Tom W J Huizinga

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Prevalence of vertebral fractures in a disease activity steered cohort of patients with early active rheumatoid arthritis
    Linda Dirven
    Department of Rheumatology, Leiden University Medical Center, PO BOX 96002300 RC Leiden, The Netherlands
    BMC Musculoskelet Disord 13:125. 2012
  2. pmc Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity
    Y K Onno Teng
    Department of Rheumatology, C1 R, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 14:R57. 2012
  3. pmc A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study
    Shintaro Hirata
    Leiden University Medical Center, PO Box 9600, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 52:1202-7. 2013
  4. pmc The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
    Parawee Suwannalai
    Department of Rheumatology, Leiden University Medical Center LUMC, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R195. 2011
  5. pmc Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study
    Linda van Wyk
    Department of Obstetrics, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R183. 2011
  6. pmc Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium
    Jolien Suurmond
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Albinusdreef 2, C1 R, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R150. 2011
  7. pmc Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 13:R180. 2011
  8. pmc Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
    Mehmet Küçükaycan
    Nutrition and Toxicology Research Institute Maastricht, Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Respir Res 3:29. 2002
  9. pmc Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling
    Jérémie Jp Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, P, O, Box 9604, 2300 RC Leiden, The Netherlands
    BMC Proc 3:S94. 2009
  10. pmc Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Arthritis Res Ther 8:216. 2006

Detail Information

Publications185 found, 100 shown here

  1. pmc Prevalence of vertebral fractures in a disease activity steered cohort of patients with early active rheumatoid arthritis
    Linda Dirven
    Department of Rheumatology, Leiden University Medical Center, PO BOX 96002300 RC Leiden, The Netherlands
    BMC Musculoskelet Disord 13:125. 2012
    ....
  2. pmc Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity
    Y K Onno Teng
    Department of Rheumatology, C1 R, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 14:R57. 2012
    ..The latter has led to the hypothesis that the beneficial effects of B-cell depletion might act through their influence on pathogenic autoreactive plasma cells...
  3. pmc A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study
    Shintaro Hirata
    Leiden University Medical Center, PO Box 9600, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 52:1202-7. 2013
    ..To evaluate a multi-biomarker disease activity (MBDA) score, a novel index based on 12 serum proteins, as a tool to guide management of RA patients...
  4. pmc The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
    Parawee Suwannalai
    Department of Rheumatology, Leiden University Medical Center LUMC, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R195. 2011
    ..In this study, we analyzed whether a difference exists between the fine specificity of IgM versus IgG anti-citrullinated protein antibodies (ACPAs)...
  5. pmc Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study
    Linda van Wyk
    Department of Obstetrics, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R183. 2011
    ..From these prior studies we hypothesized that preeclampsia and other pregnancy complications could be associated with increased levels of fetal cell trafficking, and later be involved in the development of scleroderma...
  6. pmc Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium
    Jolien Suurmond
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Albinusdreef 2, C1 R, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R150. 2011
    ..We aimed to identify IL-17 expression by mast cells and T cells in synovium of arthritis patients...
  7. pmc Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 13:R180. 2011
    ..We aimed to evaluate the validity of this notion and explored whether clinical subphenotypes can be discerned within anti-CCP-negative RA...
  8. pmc Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
    Mehmet Küçükaycan
    Nutrition and Toxicology Research Institute Maastricht, Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Respir Res 3:29. 2002
    ..In the present study the putative involvement of TNF-alpha gene polymorphisms in pathogenesis of COPD was studied by analysis of four TNF-alpha gene polymorphisms in a Caucasian COPD population...
  9. pmc Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling
    Jérémie Jp Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, P, O, Box 9604, 2300 RC Leiden, The Netherlands
    BMC Proc 3:S94. 2009
    ..Using case-control study data from the North American Rheumatoid Arthritis Consortium and gene annotation data from the Gene Ontology, we illustrate how the method can be used to prioritize candidate genes for further investigation...
