Heleen Lie Venema

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development
    Edris A F Mahtab
    Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands
    Dev Dyn 237:847-57. 2008
  2. ncbi request reprint Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    ScientificWorldJournal 7:1777-98. 2007
  3. doi request reprint Epicardium-derived cells in development of annulus fibrosis and persistence of accessory pathways
    Denise P Kolditz
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Circulation 117:1508-17. 2008
  4. pmc The role of the epicardium and neural crest as extracardiac contributors to coronary vascular development
    Robert E Poelmann
    Department of Anatomy and Embryology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Tex Heart Inst J 29:255-61. 2002
  5. ncbi request reprint Myocardial heterogeneity in permissiveness for epicardium-derived cells and endothelial precursor cells along the developing heart tube at the onset of coronary vascularization
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Anat Rec A Discov Mol Cell Evol Biol 282:120-9. 2005
  6. doi request reprint PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 237:494-503. 2008
  7. doi request reprint Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden Postal zone S 1 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Differentiation 76:809-19. 2008
  8. ncbi request reprint Platelet-derived growth factors in the developing avian heart and maturating coronary vasculature
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 233:1579-88. 2005
  9. ncbi request reprint Coronary artery and orifice development is associated with proper timing of epicardial outgrowth and correlated Fas-ligand-associated apoptosis patterns
    Ismail Eralp
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Circ Res 96:526-34. 2005
  10. ncbi request reprint Ets-1 and Ets-2 transcription factors are essential for normal coronary and myocardial development in chicken embryos
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, 2300 RC Leiden, The Netherlands
    Circ Res 92:749-56. 2003

Collaborators

  • Adriana C Gittenberger-de Groot
  • Nico A Blom
  • ROBERT GOURDIE
  • Heleen Lie-Venema
  • Robert E Poelmann
  • Nynke M S Van Den Akker
  • Ismail Eralp
  • Marco C DeRuiter
  • Martin J Schalij
  • Maurits C E F Wijffels
  • Saskia Maas
  • Denise P Kolditz
  • Arnoud van der Laarse
  • Ad J J C Bogers
  • Lambertus J Wisse
  • Roger R Markwald
  • Nathan D Hahurij
  • Edris A F Mahtab
  • Noortje A M Bax
  • Christer Betsholtz
  • Bernd R Binder
  • Pavel Uhrin
  • Maya H Nisancioglu
  • Annika Armulik
  • Jan Zaujec
  • Leah C J Winkel
  • Elizabeth M Winter
  • Tuija Kekarainen
  • Rob C Hoeben
  • Monica M T Mentink
  • Henri Kerkdijk
  • Louis J P van Empel
  • Eric de Kant
  • Marit J Boot

Detail Information

Publications11

  1. doi request reprint Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development
    Edris A F Mahtab
    Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands
    Dev Dyn 237:847-57. 2008
    ..Abnormal epicardial differentiation and reduced epithelial-mesenchymal transformation result in deficient epicardium-derived cells leading to myocardial pathology and cardiac anomalies...
  2. ncbi request reprint Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    ScientificWorldJournal 7:1777-98. 2007
    ..Lastly, we focus on the congenital heart anomalies that might be caused primarily by an epicardial developmental defect...
  3. doi request reprint Epicardium-derived cells in development of annulus fibrosis and persistence of accessory pathways
    Denise P Kolditz
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Circulation 117:1508-17. 2008
    ..In the present study, we investigated the role of epicardium-derived cells (EPDCs) in annulus fibrosis formation and the occurrence of APs...
  4. pmc The role of the epicardium and neural crest as extracardiac contributors to coronary vascular development
    Robert E Poelmann
    Department of Anatomy and Embryology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Tex Heart Inst J 29:255-61. 2002
    ....
  5. ncbi request reprint Myocardial heterogeneity in permissiveness for epicardium-derived cells and endothelial precursor cells along the developing heart tube at the onset of coronary vascularization
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Anat Rec A Discov Mol Cell Evol Biol 282:120-9. 2005
    ..We conclude that early coronary formation starts in the inner curvature and hypothesize that the presence of PEO-derived cells is essential for the maturation of the inner curvature and subsequent looping of the heart tube...
  6. doi request reprint PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 237:494-503. 2008
    ..This implies a role for PDGF-B/PDGFR-beta-signaling specifically in the contribution of these cell lineages to cardiac development...
  7. doi request reprint Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden Postal zone S 1 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Differentiation 76:809-19. 2008
    ..The resulting cardiac anomalies might link to Wolff-Parkinson White syndrome with persistent AV myocardial connections...
  8. ncbi request reprint Platelet-derived growth factors in the developing avian heart and maturating coronary vasculature
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 233:1579-88. 2005
    ..Epicardium-derived cells in the atrioventricular cushions expressed PDGFR-beta. We conclude that all four proteins are involved in myocardial development, whereas PDGF-B and PDGFR-beta are specifically important in coronary maturation...
  9. ncbi request reprint Coronary artery and orifice development is associated with proper timing of epicardial outgrowth and correlated Fas-ligand-associated apoptosis patterns
    Ismail Eralp
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Circ Res 96:526-34. 2005
    ..Also apoptosis in the peritruncal region is diminished. During later development, this leads to defective or absent connections of the coronary system to the systemic circulation...
  10. ncbi request reprint Ets-1 and Ets-2 transcription factors are essential for normal coronary and myocardial development in chicken embryos
    Heleen Lie-Venema
    Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, 2300 RC Leiden, The Netherlands
    Circ Res 92:749-56. 2003
    ..The presence of coronary vascular aberrations in the antisense-Ets phenotype enabled us for the first time to study abnormal coronary development in a model that is not lethal to the embryo...
  11. pmc Epicardium-derived cells are important for correct development of the Purkinje fibers in the avian heart
    Ismail Eralp
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Anat Rec A Discov Mol Cell Evol Biol 288:1272-80. 2006
    ..We conclude that EPDCs are instrumental in Purkinje fiber differentiation, and we hypothesize that they cooperate directly with endothelial and endocardial cells in the development of the peripheral conduction system...