A M Karssen

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
  2. ncbi request reprint Low doses of dexamethasone can produce a hypocorticosteroid state in the brain
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 146:5587-95. 2005
  3. ncbi request reprint Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Endocrinol 178:13-8. 2003
  4. ncbi request reprint The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
    A M Karssen
    Divisions of Medical Pharmacology and Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Centre, PO Box 9502, Leiden, 2300 RA, The Netherlands
    J Endocrinol 175:251-60. 2002
  5. ncbi request reprint Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, The Netherlands
    Ann N Y Acad Sci 1032:308-11. 2004

Detail Information

Publications5

  1. ncbi request reprint Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
    ..This finding suggests a more prominent role for corticosterone in control of human brain function than hitherto recognized...
  2. ncbi request reprint Low doses of dexamethasone can produce a hypocorticosteroid state in the brain
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 146:5587-95. 2005
    ..The results support the concept that low doses of dex can create a hypocorticoid state in the brain...
  3. ncbi request reprint Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Endocrinol 178:13-8. 2003
    ....
  4. ncbi request reprint The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
    A M Karssen
    Divisions of Medical Pharmacology and Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Centre, PO Box 9502, Leiden, 2300 RA, The Netherlands
    J Endocrinol 175:251-60. 2002
    ..Furthermore, the ensuing imbalance in activation of the two types of brain corticosteroid receptors may have consequences for cognitive performance and mood...
  5. ncbi request reprint Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, The Netherlands
    Ann N Y Acad Sci 1032:308-11. 2004
    ..Our data indicate that P-glycoprotein is expressed by endothelial cells and possibly dentate gyrus neurons The functional role of P-glycoprotein at dentate gyrus neurons is presently unknown...