Frits Koning

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes
    Teun W J M van Herpen
    Allergy Consortium Wageningen, PO Box 16, NL 6700 AA Wageningen, The Netherlands
    BMC Genomics 7:1. 2006
  2. ncbi request reprint Celiac disease--sandwiched between innate and adaptive immunity
    Dariusz Stepniak
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
    Hum Immunol 67:460-8. 2006
  3. pmc Specificity of tissue transglutaminase explains cereal toxicity in celiac disease
    L Willemijn Vader
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
    J Exp Med 195:643-9. 2002
  4. pmc Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule
    Martina Wiesner
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Immunogenetics 60:551-5. 2008
  5. pmc Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation
    Elma M J Salentijn
    Plant Research International, Wageningen UR, P O Box 16, NL 6700 AA, Wageningen, The Netherlands
    BMC Genomics 13:277. 2012
  6. pmc Celiac disease: quantity matters
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Semin Immunopathol 34:541-9. 2012
  7. ncbi request reprint Celiac disease: caught between a rock and a hard place
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
    Gastroenterology 129:1294-301. 2005
  8. ncbi request reprint Gluten: a two-edged sword. Immunopathogenesis of celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, E3 Q, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Springer Semin Immunopathol 27:217-32. 2005
  9. ncbi request reprint Pathomechanisms in celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 19:373-87. 2005
  10. pmc A tertiary twist to the transglutaminase tale
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Biol 5:e337. 2007

Detail Information

Publications63

  1. pmc Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes
    Teun W J M van Herpen
    Allergy Consortium Wageningen, PO Box 16, NL 6700 AA Wageningen, The Netherlands
    BMC Genomics 7:1. 2006
    ..However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the alpha-gliadins contain several peptides that are associated to the disease...
  2. ncbi request reprint Celiac disease--sandwiched between innate and adaptive immunity
    Dariusz Stepniak
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
    Hum Immunol 67:460-8. 2006
    ..Once tolerance is broken, a broad gluten-reactive T cell repertoire may develop through determinant spreading. This may be a critical step toward full-blown disease...
  3. pmc Specificity of tissue transglutaminase explains cereal toxicity in celiac disease
    L Willemijn Vader
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
    J Exp Med 195:643-9. 2002
    ..This provides a rationale for the observation that celiac disease patients are intolerant to these cereal proteins but not to other common food proteins...
  4. pmc Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule
    Martina Wiesner
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Immunogenetics 60:551-5. 2008
    ..Together, these results indicate that HLA-DQ2 and HLA-DQ8 associate with an alternative CLIP sequence, a property that may relate to the strong association between HLA-DQ molecules and human autoimmune diseases...
  5. pmc Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation
    Elma M J Salentijn
    Plant Research International, Wageningen UR, P O Box 16, NL 6700 AA, Wageningen, The Netherlands
    BMC Genomics 13:277. 2012
    ..To pinpoint CD-toxic γ-gliadins in hexaploid bread wheat, we examined the variation of T-cell epitopes involved in CD in γ-gliadin transcripts of developing bread wheat grains...
  6. pmc Celiac disease: quantity matters
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Semin Immunopathol 34:541-9. 2012
    ..Moreover, I discuss whether it is feasible to alter wheat and/or gluten to make it suitable for consumption by CD patients...
  7. ncbi request reprint Celiac disease: caught between a rock and a hard place
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
    Gastroenterology 129:1294-301. 2005
    ..They also may be of relevance for our understanding of other multifactorial disorders including IBD and HLA-associated autoimmune diseases...
  8. ncbi request reprint Gluten: a two-edged sword. Immunopathogenesis of celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, E3 Q, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Springer Semin Immunopathol 27:217-32. 2005
    ..Although long thought to be impossible, recent results suggest that the development of nontoxic wheat varieties may be feasible, which would aid disease prevention and provide an alternative food source for patients...
  9. ncbi request reprint Pathomechanisms in celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 19:373-87. 2005
    ..Together, these observations provide a unique explanation for the disease inducing capacity of gluten...
