Marion Maat Schieman

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
    Marion L C Maat-Schieman
    Department of Neurology, K5Q 97, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 107:389-98. 2004
  2. ncbi Neuronal intranuclear and neuropil inclusions for pathological assessment of Huntington's disease
    Marion Maat-Schieman
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Brain Pathol 17:31-7. 2007
  3. ncbi Hereditary cerebral hemorrhage with amyloidosis-Dutch type
    Marion Maat-Schieman
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Neuropathology 25:288-97. 2005
  4. ncbi Hypocretin and melanin-concentrating hormone in patients with Huntington disease
    Ahmad Aziz
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Brain Pathol 18:474-83. 2008
  5. ncbi Famous Russian brains: historical attempts to understand intelligence
    Alla A Vein
    Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Brain 131:583-90. 2008
  6. ncbi Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
  7. ncbi Inclusion body myositis. Clinical features and clinical course of the disease in 64 patients
    Umesh A Badrising
    Dept of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol 252:1448-54. 2005
  8. ncbi Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
    Martin C Herzig
    Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, , , Germany
    Nat Neurosci 7:954-60. 2004
  9. ncbi Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 106:107-11. 2003
  10. ncbi Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo
    Umesh A Badrising
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Ann Neurol 51:369-72. 2002

Collaborators

Detail Information

Publications16

  1. ncbi Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
    Marion L C Maat-Schieman
    Department of Neurology, K5Q 97, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 107:389-98. 2004
    ..Abeta sequestration by glial cells may be a factor limiting the levels of neurotoxic soluble Abeta oligomers in HCHWA-D brain...
  2. ncbi Neuronal intranuclear and neuropil inclusions for pathological assessment of Huntington's disease
    Marion Maat-Schieman
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Brain Pathol 17:31-7. 2007
    ..These results indicate that immunohistochemical analysis for HD inclusions facilitates the pathological evaluation of HD and enhances its accuracy...
  3. ncbi Hereditary cerebral hemorrhage with amyloidosis-Dutch type
    Marion Maat-Schieman
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Neuropathology 25:288-97. 2005
    ..However, the relative importance of cerebral hemorrhages/infarcts, white matter damage and/or other CAA- or Abeta-related factors for cognitive deterioration in HCHWA-D remains to be determined...
  4. ncbi Hypocretin and melanin-concentrating hormone in patients with Huntington disease
    Ahmad Aziz
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Brain Pathol 18:474-83. 2008
    ..As the number of MCH-expressing neurons was not affected, alterations in MCH signaling are unlikely to have clinical effects in HD patients...
  5. ncbi Famous Russian brains: historical attempts to understand intelligence
    Alla A Vein
    Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Brain 131:583-90. 2008
    ..The (re)discovery of the records of the brain autopsies is meaningful, maybe not so much from a neuroanatomical point of view as from a historical perspective...
  6. ncbi Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
    ..We conclude that HspB8 might play an important role in regulating Abeta aggregation and, therefore, the development of classic SPs in AD and CAA in HCHWA-D...
  7. ncbi Inclusion body myositis. Clinical features and clinical course of the disease in 64 patients
    Umesh A Badrising
    Dept of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol 252:1448-54. 2005
    ..IBM has a unique distribution of muscle weakness. Ankylotic contractures are common. We feel that their joint impact on daily functioning is characteristic for the disease...
  8. ncbi Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
    Martin C Herzig
    Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, , , Germany
    Nat Neurosci 7:954-60. 2004
    ....
  9. ncbi Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 106:107-11. 2003
    ..Confirmation by DNA analysis is requisite for positive results, and when there exists high clinical suspicion, also for negative results...
  10. ncbi Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo
    Umesh A Badrising
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Ann Neurol 51:369-72. 2002
    ..Serum creatine kinase activity decreased significantly in the methotrexate group. We conclude that oral methotrexate did not slow down progression of muscle weakness but decreased serum creatine kinase activity...
  11. ncbi Orexin loss in Huntington's disease
    Asa Petersen
    Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden
    Hum Mol Genet 14:39-47. 2005
    ..Our results show that the loss of orexin is a novel and potentially very important pathology in HD...
  12. ncbi The cerebral beta-amyloid angiopathies: hereditary and sporadic
    Sandy X Zhang-Nunes
    Neurology Clinical Trials Unit and MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Brain Pathol 16:30-9. 2006
    ....
  13. ncbi Cholinergic neuronal defect without cell loss in Huntington's disease
    Ruben Smith
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden
    Hum Mol Genet 15:3119-31. 2006
    ..Taken together, our data show that the cholinergic system is dysfunctional in R6/1 and HD patients. Consequently, they provide a rationale for testing of pro-cholinergic drugs in this disease...
  14. ncbi Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases
    Remko de Pril
    Research Team Molecular Misreading, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Hum Mol Genet 13:1803-13. 2004
    ..These findings implicate UBB(+1) as an aggravating factor in polyglutamine-induced neurodegeneration, and clearly identify an important role for the ubiquitin-proteasome system in polyglutamine diseases...
  15. ncbi Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Center, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 171:1989-99. 2007
    ..Although perivascular cells may adapt their A beta internalization capacity to the levels of A beta present, saturated LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells...
  16. ncbi Islet beta-cell area and hormone expression are unaltered in Huntington's disease
    Karl Bacos
    Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91 11, 205 02 Malmo, Sweden
    Histochem Cell Biol 129:623-9. 2008
    ..This may lead to a better understanding of HD and provide novel therapeutic targets for symptomatic treatment in HD...