Martine J Jager

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Retinoic acid elicits cytostatic, cytotoxic and immunomodulatory effects on uveal melanoma cells
    Simona Vertuani
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Cancer Immunol Immunother 56:193-204. 2007
  2. doi request reprint Macrophages in uveal melanoma and in experimental ocular tumor models: Friends or foes?
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Prog Retin Eye Res 30:129-46. 2011
  3. pmc Activation of tonsil dendritic cells with immuno-adjuvants
    Marta E Polak
    Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK
    BMC Immunol 9:10. 2008
  4. ncbi request reprint HLA expression in uveal melanoma: there is no rule without some exception
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 63:444-51. 2002
  5. pmc Macrophages feel their age in macular degeneration
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Invest 117:3182-4. 2007
  6. doi request reprint In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages
    Long V Ly
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 185:3481-8. 2010
  7. doi request reprint Regulation of VEGF-A in uveal melanoma
    Mariam El Filali
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 51:2329-37. 2010
  8. doi request reprint Detection of M2-macrophages in uveal melanoma and relation with survival
    Inge H G Bronkhorst
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 52:643-50. 2011
  9. doi request reprint Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 49:1291-8. 2008
  10. doi request reprint Changes in immunological markers and influx of macrophages following trans-scleral thermotherapy of uveal melanoma
    Jihan Dennaoui
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Acta Ophthalmol 89:268-73. 2011

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Retinoic acid elicits cytostatic, cytotoxic and immunomodulatory effects on uveal melanoma cells
    Simona Vertuani
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Cancer Immunol Immunother 56:193-204. 2007
    ..Taken together, our results implicate UM as a new target for treatment with retinoids and suggest that retinoids and T- or NK-cell based immunotherapy can have mutually enhancing effects in UM patients...
  2. doi request reprint Macrophages in uveal melanoma and in experimental ocular tumor models: Friends or foes?
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Prog Retin Eye Res 30:129-46. 2011
    ..A better understanding of these multifaceted cells will help in developing new treatments to prevent the growth of metastases in uveal melanoma patients...
  3. pmc Activation of tonsil dendritic cells with immuno-adjuvants
    Marta E Polak
    Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK
    BMC Immunol 9:10. 2008
    ..In humans, although much is known about the responses of monocyte derived DC, relatively little is known about effect of immuno-stimulatory adjuvants on DC found in tonsil...
  4. ncbi request reprint HLA expression in uveal melanoma: there is no rule without some exception
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 63:444-51. 2002
    ....
  5. pmc Macrophages feel their age in macular degeneration
    Martine J Jager
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Invest 117:3182-4. 2007
    ..These data provide insight into the effect of senescence on macrophage function and angiogenesis and have important implications for age-related diseases such as macular degeneration...
  6. doi request reprint In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages
    Long V Ly
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 185:3481-8. 2010
    ..We conclude that tumor-associated macrophages are directly involved in tumor outgrowth of intraocular melanoma and that macrophages in aged mice have a predisposition for an M2-type profile...
  7. doi request reprint Regulation of VEGF-A in uveal melanoma
    Mariam El Filali
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 51:2329-37. 2010
    ..This study was undertaken to examine the regulation of the proangiogenic factor vascular endothelial growth factor (VEGF-A)...
  8. doi request reprint Detection of M2-macrophages in uveal melanoma and relation with survival
    Inge H G Bronkhorst
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 52:643-50. 2011
    ..This study was conducted to determine whether the tumor-infiltrating macrophages in uveal melanoma are of this M2 subtype...
  9. doi request reprint Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 49:1291-8. 2008
    ..In this study, the RASEF gene was investigated for potential mutations and gene silencing by promoter methylation in uveal melanoma...
  10. doi request reprint Changes in immunological markers and influx of macrophages following trans-scleral thermotherapy of uveal melanoma
    Jihan Dennaoui
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Acta Ophthalmol 89:268-73. 2011
    ..We investigated whether TSTT induced similar changes...
  11. ncbi request reprint A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 179:5317-25. 2007
    ..Our data therefore reveal that EZH2 contributes to silencing of IFN-gamma-inducible transcription of MHC2TA in uveal melanoma cells...
  12. doi request reprint Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 49:505-10. 2008
    ....
  13. doi request reprint Analysis of inflammatory cells in uveal melanoma after prior irradiation
    T H Khanh Vu
    Departments of Ophthalmology
    Invest Ophthalmol Vis Sci 54:360-9. 2013
    ..We wondered whether local inflammatory responses were affected by irradiation and therefore determined the presence of inflammatory cells in uveal melanomas enucleated after prior irradiation...