  10. pmc A tertiary twist to the transglutaminase tale
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Biol 5:e337. 2007
  11. ncbi request reprint The molecular basis of celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Mol Recognit 16:333-6. 2003
    ..Thus, gluten molecules contain a large number of immunogenic peptides and this is likely to play an important role in the breaking of oral tolerance to gluten...
  12. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
    ..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
  13. ncbi request reprint Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2
    Dariusz Stepniak
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 180:3268-78. 2008
    ..This knowledge may be an important asset in the development of future treatment strategies...
  14. doi request reprint Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer
    Yvonne Kooy-Winkelaar
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 187:5123-9. 2011
    ..Because type 1 diabetes is strongly associated with the presence of HLA-DQ8trans, our findings may bear relevance to this disease as well...
  15. pmc Celiac disease: how complicated can it get?
    Jennifer May Ling Tjon
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, RC Leiden, The Netherlands
    Immunogenetics 62:641-51. 2010
    ..This threshold model might also help to understand the development of refractory celiac disease and lymphoma...
  16. ncbi request reprint Characterization of cereal toxicity for celiac disease patients based on protein homology in grains
    L Willemijn Vader
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 125:1105-13. 2003
    ..Celiac disease is caused by T-cell responses to wheat gluten-derived peptides. The presence of such peptides in other widely consumed grains, however, has hardly been studied...
  17. ncbi request reprint T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1
    Dariusz Stepniak
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Immunogenetics 57:8-15. 2005
    ..This knowledge may be of importance for the identification of additional T-cell stimulatory gluten peptides and the design of a peptide-based, tolerance-inducing therapy...
  18. ncbi request reprint Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome
    Cristina Mitea
    Department of Blood Transfusion and Immunohematology, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 88:1057-66. 2008
    ..Such immune-stimulatory peptides are found in both gliadins and glutenins. Monoclonal antibodies (mAbs) against these peptides can be used to screen food for the presence of such peptides...
  19. doi request reprint Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule
    Varsha V Kapoerchan
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden, The Netherlands
    Mol Immunol 47:1091-7. 2010
    ..Such peptides are candidate lead peptides for further optimization. Our results, however, also indicate that in order to obtain further significant increases in binding affinity alternative approaches will have to be explored...
  20. pmc The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses
    Willemijn Vader
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, E3 Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Proc Natl Acad Sci U S A 100:12390-5. 2003
    ..This model may have important implications for disease prevention...
  21. doi request reprint Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II
    Frederike Schmitz
    Department of Immunohematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Gut 62:509-19. 2013
    ..In approximately 40% of patients with RCDII these lymphocytes develop into an invasive lymphoma. In the current study we aimed to identify the physiological counterpart of these cells...
  22. ncbi request reprint Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients
    Liesbeth Spaenij-Dekking
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 129:797-806. 2005
    ..The only cure for CD is a lifelong gluten-free diet. It is unknown, however, if all wheat varieties are equally harmful for patients. We investigated whether wheat varieties exist with a natural low number of T-cell-stimulatory epitopes...
  23. ncbi request reprint Cutting edge: killer Ig-like receptors mediate "missing self" recognition in vivo
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 182:2569-72. 2009
    ..Hence, the KIR transgene mediated "missing self" recognition in vivo. We anticipate that this KIR and HLA transgenic mouse will help shed light on KIR and HLA effects in disease and transplantation...
  24. doi request reprint Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect
    Beatrijs A N Vermeulen
    Department of Paediatric Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands
    Scand J Gastroenterol 44:40-5. 2009
    ..The aim of this study was to determine the correlation between HLA-DQ/DR-based genotypes and the variation in phenotypes of the disease...
  25. doi request reprint DNAM-1 mediates epithelial cell-specific cytotoxicity of aberrant intraepithelial lymphocyte lines from refractory celiac disease type II patients
    Jennifer M L Tjon
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 186:6304-12. 2011
    ..This study confirms previous work on epithelial lysis by RCD cell lines and identifies a novel mechanism that potentially contributes to the gluten-independent tissue damage in RCD II and RCD-associated lymphoma...
