Suzanne Korporaal

Summary

Publications

  1. ncbi request reprint Relative importance of the LDL receptor and scavenger receptor class B in the beta-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages
    N Herijgers
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
    J Lipid Res 41:1163-71. 2000
  2. doi request reprint Genetic variant of the scavenger receptor BI in humans
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 364:136-45. 2011
  3. doi request reprint Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration
    Ramadhan B Matondo
    Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3508 TD Utrecht, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 296:G963-8. 2009
  4. doi request reprint Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2
    Suzanne J A Korporaal
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 29:372-9. 2009
  5. ncbi request reprint Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A
    Suzanne J A Korporaal
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, and Institute of Biomembranes, Utrecht University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2476-83. 2007
  6. ncbi request reprint Activation of human platelets by misfolded proteins
    Eszter Herczenik
    Laboratory of Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1657-65. 2007
  7. ncbi request reprint Lipoprotein-associated proteins involved in platelet signaling
    Suzanne J A Korporaal
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht and The Institute for Biomembranes, University of Utrecht, The Netherlands
    Pathophysiol Haemost Thromb 35:305-13. 2006
  8. ncbi request reprint Platelet activation by low density lipoprotein and high density lipoprotein
    Suzanne J A Korporaal
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht and The Institute for Biomembranes, University of Utrecht, The Netherlands
    Pathophysiol Haemost Thromb 35:270-80. 2006
  9. ncbi request reprint Platelet signaling induced by lipoproteins
    S J A Korporaal
    Thrombosis and Haemostasis Laboratory G03 647, Department of Haematology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cardiovasc Hematol Agents Med Chem 4:93-109. 2006
  10. ncbi request reprint Effect of oxidation on the platelet-activating properties of low-density lipoprotein
    Suzanne J A Korporaal
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:867-72. 2005

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Relative importance of the LDL receptor and scavenger receptor class B in the beta-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages
    N Herijgers
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
    J Lipid Res 41:1163-71. 2000
    ..When the LDL receptor is absent, SR-B appears to mediate the remaining metabolism of cholesteryl esters from beta-VLDL...
  2. doi request reprint Genetic variant of the scavenger receptor BI in humans
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 364:136-45. 2011
    ..Paradoxically, elevated HDL cholesterol levels are associated with increased atherosclerosis in SR-BI-knockout mice. It is unclear what role SR-BI plays in human metabolism...
  3. doi request reprint Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration
    Ramadhan B Matondo
    Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3508 TD Utrecht, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 296:G963-8. 2009
    ..These results provide evidence that liver regeneration is not dependent on the release of serotonin from platelets. Our findings indicate that very low levels of serotonin in blood are sufficient for liver regeneration...
  4. doi request reprint Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2
    Suzanne J A Korporaal
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 29:372-9. 2009
    ..We report a second mechanism that halts LDL signaling and in addition lowers platelet responsiveness to aggregating agents...
  5. ncbi request reprint Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A
    Suzanne J A Korporaal
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, and Institute of Biomembranes, Utrecht University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2476-83. 2007
    ..Here we report a new mechanism for platelet activation by oxLDL...
  6. ncbi request reprint Activation of human platelets by misfolded proteins
    Eszter Herczenik
    Laboratory of Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1657-65. 2007
    ..Amyloids are found in Alzheimer disease, atherosclerosis, diabetes mellitus, and systemic amyloidosis, which are diseases where platelet activation might be implicated...
  7. ncbi request reprint Lipoprotein-associated proteins involved in platelet signaling
    Suzanne J A Korporaal
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht and The Institute for Biomembranes, University of Utrecht, The Netherlands
    Pathophysiol Haemost Thromb 35:305-13. 2006
    ..This review provides a summary of the activation of signaling pathways after platelet-lipoprotein interactions initiated by lipoprotein-associated proteins and lipids...
  8. ncbi request reprint Platelet activation by low density lipoprotein and high density lipoprotein
    Suzanne J A Korporaal
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht and The Institute for Biomembranes, University of Utrecht, The Netherlands
    Pathophysiol Haemost Thromb 35:270-80. 2006
    ..This review provides a summary of the activation of signaling pathways after platelet-LDL and platelet-HDL interaction, with special emphasis on their role in the development of thrombosis and atherosclerosis...
  9. ncbi request reprint Platelet signaling induced by lipoproteins
    S J A Korporaal
    Thrombosis and Haemostasis Laboratory G03 647, Department of Haematology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cardiovasc Hematol Agents Med Chem 4:93-109. 2006
    ..This review provides a summary of the activation of signaling pathways after platelet-lipoprotein interactions, with special emphasis on the role of these interactions in the development of thrombosis and atherosclerosis...
  10. ncbi request reprint Effect of oxidation on the platelet-activating properties of low-density lipoprotein
    Suzanne J A Korporaal
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:867-72. 2005
    ..This study aims to compare platelet activation by native LDL (nLDL) and oxidized LDL (oxLDL)...
  11. ncbi request reprint Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK
    Suzanne J A Korporaal
    Laboratory for Thrombosis and Haemostasis, Department of Haematology, University Medical Center Utrecht and Institute of Biomembranes, University of Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 279:52526-34. 2004
    ..This suggests that exposure of platelets to LDL induces association of apoER2' to Fgr, a kinase that is able to activate p38MAPK. In conclusion, our data indicate that apoER2' contributes to LDL-dependent sensitization of platelets...
  12. ncbi request reprint Lysophosphatidic acid-independent platelet activation by low-density lipoprotein
    S J Korporaal
    Department of Haematology, Laboratory Thrombosis and Haemostasis, Institute for Biomembranes, University Medical Center Utrecht, The Netherlands
    FEBS Lett 494:121-4. 2001
    ..Inhibitors of p38(MAPK) and ADP secretion interfered only partially. Blockade of Rho-kinase increased ligand binding 2-3-fold. We conclude that nLDL enhances TRAP-induced fibrinogen binding independent of LPA...
  13. doi request reprint Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids
    Martin F Brodde
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Muenster, Muenster, Germany
    Atherosclerosis 215:374-82. 2011
    ..We here investigated the role of scavenger receptor class B type I (SR-BI) and CD36 in mediating inhibitory effects of native HDL3 on thrombin-induced platelet activation...
  14. doi request reprint Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice
    Menno Hoekstra
    Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 299:E1038-43. 2010
    ..Therefore, it is suggested that plasma lipoproteins are required for optimal adrenal steroidogenesis and protection against endotoxemia in mice...
  15. doi request reprint Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol
    Suzanne J A Korporaal
    Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:34-42. 2011
    ..In mice, SR-BI deficiency results in increased plasma HDL cholesterol levels and enhanced susceptibility to atherosclerosis. The aim of this study was to investigate the role of SR-BI deficiency on platelet function...
  16. ncbi request reprint Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency
    Reeni B Hildebrand
    Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1439-45. 2010
    ..In this study, it was investigated whether introduction of cholesteryl ester transfer protein (CETP) can normalize HDL-C transport to the liver and reduce atherosclerosis in SR-BI knockout (KO) mice...