Affiliation: Leiden University
Country: The Netherlands
Lammers B, Out R, Hildebrand R, Quinn C, Williamson D, Hoekstra M, et al
. Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development. Atherosclerosis. 2009;205:420-6 pubmed publisher
..A possible interaction between Abcg1 and Apoe in cholesterol efflux was postulated, but the potential combined action of these proteins on atherosclerotic lesion formation is unclear...
Lammers B, Zhao Y, Hoekstra M, Hildebrand R, Ye D, Meurs I, et al
. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. PLoS ONE. 2011;6:e26095 pubmed publisher
..In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored...
Lammers B, Zhao Y, Foks A, Hildebrand R, Kuiper J, Van Berkel T, et al
. Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice. PLoS ONE. 2012;7:e48080 pubmed publisher
..In the present study, we aimed to explore the importance of the spleen for the atheroprotective effects of leukocyte ABCA1...
Lammers B, Chandak P, Aflaki E, van Puijvelde G, Radovic B, Hildebrand R, et al
. Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2011;31:67-73 pubmed publisher
..We conclude that the attenuation of atherogenesis in ATGL KO?LDLr KO mice is due to decreased infiltration of less inflammatory macrophages into the arterial wall and increased macrophage apoptosis. ..