  26. ncbi request reprint Validation of a new enzyme-linked immunosorbent assay to detect the triggering proteins and peptides for celiac disease: interlaboratory study
    Jorge R Mujico
    Leiden University Medical Center, Department of Immunology and Blood Transfusion, Leiden, The Netherlands
    J AOAC Int 95:206-15. 2012
    ..6 to 45.9%. Both statistical parameters were in the acceptable range of ELISAs under these conditions, and the method will be presented to the Codex Alimentarius as a preferred method for gluten analysis...
  27. ncbi request reprint Dendritic cells promote expansion and survival of aberrant TCR-negative intraepithelial lymphocyte lines from refractory celiac disease type II patients
    Frederike Schmitz
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 58:10-6. 2014
    ..Our results suggest that contact with DC, either in the epithelium or upon dissemination, contributes to uncontrolled expansion of a-IEL in RCDII, independent of HLA-genotype and IL-15. ..
  28. ncbi request reprint The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides
    Willemijn Vader
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Gastroenterology 122:1729-37. 2002
    ..The aim of the current study was to determine which GLU peptide(s) are involved early in disease...
  29. pmc A universal approach to eliminate antigenic properties of alpha-gliadin peptides in celiac disease
    Cristina Mitea
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e15637. 2010
    ..It also provides the information to design and introduce safe gluten genes in other cereals, which would exhibit improved quality while remaining safe for consumption by celiac disease patients...
  30. doi request reprint Celiac disease: sandwiched between innate and adaptive immune responses induced by gluten
    Frits Koning
    Leiden University Medical Centre, Leiden, The Netherlands
    J Pediatr Gastroenterol Nutr 46:E8-9. 2008
  31. doi request reprint Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells
    Junda M Kel
    Business Unit Biosciences, TNO Quality of Life, Leiden, The Netherlands
    J Leukoc Biol 84:182-90. 2008
    ..Our results suggest that M-PLP139-151 inhibits EAE development by affecting the differentiation of T cells into encephalitogenic effector cells...
  32. ncbi request reprint Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease
    Varsha V Kapoerchan
    Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA, Leiden, The Netherlands
    Bioorg Med Chem 16:2053-62. 2008
    ..Moreover, some of these peptides were found to be non-immunogenic and block gluten induced immune responses. These can thus serve as lead compounds for the development of HLA-DQ2 blocker peptides...
  33. doi request reprint Screening for unrecognized coeliac disease in subfertile couples
    Caroline E Hogen Esch
    Department of Paediatric Gastroenterology, Leiden University Medical Center, Leiden, Netherlands
    Scand J Gastroenterol 46:1423-8. 2011
    ..We aimed to determine the prevalence of unrecognized CD in subfertile male-female couples visiting a fertility clinic compared with the general population...
  34. ncbi request reprint Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease
    Dariusz Stepniak
    Dept of Immunohematology and Blood Transfusion, Leiden Univ Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 291:G621-9. 2006
    ..niger efficiently degrades gluten proteins. Future studies are required to determine if the prolyl endoprotease can be used as an oral supplement to reduce gluten intake in patients...
  35. ncbi request reprint Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma
    Jennifer M L Tjon
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, USA
    Blood 112:5103-10. 2008
    ..Pre)malignant transformation in RCD II thus correlates with defective synthesis or defective association of the TCR chains, resulting in loss of surface TCR-CD3 expression...
  36. pmc The tortoise and the hare: slowly evolving T-cell responses take hastily evolving KIR
    Jeroen van Bergen
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Immunology 131:301-9. 2010
    ..Thus, the rapid evolution of activating KIR may have allowed for efficient NK-cell control of viruses, but may also have increased the risk that slowly evolving T-cell responses to persistent pathogens derail into autoimmunity...
