Matthew S Hestand
Affiliation: Leiden University Medical Center
Country: The Netherlands
- CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genesMatthew S Hestand
The Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 0P, PO Box 9600, 2300 RC Leiden, The Netherlands
BMC Bioinformatics 9:495. 2008..Computational methods to reduce false positives are to look for over-representation of transcription factor binding sites in a set of similarly regulated promoters or to look for conservation in orthologous promoter alignments...
- Genome-wide assessment of differential roles for p300 and CBP in transcription regulationYolande F M Ramos
Department of Molecular Cell Biology, Leiden University Medical Center, Postzone S4 0P, PO Box 9600, 2300 RC Leiden, The Netherlands
Nucleic Acids Res 38:5396-408. 2010..Taken together, our findings further elucidate the distinct roles of coactivators p300 and CBP in transcriptional regulation...
- Tissue-specific transcript annotation and expression profiling with complementary next-generation sequencing technologiesMatthew S Hestand
The Center for Human and Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Nucleic Acids Res 38:e165. 2010..Next-generation sequencing of CAGE and SAGE libraries provides consistent expression levels and can enrich current genome annotations with tissue-specific promoters and alternative 3'-UTR usage...