  10. pmc Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Arthritis Res Ther 8:216. 2006
    ..These definitions of remission refer to different disease states; therefore, we propose that the term remission is reserved for patients that are not treated with antirheumatic drugs...
  11. pmc Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus
    Stefan C A Steens
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 8:R38. 2006
    ..This is the first report of an association between the presence of aCLs and cerebral damage in grey and white matter in NPSLE. Our findings suggest that aCLs are associated with diffuse brain involvement in NPSLE patients...
  12. pmc The prognostic value of baseline erosions in undifferentiated arthritis
    Mohamed M Thabet
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden, PO Box 9600, 2300RC, The Netherlands
    Arthritis Res Ther 11:R155. 2009
    ..This study evaluates the predictive value of erosive joints for the disease outcome in UA as measured by RA development and disease persistency...
  13. pmc Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics
    Marjan M C Steenvoorden
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Res Ther 8:R165. 2006
    ..Therefore, BMP-7 may represent a promising agent to counteract the transition imposed on synoviocytes in the RA joint...
  14. pmc Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 7:R949-58. 2005
    ..In conclusion, the phenotype of RA patients with or without anti-CCP antibodies is similar with respect to clinical presentation but differs with respect to disease course...
  15. pmc TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies
    Jessica A B van Nies
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Res Ther 12:R38. 2010
    ..As TRAF1/C5 associated mortality may not be restricted to RA, we also studied a large cohort of non-RA patients...
  16. pmc Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study
    Y K Onno Teng
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Res Ther 9:R106. 2007
    ..The distinct clinical disease course after immunoablative therapy based on levels and avidity of ACPA-IgG indicates that refractory RA is not a single disease entity...
  17. ncbi request reprint Genetics in rheumatoid arthritis
    Tom W J Huizinga
    Department of Rheumatology, C4 R, Leiden University Medical Center, P O Box 9600, RC 2300, Leiden, The Netherlands
    Best Pract Res Clin Rheumatol 17:703-16. 2003
    ..practice? * What methods are used for identifying genetic risk factors? * Which genetic regions have been identified in susceptibility to RA? * What risk factors have been identified? * What are the future prospects and research agenda?..
  18. ncbi request reprint Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    Tom W J Huizinga
    Department of Rheumatology C4R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 52:3433-8. 2005
    ..We undertook this study to make the first comparison of SE allele frequencies in the healthy population with those in RA patients who do or do not harbor anti-CCP antibodies...
  19. ncbi request reprint Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism
    Tom W J Huizinga
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2066-71. 2004
  20. doi request reprint Lupus and the central nervous system
    T W J Huizinga
    Leiden University Medical Center, Leiden, The Netherlands
    Lupus 17:376-9. 2008
  21. doi request reprint A European perspective on the 50th anniversary of Arthritis & Rheumatism
    Tom W J Huizinga
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:S136-9. 2008
  22. ncbi request reprint Early aggressive therapy in rheumatoid arthritis: a 'window of opportunity'?
    Tom W J Huizinga
    Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    Nat Clin Pract Rheumatol 1:2-3. 2005
  23. ncbi request reprint Is the tuberculin skin test an accurate method of detecting tuberculosis in patients with rheumatoid arthritis?
    Tom W J Huizinga
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Nat Clin Pract Rheumatol 2:188-9. 2006
  24. ncbi request reprint A quantitative approach to early rheumatoid arthritis
    Tom W J Huizinga
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Bull NYU Hosp Jt Dis 69:116-21. 2011
    ....
  25. ncbi request reprint Genetics in rheumatoid arthritis
    Tom W J Huizinga
    Leiden University Medical Center, Department of Rheumatology, C4 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Curr Rheumatol Rep 4:195-200. 2002
    ..Several candidate loci/genes have been suggested from association studies. However, these associations have not been reproduced by different groups in several different cohorts...
  26. doi request reprint Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression
    L Dirven
    Leiden University Medical Centre, Leiden, The Netherlands
    Scand J Rheumatol 41:15-9. 2012
    ..However, for some patients this outcome is less relevant, whereas short-term functional ability is relevant to all. Do these various treatment goals share the same predictors?..