  37. doi request reprint Functional killer Ig-like receptors on human memory CD4+ T cells specific for cytomegalovirus
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    J Immunol 182:4175-82. 2009
    ..Thus, the CMV-induced down-regulation of HLA class I may in fact enhance memory CMV-specific CD4(+) T cell responses restricted by HLA class II...
  38. doi request reprint Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Gut 59:1662-9. 2010
    ..Our objective was to determine the safety and feasibility of autologous bone marrow derived MSC therapy in patients with refractory Crohn's disease...
  39. doi request reprint The PreventCD Study design: towards new strategies for the prevention of coeliac disease
    Caroline Elisabeth Hogen Esch
    Department of Pediatric Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Gastroenterol Hepatol 22:1424-30. 2010
    ....
  40. doi request reprint Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?
    Erica G D Hopman
    Department of Dietetics and Nutrition, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Gastroenterol Hepatol 20:423-9. 2008
    ..A number of patients, however, discontinue the gluten-free diet (GFD) without developing symptoms or signs. The aim of our study was to investigate whether CD patients are capable of developing tolerance to gluten...
  41. doi request reprint HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 190:2880-5. 2013
    ..In line with these findings, both transgene-encoded KIR and endogenous NKG2A contributed to the rejection of cells lacking HLA-Cw3. These findings support the idea that HLA influences the human KIR repertoire...
  42. doi request reprint Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics
    Rob Mariman
    Department of Metabolic Health Research, TNO, Leiden, The Netherlands
    Inflamm Bowel Dis 18:1424-33. 2012
    ..The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid (TNBS)-induced colitis model and gain more insight into protective mechanisms...
  43. ncbi request reprint Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants
    Thorbald van Hall
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Med 12:417-24. 2006
    ..This explains why they act as immunogenic neoantigens. The newly discovered epitopes can be exploited for immune intervention against processing-deficient tumors through adoptive T-cell transfer or peptide vaccination...
  44. pmc Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis
    Junda Kel
    Business Unit Biomedical Research, TNO Quality of Life, Leiden, The Netherlands
    Am J Pathol 170:272-80. 2007
    ..Therefore, mannosylated antigens may represent a novel therapeutic approach for antigen-specific modulation of autoreactive T cells in vivo...
  45. doi request reprint Evidence for natural killer cell-mediated protection from metastasis formation in uveal melanoma patients
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 50:2888-95. 2009
    ..In this study, three novel lines of evidence were identified that support a role for NK cells...
  46. ncbi request reprint Enzymatic gluten detoxification: the proof of the pudding is in the eating!
    Dariusz Stepniak
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Trends Biotechnol 24:433-4. 2006
    ..The enzymatic degradation of gluten might become an alternative to the gluten-free diet, and recent work indicates that such approaches are getting close to being tested in clinical trials...
  47. doi request reprint Tef in the diet of celiac patients in The Netherlands
    Erica Hopman
    Department of Dietetics and Nutrition, Leiden University Medical Center, Leiden, The Netherlands
    Scand J Gastroenterol 43:277-82. 2008
    ..The treatment is a strict gluten-free diet (GFD). The purpose of this study was to investigate whether the naturally gluten-free cereal Eragrostis tef (tef) is associated with health problems when used by CD patients...
  48. ncbi request reprint Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 173:6719-26. 2004
    ..Together, our data indicate that KIR-expressing CD4 T cells are predominantly HLA class II-restricted effector memory Th1 cells, and that a significant, previously unrecognized fraction of effector memory Th1 cells expresses KIR...
  49. ncbi request reprint Morphological changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane
    Pauline Verdijk
    Department of Dermatology, LUMC, Leiden, The Netherlands
    Eur J Immunol 34:156-64. 2004
    ..Importantly, this correlated with an increase in filamentous actin and the appearance of veils, suggesting a role for cofilin in cytoskeletal rearrangements during maturation...
