O C Meijer

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Understanding stress through the genome
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, PO Box 9503, Leiden, 2300 RA, The Netherlands
    Stress 9:61-7. 2006
  2. ncbi request reprint Correlations between hypothalamus-pituitary-adrenal axis parameters depend on age and learning capacity
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, P O Box 9502, 2300 RA Leiden, The Netherlands
    Endocrinology 146:1372-81. 2005
  3. ncbi request reprint Steroid receptor coregulator diversity: what can it mean for the stressed brain?
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands
    Neuroscience 138:891-9. 2006
  4. ncbi request reprint Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Endocrinology 146:1438-48. 2005
  5. ncbi request reprint Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Endocrinol 178:13-8. 2003
  6. ncbi request reprint Coregulator proteins and corticosteroid action in the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    J Neuroendocrinol 14:499-505. 2002
  7. ncbi request reprint Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 141:2192-9. 2000
  8. ncbi request reprint Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene
    S van der Laan
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research and Leiden University Medical Centre, 2300 RA, Leiden, The Netherlands
    Endocrinology 149:725-32. 2008
  9. ncbi request reprint Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
  10. ncbi request reprint The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells
    M C Morsink
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Amsterdam, The Netherlands
    J Neurochem 99:1282-98. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Understanding stress through the genome
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, PO Box 9503, Leiden, 2300 RA, The Netherlands
    Stress 9:61-7. 2006
    ....
  2. ncbi request reprint Correlations between hypothalamus-pituitary-adrenal axis parameters depend on age and learning capacity
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, P O Box 9502, 2300 RA Leiden, The Netherlands
    Endocrinology 146:1372-81. 2005
    ..These distinct interdependencies may reflect adjusted set-points of the HPA axis, resulting in adaptation (or maladaptation) to the environment and, possibly, an age-independent determination of learning ability...
  3. ncbi request reprint Steroid receptor coregulator diversity: what can it mean for the stressed brain?
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands
    Neuroscience 138:891-9. 2006
    ....
  4. ncbi request reprint Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Endocrinology 146:1438-48. 2005
    ..We conclude that the cellular differences in SRC-1a to SRC-1e ratio demonstrated in vivo might be involved in cell-specific responses to corticosteroids in a promoter- and ligand-dependent way...
  5. ncbi request reprint Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Endocrinol 178:13-8. 2003
    ....
  6. ncbi request reprint Coregulator proteins and corticosteroid action in the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    J Neuroendocrinol 14:499-505. 2002
    ..These characteristics make coregulator proteins of outstanding interest as determinants of receptor, cell and state-dependent effects of MR and GR signalling (and steroid receptor signalling in general) in the brain...
  7. ncbi request reprint Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 141:2192-9. 2000
    ..The differential and uneven neuroanatomical distribution of these coactivators may underlie diversity and cell-specificity of steroid receptor mediated signals in the brain...
  8. ncbi request reprint Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene
    S van der Laan
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research and Leiden University Medical Centre, 2300 RA, Leiden, The Netherlands
    Endocrinology 149:725-32. 2008
    ..We conclude that modulation of coregulator activity may play a role in the control of the hypothalamus-pituitary-adrenal axis...
  9. ncbi request reprint Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
    ..This finding suggests a more prominent role for corticosterone in control of human brain function than hitherto recognized...
  10. ncbi request reprint The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells
    M C Morsink
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Amsterdam, The Netherlands
    J Neurochem 99:1282-98. 2006
    ..Finally, we identified a number of interesting genes, such as SWI/SNF, synaptosomal-associated protein 25 and certain Rab proteins which may play a role in the effects of glucocorticoids on catecholaminergic neuronal functioning...
  11. doi request reprint Glucocorticoid signaling and stress-related limbic susceptibility pathway: about receptors, transcription machinery and microRNA
    E R de Kloet
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Brain Res 1293:129-41. 2009
    ..We focus on the question how the action of CORT can change from protective to harmful...
  12. ncbi request reprint Neuroanatomical distribution and colocalisation of nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid receptors (SMRT) in rat brain
    S van der Laan
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research and Leiden University Medical Center, The Netherlands
    Brain Res 1059:113-21. 2005
    ..Taken together, these findings are consistent with the idea that the uneven neuroanatomical distribution of N-CoR and SMRT protein may contribute to the site-specific effects exerted by hormones, such as glucocorticoids, in the brain...
  13. ncbi request reprint Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Eur J Neurosci 20:2541-54. 2004
    ....
