J H N Lindeman

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Ghrelin and the hyposomatotropism of obesity
    Jan H N Lindeman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Obes Res 10:1161-6. 2002
  2. pmc A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation
    Evelien van der Meij
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e53882. 2013
  3. pmc Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study
    C Arnoud Meijer
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
    Clin Sci (Lond) 122:421-8. 2012
  4. doi request reprint Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells
    Jan H N Lindeman
    Department of Vascular Surgery, K6R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 119:2209-16. 2009
  5. ncbi request reprint Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
    Jan H N Lindeman
    Department of Vascular and Transplantation Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin Sci (Lond) 114:687-97. 2008
  6. ncbi request reprint Human visceral adipose tissue and the plasminogen activator inhibitor type 1
    J H N Lindeman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Int J Obes (Lond) 31:1671-9. 2007
  7. ncbi request reprint Postnatal changes in plasma ceruloplasmin and transferrin antioxidant activities in preterm babies
    J H Lindeman
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Biol Neonate 78:73-6. 2000
  8. pmc Cathepsin K is the principal protease in giant cell tumor of bone
    Jan H N Lindeman
    Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
    Am J Pathol 165:593-600. 2004
  9. ncbi request reprint The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms
    Hazem Abdul-Hussien
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 51:1479-87. 2010
  10. ncbi request reprint Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms
    Lars Verschuren
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Antioxid Redox Signal 7:1195-202. 2005

Collaborators

  • Robert Kleemann
  • Dieter Bromme
  • P H C Eilers
  • Karoly Szuhai
  • H Pijl
  • Pancras Cw Hogendoorn
  • Dave Roelen
  • Juanita H Vernooy
  • M S Westerterp-Plantenga
  • P ten Dijke
  • C J Hukshorn
  • Emiel F M Wouters
  • W H Saris
  • J Hajo van Bockel
  • Hazem Abdul-Hussien
  • Roeland Hanemaaijer
  • C Arnoud Meijer
  • L J A C Hawinkels
  • Evelien van der Meij
  • C A Meijer
  • J F Hamming
  • R A van Dijk
  • Teake Kooistra
  • Vincent van Weel
  • Lars Verschuren
  • E Wiercinska
  • W Mesker
  • J M Van der Zon
  • H W Verspaget
  • C F M Sier
  • M Paauwe
  • K Van der Ploeg
  • P J Koelink
  • Giel G Koning
  • Marcel F Peeters
  • Ronald L Dalman
  • Kim E Kortekaas
  • Patrick W Vriens
  • C C Engels
  • A Mulder-Stapel
  • Pum A A Le Haen
  • V B C Kokje
  • A F Schaapherder
  • Mitsuhisa Hira
  • R B M Van Tongeren
  • G M Möller
  • J H van Bockel
  • Rogier A van Dijk
  • Jaap F Hamming
  • Ben F J Verhaaren
  • Robert H Geelkerken
  • Jan H Verheijen
  • Victor W M van Hinsbergh
  • Adri Mulder
  • Pien M Delis-van Diemen
  • Jan H von der Thüsen
  • Ratna G V Soekhoe
  • Ingeborg M Bajema
  • Paul H A Quax
  • Reinier O Schlingemann
  • Esther J Kuiper
  • Ekkehard Weber
  • Margreet R De Vries
  • Leonard Seghers

