Research Topics
Genomes and GenesSpecies | I MeulenbeltSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hipIngrid Meulenbelt
Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 50:1179-86. 2004..To study the role of the interleukin-1 beta gene (IL1B) and the IL-1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine...
Osteoarthritis year 2011 in review: geneticsI Meulenbelt
Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Osteoarthritis Cartilage 20:218-22. 2012....
Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysisHanneke J M Kerkhof
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
BMC Med Genet 11:164. 2010..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...- Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populationsIngrid Meulenbelt
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Hum Mol Genet 18:1518-23. 2009.... - Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP studyI Meulenbelt
Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Osteoarthritis Cartilage 15:379-85. 2007..To assess the relationship of biochemical markers and radiographic signs of osteoarthritis (ROA) in the subjects with symptomatic osteoarthritis (OA) at multiple sites of the Genetics osteoARthritis and Progression (GARP) study... - Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genesIngrid Meulenbelt
Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The Netherlands
Eur J Hum Genet 14:1280-7. 2006..3 for FOA. Candidate gene analysis suggested a possible association of a PTHR2 variant with generalized radiographic OA; it is, however, unlikely the major disease gene for the observed linkage to the FOA phenotype... - Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritisIngrid Meulenbelt
Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Hum Mol Genet 17:1867-75. 2008..Our results indicate a new susceptibility gene (DIO2) conferring risk to osteoarthritis... - Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP studyI Meulenbelt
Leiden University Medical Centre, Section of Molecular Epidemiology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
Ann Rheum Dis 65:360-5. 2006..To assess the relation between the urinary concentrations of type II collagen C-telopeptide (UCTX-II) and radiographic signs of osteoarthritis (ROA) in the GARP (Genetics, Arthrosis and Progression) study... - Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression StudyIngrid Meulenbelt
Leiden University Medical Center, 2333 ZC Leiden, The Netherlands
Arthritis Rheum 62:1119-26. 2010..To assess whether genetic variation in the interleukin-1 (IL-1) gene cluster contributes to familial osteoarthritis (OA) by influencing innate ex vivo production of IL-1beta or IL-1 receptor antagonist (IL-1Ra)... - Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibilityIngrid Meulenbelt
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Ann Rheum Dis 70:164-7. 2011..To study whether common genetic variants of the genes involved in the complex regulatory mechanism determining the intracellular bio-availability of T3 influence osteoarthritis onset... - Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OAI Meulenbelt
Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands
Osteoarthritis Cartilage 19:1091-4. 2011..With those tools in hand, clinicians and industry can develop protocols to ultimately improve patient care... - Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the handJ L Min
Section of Molecular Epidemiology, Leiden University Medical Centre, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
Ann Rheum Dis 65:1060-6. 2006..One of the variants, involving a conserved amino acid substitution (T303M; SNP5), was related to idiopathic hand osteoarthritis... - Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP studyS D Bos
Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Ann Rheum Dis 67:877-9. 2008..To gain more insight into the role of genetic variation of the C-reactive protein (CRP) gene in serum CRP levels and osteoarthritis (OA)... - Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritisI Meulenbelt
TNO Prevention and Health, Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
Ann Hum Genet 63:393-400. 1999..3, 95% CI 2.3-12.7). Our results suggest that a specific haplotype of the COL2A1 locus may predispose to generalised ROA... - Systemic and local factors are involved in the evolution of erosions in hand osteoarthritisJ Bijsterbosch
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Ann Rheum Dis 70:326-30. 2011..In order to gain insight in the pathogenesis of erosive hand osteoarthritis (OA), the evolution of erosions in hand OA and risk factors involved were investigated... - Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sitesJ L Min
Leiden University Medical Center, Section of Molecular Epidemiology, Leiden, The Netherlands
Arthritis Rheum 52:1077-80. 2005..To confirm the association of 2 variants of the Frizzled-related protein gene (FRZB) with osteoarthritis (OA) of the hip, and to investigate whether these variants also associate with other heritable generalized OA phenotypes... - The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OAS D Bos
Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Osteoarthritis Cartilage 17:621-6. 2009..Investigating the association between plasma levels of cytokines and chemokines, Selenoprotein S (SELS) gene variation and osteoarthritis (OA) subtypes... - Allele-sharing statistics using information on family historyA Callegaro
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
Ann Hum Genet 74:547-54. 2010..Allele-sharing methods were applied to the symptomatic osteoarthritis GARP study where taking into account the family-history increased considerably the evidence of linkage in the region of the DIO2 susceptibility locus... - Accelerated metacarpal bone mineral density loss is associated with radiographic progressive hand osteoarthritisM Güler-Yüksel
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Ann Rheum Dis 70:1625-30. 2011..To study the association between metacarpal bone mineral density (BMD) loss and progressive hand osteoarthritis (OA) over 2 years... - Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP studyN Riyazi
Leiden University Medical Centre, Department of Rheumatology, PO Box 9600, 2300 RC Leiden, The Netherlands
Ann Rheum Dis 64:438-43. 2005..CONCLUSIONS: In middle aged patients with familial osteoarthritis at multiple sites, familial aggregation of osteoarthritis was most striking for hand and hip but remarkably absent for the knee... - Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 yearsJ Bijsterbosch
