A M Karssen

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
    A M Karssen
    Divisions of Medical Pharmacology and Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Centre, PO Box 9502, Leiden, 2300 RA, The Netherlands
    J Endocrinol 175:251-60. 2002
  2. ncbi Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Endocrinol 178:13-8. 2003
  3. ncbi Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
  4. ncbi Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, The Netherlands
    Ann N Y Acad Sci 1032:308-11. 2004
  5. ncbi Low doses of dexamethasone can produce a hypocorticosteroid state in the brain
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 146:5587-95. 2005

Detail Information

Publications5

  1. ncbi The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
    A M Karssen
    Divisions of Medical Pharmacology and Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Centre, PO Box 9502, Leiden, 2300 RA, The Netherlands
    J Endocrinol 175:251-60. 2002
    ..Furthermore, the ensuing imbalance in activation of the two types of brain corticosteroid receptors may have consequences for cognitive performance and mood...
  2. ncbi Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain
    O C Meijer
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Endocrinol 178:13-8. 2003
    ....
  3. ncbi Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
    ..This finding suggests a more prominent role for corticosterone in control of human brain function than hitherto recognized...
  4. ncbi Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, The Netherlands
    Ann N Y Acad Sci 1032:308-11. 2004
    ..Our data indicate that P-glycoprotein is expressed by endothelial cells and possibly dentate gyrus neurons The functional role of P-glycoprotein at dentate gyrus neurons is presently unknown...
  5. ncbi Low doses of dexamethasone can produce a hypocorticosteroid state in the brain
    A M Karssen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, The Netherlands
    Endocrinology 146:5587-95. 2005
    ..The results support the concept that low doses of dex can create a hypocorticoid state in the brain...