  14. ncbi request reprint Low doses of dexamethasone can produce a hypocorticosteroid state in the brain
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 146:5587-95. 2005
    ..The results support the concept that low doses of dex can create a hypocorticoid state in the brain...
  15. doi request reprint Recovery from disrupted ultradian glucocorticoid rhythmicity reveals a dissociation between hormonal and behavioural stress responsiveness
    R A Sarabdjitsingh
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research LACDR Leiden University Medical Centre LUMC, University of Leiden, Leiden, The Netherlands
    J Neuroendocrinol 22:862-71. 2010
    ..Upon reinstatement of the ultradian rhythm, and despite the fact that these animals did not differ from controls in their response to noise stress, they did show substantial changes in their behavioural response to stress...
  16. ncbi request reprint Effects of flesinoxan on corticosteroid receptor expression in the rat hippocampus
    R M Sibug
    Leiden Amsterdam Center for Drug Research, Division of Medical Pharmacology, Sylvius Laboratories, P O Box 9503, 2300 RA, Leiden, Netherlands
    Eur J Pharmacol 404:111-9. 2000
    ....
  17. ncbi request reprint The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
    A M Karssen
    Divisions of Medical Pharmacology and Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Centre, PO Box 9502, Leiden, 2300 RA, The Netherlands
    J Endocrinol 175:251-60. 2002
    ..Furthermore, the ensuing imbalance in activation of the two types of brain corticosteroid receptors may have consequences for cognitive performance and mood...
  18. ncbi request reprint Brain mineralocorticoid receptors and centrally regulated functions
    E R de Kloet
    Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Kidney Int 57:1329-36. 2000
    ..It is presently unknown in which brain cells the MR-mediated effects on these aspects of central cardiovascular regulation occur...
  19. doi request reprint Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Endocrinology 152:3749-57. 2011
    ..GC-binding transcription factors therefore may be unique partners for DNA-bound GR and may in part explain cell-specific transcriptional regulation by glucocorticoids in the context of the hippocampus...
  20. ncbi request reprint Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice
    S M Korte
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, University of Leiden, The Netherlands
    Brain Res 736:338-43. 1996
    ..In conclusion, genetic selection for high offensive aggression co-selects for reduced (circadian peak) level in plasma corticosterone and increased postsynaptic 5-HT1A receptor number in limbic and cortical regions...
  21. ncbi request reprint The Yin and Yang of nuclear receptors: symposium on nuclear receptors in brain, Oegstgeest, The Netherlands, 13-14 April 2000
    E R de Kloet
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, PO Box 9503, 2300 RA Leiden, The Netherlands
    Trends Endocrinol Metab 11:245-8. 2000
    ..By elucidating the signalling pathway of nuclear receptors in brain, potential targets for therapeutic treatment of brain disorders can be identified...
  22. doi request reprint Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior
    C P Fitzsimons
    1 Department of Medical Pharmacology, Leiden University Medical Center Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands 2 Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Mol Psychiatry 18:993-1005. 2013
    ....
  23. doi request reprint Blocking dopamine D2 receptors by haloperidol curtails the beneficial impact of calorie restriction on the metabolic phenotype of high-fat diet induced obese mice
    J E de Leeuw van Weenen
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    J Neuroendocrinol 23:158-67. 2011
    ....
  24. ncbi request reprint Chronic unpredictable stress causes attenuation of serotonin responses in cornu ammonis 1 pyramidal neurons
    E Van Riel
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Neuroscience 120:649-58. 2003
    ..The data indicate that unpredictable stress exposure for 3 weeks results in suppression of 5-HT(1A) receptor-mediated responses, possibly due to posttranslational modification of the receptor...
  25. ncbi request reprint Genetic selection for coping style predicts stressor susceptibility
    A H Veenema
    Department of Animal Physiology, Centre for Behavioural and Cognitive Neuroscience, University of Groningen, The Netherlands
    J Neuroendocrinol 15:256-67. 2003
    ..This latter stress paradigm therefore seems promising to analyse the role of genetic factors in the individual differences in stress-related psychopathology...
  26. ncbi request reprint Hippocampal serotonin responses in short and long attack latency mice
    E Van Riel
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    J Neuroendocrinol 14:234-9. 2002
    ..We tentatively conclude that long attack latency mice show attenuated functional responses to serotonin in the hippocampus, possibly linked to a chronic perturbation of hormonal levels...