  50. ncbi request reprint Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies
    Arend Mulder
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 175:5950-7. 2005
    ..Since Abs that are only reactive with HLA loaded with irrelevant peptides are expected to be harmless toward allografts, the practice of HLA Ab determination on lymphocyte-derived HLA deserves reconsideration...
  51. ncbi request reprint Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance
    Lianne van Beek
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Metabolism 63:492-501. 2014
    ..This study determined to what extent differences in metabolic health in obese women are associated with differences in adipose tissue and/or systemic inflammation...
  52. pmc The molecular basis for oat intolerance in patients with celiac disease
    Helene Arentz-Hansen
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    PLoS Med 1:e1. 2004
    ..This study aimed to investigate whether oat intolerance exists in celiac disease and to characterize the cells and processes underlying this intolerance...
  53. ncbi request reprint HLA-DR4 molecules in neuroendocrine epithelial cells associate to a heterogeneous repertoire of cytoplasmic and surface self peptides
    Aura Muntasell
    Immunology Unit and Institute of Biotechnology and Biomedicine, Universitat Autonoma de Barcelona, Spain
    J Immunol 169:5052-60. 2002
    ..This is specially relevant to processes involving epithelial T cell interactions such as organ-specific autoimmunity and transplant rejection...
  54. ncbi request reprint Gluten peptides and celiac disease
    Frits Koning
    Science 299:513-5; author reply 513-5. 2003
  55. ncbi request reprint Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation
    Junda M Kel
    Business Unit Biosciences, TNO Quality of Life, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    Int Immunol 20:117-27. 2008
    ..In conclusion, mannosylated peptide induces proliferation of T cells with impaired T(h)1 cell effector functions and additionally abrogates the activity of pre-existing effector T cells...
  56. ncbi request reprint The Ethiopian cereal tef in celiac disease
    Liesbeth Spaenij-Dekking
    N Engl J Med 353:1748-9. 2005
  57. ncbi request reprint Mannosylated PLP(139-151) induces peptide-specific tolerance to experimental autoimmune encephalomyelitis
    Mariken E Luca
    Division of Biomedical Research, TNO Prevention and Health, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    J Neuroimmunol 160:178-87. 2005
    ..Our data suggest that M-PLP(139-151) induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells...
  58. ncbi request reprint No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population
    Begona Diosdado
    Complex Genetics Section, Dept of Biomedical Genetics, Univ Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 289:G495-500. 2005
    ..These are further supported by the activity determinations in which we observed no differences in PREP activity between CD patients and controls...
  59. ncbi request reprint Tissue transglutaminase: master regulator of celiac disease?
    M Luisa Mearin
    J Pediatr Gastroenterol Nutr 36:9-11. 2003
  60. ncbi request reprint Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: strong influence of invariant chain and HLA-DM expression on the nature of ligands
    Aura Muntasell
    Immunology Unit and Institute of Biotechnology and Biomedicine IBB, Universitat Autonoma de Barcelona, Campus de Bellaterra, Barcelona, Spain
    J Immunol 173:1085-93. 2004
    ....
  61. ncbi request reprint Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease
    Alienke J Monsuur
    Complex Genetics Section, DBG Department of Medical Genetics, University Medical Centre, Utrecht, The Netherlands
    Eur J Gastroenterol Hepatol 18:637-44. 2006
    ..We also determined the enzymatic activity of PGPEPI in duodenal biopsies. Our results uniformly indicate that PGPEP1 is not involved in the aetiology and pathology of CD...
  62. ncbi request reprint Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer
    Hiroto Kita
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    Gastroenterology 123:1031-43. 2002
    ..However, there have been only limited studies attempting to quantitate the number of NKT cells in autoimmune disease, particularly because of difficulties associated with definition of this subpopulation...
  63. pmc A new type of metal recognition by human T cells: contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel
    Katharina Gamerdinger
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Exp Med 197:1345-53. 2003
    ..However, unlike superantigens, Ni requires idiotypic, i.e., CDR3alpha-determined TCR amino acids. This new type of TCR-MHC linkage might explain the high frequency of Ni-reactive T cells in the human population...