  14. pmc Bevacizumab and intraocular tumors: an intriguing paradox
    Mariam El Filali
    Department of Ophthalmology, LUMC, Leiden, The Netherlands
    Mol Vis 18:2454-67. 2012
    ..We determined the effect of bevacizumab on the growth of B16F10 cells inside the eye and on B16F10 and UM cells cultured in vitro...
  15. doi request reprint A comparison of HLA genotype with inflammation in uveal melanoma
    T Huibertus van Essen
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 53:2640-6. 2012
    ..Inflammation has an important role in this malignancy. The goal of our study was to determine whether specific HLA alleles are associated with increased inflammation...
  16. ncbi request reprint Vascular endothelial growth factor a in eyes with uveal melanoma
    Guy S O Missotten
    Departments of Ophthalmology, Pathology, and Medical Statistics, Leiden University Medical Center, Leiden
    Arch Ophthalmol 124:1428-34. 2006
    ..To determine the presence of vascular endothelial growth factor A (VEGF-A) in the aqueous humor of eyes with uveal melanoma and to identify its source...
  17. ncbi request reprint Epigenetic inactivation of RASSF1a in uveal melanoma
    Willem Maat
    Departments of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 48:486-90. 2007
    ..The purpose of this study was to evaluate the methylation status of RASSF1a in human uveal melanoma...
  18. ncbi request reprint Macrophages are vital in spontaneous intraocular tumor eradication
    Zita F H M Boonman
    Department of Ophthalmology, Leiden University Medical Center, The Netherlands
    Invest Ophthalmol Vis Sci 47:2959-65. 2006
    ..This study was conducted to determine whether macrophages are involved in the natural elimination of this intraocular tumor...
  19. pmc Inflammatory cytokines in eyes with uveal melanoma and relation with macrophage infiltration
    Long V Ly
    Departments of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 51:5445-51. 2010
    ..This study was conducted to determine whether the aqueous humor (AqH) from eyes with uveal melanoma contains inflammatory cytokines and whether their presence is associated with inflammation...
  20. doi request reprint Effect of heterogeneous distribution of monosomy 3 on prognosis in uveal melanoma
    Inge H G Bronkhorst
    Department of Ophthalmology, Leiden University Medical Center, The Netherlands
    Arch Pathol Lab Med 135:1042-7. 2011
    ..Fluorescence in situ hybridization (FISH) analyses on tumor sections and on isolated nuclei showed that even low numbers of cells with monosomy of chromosome 3 adversely affected survival...
  21. doi request reprint Different subsets of tumor-infiltrating lymphocytes correlate with macrophage influx and monosomy 3 in uveal melanoma
    Inge H G Bronkhorst
    Departments of Ophthalmology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 53:5370-8. 2012
    ..An analysis of the different functional phenotypes of tumor-infiltrating leukocytes (TIL) and a comparison with the genetic background of the tumors may help to explain this apparent anomaly...
  22. doi request reprint Intravascular presence of tumor cells as prognostic parameter in uveal melanoma: a 35-year survey
    Long V Ly
    Department of Ophthalmology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 51:658-65. 2010
    ..The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients...
  23. doi request reprint Evidence for natural killer cell-mediated protection from metastasis formation in uveal melanoma patients
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 50:2888-95. 2009
    ..In this study, three novel lines of evidence were identified that support a role for NK cells...
  24. ncbi request reprint Uveal and cutaneous melanoma: shared expression characteristics of melanoma-associated antigens
    Leonie C van Dinten
    Department of Immunohematology and Blood Transfusion, Division of Molecular Biology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 46:24-30. 2005
    ..In view of putative re-expression strategies for MAAs during immunotherapy, this study was conducted to investigate MAA silencing in malignant melanoma...
  25. doi request reprint Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm
    Long V Ly
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:8339-46. 2010
    ..Together, these results identify a peptide vaccination strategy that can potently accentuate effective ACT in non-lymphodepleted hosts...
  26. ncbi request reprint Proteomic analysis of uveal melanoma reveals novel potential markers involved in tumor progression
    Wieke Zuidervaart
    Department of Ophthalmology, Leiden University Medical Center, The Netherlands
    Invest Ophthalmol Vis Sci 47:786-93. 2006
    ....
  27. doi request reprint Cytokines and chemokines in the vitreous fluid of eyes with uveal melanoma
    Nisha Nagarkatti-Gude
    Departments of Ophthalmology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 53:6748-55. 2012
    ....
  28. pmc Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth
    Mariam El Filali
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
    Mol Vis 14:1752-9. 2008
    ....
  29. doi request reprint Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 49:23-7. 2008
    ..An assay with increased potential to identify mutations is now available, and this study was therefore conducted to reanalyze uveal melanoma cell lines and primary tumors for this mutation...
  30. doi request reprint Effective cooperation of monoclonal antibody and Peptide vaccine for the treatment of mouse melanoma
    Long V Ly
    Department of Ophthalmology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 190:489-96. 2013
    ..Moreover, we advocate that tumor Ag-specific T cell immunity directed against self-proteins can be exploited from the endogenous repertoire...
