Research Topics
Genomes and Genes | Daan W HommesSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's diseaseDaniel W Hommes
Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
J Crohns Colitis 5:543-9. 2011..Recently, several cases have been reported of successful remission induction in Crohn's disease patients by means of hematopoietic stem cell transplantation (HSCT). Here we report our long-term (4 to 6 years) outcome in three patients...
Circulating cell death products predict clinical outcome of colorectal cancer patientsPim J Koelink
Department of Gastroenterology and Hepatology, Leiden University Medical Centre, C4 P, P, O, Box 9600, 2300 RC Leiden, The Netherlands
BMC Cancer 9:88. 2009..CK18-Asp396 (M30 antigen) is a caspase-degraded product of cytokeratin 18 (CK18), produced by apoptotic epithelial cells, and is elevated in breast and lung cancer patients...- A double-blind, placebo-controlled, randomized study of infliximab in primary sclerosing cholangitisDaan W Hommes
Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
J Clin Gastroenterol 42:522-6. 2008..To evaluate the safety and efficacy of infliximab in patients with primary sclerosing cholangitis... - Misclassification of dysplasia in patients with inflammatory bowel disease: consequences for progression rates to advanced neoplasiaFiona D M van Schaik
University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands
Inflamm Bowel Dis 17:1108-16. 2011..We studied the progression rate of flat LGD and IND to advanced neoplasia (high-grade dysplasia [HGD] or colorectal cancer [CRC]) before and after histopathological review by a panel of gastrointestinal expert pathologists... 
Infliximab treatment for Crohn's disease: one-year experience in a Dutch academic hospitalDaan W Hommes
Department of Gastroenterology and Hepatology, Academic Medical Center, C2 116, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Inflamm Bowel Dis 8:81-6. 2002..Higher response rates were seen with methotrexate as concomitant medication...- 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cellsPim J Koelink
Department of Gastroenterology Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Cancer Lett 287:82-90. 2010..We conclude that 5-ASA inhibits TGF-beta1 signalling in colorectal cancer cells, and might be a potent adjuvant therapeutic drug, interfering with aberrant TGF-beta signalling in colorectal cancer... - A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac diseaseEleonora A M Festen
Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
PLoS Genet 7:e1001283. 2011..The combined analysis of the two datasets provided the power, lacking in the individual GWAS for single diseases, to detect shared loci with a relatively small effect... - Flexible limited sampling model for monitoring tacrolimus in stable patients having undergone liver transplantation with samples 4 to 6 hours after dosing is superior to trough concentrationPieter Langers
Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
Ther Drug Monit 30:456-61. 2008..This new limited sampling model, based on single time points C4-C6, shows excellent performance in estimating the AUC0-12h... - Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestineWillemijn A van Dop
Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
Gastroenterology 139:1665-76, 1676.e1-10. 2010..Recently, genetic variants in the Hh pathway have been linked to the development of inflammatory bowel disease... - Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohn's diseaseMartin J Meijer
LUMC, Department of Gastroenterology Hepatology, Leiden, The Netherlands
Inflamm Bowel Dis 15:84-92. 2009.... - Immunomodulation of mucosal inflammationDaan W Hommes
Department of Gastroenterology and Hepatology, C2-111 Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Pediatr Gastroenterol Nutr 39:S744-5. 2004 - Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory moleculeHenri Braat
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Gut 56:351-7. 2007..Hypothesis: Injection of FHA would ameliorate disease in a T cell-dependent model of colitis via the induction of anti-inflammatory cytokines and regulatory T cells... - Infliximab use in children and adolescents with inflammatory bowel diseaseLissy de Ridder
Department of Pediatric Gastroenterology, VU University Medical Centre, The Netherlands
J Pediatr Gastroenterol Nutr 45:3-14. 2007..Major points of discussion are whether infliximab maintenance treatment should be episodic (on demand) or scheduled and when infliximab therapy can be discontinued... - Synergistic effect of methotrexate and infliximab on activated lymphocyte apoptosisJan M H Van Den Brande
Inflamm Bowel Dis 13:118-9. 2007 - A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel diseaseAlexander Teml
Medical University of Vienna, Austria
Wien Klin Wochenschr 119:519-26. 2007..The aim of the study was to evaluate the prevalence of 6-TG-related hepatotoxicity in a large multi-centered IBD population by means of a systematic online survey... - Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's diseaseJan M H Van Den Brande
Laboratory for Experimental Internal Medicine, G2 133, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
Gastroenterology 124:1774-85. 2003..Because both infliximab and etanercept are TNF-alpha-neutralizing drugs, we investigated the differences in TNF-alpha-neutralizing capacity and human lymphocyte binding and apoptosis-inducing capacity of both molecules... - Steroid-independent Crohn's disease patients also benefit from combination therapy of infliximab plus azathioprineJan M H Van Den Brande
Gastroenterology 131:1362-3. 2006 - Infliximab induced T lymphocyte apoptosis in Crohn's diseaseJan van den Brande
Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands
J Rheumatol Suppl 74:26-30. 2005..This brief review considers the question of whether this disparity can be explained by the different structure of the proteins, their different binding affinities, or the subsequent effects on T lymphocytes...