  27. doi request reprint A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study
    K Visser
    Department of Rheumatology C1 R, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Ann Rheum Dis 69:1333-7. 2010
    ..To develop a matrix model for the prediction of rapid radiographic progression (RRP) in subpopulations of patients with recent-onset rheumatoid arthritis (RA) receiving different dynamic treatment strategies...
  28. pmc Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
    S P Linn-Rasker
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 65:366-71. 2006
    ..To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis...
  29. ncbi request reprint Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients
    A L Feitsma
    Departments of Rheumatology, University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 46:1092-5. 2007
    ..We investigated whether the combination of these two biomarkers yielded better test characteristics to predict progression from undifferentiated arthritis (UA) to RA compared with ACPA alone...
  30. doi request reprint Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis
    S M van der Kooij
    Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 68:914-21. 2009
    ..To compare the occurrence of drug-free remission, functional ability and radiological damage after 4 years of response-driven treatment according to four different treatment strategies for rheumatoid arthritis (RA)...
  31. doi request reprint Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study
    N B Klarenbeek
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:315-9. 2011
    ..To determine the relapse rate after discontinuing treatment in patients with rheumatoid arthritis (RA) in sustained clinical remission, to identify predictors of a relapse and to evaluate treatment response after restarting treatment...
  32. ncbi request reprint Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles
    K N Verpoort
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:2913-8. 2007
    ..The aim of this study was to determine the influence of smoking on anti-CCP isotypes in RA patients, and to determine whether this influence is observed in the presence and/or absence of SE alleles...
  33. doi request reprint Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis
    S M van der Kooij
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:4-12. 2009
    ..To investigate the effectiveness of 4 different treatment strategies for recent-onset rheumatoid arthritis (RA) on 2-year patient-reported outcomes, including functioning and quality of life...
  34. pmc Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage
    J K de Vries-Bouwstra
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 66:1033-7. 2007
    ....
  35. ncbi request reprint Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles
    K N Verpoort
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:3949-52. 2007
    ..ACPA levels are higher in SE-positive patients with RA than in SE-negative patients with RA. The aim of the present study was to determine whether SE influences not only the magnitude but also the specificity of the ACPA response...
  36. doi request reprint The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study
    M van Den Broek
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 71:245-8. 2012
    ..The authors compared the clinical and radiological responses to Disease Activity Score (DAS)-steered treatment in patients with RA positive or RA negative for ACPA...
  37. ncbi request reprint Evidence for additional genetic risk indicators of relapse-onset MS within the HLA region
    B A de Jong
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Neurology 59:549-55. 2002
    ..Human leukocyte antigen (HLA)-DR2 carriership is associated with an increased risk for MS. Genome searches using microsatellite markers have consistently shown that additional genetic factors contribute to susceptibility for MS...
  38. doi request reprint Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis
    H M Albers
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:46-51. 2009
    ..Currently, individual response to MTX cannot be reliably predicted. Identification of clinical and genetic factors that influence the response to MTX could be helpful in realizing the optimal treatment for individual patients...
  39. doi request reprint Changes in hand bone mineral density and the association with the level of disease activity in patients with rheumatoid arthritis: bone mineral density measurements in a multicenter randomized clinical trial
    L Dirven
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Care Res (Hoboken) 63:1691-9. 2011
    ..To determine if metacarpal bone mineral density (mBMD) gain occurs in patients with rheumatoid arthritis (RA). If mBMD loss is driven by inflammation, we expect to find mBMD gain in patients who are in remission...
  40. doi request reprint Clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis
    H M Albers
    Leiden University Medical Centre, Leiden, The Netherlands
    Arthritis Care Res (Hoboken) 62:204-12. 2010
    ..We have described in detail the clinical course in different JIA subtypes during the first 2 years after diagnosis and studied its relationship to disease activity in the following years...
