Menno Hoekstra


Affiliation: Leiden University
Country: The Netherlands


  1. Hoekstra M, Nahon J, de Jong L, Kröner M, de Leeuw L, Van Eck M. Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice. Biochim Biophys Acta Mol Basis Dis. 2019;: pubmed publisher
    ..As such, our studies highlight that PRMT3 inhibition may constitute a novel therapeutic approach to limit the development of fatty liver disease in humans. ..
  2. Nahon J, Hoekstra M, van Hulst S, Manta C, Goerdt S, Geerling J, et al. Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice. Atherosclerosis. 2019;281:47-55 pubmed publisher
    ..However, the increased body weight gain and adipocyte cell size highlight a potential role for leukocyte STAB1 in the development of metabolic disorders. ..
  3. Hoekstra M, Ouweneel A, Nahon J, van der Geest R, Kröner M, van der Sluis R, et al. ATP-binding cassette transporter G1 deficiency is associated with mild glucocorticoid insufficiency in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:443-451 pubmed publisher
    ..05) and apolipoprotein E (+59%; P < 0.01) mRNA expression. ABCG1 deficiency is associated with mild glucocorticoid insufficiency in mice. ..
  4. Hoekstra M, Van Berkel T, Van Eck M. Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism. World J Gastroenterol. 2010;16:5916-24 pubmed
    ..Studies using these mice have identified SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. ..
  5. van der Sluis R, Van Eck M, Hoekstra M. Adrenocortical LDL receptor function negatively influences glucocorticoid output. J Endocrinol. 2015;226:145-54 pubmed publisher
    ..In conclusion, our studies in a mouse model with a human-like lipoprotein profile provide the first in vivo evidence for a novel inhibitory role of the LDLR in the control of adrenal glucocorticoid production. ..
  6. Ouweneel A, van der Sluis R, Nahon J, Van Eck M, Hoekstra M. Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice. Atherosclerosis. 2017;261:99-104 pubmed publisher
  7. van der Geest R, Ouweneel A, van der Sluis R, Groen A, Van Eck M, Hoekstra M. Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice. Toxicol Appl Pharmacol. 2016;306:1-7 pubmed publisher
    ..In conclusion, we have shown that endogenous glucocorticoids exacerbate the liver injury and hypercholesterolemia associated with acute cholestasis in mice. ..
  8. Hoekstra M, Van Eck M. HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile. J Lipid Res. 2016;57:631-7 pubmed publisher
    ..Our findings provide the first experimental evidence that APOB-containing lipoproteins may facilitate adrenal steroidogenesis, in an LDLR-independent manner, in vivo in mice. ..
  9. Hoekstra M, Korporaal S, Li Z, Zhao Y, Van Eck M, Van Berkel T. Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice. Am J Physiol Endocrinol Metab. 2010;299:E1038-43 pubmed publisher
    ..Therefore, it is suggested that plasma lipoproteins are required for optimal adrenal steroidogenesis and protection against endotoxemia in mice. ..

More Information


  1. Hoekstra M, Korporaal S, van der Sluis R, Hirsch Reinshagen V, Bochem A, Wellington C, et al. LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function. J Lipid Res. 2013;54:358-64 pubmed publisher
    ..These findings further highlight the important novel role for HDL as cholesterol donor for the synthesis of glucocorticoids by the adrenals. ..
  2. Hoekstra M, Van der Lans C, Halvorsen B, Gullestad L, Kuiper J, Aukrust P, et al. The peripheral blood mononuclear cell microRNA signature of coronary artery disease. Biochem Biophys Res Commun. 2010;394:792-7 pubmed publisher
    ..Our findings highlight the importance of microRNAs signatures as novel tool to predict clinical disease outcomes. ..
  3. Hoekstra M, Meurs I, Koenders M, Out R, Hildebrand R, Kruijt J, et al. Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting. J Lipid Res. 2008;49:738-45 pubmed publisher
  4. Hoekstra M, Van Eck M. Mouse models of disturbed HDL metabolism. Handb Exp Pharmacol. 2015;224:301-36 pubmed publisher
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    Hoekstra M, Stitzinger M, van Wanrooij E, Michon I, Kruijt J, Kamphorst J, et al. Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet. J Lipid Res. 2006;47:2198-207 pubmed
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    Hoekstra M, Kruijt J, Van Eck M, Van Berkel T. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. J Biol Chem. 2003;278:25448-53 pubmed
  7. Hoekstra M, Li Z, Kruijt J, Van Eck M, Van Berkel T, Kuiper J. The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status. J Hepatol. 2010;52:244-51 pubmed publisher
    ..It appears that the NAFLD-related gene PNPLA3 is highly responsive to metabolic changes in hepatocytes within the liver and its relative change in expression level suggests an essential function in lipogenesis. ..
  8. Hoekstra M. SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease. Atherosclerosis. 2017;258:153-161 pubmed publisher
  9. Hoekstra M, Ye D, Hildebrand R, Zhao Y, Lammers B, Stitzinger M, et al. Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production. J Lipid Res. 2009;50:1039-46 pubmed publisher
    ..In conclusion, we have shown that CETP-mediated transfer of HDL-CE is not able to reverse adrenal insufficiency in SR-BI knockout mice. Thus, SR-BI-mediated uptake of serum cholesterol is essential for optimal adrenal function. ..
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    Hoekstra M, Out R, Kruijt J, Van Eck M, Van Berkel T. Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. J Hepatol. 2005;42:400-7 pubmed
    ..Heavy lipid loading of parenchymal cells leads to moderate gene expression changes, while Kupffer cells respond in a highly adaptive fashion by stimulating the expression of genes involved in cholesterol metabolism and transport. ..