Relative importance of the LDL receptor and scavenger receptor class B in the beta-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophagesN Herijgers
Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
J Lipid Res 41:1163-71. 2000
..When the LDL receptor is absent, SR-B appears to mediate the remaining metabolism of cholesteryl esters from beta-VLDL...
Genetic variant of the scavenger receptor BI in humansMenno Vergeer
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
N Engl J Med 364:136-45. 2011
..Paradoxically, elevated HDL cholesterol levels are associated with increased atherosclerosis in SR-BI-knockout mice. It is unclear what role SR-BI plays in human metabolism...
- Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration
Ramadhan B Matondo
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3508 TD Utrecht, The Netherlands
Am J Physiol Gastrointest Liver Physiol 296:G963-8. 2009
..These results provide evidence that liver regeneration is not dependent on the release of serotonin from platelets. Our findings indicate that very low levels of serotonin in blood are sufficient for liver regeneration...
- Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2
Suzanne J A Korporaal
Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
Arterioscler Thromb Vasc Biol 29:372-9. 2009
..We report a second mechanism that halts LDL signaling and in addition lowers platelet responsiveness to aggregating agents...
- Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A
Suzanne J A Korporaal
Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, and Institute of Biomembranes, Utrecht University, The Netherlands
Arterioscler Thromb Vasc Biol 27:2476-83. 2007
..Here we report a new mechanism for platelet activation by oxLDL...
- Activation of human platelets by misfolded proteins
Eszter Herczenik
Laboratory of Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Arterioscler Thromb Vasc Biol 27:1657-65. 2007
..Amyloids are found in Alzheimer disease, atherosclerosis, diabetes mellitus, and systemic amyloidosis, which are diseases where platelet activation might be implicated...
- Lipoprotein-associated proteins involved in platelet signaling
Suzanne J A Korporaal
Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht and The Institute for Biomembranes, University of Utrecht, The Netherlands
Pathophysiol Haemost Thromb 35:305-13. 2006
..This review provides a summary of the activation of signaling pathways after platelet-lipoprotein interactions initiated by lipoprotein-associated proteins and lipids...
- Platelet activation by low density lipoprotein and high density lipoprotein
Suzanne J A Korporaal
Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht and The Institute for Biomembranes, University of Utrecht, The Netherlands
Pathophysiol Haemost Thromb 35:270-80. 2006
..This review provides a summary of the activation of signaling pathways after platelet-LDL and platelet-HDL interaction, with special emphasis on their role in the development of thrombosis and atherosclerosis...
- Platelet signaling induced by lipoproteins
S J A Korporaal
Thrombosis and Haemostasis Laboratory (G03.647, Department of Haematology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands
Cardiovasc Hematol Agents Med Chem 4:93-109. 2006
..This review provides a summary of the activation of signaling pathways after platelet-lipoprotein interactions, with special emphasis on the role of these interactions in the development of thrombosis and atherosclerosis...
- Effect of oxidation on the platelet-activating properties of low-density lipoprotein
Suzanne J A Korporaal
Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
Arterioscler Thromb Vasc Biol 25:867-72. 2005
..CONCLUSIONS: At >30% oxidation, LDL interferes with ligand binding to integrin alpha(IIb)beta3, thereby attenuating platelet functions...
- Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK
Suzanne J A Korporaal
Laboratory for Thrombosis and Haemostasis, Department of Haematology, University Medical Center Utrecht and Institute of Biomembranes, University of Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Biol Chem 279:52526-34. 2004
..This suggests that exposure of platelets to LDL induces association of apoER2' to Fgr, a kinase that is able to activate p38MAPK. In conclusion, our data indicate that apoER2' contributes to LDL-dependent sensitization of platelets...
- Lysophosphatidic acid-independent platelet activation by low-density lipoprotein
S J Korporaal
Department of Haematology, Laboratory Thrombosis and Haemostasis, Institute for Biomembranes, University Medical Center Utrecht, The Netherlands
FEBS Lett 494:121-4. 2001
..Inhibitors of p38(MAPK) and ADP secretion interfered only partially. Blockade of Rho-kinase increased ligand binding 2-3-fold. We conclude that nLDL enhances TRAP-induced fibrinogen binding independent of LPA...
- Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids
Martin F Brodde
Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Muenster, Muenster, Germany
Atherosclerosis 215:374-82. 2011
..We here investigated the role of scavenger receptor class B type I (SR-BI) and CD36 in mediating inhibitory effects of native HDL3 on thrombin-induced platelet activation...
- Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice
Menno Hoekstra
Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
Am J Physiol Endocrinol Metab 299:E1038-43. 2010
..Therefore, it is suggested that plasma lipoproteins are required for optimal adrenal steroidogenesis and protection against endotoxemia in mice...
- Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol
Suzanne J A Korporaal
Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 31:34-42. 2011
..In mice, SR-BI deficiency results in increased plasma HDL cholesterol levels and enhanced susceptibility to atherosclerosis. The aim of this study was to investigate the role of SR-BI deficiency on platelet function...
- Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency
Reeni B Hildebrand
Leiden Amsterdam Center for Drug Research, Division of Biopharmaceutics, Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 30:1439-45. 2010
..In this study, it was investigated whether introduction of cholesteryl ester transfer protein (CETP) can normalize HDL-C transport to the liver and reduce atherosclerosis in SR-BI knockout (KO) mice...
