J Gussekloo

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Auditory rehabilitation of older people from the general population--the Leiden 85-plus study
    Jacobijn Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, C 2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Gen Pract 53:536-40. 2003
  2. ncbi request reprint [Causes and consequences of cognitive decline in the very elderly; the 'Leiden 85-plus Study']
    J Gussekloo
    Leids Universitair Medisch Centrum, afd Algemene Interne Geneeskunde, Sectie Gerontologie en Geriatrie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 148:979-83. 2004
  3. ncbi request reprint Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study
    Jacobijn Gussekloo
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Geriatr Psychiatry 13:781-6. 2005
  4. ncbi request reprint Thyroid status, disability and cognitive function, and survival in old age
    Jacobijn Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 292:2591-9. 2004
  5. ncbi request reprint [Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study']
    J Gussekloo
    Leids Universitair Medisch Centrum, Leiden
    Ned Tijdschr Geneeskd 150:90-6. 2006
  6. ncbi request reprint Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function
    E van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Neurology 61:1695-701. 2003
  7. ncbi request reprint Disability in the oldest old: "can do" or "do do"?
    A Bootsma-van der Wiel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    J Am Geriatr Soc 49:909-14. 2001
  8. pmc Cognitive function in the oldest old: women perform better than men
    E van Exel
    Gerontology and Geriatrics, Department of General and Internal Medicine, Leiden University Medical Center, Building 1 C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 71:29-32. 2001
  9. ncbi request reprint Successful aging in the oldest old: Who can be characterized as successfully aged?
    M von Faber
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 161:2694-700. 2001
  10. ncbi request reprint Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
    D J Vinkers
    Department of Gerontology and Geriatrics, Leiden University Medical Center, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 65:107-12. 2005