  41. ncbi request reprint Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis
    S Botha-Scheepers
    Leiden University Medical Centre, Department of Rheumatology, C01 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 67:1165-9. 2008
    ..Therefore, we investigated whether innate differences in the inflammatory response regarding cytokine production were associated with radiological progression of knee OA...
  42. doi request reprint Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis
    M M Thabet
    Department of Rheumatology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 68:1775-80. 2009
    ..There is increasing evidence that anti-citrullinated peptide antibody (ACPA)-positive RA and ACPA-negative RA have a different genetic background...
  43. doi request reprint Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 69:2107-13. 2010
    ..To assess the relationship between joint tenderness, swelling and joint damage progression in individual joints and to evaluate the influence of treatment on these relationships...
  44. doi request reprint Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis
    M Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Osteoarthritis Cartilage 18:1256-62. 2010
    ....
  45. doi request reprint Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
    L A Trouw
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1923-31. 2009
    ..This study was undertaken to investigate whether human anti-cyclic citrullinated peptide (anti-CCP) antibodies activate the complement system in vitro and, if so, which pathways of complement activation are used...
  46. doi request reprint Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and disease activity score-steered therapy: subanalysis of the BeSt study
    M van Den Broek
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:1389-94. 2011
    ..To describe the disease course after the cessation of infliximab in early rheumatoid arthritis patients with disease activity score (DAS)-steered treatment and to identify predictors of persistent low disease activity...
  47. doi request reprint Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis
    L Damjanovska
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 69:730-2. 2010
    ....
  48. doi request reprint Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis
    H M Albers
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:901-4. 2009
    ..In several autoimmune diseases, including rheumatoid arthritis (RA), an association with the 4q27 locus has been reported. We undertook this study to investigate the possible role of the 4q27 locus in JIA...
  49. doi request reprint Systemic and local factors are involved in the evolution of erosions in hand osteoarthritis
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:326-30. 2011
    ..In order to gain insight in the pathogenesis of erosive hand osteoarthritis (OA), the evolution of erosions in hand OA and risk factors involved were investigated...
  50. doi request reprint Efficacy of intraarticular infliximab in patients with chronic or recurrent gonarthritis: a clinical randomized trial
    A E van der Bijl
    Leiden University Medical Centre, Leiden, The Netherlands
    Arthritis Rheum 61:974-8. 2009
    ..To evaluate the efficacy and safety of intraarticular infliximab compared with intraarticular methylprednisolone in patients with gonarthritis...
  51. doi request reprint Association with joint damage and physical functioning of nine composite indices and the 2011 ACR/EULAR remission criteria in rheumatoid arthritis
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 70:1815-21. 2011
    ....
  52. doi request reprint Simplified versions of the original disease activity score: validation in the BeSt trial
    R Koevoets
    Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 70:1471-4. 2011
    ..To compare the use of patient global assessment (PGA) of disease activity versus global assessment of health (GH) in DAS, DAS alternatives and DAS28...
  53. ncbi request reprint Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients
    I Tchetverikov
    Leiden University Medical Centre, Leiden, Location C4R 70, The Netherlands
    Ann Rheum Dis 67:128-30. 2008
    ..To analyse the effects of leflunomide and methotrexate treatment on matrix metalloproteinase (MMP) activity levels in alpha2 macroglobulin/MMP (alpha2M/MMP) complexes in the systemic circulation of rheumatoid arthritis (RA) patients...
  54. ncbi request reprint Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort
    J Wesoly
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 52:2948-50. 2005
  55. pmc MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
    I Tchetverikov
    Division of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE, Leiden, Netherlands
    Ann Rheum Dis 64:694-8. 2005
    ..To determine protein and activity levels of matrix metalloproteinases 1 and 3 (MMP-1 and MMP-3) in synovial fluid of patients with knee joint injury, primary osteoarthritis, and acute pyrophosphate arthritis (pseudogout)...
