N B Klarenbeek

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study
    M van Den Broek
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 71:245-8. 2012
  2. pmc Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis
    Melek Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Arthritis Res Ther 12:R96. 2010
  3. doi request reprint The BeSt story: on strategy trials in rheumatoid arthritis
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Curr Opin Rheumatol 21:291-8. 2009
  4. doi request reprint The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 70:1039-46. 2011
  5. doi request reprint Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study
    N B Klarenbeek
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:315-9. 2011
  6. doi request reprint Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 69:2107-13. 2010
  7. doi request reprint Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Ann Rheum Dis 69:1342-5. 2010
  8. doi request reprint Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression
    L Dirven
    Leiden University Medical Centre, Leiden, The Netherlands
    Scand J Rheumatol 41:15-9. 2012
  9. doi request reprint Association with joint damage and physical functioning of nine composite indices and the 2011 ACR/EULAR remission criteria in rheumatoid arthritis
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 70:1815-21. 2011
  10. doi request reprint Risk of alanine transferase (ALT) elevation in patients with rheumatoid arthritis treated with methotrexate in a DAS-steered strategy
    L Dirven
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 Leiden, The Netherlands
    Clin Rheumatol 32:585-90. 2013

Collaborators

Detail Information

Publications15

  1. doi request reprint The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study
    M van Den Broek
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 71:245-8. 2012
    ..The authors compared the clinical and radiological responses to Disease Activity Score (DAS)-steered treatment in patients with RA positive or RA negative for ACPA...
  2. pmc Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis
    Melek Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Arthritis Res Ther 12:R96. 2010
    ....
  3. doi request reprint The BeSt story: on strategy trials in rheumatoid arthritis
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Curr Opin Rheumatol 21:291-8. 2009
    ..To give an overview of recent strategy trials for the treatment of rheumatoid arthritis...
  4. doi request reprint The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 70:1039-46. 2011
    ..To compare clinical and radiological outcomes of four dynamic treatment strategies in recent-onset rheumatoid arthritis (RA) after 5 years follow-up...
  5. doi request reprint Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study
    N B Klarenbeek
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:315-9. 2011
    ..To determine the relapse rate after discontinuing treatment in patients with rheumatoid arthritis (RA) in sustained clinical remission, to identify predictors of a relapse and to evaluate treatment response after restarting treatment...
  6. doi request reprint Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 69:2107-13. 2010
    ..To assess the relationship between joint tenderness, swelling and joint damage progression in individual joints and to evaluate the influence of treatment on these relationships...
  7. doi request reprint Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Ann Rheum Dis 69:1342-5. 2010
    ..To evaluate the effect of disease activity and antirheumatic treatment on blood pressure (BP) in patients with recent-onset rheumatoid arthritis (RA)...
  8. doi request reprint Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression
    L Dirven
    Leiden University Medical Centre, Leiden, The Netherlands
    Scand J Rheumatol 41:15-9. 2012
    ..However, for some patients this outcome is less relevant, whereas short-term functional ability is relevant to all. Do these various treatment goals share the same predictors?..
  9. doi request reprint Association with joint damage and physical functioning of nine composite indices and the 2011 ACR/EULAR remission criteria in rheumatoid arthritis
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 70:1815-21. 2011
    ....
  10. doi request reprint Risk of alanine transferase (ALT) elevation in patients with rheumatoid arthritis treated with methotrexate in a DAS-steered strategy
    L Dirven
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 Leiden, The Netherlands
    Clin Rheumatol 32:585-90. 2013
    ..To determine incidence of increased levels of alanine transferase (ALT) >2× upper limit of normal (ULN) in patients receiving methotrexate (MTX), treated according to a dynamic strategy, and to identify predictors of ALT of >2× ULN...
  11. doi request reprint 'Insights in the relationship of joint space narrowing versus erosive joint damage and physical functioning of patients with RA'
    R Koevoets
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 72:870-4. 2013
    ..To evaluate the contribution of joint space narrowing (JSN) and erosions in general and in four different joint groups in relation to physical disability in rheumatoid arthritis (RA)...
  12. doi request reprint Simplified versions of the original disease activity score: validation in the BeSt trial
    R Koevoets
    Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 70:1471-4. 2011
    ..To compare the use of patient global assessment (PGA) of disease activity versus global assessment of health (GH) in DAS, DAS alternatives and DAS28...
  13. doi request reprint Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and disease activity score-steered therapy: subanalysis of the BeSt study
    M van Den Broek
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:1389-94. 2011
    ..To describe the disease course after the cessation of infliximab in early rheumatoid arthritis patients with disease activity score (DAS)-steered treatment and to identify predictors of persistent low disease activity...
  14. doi request reprint A decrease in disease activity score (DAS) level is associated with a decrease in health assessment questionnaire (HAQ) score, independent of follow-up duration, during 5 years of tightly controlled treatment: results from the BeSt study
    E van der Kooi
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:168-71. 2011
    ....
  15. doi request reprint Repair of joint erosions in rheumatoid arthritis: prevalence and patient characteristics in a large inception cohort
    Michael P M van der Linden
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 69:727-9. 2010
    ..Joint destruction in rheumatoid arthritis (RA) was until recently seen as an irreversible state. Lately, it was found that repair of bone erosions occurs; however, little is known about its prevalence...