  31. doi request reprint Uveal melanoma: the inflammatory microenvironment
    Inge H G Bronkhorst
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Innate Immun 4:454-62. 2012
    ..This review focuses on the roles of the local inflammatory microenvironment in the development and progression of uveal melanoma...
  32. doi request reprint Anti-angiogenic therapy in uveal melanoma
    Mariam El Filali
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
    Dev Ophthalmol 49:117-36. 2012
    ..The role of VEGF and the potential use of current commercially and experimentally available anti-angiogenic drugs for the treatment of primary uveal melanoma and/or metastatic disease will be explained below...
  33. ncbi request reprint Expression of Wnt5a and its downstream effector beta-catenin in uveal melanoma
    Wieke Zuidervaart
    Department of Ophthalmology, Skin Research Lab, Leiden University Medical Centre, Leiden, The Netherlands
    Melanoma Res 17:380-6. 2007
    ....
  34. ncbi request reprint Prognostic value of S-100-beta serum concentration in patients with uveal melanoma
    Guy S O A Missotten
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Ophthalmol 121:1117-9. 2003
    ..In cutaneous melanoma, the S-100-beta serum level is recognized as a marker of metastatic disease...
  35. ncbi request reprint Prognostic value of the disodium phosphate 32P uptake test in uveal melanoma: a long-term study
    Esther N M Overkleeft
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Ophthalmol 121:1398-403. 2003
    ..To evaluate whether nuclear activity as measured by the disodium phosphate 32P (32P) uptake test for uveal melanoma is of prognostic value and corresponds to known prognostic factors...
  36. ncbi request reprint Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis
    Irene C Notting
    Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 46:1581-7. 2005
    ..Therefore, the development of novel anticancer strategies is urgent, and more sensitive and less invasive methods of detecting and monitoring in vivo tumor growth and metastatic disease in cancer models are needed...
  37. ncbi request reprint The heterogeneous distribution of monosomy 3 in uveal melanomas: implications for prognostication based on fine-needle aspiration biopsies
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Pathol Lab Med 131:91-6. 2007
    ..Fine-needle aspiration biopsy is being used to detect monosomy 3 in these tumors, based on the assumption that this chromosomal abnormality is distributed homogeneously throughout the tumor...
  38. ncbi request reprint HLA Class I and II genotype in uveal melanoma: relation to occurrence and prognosis
    Willem Maat
    Department of Ophthalmology, Leiden University Medical Center, Keiden, The Netherlands
    Invest Ophthalmol Vis Sci 47:3-6. 2006
    ..To assess whether human leukocyte antigen class I and class II alleles confer susceptibility to uveal melanoma or are related to specific clinical or tumor characteristics and survival...
  39. ncbi request reprint Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development
    Pieter A van der Velden
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Cancer 106:472-9. 2003
    ..We demonstrate in the cell lines that TIMP3 expression is regulated by methylation. These observations were confirmed in primary uveal melanoma and suggests a role for TIMP3 in uveal melanoma development...
  40. pmc Genetics of primary intraocular tumors
    Nisha Nagarkatti-Gude
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Ocul Immunol Inflamm 20:244-54. 2012
    ..Other factors related to the genetics of these three common malignancies in the eye are discussed and reviewed...
  41. doi request reprint A fish scale-derived collagen matrix as artificial cornea in rats: properties and potential
    T Huibertus van Essen
    Department of Ophthalmology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 54:3224-33. 2013
    ..Transparency, neovascularization, and epithelial damage were followed for 21 days. Morphology and cellular infiltration were assessed histologically...
  42. ncbi request reprint Epigenetic silencing of MHC2TA transcription in cancer
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biochem Pharmacol 72:1570-6. 2006
    ..Here we discuss our current knowledge on the expression characteristics of MHC2TA and argue for an important role of epigenetic factors and mechanisms in the transcriptional silencing of MHC2TA in cancer cells...
  43. ncbi request reprint Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction
    Zita F H M Boonman
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 172:1567-74. 2004
    ..However, the induced tumor-specific immunity is insufficient for tumor clearance, even combined with otherwise highly effective immune intervention protocols...
  44. ncbi request reprint The value of combining anterior segment fluorescein angiography with indocyanine green angiography in scleral inflammation
    Jeroen Nieuwenhuizen
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Ophthalmology 110:1653-66. 2003
    ..To determine the value of anterior segment indocyanine green (ICG) angiography combined with anterior segment fluorescein angiography in scleral inflammation...
