Research Topics
Species | J H N LindemanSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Ghrelin and the hyposomatotropism of obesityJan H N Lindeman
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
Obes Res 10:1161-6. 2002..It may thus be hypothesized that low ghrelin levels underlie the hyposomatropism in obesity...- Postnatal changes in plasma ceruloplasmin and transferrin antioxidant activities in preterm babiesJ H Lindeman
Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
Biol Neonate 78:73-6. 2000..We have previously shown that this phenomenon is probably due to the presence of non-protein-bound iron... - Human visceral adipose tissue and the plasminogen activator inhibitor type 1J H N Lindeman
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
Int J Obes (Lond) 31:1671-9. 2007..The objective of this study was to systematically evaluate the molecular basis of the association between visceral fat mass and plasma plasminogen activator inhibitor-1 (PAI-1) levels in man... - Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysmJan H N Lindeman
Department of Vascular and Transplantation Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Clin Sci (Lond) 114:687-97. 2008.... - Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cellsJan H N Lindeman
Department of Vascular Surgery, K6R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Circulation 119:2209-16. 2009..We thus hypothesized that doxycycline acts through an effect on vascular inflammation... - Cathepsin K is the principal protease in giant cell tumor of boneJan H N Lindeman
Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
Am J Pathol 165:593-600. 2004..Inhibition of cathepsin K or its associated proton-pump may provide new therapeutic opportunities for GCT... - The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysmsHazem Abdul-Hussien
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
J Vasc Surg 51:1479-87. 2010..On this basis, we reasoned that information of corresponding and discordant processes in these aneurysms might provide critical clues on the processes that are crucial for aneurysm progression... - Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysmsLars Verschuren
Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
Antioxid Redox Signal 7:1195-202. 2005..MMP-1 (in SMCs and macrophages) and MMP-9 (in macrophages) were colocalized with MIF at the cellular level in ruptured AAA. The up-regulation of aneurysmal MIF/MMP expression was associated with an increased content of cytotoxic T cells... - Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil contentHazem Abdul-Hussien
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
J Vasc Surg 49:741-9. 2009.... - Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenasesHazem Abdul Hussien
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
Am J Pathol 170:809-17. 2007..We found indications that this secondary deficiency relates to cystatin C degradation by (neutrophil-derived) proteases... - An association between chronic obstructive pulmonary disease and abdominal aortic aneurysm beyond smoking: results from a case-control studyC A Meijer
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
Eur J Vasc Endovasc Surg 44:153-7. 2012..Given the persistent controversy with regard to the association between AAA and COPD, we studied this association in depth... - Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndromeJan H N Lindeman
Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Proc Natl Acad Sci U S A 107:862-5. 2010..These studies demonstrate that the mechanical properties of tissue are strongly influenced by collagen microarchitecture and that perturbations in the collagen networks may lead to mechanical failure... - Leptin and the proinflammatory state associated with human obesityChris J Hukshorn
NUTRIM, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
J Clin Endocrinol Metab 89:1773-8. 2004..05) was the sole indication for a humoral proinflammatory action of leptin. Although PEG-OB treatment significantly increased weight loss (P < 0.03), the data do not support a proinflammatory role of leptin in human obesity... - Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPDJuanita H J Vernooy
Department of Respiratory Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Chest 126:1802-10. 2004..Yet, quantitative data on MMP activity in the airways of COPD patients are lacking... - Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemiaVincent van Weel
Gaubius Laboratory TNO Quality of Life, P O Box 2215, 2301CE Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 27:1426-32. 2007..Here, evidence for this is provided in patients with peripheral artery disease...