M K Liem
Affiliation: Leiden University Medical Center
Country: The Netherlands
Liem M, van der Grond J, Haan J, van den Boom R, Ferrari M, Knaap Y, et al
. Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL. Stroke. 2007;38:923-8 pubmed
..Lacunar infarct lesion load is the most important MRI parameter associated with cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. ..
Liem M, Lesnik Oberstein S, Haan J, van der Neut I, van den Boom R, Ferrari M, et al
. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: progression of MR abnormalities in prospective 7-year follow-up study. Radiology. 2008;249:964-71 pubmed publisher
..Patients with CADASIL who have a high MR abnormality lesion load at baseline are at risk for faster progression of MR abnormalities. ..
Liem M, Oberstein S, van der Grond J, Ferrari M, Haan J. CADASIL and migraine: A narrative review. Cephalalgia. 2010;30:1284-9 pubmed
..In this narrative review we summarize the literature about migraine in CADASIL, with a special focus on what CADASIL might teach us about the pathophysiology of migraine. ..
Liem M, Lesnik Oberstein S, Haan J, van der Neut I, Ferrari M, van Buchem M, et al
. MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study. Neurology. 2009;72:143-8 pubmed publisher
..Increase in lacunar infarcts, microbleeds, and ventricular volume, but not white matter lesions or atrophy, are associated with cognitive decline in the process of CADASIL in younger-aged, mildly affected patients with CADASIL. ..
Liem M, van der Grond J, Versluis M, Haan J, Webb A, Ferrari M, et al
. Lenticulostriate arterial lumina are normal in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a high-field in vivo MRI study. Stroke. 2010;41:2812-6 pubmed publisher
..The aim of this study is to examine the luminal diameters of lenticulostriate arteries in living patients with CADASIL and to investigate whether luminal narrowing is correlated with the number of lacunar infarcts in the basal ganglia...
Liem M, Lesnik Oberstein S, Versluis M, Maat Schieman M, Haan J, Webb A, et al
. 7 T MRI reveals diffuse iron deposition in putamen and caudate nucleus in CADASIL. J Neurol Neurosurg Psychiatry. 2012;83:1180-5 pubmed publisher
..This supports the hypothesis that small vessel disease contributes to the process of increased iron accumulation in the general population. ..