B T Heijmans

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Leiden University Medical Centre, Leiden, The Netherlands
    Twin Res 7:192-6. 2004
  2. ncbi Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
  3. pmc Lipoprotein particle profiles mark familial and sporadic human longevity
    Bastiaan T Heijmans
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 3:e495. 2006
  4. ncbi Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Leiden University Medical Centre, Leiden 2333 ZC, The Netherlands
    Hum Mol Genet 16:547-54. 2007
  5. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
  6. ncbi Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort
    B T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Genes Immun 3:225-8. 2002
  7. ncbi The epigenome: archive of the prenatal environment
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epigenetics 4:526-31. 2009
  8. ncbi Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age
    Bastiaan T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Am J Med Genet 107:201-8. 2002
  9. pmc Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction
    Rudolf P Talens
    Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Epidemiol 41:106-15. 2012
  10. pmc Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85
    J Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 67:535-8. 1999

Collaborators

Detail Information

Publications34

  1. ncbi Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Leiden University Medical Centre, Leiden, The Netherlands
    Twin Res 7:192-6. 2004
    ..An obvious positional candidate in the 7p linkage region is the gene encoding neuropeptide Y (NPY) that controls satiety and food intake...
  2. ncbi Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
    ..In conclusion, application of a new meta-analysis approach maximised the power to detect QTLs for lipid levels and improved the precision of their location estimate...
  3. pmc Lipoprotein particle profiles mark familial and sporadic human longevity
    Bastiaan T Heijmans
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 3:e495. 2006
    ..Here, we investigate whether this observation can be confirmed for familial longevity in an outbred European population and whether it can be extended to sporadic longevity in the general population...
  4. ncbi Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Leiden University Medical Centre, Leiden 2333 ZC, The Netherlands
    Hum Mol Genet 16:547-54. 2007
    ....
  5. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
    ..These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life...
  6. ncbi Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort
    B T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Genes Immun 3:225-8. 2002
    ..In conclusion, the -308G/A polymorphism in the TNF promoter is strongly associated with the risk of diabetes but not cardiovascular mortality in old age...
  7. ncbi The epigenome: archive of the prenatal environment
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epigenetics 4:526-31. 2009
    ..Well-designed epigenome-wide studies will be crucial in creating a catalog of epigenomic regions that are sensitive to the prenatal environment to evaluate developmental influences on common human disease...
  8. ncbi Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age
    Bastiaan T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Am J Med Genet 107:201-8. 2002
    ..Furthermore, they emphasize that variation at the APOE locus has a higher impact on the risk of dementia than on the risk of cardiovascular disease in old age...
  9. pmc Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction
    Rudolf P Talens
    Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Epidemiol 41:106-15. 2012
    ..Methylation at IL10, LEP, ABCA1, IGF2, INS and GNASAS was measured in DNA extracted from leucocytes using mass spectrometry...
  10. pmc Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85
    J Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 67:535-8. 1999
    ..Homozygous carriers of this mutation are characterised by a lifelong exposure to moderately raised plasma concentrations of homocysteine...
  11. pmc Genomics of human longevity
    P E Slagboom
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 366:35-42. 2011
    ..By the integration of research in different study cohorts, and with research in animal models, biological research into human longevity is thus making considerable progress...
  12. ncbi Genetics of human aging. The search for genes contributing to human longevity and diseases of the old
    P E Slagboom
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Ann N Y Acad Sci 908:50-63. 2000
    ..These issues will be illustrated from research on cardiovascular disease and osteoarthritis...
  13. ncbi Combined association and linkage analysis applied to the APOE locus
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Genet Epidemiol 26:328-37. 2004
    ....
  14. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  15. doi Genomic studies in ageing research: the need to integrate genetic and gene expression approaches
    W M Passtoors
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Intern Med 263:153-66. 2008
    ..New study designs such as the Leiden Longevity Study, including two generations of subjects from longevity families, aim to achieve these combined approaches...
  16. ncbi Heritabilities of apolipoprotein and lipid levels in three countries
    Marian Beekman
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Center, Leiden, The Netherlands
    Twin Res 5:87-97. 2002
    ..Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries...
  17. pmc Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
    Marian Beekman
    Molecular Epidemiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:18046-9. 2010
    ..Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease...
  18. pmc DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epigenetics 6:171-6. 2011
    ..Our and previous results by others indicate that prenatal growth restriction and famine exposure may be associated with different epigenetic changes or non epigenetic mechanisms that may lead to similar later health outcomes...
  19. ncbi Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Twin Res 6:322-4. 2003
    ..Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs...
  20. ncbi Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 11:845-50. 2003
    ..Our study provides strong evidence for the presence of a QTL on chromosome 19 with a major effect on LDL-C plasma levels in outbred Caucasian populations...
  21. ncbi Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming
    Anita H J van den Biggelaar
    Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2 R, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    FASEB J 18:1022-4. 2004
    ..77; 95% CI: 0.68-0.88), while a positive association with IL-10 was found (RR = 1.22; 95% CI: 1.05-1.41). We suggest that cardiovascular mortality is a late consequence of evolutionary programming for a pro-inflammatory response...
  22. ncbi Reduced insulin/IGF-1 signalling and human longevity
    Diana van Heemst
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 4:79-85. 2005
    ..This effect was stronger for the GH1 SNP than for variation in the conserved IIS genes that were found to affect longevity in model organisms...
  23. ncbi Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study
    Anita H J van den Biggelaar
    Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2 R, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Exp Gerontol 39:1407-14. 2004
    ..We conclude that a malfunctioning innate immune response predicts frailty in old age and is under specific (immuno-) genetic control...
  24. ncbi Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level
    Fina A S Kurreeman
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    Hum Mol Genet 13:1755-62. 2004
    ..These findings show that interindividual differences in IL10 protein levels can be explained at the transcriptional level...
  25. doi Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    ....
  26. ncbi Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Hum Reprod 21:967-71. 2006
    ..This was studied in subjects who were of childbearing age in a time with minimal fertility control without modern contraceptive methods...
  27. pmc Human insulin/IGF-1 and familial longevity at middle age
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Aging (Albany NY) 1:714-22. 2009
    ....
  28. doi Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology
    Rudolf P Talens
    Department of Molecular Epidemiology, Leiden University Medical Center, Postal Zone S 05 P, PO Box 9600, 2300RC, Leiden, The Nethelands
    FASEB J 24:3135-44. 2010
    ..75). Our data suggest that epigenetic studies on complex diseases may be feasible for a proportion of genomic loci provided that they are carefully designed...
  29. ncbi A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Cancer Res 63:1249-53. 2003
    ..The mechanism underlying this association might involve genomic instability as a result of insufficient methylation of genomic DNA...
  30. ncbi No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study
    M O van Aken
    LUMC, Leiden, The Netherlands
    Eur J Clin Invest 32:750-4. 2002
    ..However, recent studies indicate that penetrance of the C282Y mutation is low. We explored the association between the C282Y mutation, iron metabolism, and morbidity and mortality in participants of the Leiden 85-plus...
  31. doi Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study
    Maarten P Rozing
    Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Am Geriatr Soc 58:564-9. 2010
    ..To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity...
  32. doi Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:365-8. 2010
    ..In human populations, an association was observed between low thyroid function and longevity at old age, but the beneficial effects of low thyroid hormone metabolism at middle age remain elusive...
  33. doi Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, C5 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Heart J 30:266-77. 2009
    ....
  34. ncbi Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families
    Belinda K Cornes
    Genetic Epidemiology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD, Australia
    Twin Res Hum Genet 8:616-32. 2005
    ....