J P Medema

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles
    Elza C de Bruin
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Genomics 6:142. 2005
  2. ncbi request reprint The uncertain glory of APRIL
    J P Medema
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands
    Cell Death Differ 10:1121-5. 2003
  3. pmc Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells
    J P Medema
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center LUMC, 2333ZA Leiden, The Netherlands
    J Exp Med 194:657-67. 2001
  4. pmc Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
    J P Medema
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 98:11515-20. 2001
  5. ncbi request reprint Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis
    L R Schurmans
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 167:5832-7. 2001
  6. ncbi request reprint Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation
    J Hendriks
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    Cell Death Differ 12:637-48. 2005
  7. ncbi request reprint T cell signaling: a decision of life and death
    J P Medema
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, The Netherlands
    Hum Immunol 60:403-11. 1999
  8. ncbi request reprint Mechanisms of antibody immunotherapy on clonal islet reactive T cells
    P van de Linde
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 67:264-73. 2006
  9. ncbi request reprint A serine protease is involved in the initiation of DNA damage-induced apoptosis
    E C de Bruin
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Death Differ 10:1204-12. 2003
  10. pmc Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    J P Medema
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Exp Med 190:1033-8. 1999

Collaborators

  • R Offringa
  • D Rea
  • E M Verdegaal
  • F Ossendorp
  • D L Roelen
  • J A Kummer
  • B O Roep
  • L R Schurmans
  • H Waldmann
  • M Spaargaren
  • A Gorter
  • G Hale
  • P van de Linde
  • J Hendriks
  • Elza C de Bruin
  • M Hahne
  • E C de Bruin
  • B Pradet-Balade
  • A van Elsas
  • M van Eijk
  • O M H Tysma
  • Cornelis J H Van De Velde
  • Minke M C van der Zee
  • Lucy T C Peltenburg
  • J Han J M van Krieken
  • Corrie A M Marijnen
  • Paul H C Eilers
  • J de Jong-Odding
  • S T Pals
  • Marcel Lombaerts
  • Simone van de Pas
  • G Hardenberg
  • Esther H Lips
  • Tom van Wezel
  • Ronald van Eijk
  • L Planelles
  • L T C Peltenburg
  • I den Otter
  • E M Schipper
  • J de Wilde
  • D Meersma
  • G M Kolfschoten
  • M L√≥pez-Fraga
  • C Martinez-A
  • J A Garcia-Sanz
  • J C Lozano
  • A Picard
  • J Ziskin
  • J Villasenor
  • R P Sutmuller
  • N P Restifo
  • C J Melief
  • W W Overwijk
  • J P Allison
  • C de Groot
  • A A Hurwitz

Detail Information

Publications16

  1. pmc Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles
    Elza C de Bruin
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Genomics 6:142. 2005
    ....
  2. ncbi request reprint The uncertain glory of APRIL
    J P Medema
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands
    Cell Death Differ 10:1121-5. 2003
    ..BLyS has recently been the subject of several reviews (for an extensive review, see Mackay et al.). The present review will thus focus on APRIL, and discuss BLyS only briefly for the sake of clarity...
  3. pmc Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells
    J P Medema
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center LUMC, 2333ZA Leiden, The Netherlands
    J Exp Med 194:657-67. 2001
    ..Our data identify SPI-6 as a novel marker for DC function, which protects DCs against CTL-induced apoptosis...
  4. pmc Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
    J P Medema
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 98:11515-20. 2001
    ..Our data reveal that PI-9/SPI-6 is an important parameter determining the success of T cell-based immunotherapeutic modalities against cancer...
  5. ncbi request reprint Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis
    L R Schurmans
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 167:5832-7. 2001
    ..Taken together, these observations demonstrate that CD4(+) T cells are able to eradicate MHC class II-negative tumors in an immune-privileged site without affecting surrounding tissues or the induction of phthisis...
  6. ncbi request reprint Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation
    J Hendriks
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    Cell Death Differ 12:637-48. 2005
    ..We therefore conclude that either HSPG serve as a receptor for APRIL or that HSPG binding allows APRIL to interact with a receptor that promotes tumor growth...
  7. ncbi request reprint T cell signaling: a decision of life and death
    J P Medema
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, The Netherlands
    Hum Immunol 60:403-11. 1999
    ....
  8. ncbi request reprint Mechanisms of antibody immunotherapy on clonal islet reactive T cells
    P van de Linde
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 67:264-73. 2006
    ..ATG and the humanized monoclonal antibodies displayed contrasting mechanisms of action...
  9. ncbi request reprint A serine protease is involved in the initiation of DNA damage-induced apoptosis
    E C de Bruin
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Death Differ 10:1204-12. 2003
    ..This indicates that this novel pathway fulfills a critical role in the execution of etoposide-induced programmed cell death...
  10. pmc Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    J P Medema
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Exp Med 190:1033-8. 1999
    ....
  11. pmc An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein
    B Pradet-Balade
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, E 28049 Madrid, Spain
    EMBO J 21:5711-20. 2002
    ..Much like membrane-bound and secreted TNF-alpha, the different cellular localizations of TWE-PRIL and APRIL suggest that they exert distinct biological roles...
  12. pmc Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy
    A van Elsas
    Howard Hughes Medical Institute and Cancer Research Lab, University of California, Berkeley, CA 94720, USA
    J Exp Med 194:481-9. 2001
    ..Our data demonstrate that therapeutic autoreactive CD8(+) T cell responses can effectively be generated in tumor-bearing mice and stresses the value of studying tumor immunity in a therapeutic rather than a prophylactic setting...
  13. ncbi request reprint Suicide determines self
    J P Medema
    Cell Death Differ 9:364-6. 2002
  14. ncbi request reprint Cutting edge: cellular Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein protects germinal center B cells from apoptosis during germinal center reactions
    M van Eijk
    Department of Cell Biology and Histology, Cellular Immunology Group, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Immunol 166:6473-6. 2001
    ....
  15. pmc FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
    J P Medema
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    EMBO J 16:2794-804. 1997
    ..Taken together, our data indicate that FLICE is the first in a cascade of ICE-like proteases activated by CD95 and that this activation requires a functional CD95 DISC...
  16. ncbi request reprint Nucleotide sequence of the tumor necrosis factor: a gene in seven different inbred mouse strains
    J P Medema
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    Immunogenetics 40:243-4. 1994