  45. ncbi request reprint Heat shock protein expression in the eye and in uveal melanoma
    Guy S Missotten
    Department of Ophthalmology, Leiden University Medical Center, University of Leiden, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 44:3059-65. 2003
    ..HSP expression levels were determined in normal eyes and in uveal melanoma and tested whether HSPs expression was associated with prognostic parameters in the uveal melanoma...
  46. doi request reprint Pancorneal contact lens with a toric edge: a new concept in keratoconus
    Sizar Kamar
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Ophthalmol 21:685-90. 2011
    ..To investigate whether fitting a patient with keratoconus to a pancorneal toric rigid gas-permeable (RGP) contact lens leads to a change in corneal compression and improves the best-corrected visual acuity (BCVA) and keratometry values...
  47. pmc Presence and phenotype of dendritic cells in uveal melanoma
    Marta E Polak
    Translational Oncology Research Centre, Queen Alexandra Hospital, Southwick Hill, Portsmouth PO6 3LY, UK
    Br J Ophthalmol 91:971-6. 2007
    ..Previous studies on cutaneous melanoma have shown the presence of tolerogenic dendritic cells (DCs), which could play an important role in the progression of the tumour...
  48. ncbi request reprint Expression and distribution of MUC18 in human uveal melanoma
    Kenneth Lai
    Save Sight Institute, Discipline of Clinical Ophthalmology, University of Sydney, Sydney NSW 2006, Australia
    Virchows Arch 451:967-76. 2007
    ..These observations further suggest a role for MUC18 in uveal melanoma growth; moreover, interactions between MUC18-positive melanoma cells and vasculature may be important for the hematogenous spread of cells during metastases...
  49. ncbi request reprint Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes
    Kristian Hallermalm
    Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    J Immunol 180:3766-74. 2008
    ....
  50. ncbi request reprint Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target
    Charlotta All-Ericsson
    St Erik s Eye Hospital, Stockholm, Sweden
    Invest Ophthalmol Vis Sci 43:1-8. 2002
    ..To investigate the expression of the insulin-like growth factor-1 receptor (IGF-1R) with special focus on its role in cell growth in uveal melanoma...
  51. ncbi request reprint In vitro targeting of NG2 antigen by 213Bi-9.2.27 alpha-immunoconjugate induces cytotoxicity in human uveal melanoma cells
    Yong Li
    Centre for Experimental Radiation Oncology, Cancer Care Centre, St George Hospital, Kogarah, NSW, Australia
    Invest Ophthalmol Vis Sci 46:4365-71. 2005
    ..2.27 and subsequently to assess the in vitro specificity and cytotoxicity of mAb 9.2.27 conjugated to the alpha-particle-emitting radioisotope 213bismuth (213Bi-9.2.27) for uveal melanoma cells...
  52. ncbi request reprint Role of TRAIL and IFN-gamma in CD4+ T cell-dependent tumor rejection in the anterior chamber of the eye
    Shixuan Wang
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 171:2789-96. 2003
    ....
  53. ncbi request reprint Angiogenesis in uveal melanoma
    Martine J Jager
    Ophthalmic Res 38:248-50. 2006
  54. ncbi request reprint Maintenance of immune tolerance depends on normal tissue homeostasis
    Zita F H M Boonman
    Department of Ophthalmology
    J Immunol 175:4247-54. 2005
    ..These data also indicate that tissue injury in the absence of viral or microbial infection can act as a switch for the induction of CTL immunity...
  55. pmc Authenticating cell lines in ophthalmic research laboratories
    Robert Folberg
    Oakland University William Beaumont School of Medicine, Rochester, Michigan 48309 4401, USA
    Invest Ophthalmol Vis Sci 49:4697-701. 2008
  56. ncbi request reprint The effect of ultraviolet radiation on choroidal melanocytes and melanoma cell lines: cell survival and matrix metalloproteinase production
    Kenneth Lai
    Save Sight Institute, Discipline of Clinical Ophthalmology, University of Sydney, Sydney, NSW, Australia
    Graefes Arch Clin Exp Ophthalmol 245:715-24. 2007
    ..In this study, we investigated if UV(R)-B affected the in vitro survival, growth and MMP production of choroidal melanocytes and melanoma cells...
  57. ncbi request reprint MICA association with presumed ocular histoplasmosis syndrome (POHS)
    Judith Reinders
    Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Vis 9:420-4. 2003
    ..Previous research indicated an association with the HLA-B7-DR2 haplotype. In this study we investigated the association of the polymorphic MICA alanine repeat and the ocular disease presumed ocular histoplasmosis syndrome (POHS)...
  58. ncbi request reprint Presence and maturity of dendritic cells in melanoma lymph node metastases
    Marta E Polak
    Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK
    J Pathol 207:83-90. 2005
    ..Immature DCs, characterized by phenotypic and morphological features, are therefore present within the tumour deposits in lymph nodes infiltrated by melanoma and may specifically modulate the anti-melanoma immune response...