Aart G Jochemsen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Functions of MDMX in the modulation of the p53-response
    Kristiaan Lenos
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Biomed Biotechnol 2011:876173. 2011
  2. doi request reprint USP10: friend and foe
    Aart G Jochemsen
    Department of Molecular Cell Biology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    Cell 140:308-10. 2010
  3. ncbi request reprint ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Cycle 4:1166-70. 2005
  4. ncbi request reprint Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    Mol Cell 18:565-76. 2005
  5. ncbi request reprint Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer
    Kristiaan Lenos
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 72:4074-84. 2012
  6. pmc Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
    Kristiaan Lenos
    Department of Molecular Cell Biology, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    Mol Cancer 10:111. 2011
  7. doi request reprint Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Mech Ageing Dev 133:498-507. 2012
  8. doi request reprint Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice
    Lianne S M Boesten
    Dept of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 207:399-404. 2009
  9. ncbi request reprint Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
    Petra de Graaf
    Leiden University Medical Center, Department of Molecular and Cell Biology and Center for Biomedical Genetics, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Biol Chem 278:38315-24. 2003
  10. doi request reprint Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro
    Yvonne M Schrage
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 13:2843-52. 2009

Collaborators

Detail Information

Publications10

  1. pmc Functions of MDMX in the modulation of the p53-response
    Kristiaan Lenos
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Biomed Biotechnol 2011:876173. 2011
    ..Lastly, in contrast to common belief, we have recently shown the existence of a p53-MDMX feedback loop, which is important for dampening the p53-response at later phases after genotoxic stress...
  2. doi request reprint USP10: friend and foe
    Aart G Jochemsen
    Department of Molecular Cell Biology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    Cell 140:308-10. 2010
    ..In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development...
  3. ncbi request reprint ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Cycle 4:1166-70. 2005
    ..Further insight into the mechanism by which ATM switches the interactions between HAUSP, Mdmx, Mdm2 and p53, to favor p53 activation may offer new tools for therapeutic intervention in the p53 pathway for cancer treatment...
  4. ncbi request reprint Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    Mol Cell 18:565-76. 2005
    ..Importantly, impaired deubiquitination of Hdmx/Hdm2 by HAUSP contributes to the DNA damage-induced degradation of Hdmx and transient instability of Hdm2...
  5. ncbi request reprint Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer
    Kristiaan Lenos
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 72:4074-84. 2012
    ..Alternative splicing of HDMX could, therefore, serve as a more effective biomarker for p53 pathway attenuation in cancers than p53 gene mutation...
  6. pmc Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
    Kristiaan Lenos
    Department of Molecular Cell Biology, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    Mol Cancer 10:111. 2011
    ..Here we study the role of hMDMX in the neoplastic transformation of human fibroblasts and embryonic retinoblasts, since a high number of retinoblastomas contain elevated hMDMX levels...
  7. doi request reprint Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Mech Ageing Dev 133:498-507. 2012
    ..p16 was then investigated using qPCR, Western blotting and immunocytochemistry. In conclusion, we have identified cellular pathways that are differentially expressed between fibroblast strains from young and old subjects...
  8. doi request reprint Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice
    Lianne S M Boesten
    Dept of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 207:399-404. 2009
    ..Our data demonstrate that macrophage p53 is an important regulator of macrophage apoptosis, thereby preventing necrotic death of lesional macrophages. The regulation of this cell death balance directly affects lesion composition...
  9. ncbi request reprint Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
    Petra de Graaf
    Leiden University Medical Center, Department of Molecular and Cell Biology and Center for Biomedical Genetics, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Biol Chem 278:38315-24. 2003
    ..Mdm2 appears only to require an intact RING domain to be able to ubiquitinate Hdmx and target it for proteasomal degradation. These findings highlight the intricate functional relationships between p53, Mdm2, and Hdmx...
  10. doi request reprint Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro
    Yvonne M Schrage
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 13:2843-52. 2009
    ..This suggests a role for the use of CDK4 inhibitors as a treatment of metastatic or inoperable high-grade chondrosarcoma...