  56. pmc Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study
    J Van Aken
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    Ann Rheum Dis 65:20-5. 2006
    ..The outcome of undifferentiated arthritis (UA) ranges from remission to rheumatoid arthritis (RA) fulfilling the American College of Rheumatology (ACR) classification criteria...
  57. ncbi request reprint Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis
    L R Lard
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:1841-8. 2003
    ....
  58. ncbi request reprint The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population
    J Wesoly
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 46:617-21. 2007
    ..We tested this hypothesis in an independent white Dutch study...
  59. pmc Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis
    A J M Schuerwegh
    Department of Rheumatology and Pathology, and Central Medical Immunology Laboratory, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Proc Natl Acad Sci U S A 107:2586-91. 2010
    ..Moreover, these data indicate a role for IgE-ACPAs and FcepsilonRI-positive cells in the pathogenesis of RA...
  60. ncbi request reprint Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study
    F A Van Gaalen
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:709-15. 2004
    ....
  61. ncbi request reprint A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Rheumatology (Oxford) 44:111-9. 2005
    ..To investigate the possible association of the mannose binding lectin (MBL) pathway of complement activation with different disease parameters and disease activity in patients with systemic lupus erythematosus (SLE)...
  62. pmc Arthritis of the large joints - in particular, the knee - at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis
    S P Linn-Rasker
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 66:646-50. 2007
    ..To investigate the predictive value of the distribution of inflamed joints at first presentation for the severity of the disease course in rheumatoid arthritis (RA)...
  63. doi request reprint Limitations in daily activities are the major determinant of reduced health-related quality of life in patients with hand osteoarthritis
    W Y Kwok
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:334-6. 2011
    ..To determine the impact of limitations in daily activities and pain on quality of life (QoL) in patients with osteoarthritis (OA) visiting a rheumatologist...
  64. ncbi request reprint A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis
    A H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300RC Leiden, The Netherlands
    Ann Rheum Dis 67:769-74. 2008
    ..Rheumatoid arthritis (RA) is marked by the presence of proinflammatory cytokines and, in general, the presence of high levels of inflammatory markers is associated with a severe disease course and joint damage...
  65. ncbi request reprint No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes
    A H M van der Helm-van Mil
    Department of Rheumatology, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 43:1232-4. 2004
    ..To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis...
  66. ncbi request reprint Correlation between expression of CD44 splice variant v8-v9 and invasiveness of fibroblast-like synoviocytes in an in vitro system
    T C A Tolboom
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Rheumatol 22:158-64. 2004
    ....
  67. doi request reprint Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:68-73. 2011
    ..To investigate the long-term clinical and radiographic disease course of hand osteoarthritis (OA) and determinants of outcome...
  68. doi request reprint Synergistic immunosuppressive effect of anti-TNF combined with methotrexate on antibody responses to the 23 valent pneumococcal polysaccharide vaccine
    L B S Gelinck
    Department of Infectious Diseases, Leiden University Medical Center, The Netherlands
    Vaccine 26:3528-33. 2008
    ..We studied the effect of immunosuppressive treatment, including anti-TNF and methotrexate, on the response to pneumococcal polysaccharide (PPS) vaccine...
  69. pmc FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians
    Mohamed M Thabet
    Department of Rheumatology, C1 45 Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 66:803-6. 2007
    ..Recently, Fc receptor-like 3 (FCRL3) gene was found to be associated with RA susceptibility in Japanese, but with conflicting results in other populations...
  70. doi request reprint Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis
    M van Oosterhout
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:53-60. 2008
    ..To compare synovial tissue infiltrates from patients with anti-cyclic citrullinated peptide (anti-CCP)-positive rheumatoid arthritis (RA) with those from patients with anti-CCP-negative RA...
  71. doi request reprint Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study
    F A S Kurreeman
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:2670-4. 2008
    ..The aim of this study was to confirm this association in populations of European origin by using a family-based approach...
  72. doi request reprint Protection against rheumatoid arthritis by HLA: nature and nurture
    A L Feitsma
    Department of Rheumatology, LUMC, Leiden, The Netherlands
    Ann Rheum Dis 67:iii61-3. 2008
    ..In this review, an overview of the current knowledge on protection against RA is given and the inherited and NIMA effect of "DERAA"-containing HLA-DRB1 alleles are compared...
