Daan W Hommes

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease
    Daniel W Hommes
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Crohns Colitis 5:543-9. 2011
  2. pmc Circulating cell death products predict clinical outcome of colorectal cancer patients
    Pim J Koelink
    Department of Gastroenterology and Hepatology, Leiden University Medical Centre, C4 P, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    BMC Cancer 9:88. 2009
  3. doi request reprint A double-blind, placebo-controlled, randomized study of infliximab in primary sclerosing cholangitis
    Daan W Hommes
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Gastroenterol 42:522-6. 2008
  4. doi request reprint Misclassification of dysplasia in patients with inflammatory bowel disease: consequences for progression rates to advanced neoplasia
    Fiona D M van Schaik
    University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands
    Inflamm Bowel Dis 17:1108-16. 2011
  5. ncbi request reprint Infliximab treatment for Crohn's disease: one-year experience in a Dutch academic hospital
    Daan W Hommes
    Department of Gastroenterology and Hepatology, Academic Medical Center, C2 116, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Inflamm Bowel Dis 8:81-6. 2002
  6. doi request reprint 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells
    Pim J Koelink
    Department of Gastroenterology Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Cancer Lett 287:82-90. 2010
  7. pmc A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Genet 7:e1001283. 2011
  8. doi request reprint Flexible limited sampling model for monitoring tacrolimus in stable patients having undergone liver transplantation with samples 4 to 6 hours after dosing is superior to trough concentration
    Pieter Langers
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Ther Drug Monit 30:456-61. 2008
  9. doi request reprint Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine
    Willemijn A van Dop
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 139:1665-76, 1676.e1-10. 2010
  10. doi request reprint Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohn's disease
    Martin J Meijer
    LUMC, Department of Gastroenterology Hepatology, Leiden, The Netherlands
    Inflamm Bowel Dis 15:84-92. 2009

Collaborators

Detail Information

Publications18

  1. doi request reprint Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease
    Daniel W Hommes
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Crohns Colitis 5:543-9. 2011
    ..Recently, several cases have been reported of successful remission induction in Crohn's disease patients by means of hematopoietic stem cell transplantation (HSCT). Here we report our long-term (4 to 6 years) outcome in three patients...
  2. pmc Circulating cell death products predict clinical outcome of colorectal cancer patients
    Pim J Koelink
    Department of Gastroenterology and Hepatology, Leiden University Medical Centre, C4 P, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    BMC Cancer 9:88. 2009
    ..CK18-Asp396 (M30 antigen) is a caspase-degraded product of cytokeratin 18 (CK18), produced by apoptotic epithelial cells, and is elevated in breast and lung cancer patients...
  3. doi request reprint A double-blind, placebo-controlled, randomized study of infliximab in primary sclerosing cholangitis
    Daan W Hommes
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Gastroenterol 42:522-6. 2008
    ..To evaluate the safety and efficacy of infliximab in patients with primary sclerosing cholangitis...
  4. doi request reprint Misclassification of dysplasia in patients with inflammatory bowel disease: consequences for progression rates to advanced neoplasia
    Fiona D M van Schaik
    University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands
    Inflamm Bowel Dis 17:1108-16. 2011
    ..We studied the progression rate of flat LGD and IND to advanced neoplasia (high-grade dysplasia [HGD] or colorectal cancer [CRC]) before and after histopathological review by a panel of gastrointestinal expert pathologists...
  5. ncbi request reprint Infliximab treatment for Crohn's disease: one-year experience in a Dutch academic hospital
    Daan W Hommes
    Department of Gastroenterology and Hepatology, Academic Medical Center, C2 116, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Inflamm Bowel Dis 8:81-6. 2002
    ..Higher response rates were seen with methotrexate as concomitant medication...
  6. doi request reprint 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells
    Pim J Koelink
    Department of Gastroenterology Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Cancer Lett 287:82-90. 2010
    ..We conclude that 5-ASA inhibits TGF-beta1 signalling in colorectal cancer cells, and might be a potent adjuvant therapeutic drug, interfering with aberrant TGF-beta signalling in colorectal cancer...
  7. pmc A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Genet 7:e1001283. 2011
    ..The combined analysis of the two datasets provided the power, lacking in the individual GWAS for single diseases, to detect shared loci with a relatively small effect...
  8. doi request reprint Flexible limited sampling model for monitoring tacrolimus in stable patients having undergone liver transplantation with samples 4 to 6 hours after dosing is superior to trough concentration
    Pieter Langers
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Ther Drug Monit 30:456-61. 2008
    ..This new limited sampling model, based on single time points C4-C6, shows excellent performance in estimating the AUC0-12h...
  9. doi request reprint Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine
    Willemijn A van Dop
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 139:1665-76, 1676.e1-10. 2010
    ..Recently, genetic variants in the Hh pathway have been linked to the development of inflammatory bowel disease...
  10. doi request reprint Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohn's disease
    Martin J Meijer
    LUMC, Department of Gastroenterology Hepatology, Leiden, The Netherlands
    Inflamm Bowel Dis 15:84-92. 2009
    ....
  11. ncbi request reprint Immunomodulation of mucosal inflammation
    Daan W Hommes
    Department of Gastroenterology and Hepatology, C2 111 Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 39:S744-5. 2004
  12. pmc Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule
    Henri Braat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gut 56:351-7. 2007
    ..Hypothesis: Injection of FHA would ameliorate disease in a T cell-dependent model of colitis via the induction of anti-inflammatory cytokines and regulatory T cells...
  13. ncbi request reprint Infliximab use in children and adolescents with inflammatory bowel disease
    Lissy de Ridder
    Department of Pediatric Gastroenterology, VU University Medical Centre, The Netherlands
    J Pediatr Gastroenterol Nutr 45:3-14. 2007
    ..Major points of discussion are whether infliximab maintenance treatment should be episodic (on demand) or scheduled and when infliximab therapy can be discontinued...
  14. ncbi request reprint Synergistic effect of methotrexate and infliximab on activated lymphocyte apoptosis
    Jan M H Van Den Brande
    Inflamm Bowel Dis 13:118-9. 2007
  15. ncbi request reprint A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease
    Alexander Teml
    Medical University of Vienna, Austria
    Wien Klin Wochenschr 119:519-26. 2007
    ..The aim of the study was to evaluate the prevalence of 6-TG-related hepatotoxicity in a large multi-centered IBD population by means of a systematic online survey...
  16. ncbi request reprint Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease
    Jan M H Van Den Brande
    Laboratory for Experimental Internal Medicine, G2 133, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 124:1774-85. 2003
    ..Because both infliximab and etanercept are TNF-alpha-neutralizing drugs, we investigated the differences in TNF-alpha-neutralizing capacity and human lymphocyte binding and apoptosis-inducing capacity of both molecules...
  17. ncbi request reprint Steroid-independent Crohn's disease patients also benefit from combination therapy of infliximab plus azathioprine
    Jan M H Van Den Brande
    Gastroenterology 131:1362-3. 2006
  18. ncbi request reprint Infliximab induced T lymphocyte apoptosis in Crohn's disease
    Jan van den Brande
    Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands
    J Rheumatol Suppl 74:26-30. 2005
    ..This brief review considers the question of whether this disparity can be explained by the different structure of the proteins, their different binding affinities, or the subsequent effects on T lymphocytes...