Saskia A J Lesnik Oberstein
Affiliation: Leiden University Medical Center
Country: The Netherlands
Lesnik Oberstein S, van den Boom R, Middelkoop H, Ferrari M, Knaap Y, van Houwelingen H, et al
. Incipient CADASIL. Arch Neurol. 2003;60:707-12 pubmed
..Awareness of the clinical and radiological features of CADASIL in those younger than 35 years should increase early diagnosis and allow for customized counseling of young adults from families with CADASIL. ..
Lesnik Oberstein S, van Duinen S, van den Boom R, Maat Schieman M, van Buchem M, van Houwelingen H, et al
. Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. Acta Neuropathol. 2003;106:107-11 pubmed
..Confirmation by DNA analysis is requisite for positive results, and when there exists high clinical suspicion, also for negative results. ..
Lesnik Oberstein S, Jukema J, van Duinen S, Macfarlane P, van Houwelingen H, Breuning M, et al
. Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Medicine (Baltimore). 2003;82:251-6 pubmed
..To our knowledge, this is the first study showing that NOTCH3 mutation carriers may be at increased risk of early acute myocardial infarction, expanding CADASIL disease expression beyond the central nervous system to include the heart. ..