  73. pmc A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis
    F A Van Gaalen
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 64:1510-2. 2005
    ..To compare the diagnostic performance and prognostic value of the anti-cyclic citrullinated peptide (CCP1) and anti-CCP2 autoantibody tests in a clinical setting...
  74. ncbi request reprint Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents
    A E van der Bijl
    Departments of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Rheumatol 25:301-4. 2007
    ..Neurological symptoms have been reported in patients treated with anti-TNF-alpha. In a pilot study we evaluated the effect of anti-TNF-alpha on cerebral parenchyma using advanced Magnetic Resonance (MR) techniques...
  75. doi request reprint Clinical burden of erosive hand osteoarthritis and its relationship to nodes
    J Bijsterbosch
    Leiden University Medical Centre, Department of Rheumatology, C1 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 69:1784-8. 2010
    ..To describe the clinical burden of erosive osteoarthritis (EOA) of the hand in terms of pain, functioning and health-related quality of life (HRQL) and its relationship to nodal osteoarthritis (OA)...
  76. pmc Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis
    J Van Aken
    Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 63:274-9. 2004
    ..Additionally, to determine the effect of treatment strategy on the association of HLA class II alleles and joint damage...
  77. doi request reprint Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens
    P Suwannalai
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:373-9. 2011
    ..Nonetheless, the evolution of the ACPA response is still poorly understood and might intrinsically differ from the protective responses against pathogens...
  78. ncbi request reprint Interleukin-10 promoter polymorphisms in male and female fertility and fecundity
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Genes Immun 7:688-92. 2006
    ..2, 95% CI: 0.04-0.7, P=0.01). This suggests an association between the -2849 AA genotype and a decreased fertility and fecundity in females...
  79. doi request reprint A decrease in disease activity score (DAS) level is associated with a decrease in health assessment questionnaire (HAQ) score, independent of follow-up duration, during 5 years of tightly controlled treatment: results from the BeSt study
    E van der Kooi
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:168-71. 2011
    ....
  80. ncbi request reprint The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:425-32. 2007
    ....
  81. doi request reprint Reliability, sensitivity to change and feasibility of three radiographic scoring methods for hand osteoarthritis
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:1465-7. 2011
    ..To compare the reliability, sensitivity to change and feasibility of three radiographic scoring methods for hand osteoarthritis (OA)...
  82. ncbi request reprint Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis
    J P Bayley
    Department of Rheumatology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Rheumatology (Oxford) 42:969-71. 2003
    ..To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients...
  83. doi request reprint Gene therapy for the treatment of hip prosthesis loosening: adverse events in a phase 1 clinical study
    Jolanda J de Poorter
    Department of Orthopedics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Hum Gene Ther 19:1029-38. 2008
    ..There was no dose-limiting toxicity. However, the extensive comorbidity in these patients makes it difficult to fully establish the safety of the approach in this small and heterogeneous patient population...
  84. ncbi request reprint Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment
    Y K Onno Teng
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:3909-18. 2007
    ..The aim of this study was to investigate B cell depletion in different compartments (PB, bone marrow, and synovium) and determine predictive variables for responsiveness to rituximab therapy...
  85. ncbi request reprint A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis
    Judith A M Wessels
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1765-75. 2007
    ..To develop a clinical pharmacogenetic model to predict the efficacy of methotrexate (MTX) in rheumatoid arthritis (RA)...
  86. doi request reprint Survival, comorbidities and joint damage 11 years after the COBRA combination therapy trial in early rheumatoid arthritis
    Lilian H D van Tuyl
    VU University Medical Center, Department of Rheumatology, ZH 3A 56, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Ann Rheum Dis 69:807-12. 2010
    ..This study evaluates survival, comorbidities and joint damage in the original COBRA trial cohort...