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Ann Rheum Dis 70:68-73. 2011..To investigate the long-term clinical and radiographic disease course of hand osteoarthritis (OA) and determinants of outcome... - Clinical burden of erosive hand osteoarthritis and its relationship to nodesJ Bijsterbosch
Leiden University Medical Centre, Department of Rheumatology, C1 R, P O Box 9600, 2300 RC Leiden, The Netherlands
Ann Rheum Dis 69:1784-8. 2010..To describe the clinical burden of erosive osteoarthritis (EOA) of the hand in terms of pain, functioning and health-related quality of life (HRQL) and its relationship to nodal osteoarthritis (OA)... - Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritisS Botha-Scheepers
Leiden University Medical Centre, Department of Rheumatology, C01 R, PO Box 9600, 2300 RC Leiden, The Netherlands
Ann Rheum Dis 67:1165-9. 2008..Therefore, we investigated whether innate differences in the inflammatory response regarding cytokine production were associated with radiological progression of knee OA... - Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritisM J E Wassenaar
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
Ann Rheum Dis 70:320-5. 2011.... - Validity of joint space width measurements in hand osteoarthritisW Y Kwok
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Osteoarthritis Cartilage 19:1349-55. 2011..To investigate the validity of joint space width (JSW) measurements in millimeters (mm) in hand osteoarthritis (OA) patients by comparison to controls, grading of joint space narrowing (JSN), and clinical features... - Illness perceptions in patients with osteoarthritis: change over time and association with disabilityJ Bijsterbosch
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 61:1054-61. 2009..To investigate changes in illness perceptions in patients with osteoarthritis (OA) and the association of those changes with disability, and to determine the predictive value of illness perceptions in disability... - Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort studyStella A Botha Scheepers
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 57:626-32. 2007.... - Relative efficiency of haplotype frequency estimation in sibships and nuclear families compared to unrelated individualsH Putter
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
Hum Hered 64:52-62. 2007..We argue that the relative efficiencies can also be used to correct for dependence in the calculation of standard errors after initially ignoring the dependence in the estimation phase... - Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disabilityJessica Bijsterbosch
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Ann Rheum Dis 69:585-7. 2010..To assess the impact of different subsets of symptomatic hand osteoarthritis (OA) on pain and disability... - Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometryOleg A Mayboroda
Biomolecular Mass Spectrometry Unit, Department of Parasitology, LUMC, Leiden, The Netherlands
J Chromatogr A 1159:149-53. 2007..Finally, the introduction of multivariate data analysis in the work flow was evaluated on spiked urine samples and real clinical material... - High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypesJosine L Min
Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Twin Res Hum Genet 9:501-6. 2006.... - The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birthMartijn J J Finken
Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Endocrinol Metab 92:4777-82. 2007..Preterm birth is associated with postnatal growth failure, abdominal fat accumulation, insulin resistance, and hypertension, resembling increased glucocorticoid bioactivity... - A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levelsSteffan D Bos
Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Eur J Hum Genet 18:953-9. 2010..A novel gene involved in the innate immune response of TNFalpha is identified. Genetic variation in this gene may have a role in diseases and disorders in which TNFalpha is closely involved... - Genetics of human aging. The search for genes contributing to human longevity and diseases of the oldP E Slagboom
Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
Ann N Y Acad Sci 908:50-63. 2000..These issues will be illustrated from research on cardiovascular disease and osteoarthritis... - Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritisJosine L Min
Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Eur J Hum Genet 15:791-9. 2007..0013). Two promising variants in or near NRP2 and IDH1 may not be sufficient for the onset of FOA alone but might have a modulating role with FOA. Confirmation in other OA populations is required... - Organisation of the human genome and our tools for identifying disease genesP E Slagboom
Section Molecular Epidemiology, Sylvius Laboratory, Leiden University Medical Centre, PO Box 9503, 2300 RA Leiden, The Netherlands
Biol Psychol 61:11-31. 2002..This paper constitutes a tutorial overview of the organisation of the human genome, the tools it provides for molecular genetic studies, and the genomic background of the current strategies for gene identification... - New insights into osteoarthritis: early developmental features of an ageing-related diseaseSteffan Daniël Bos
Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands
Curr Opin Rheumatol 20:553-9. 2008..This review addresses possible common mechanisms of how recently identified consistent osteoarthritis susceptibility genes influence both the onset of osteoarthritis and its progression towards clinical outcomes... - Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulationNaghmeh Riyazi
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 52:1443-50. 2005..These results suggest that a proportion of the genetic susceptibility to OA may be encoded for by variations in innate cytokine activity... - A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibilityKay Chapman
Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
Hum Mol Genet 17:1497-504. 2008..0004, OR = 1.21) and the dominant model (P < 0.0001, OR = 1.48). These findings represent the first highly significant evidence for a risk factor for the development of OA which affects two highly diverse ethnic groups... - Genetic association analysis of RHOB and TXNDC3 in osteoarthritisJohn Loughlin
Am J Hum Genet 80:383-6; author reply 386-7. 2007 - Replication in genetic association studies: Comment on the editorial by Spector et alJosine Min
Arthritis Rheum 54:3063-4; author reply 3064. 2006 - Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factorsDanielle Posthuma
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
Twin Res Hum Genet 8:132-7. 2005..We conclude that genes influencing amyloid-beta-induced cytokine response may provide clues to the progression of AD pathology...