchronization of the clock to the external light-dark cycle, we performed ex vivo recordings of spontaneous impulse activity in SCN slices of the rat...
  17. ncbi request reprint Neurohormone secretion persists after post-afterdischarge membrane depolarization and cytosolic calcium elevation in peptidergic neurons in intact nervous tissue
    Stephan Michel
    Department of Physiology, David Geffin School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 22:9063-9. 2002
    ..These findings suggest a unique relationship between membrane excitability, Ca2+ signaling, and prolonged neuropeptide secretion...
  18. ncbi request reprint Disrupted circadian rhythms in VIP- and PHI-deficient mice
    Christopher S Colwell
    Mental Retardation Res Ctr, Univ of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 285:R939-49. 2003
    ..Together, the observations suggest that VIP/PHI peptides are critically involved in both the generation of circadian oscillations as well as the normal synchronization of these rhythms to light...
  19. pmc Sleep and circadian rhythms: do sleep centers talk back to the clock?
    Christopher S Colwell
    Nat Neurosci 6:1005-6. 2003
  20. pmc Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors
    Stephan Michel
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    J Neurophysiol 88:817-28. 2002
    ..Overall, our data suggest that glutamatergic synaptic transmission mediated by AMPA/KA GluRs play an important role throughout the SCN synaptic circuitry...
  21. ncbi request reprint Synaptic stimulation of Aplysia peptidergic neurons can activate hormone secretion in the absence of an afterdischarge
    Nancy L Wayne
    Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurosci Lett 362:249-52. 2004
    ..Electrical stimulation that failed to produce afterdischarges but did lead to prolonged membrane depolarization and a rise in intracellular calcium concentration was sufficient to stimulate significant ELH release...
  22. pmc Fast delayed rectifier potassium current is required for circadian neural activity
    Jason N Itri
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    Nat Neurosci 8:650-6. 2005
    ..We conclude that the FDR is necessary for the circadian modulation of electrical activity in SCN neurons and represents an important part of the ionic basis for the generation of rhythmic output...
  23. ncbi request reprint Post-afterdischarge depolarization does not stimulate prolonged neurohormone secretion but is required for activity-dependent stimulation of neurohormone biosynthesis from peptidergic neurons
    Nancy L Wayne
    Department of Physiology, David Geffen School of Medicine at University of California Los Angeles, 90095 1751, USA
    Endocrinology 145:1678-84. 2004
    ..It also demonstrates, for the first time, a critical role for postdischarge Vm in regulating an important aspect of neuroendocrine cell function-that of hormone synthesis...
  24. pmc Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus
    Jason Itri
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Science, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    J Neurophysiol 92:311-9. 2004
    ..Overall, these data demonstrate that there is a circadian rhythm in GABAergic transmission in the dorsal region of the mouse SCN and that the VIP is required for expression of this rhythm...
  25. ncbi request reprint An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation
    John R Dyer
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University St, Montreal, Quebec H3A 2B4, Canada
    Nat Neurosci 6:219-20. 2003
  26. ncbi request reprint Activity-dependent regulation of neurohormone synthesis and its impact on reproductive behavior in aplysia
    Nancy L Wayne
    Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1751, USA
    Biol Reprod 70:277-81. 2004
    ..The IRES-regulated translation provides a unique cellular mechanism to selectively upregulate synthesis of a critical reproductive hormone at the expense of nonessential proteins...