  87. doi request reprint Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation
    Y K O Teng
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 68:1011-6. 2009
    ..To investigate the clinical effects of rituximab treatment in relation to immunological effects of rituximab on tissue-derived B lineage cells and repopulation of circulating B cells...
  88. ncbi request reprint Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production
    B A de Jong
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Genes Immun 3:25-9. 2002
    ..We conclude that the genes determing the differences in endotoxin-induced TNF production have not been yet identified...
  89. pmc MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
    I Tchetverikov
    TNO Prevention and Health, PO Box 2215, 2301 CE, Leiden, The Netherlands
    Ann Rheum Dis 63:881-3. 2004
    ....
  90. ncbi request reprint The role of interleukin 10 promoter polymorphisms in the susceptibility of distal interphalangeal osteoarthritis
    Naghmeh Riyazi
    Department of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Rheumatol 32:1571-5. 2005
    ..We investigated the association of 7 novel SNP located downstream of the IL-10 transcription start site: -2849,-2763, -1330, -1082, -819, and -592, constituting the 4 ancient haplotypes, with distal interphalangeal (DIP) OA...
  91. ncbi request reprint Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis
    Brigit A de Jong
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    J Neuroimmunol 126:172-9. 2002
    ..Taq1 polymorphism in the IL-1beta gene and the variable number of tandem repeats (VNTR) polymorphism of 86-base pairs within the IL-1Ra gene cannot explain these findings...
  92. ncbi request reprint HLA and RA revisited: citrullinated food for the SE hypothesis, the DR6 effect, and NIMA
    Rene R P de Vries
    Department of Immunohematology Bloodtransfusion, Leiden University Medical Center, The Netherlands
    Hum Immunol 67:454-9. 2006
    ..Finally we review the state of the art of the association of noninherited maternal HLA antigens with both susceptibility to and protection from RA...
  93. doi request reprint Assistive devices: usage in patients with rheumatoid arthritis
    I G de Boer
    Department of Rheumatology C1 R, Leiden University Medical Center, P O Box 9600, 2300, Leiden, The Netherlands
    Clin Rheumatol 28:119-28. 2009
    ..The latter findings underline the need for a systematic evaluation of the outcomes of assistive devices by prescribing health professionals or suppliers in every individual case...
  94. pmc Influence of guideline adherence on outcome in a randomised controlled trial on the efficacy of methotrexate with folate supplementation in rheumatoid arthritis
    J Fransen
    Department of Rheumatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, Netherlands
    Ann Rheum Dis 63:1222-6. 2004
    ..To study the influence of rheumatologists' adherence to a methotrexate guideline on efficacy and toxicity in the treatment of rheumatoid arthritis...
  95. ncbi request reprint Use of methotrexate in undifferentiated arthritis
    K Visser
    Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Rheumatol 28:S117-21. 2010
    ..During the last few years, more data on interventions in UA have become available that provide guidance in the prescription of drugs to UA patients...
  96. doi request reprint Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease
    Andreea Ioan-Facsinay
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:3000-8. 2008
    ..In order to identify the features that could confer its pathogenicity, we extensively characterized this antibody response in a unique North American native population of patients with RA and their unaffected relatives...
  97. ncbi request reprint Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  98. doi request reprint The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases
    Fina A S Kurreeman
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Ann Rheum Dis 69:696-9. 2010
    ....
  99. pmc Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo
    Judith M H de Jong
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Immunology 119:499-506. 2006
    ..These results indicate that mainly DC and not other professional APC, despite expressing FcgammaR and MHC class II, contribute significantly to IC-facilitated T cell activation in vivo under steady-state conditions...
  100. doi request reprint Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha
    Jun Wang
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:1609-18. 2008
    ....
  101. ncbi request reprint Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial
    Henrike van Dongen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1424-32. 2007
    ..To determine whether patients with undifferentiated arthritis (UA; inflammatory, nontraumatic arthritis that cannot be diagnosed using current classification criteria) benefit from treatment with methotrexate (MTX)...