F M Helmerhorst

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi Oral contraceptives and thrombotic disease: risk of venous thromboembolism
    F M Helmerhorst
    Department of Obstetrics, Gynecology and Reproductive Medicine, Leiden University, The Netherlands
    Thromb Haemost 78:327-33. 1997
  2. ncbi Interleukin-10 promoter polymorphisms in male and female fertility and fecundity
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Genes Immun 7:688-92. 2006
  3. ncbi Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Hum Reprod 21:967-71. 2006
  4. ncbi Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:802-6. 2005
  5. ncbi Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, The Netherlands
    Hum Reprod 22:75-82. 2007
  6. ncbi Gonadotrophin stimulation reduces VEGF(120) expression in the mouse uterus during the peri-implantation period
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    Hum Reprod 17:1643-8. 2002
  7. ncbi Estrogen reduces vascular endothelial growth factor(164) expression in the mouse nucleus paraventricularis of the hypothalamus
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Neurosci Lett 333:199-202. 2002
  8. ncbi Urinary gonadotrophins but not recombinant gonadotrophins reduce expression of VEGF120 and its receptors flt-1 and flk-1 in the mouse uterus during the peri-implantation period
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    Hum Reprod 20:649-56. 2005
  9. ncbi Does subfertility explain the risk of poor perinatal outcome after IVF and ovarian hyperstimulation?
    K Kapiteijn
    Division of Reproductive Medicine, Department of Gynaecology, Leiden University Medical Center, Leiden, The Netherlands
    Hum Reprod 21:3228-34. 2006
  10. ncbi The RATIO study: oral contraceptives and the risk of peripheral arterial disease in young women
    M A A J van den Bosch
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Thromb Haemost 1:439-44. 2003

Collaborators

Detail Information

Publications14

  1. ncbi Oral contraceptives and thrombotic disease: risk of venous thromboembolism
    F M Helmerhorst
    Department of Obstetrics, Gynecology and Reproductive Medicine, Leiden University, The Netherlands
    Thromb Haemost 78:327-33. 1997
    ..The clinical consequence is therefore that second-generation OCs are the first choice in prescription to first-time users...
  2. ncbi Interleukin-10 promoter polymorphisms in male and female fertility and fecundity
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Genes Immun 7:688-92. 2006
    ..2, 95% CI: 0.04-0.7, P=0.01). This suggests an association between the -2849 AA genotype and a decreased fertility and fecundity in females...
  3. ncbi Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Hum Reprod 21:967-71. 2006
    ..This was studied in subjects who were of childbearing age in a time with minimal fertility control without modern contraceptive methods...
  4. ncbi Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:802-6. 2005
    ..This may manifest itself as a reduced time to pregnancy (increased fecundity) and fewer miscarriages in the first trimester...
  5. ncbi Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, The Netherlands
    Hum Reprod 22:75-82. 2007
    ....
  6. ncbi Gonadotrophin stimulation reduces VEGF(120) expression in the mouse uterus during the peri-implantation period
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    Hum Reprod 17:1643-8. 2002
    ..Ovarian stimulation by gonadotrophin treatment exerts negative effects on implantation and embryonic development. We investigated whether gonadotrophin treatment affects VEGF(120) mRNA expression during the peri-implantation period...
  7. ncbi Estrogen reduces vascular endothelial growth factor(164) expression in the mouse nucleus paraventricularis of the hypothalamus
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Neurosci Lett 333:199-202. 2002
    ....
  8. ncbi Urinary gonadotrophins but not recombinant gonadotrophins reduce expression of VEGF120 and its receptors flt-1 and flk-1 in the mouse uterus during the peri-implantation period
    R M Sibug
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    Hum Reprod 20:649-56. 2005
    ..In this study we compared the effects of recombinant and urinary gonadotrophins during the mouse peri-implantation period...
  9. ncbi Does subfertility explain the risk of poor perinatal outcome after IVF and ovarian hyperstimulation?
    K Kapiteijn
    Division of Reproductive Medicine, Department of Gynaecology, Leiden University Medical Center, Leiden, The Netherlands
    Hum Reprod 21:3228-34. 2006
    ..A secondary objective was to test the hypothesis that ovarian hyperstimulation rather than the IVF procedure may influence the perinatal outcome...
  10. ncbi The RATIO study: oral contraceptives and the risk of peripheral arterial disease in young women
    M A A J van den Bosch
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Thromb Haemost 1:439-44. 2003
    ..6 (95% CI 1.4-4.9) and 3.0 (95% CI 1.4-6.6), respectively. This is the first study on oral contraceptive use and PAD in humans. All types of oral contraceptives were associated with an increased risk of PAD...
  11. ncbi Estrogens, progestogens and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Thromb Haemost 1:1371-80. 2003
    ..The risk of arterial disease in oral contraceptive users and users of hormone replacement therapy is at most weakly affected by the presence of prothrombotic abnormalities...
  12. ncbi Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment
    C Kluft
    Gaubius Laboratory, TNO PG, Vascular and Connective Tissue Research, Zernikedreef 9, P O Box 2215, 2333 CK Leiden, The Netherlands
    Vascul Pharmacol 39:149-54. 2002
    ..It is proposed that the pro-inflammatory effect of oestrogens should be checked for a relationship with the increased risk of thromboembolism for both oral contraceptive and HRT...
  13. ncbi Female hormones and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 22:201-10. 2002
    ..The risk becomes very high in women with a previous venous thrombosis. Randomized trials have not confirmed a beneficial effect of postmenopausal hormones on the occurrence of myocardial infarction...
  14. ncbi Immunohistochemical and ultrastructural localization of prostaglandin H synthase in the preimplantation mouse embryo
    R M van der Weiden
    Department of Obstetrics and Gynecology, Leiden University Hospital, Netherlands
    J Reprod Fertil 107:161-6. 1996
    ..Its presence before the apposition with the endometrial epithelium supports the hypothesis that arachidonic acid metabolism via the PGH synthase pathway may be crucial for implantation...