Detail Information

Publications19

  1. ncbi request reprint Ghrelin and the hyposomatotropism of obesity
    Jan H N Lindeman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Obes Res 10:1161-6. 2002
    ..It may thus be hypothesized that low ghrelin levels underlie the hyposomatropism in obesity...
  2. pmc A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation
    Evelien van der Meij
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e53882. 2013
    ..Evaluation of the clinical efficacy of statins to reduce AAA progression did not indicate an effect of statins on aneurysm growth (P<0.337). Hence, in the context of AAA the clinical relevance of statins pleiotropy appears minimal...
  3. pmc Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study
    C Arnoud Meijer
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
    Clin Sci (Lond) 122:421-8. 2012
    ..51 μg/ml, P=0.05) and did not affect any of the other markers of systemic inflammation and vascular function. Our studies do not characterize AP-1 as a therapeutic target for progressive human atherosclerotic disease...
  4. doi request reprint Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells
    Jan H N Lindeman
    Department of Vascular Surgery, K6R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 119:2209-16. 2009
    ..We thus hypothesized that doxycycline acts through an effect on vascular inflammation...
  5. ncbi request reprint Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
    Jan H N Lindeman
    Department of Vascular and Transplantation Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin Sci (Lond) 114:687-97. 2008
    ....
  6. ncbi request reprint Human visceral adipose tissue and the plasminogen activator inhibitor type 1
    J H N Lindeman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Int J Obes (Lond) 31:1671-9. 2007
    ..The objective of this study was to systematically evaluate the molecular basis of the association between visceral fat mass and plasma plasminogen activator inhibitor-1 (PAI-1) levels in man...
  7. ncbi request reprint Postnatal changes in plasma ceruloplasmin and transferrin antioxidant activities in preterm babies
    J H Lindeman
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Biol Neonate 78:73-6. 2000
    ..We have previously shown that this phenomenon is probably due to the presence of non-protein-bound iron...
  8. pmc Cathepsin K is the principal protease in giant cell tumor of bone
    Jan H N Lindeman
    Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
    Am J Pathol 165:593-600. 2004
    ..Inhibition of cathepsin K or its associated proton-pump may provide new therapeutic opportunities for GCT...
  9. ncbi request reprint The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms
    Hazem Abdul-Hussien
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 51:1479-87. 2010
    ..On this basis, we reasoned that information of corresponding and discordant processes in these aneurysms might provide critical clues on the processes that are crucial for aneurysm progression...
  10. ncbi request reprint Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms
    Lars Verschuren
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Antioxid Redox Signal 7:1195-202. 2005
    ..MMP-1 (in SMCs and macrophages) and MMP-9 (in macrophages) were colocalized with MIF at the cellular level in ruptured AAA. The up-regulation of aneurysmal MIF/MMP expression was associated with an increased content of cytotoxic T cells...
  11. doi request reprint An association between chronic obstructive pulmonary disease and abdominal aortic aneurysm beyond smoking: results from a case-control study
    C A Meijer
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Vasc Endovasc Surg 44:153-7. 2012
    ..Given the persistent controversy with regard to the association between AAA and COPD, we studied this association in depth...
  12. doi request reprint Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
    Hazem Abdul-Hussien
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 49:741-9. 2009
    ....
  13. pmc Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases
    Hazem Abdul-Hussien
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 170:809-17. 2007
    ..We found indications that this secondary deficiency relates to cystatin C degradation by (neutrophil-derived) proteases...
  14. ncbi request reprint Visualizing TGF-β and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation
    R A van Dijk
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, Netherlands
    Histol Histopathol 27:387-96. 2012
    ..However, their role in human disease remains controversial. In this study we used Smad phosphorylation as a read out for TGF-β and BMP signaling during the initiation, progression and (de)stabilization of human atherosclerotic disease...
  15. doi request reprint Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts
    L J A C Hawinkels
    1 Department of Gastroenterology Hepatology, Leiden University Medical Centre, Leiden, The Netherlands 2 Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Oncogene 33:97-107. 2014
    ..In turn this leads to cumulative production of TGF-β and proteinases within the tumor microenvironment, creating a cancer-promoting feedback loop. ..
  16. pmc Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome
    Jan H N Lindeman
    Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:862-5. 2010
    ..These studies demonstrate that the mechanical properties of tissue are strongly influenced by collagen microarchitecture and that perturbations in the collagen networks may lead to mechanical failure...
  17. ncbi request reprint Leptin and the proinflammatory state associated with human obesity
    Chris J Hukshorn
    NUTRIM, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:1773-8. 2004
    ..05) was the sole indication for a humoral proinflammatory action of leptin. Although PEG-OB treatment significantly increased weight loss (P < 0.03), the data do not support a proinflammatory role of leptin in human obesity...
  18. ncbi request reprint Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD
    Juanita H J Vernooy
    Department of Respiratory Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Chest 126:1802-10. 2004
    ..Yet, quantitative data on MMP activity in the airways of COPD patients are lacking...
  19. ncbi request reprint Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia
    Vincent van Weel
    Gaubius Laboratory TNO Quality of Life, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1426-32. 2007
    ..Here, evidence for this is provided in patients with peripheral artery disease...