Maris Kuningas

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi Genes encoding longevity: from model organisms to humans
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Aging Cell 7:270-80. 2008
  2. ncbi SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:960-5. 2007
  3. pmc Common CFTR gene variants influence body composition and survival in rural Ghana
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center LUMC, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Genet 127:201-6. 2010
  4. ncbi Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neuropsychopharmacology 32:1295-301. 2007
  5. ncbi Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 15:294-301. 2007
  6. ncbi VDR gene variants associate with cognitive function and depressive symptoms in old age
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neurobiol Aging 30:466-73. 2009
  7. pmc Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7795. 2009
  8. doi Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Biol Reprod 82:299-304. 2010
  9. ncbi Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center LUMC, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Biogerontology 7:231-8. 2006
  10. ncbi Liver X receptor alpha associates with human life span
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:343-9. 2007

Detail Information

Publications16

  1. doi Genes encoding longevity: from model organisms to humans
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Aging Cell 7:270-80. 2008
    ..In conclusion, although the study of model organisms has revealed potential candidate genetic mechanisms determining aging and lifespan, to what extent they explain variation in human populations is still uncertain...
  2. ncbi SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:960-5. 2007
    ..In conclusion, our results indicate a role for SIRT1 in cognitive functioning, but the role in life span remains to be elucidated...
  3. pmc Common CFTR gene variants influence body composition and survival in rural Ghana
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center LUMC, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Genet 127:201-6. 2010
    ..In conclusion, we identified common haplotypes in the CFTR gene that influence survival and body composition in the population at large with no evidence for heterozygote advantage...
  4. ncbi Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neuropsychopharmacology 32:1295-301. 2007
    ..In contrast, these genetic variants in the MR and GR genes do not influence cognitive functioning in old age...
  5. ncbi Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 15:294-301. 2007
    ..036) and 1.19-fold increased risk for cardiovascular mortality (P=0.052). In conclusion, this study shows that genetic variation in evolutionarily conserved Foxo1a and Foxo3a genes influences lifespan in our study population...
  6. ncbi VDR gene variants associate with cognitive function and depressive symptoms in old age
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neurobiol Aging 30:466-73. 2009
    ..In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms...
  7. pmc Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7795. 2009
    ..Pro-inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions...
  8. doi Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Biol Reprod 82:299-304. 2010
    ..003) and higher fertility (P = 0.043). The results reported here provide the first evidence, based on protein production and analysis of polymorphisms, that the long pentraxin PTX3 plays a role in female fertility in humans...
  9. ncbi Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center LUMC, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Biogerontology 7:231-8. 2006
    ..We conclude that, in spite the effect of the ER22/23EK and N363S SNPs on metabolism, these polymorphisms together with the BclI SNP, do not affect the risks of cardiovascular disease and survival at old age...
  10. ncbi Liver X receptor alpha associates with human life span
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:343-9. 2007
    ..018), and higher levels of triglycerides (p =.041). Genetic variation in the gene coding for the LXRalpha (NR1H3) associates with human life span...
  11. pmc Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 18:490-5. 2010
    ..In conclusion, we demonstrate that genetic variation within the TLR4 gene influences cytokine production capacity, but in an endemic area does not influence the susceptibility to malaria infection or mortality...
  12. pmc Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 10:686-98. 2011
    ..005). In conclusion, the major locus determining familial longevity up to high age as detected by GWAS was marked by rs2075650, which tags the deleterious effects of the ApoE ε4 allele. No other major longevity locus was found...
  13. doi When grandmothers matter
    David Van Bodegom
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Gerontology 56:214-6. 2010
    ..We also show that in a population that reflects our evolutionary past, grandmothers do not have an important role for child survival. Finally, we react on the implications for the study of cognitive ageing as put forward by Herndon...
  14. doi Socio-economic status by rapid appraisal is highly correlated with mortality risks in rural Africa
    David Van Bodegom
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, RC Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 103:795-800. 2009
    ..81 (95% CI 0.32-2.03)] and higher interviewer-reported wealth [HR 0.84 (95% CI 0.58-1.21)]. Similar discriminative mortality risks were assessed when using tertiles of the DHS wealth index (Ptrend<0.001)...
  15. ncbi Impact of genetic variations in the WRN gene on age related pathologies and mortality
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC Leiden, The Netherlands
    Mech Ageing Dev 127:307-13. 2006
    ..In conclusion, the i1-C/T, L1074F and C1367R polymorphisms in the WRN gene do not influence the aging-trajectories and survival in the population at large...
  16. pmc Adverse environmental conditions influence age-related innate immune responsiveness
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Immun Ageing 6:7. 2009
    ..CONCLUSION-: We conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions...