Research Topics
Genomes and Genes | Aart G JochemsenSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Publications
USP10: friend and foeAart G Jochemsen
Department of Molecular Cell Biology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
Cell 140:308-10. 2010..In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development...
Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancerKristiaan Lenos
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Cancer Res 72:4074-84. 2012..Alternative splicing of HDMX could, therefore, serve as a more effective biomarker for p53 pathway attenuation in cancers than p53 gene mutation...
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblastsKristiaan Lenos
Department of Molecular Cell Biology, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
Mol Cancer 10:111. 2011..Here we study the role of hMDMX in the neoplastic transformation of human fibroblasts and embryonic retinoblasts, since a high number of retinoblastomas contain elevated hMDMX levels...- Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblastsPim Dekker
Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Mech Ageing Dev 133:498-507. 2012..p16 was then investigated using qPCR, Western blotting and immunocytochemistry. In conclusion, we have identified cellular pathways that are differentially expressed between fibroblast strains from young and old subjects... - Functions of MDMX in the modulation of the p53-responseKristiaan Lenos
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
J Biomed Biotechnol 2011:876173. 2011..Lastly, in contrast to common belief, we have recently shown the existence of a p53-MDMX feedback loop, which is important for dampening the p53-response at later phases after genotoxic stress... - Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient miceLianne S M Boesten
Dept of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Atherosclerosis 207:399-404. 2009..Our data demonstrate that macrophage p53 is an important regulator of macrophage apoptosis, thereby preventing necrotic death of lesional macrophages. The regulation of this cell death balance directly affects lesion composition... - ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activationErik Meulmeester
Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Cell Cycle 4:1166-70. 2005..Further insight into the mechanism by which ATM switches the interactions between HAUSP, Mdmx, Mdm2 and p53, to favor p53 activation may offer new tools for therapeutic intervention in the p53 pathway for cancer treatment... - Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2Erik Meulmeester
Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
Mol Cell 18:565-76. 2005..Importantly, impaired deubiquitination of Hdmx/Hdm2 by HAUSP contributes to the DNA damage-induced degradation of Hdmx and transient instability of Hdm2... - Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitroYvonne M Schrage
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
J Cell Mol Med 13:2843-52. 2009..This suggests a role for the use of CDK4 inhibitors as a treatment of metastatic or inoperable high-grade chondrosarcoma...