Collaborators

Detail Information

Publications82

  1. pmc Auditory rehabilitation of older people from the general population--the Leiden 85-plus study
    Jacobijn Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, C 2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Gen Pract 53:536-40. 2003
    ..Very few older people with severe hearing loss use hearing aids to reduce the negative consequences of reduced hearing in daily functioning...
  2. ncbi request reprint [Causes and consequences of cognitive decline in the very elderly; the 'Leiden 85-plus Study']
    J Gussekloo
    Leids Universitair Medisch Centrum, afd Algemene Interne Geneeskunde, Sectie Gerontologie en Geriatrie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 148:979-83. 2004
    ..Therefore, future therapeutic research will have to demonstrate to what extent influencing the cardiovascular risk factors can lead to the prevention of cognitive decline in the very elderly...
  3. ncbi request reprint Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study
    Jacobijn Gussekloo
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Geriatr Psychiatry 13:781-6. 2005
    ..Because studies on the association of sensory impairment (both hearing and visual impairment) and cognitive functioning in elderly persons yielded conflicting results, the authors explored this association within the Leiden 85+ Study...
  4. ncbi request reprint Thyroid status, disability and cognitive function, and survival in old age
    Jacobijn Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 292:2591-9. 2004
    ..Despite the equivocal outcomes of randomized controlled trials, general clinical opinion favors screening and treatment of elderly individuals with subclinical thyroid disorders...
  5. ncbi request reprint [Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study']
    J Gussekloo
    Leids Universitair Medisch Centrum, Leiden
    Ned Tijdschr Geneeskd 150:90-6. 2006
    ....
  6. ncbi request reprint Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function
    E van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Neurology 61:1695-701. 2003
    ..To test the hypothesis that a pro-inflammatory response is associated with cognitive impairment among individuals with cardiovascular disease...
  7. ncbi request reprint Disability in the oldest old: "can do" or "do do"?
    A Bootsma-van der Wiel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    J Am Geriatr Soc 49:909-14. 2001
    ..To investigate the discrepancies between outcomes for competence (can do) and actual performance (do do) in activities of daily living (ADLs)...
  8. pmc Cognitive function in the oldest old: women perform better than men
    E van Exel
    Gerontology and Geriatrics, Department of General and Internal Medicine, Leiden University Medical Center, Building 1 C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 71:29-32. 2001
    ..This could explain sex differences in cognitive function in the oldest old. Whether limited formal education explains differences in cognitive function between elderly women and men was explored...
  9. ncbi request reprint Successful aging in the oldest old: Who can be characterized as successfully aged?
    M von Faber
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 161:2694-700. 2001
    ..Successful aging is a worldwide aim, but it is less clear which indicators characterize elderly persons as successfully aged. We explored the meaning of successful aging from 2 perspectives...
  10. ncbi request reprint Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
    D J Vinkers
    Department of Gerontology and Geriatrics, Leiden University Medical Center, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 65:107-12. 2005
    ..Atherosclerosis may be linked to cognitive decline and depression in old age...
  11. ncbi request reprint Inflammation and stroke: the Leiden 85-Plus Study
    E van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Netherlands
    Stroke 33:1135-8. 2002
    ..We analyzed the relation between low IL-10 production levels, history of stroke, and incident fatal stroke...
  12. ncbi request reprint Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study
    E van Exel
    Leiden 85 plus Study, Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, C2 R, PO Box 9600, 2300 RC, Leiden, Netherlands
    Atherosclerosis 165:353-9. 2002
    ..Since treatments for atherosclerosis appear to be particularly effective in elderly people, we consider our finding of utmost clinical importance in possibly preventing cognitive impairment and late-onset dementia...
  13. ncbi request reprint [The relationship between atherosclerosis, cognitive impairment, and depression in old age]
    D J Vinkers
    Leids Universitair Medisch Centrum, Leiden
    Ned Tijdschr Geneeskd 150:2307-11. 2006
    ..This means that the prevention of atherosclerosis might prevent cognitive impairment and hence late-onset depression in old age...
  14. ncbi request reprint Vascular disease and apathy in old age. The Leiden 85-Plus Study
    R C van der Mast
    Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Geriatr Psychiatry 23:266-71. 2008
    ..Especially in old age, apathy might be a specific neuropsychiatric syndrome separate from depression. There are indications that apathy in elderly subjects is related to vascular disease...
  15. pmc Prevalence of five common clinical abnormalities in very elderly people: population based cross sectional study
    A J M de Craen
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, Netherlands
    BMJ 327:131-2. 2003
  16. doi request reprint Predicting survival in oldest old people
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Med 125:1188-1194.e1. 2012
    ..We studied the association of gait speed and survival in a cohort of oldest old people and the association of Instrumental Activities of Daily Living by questionnaire and survival as an alternative prognostic marker of survival...
  17. doi request reprint Incidence and predictive factors of lower respiratory tract infections among the very elderly in the general population. The Leiden 85-plus Study
    A Sliedrecht
    Department of Public Health and Primary Care, Leiden University Medical Center, Post Zone V 0 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Thorax 63:817-22. 2008
    ..To target preventive strategies in old age, which of the very elderly are predisposed to developing lower respiratory tract infections was investigated...
  18. ncbi request reprint C-reactive protein is a strong but nonspecific risk factor of fatal stroke in elderly persons
    J Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Arterioscler Thromb Vasc Biol 20:1047-51. 2000
    ..01). C-reactive protein is a strong but nonspecific risk factor of fatal stroke in old persons. The data do not support the idea that C-reactive protein has direct vascular effects that underlie fatal cerebrovascular disease...
  19. ncbi request reprint Anaemia in older persons
    W P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands
    Neth J Med 69:260-7. 2011
    ..Because current guidelines on anaemia are based on the classic notions of the aetiology of anaemia, they may need to be revised for the highest age groups...
  20. ncbi request reprint A high response is not essential to prevent selection bias: results from the Leiden 85-plus study
    A Bootsma van der Wiel
    Leiden 85 plus Study, Leiden University Medical Center, C2 R Gerontology and Geriatrics, Department of Internal Medicine, P O Box 9600, The Netherlands
    J Clin Epidemiol 55:1119-25. 2002
    ..In conclusion, we showed that given a moderately high direct response the additional effort was effective in increasing the response rate, but was also selective and was not necessary to prevent selection bias...
  21. pmc Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85
    J Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 67:535-8. 1999
    ..Homozygous carriers of this mutation are characterised by a lifelong exposure to moderately raised plasma concentrations of homocysteine...
  22. ncbi request reprint Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study
    Simon P Mooijaart
    Departments of Gerontology and Geriatrics and Clinical Chemistry, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 82:866-71. 2005
    ..High concentrations of homocysteine and low concentrations of vitamin B-12 and folic acid are frequently observed in subjects with dementia...
  23. doi request reprint Low blood pressure in the very old, a consequence of imminent heart failure: the Leiden 85-plus Study
    T van Bemmel
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Hum Hypertens 23:27-32. 2009
    ..68, s.d. 0.21), indicating diastolic dysfunction. In conclusion, among the oldest old, low systolic blood pressure correlates with low cardiac output. Systolic ventricular function is not impaired...
  24. ncbi request reprint No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study
    M O van Aken
    LUMC, Leiden, The Netherlands
    Eur J Clin Invest 32:750-4. 2002
    ..However, recent studies indicate that penetrance of the C282Y mutation is low. We explored the association between the C282Y mutation, iron metabolism, and morbidity and mortality in participants of the Leiden 85-plus...
  25. ncbi request reprint Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population
    Annetje Bootsma-van der Wiel
    Departent of General Internal Medicine, Leiden University Medical Center, The Netherlands
    J Am Geriatr Soc 50:1405-10. 2002
    ..Walking disability affects older people's autonomy and well-being. We investigated the relative effect of common chronic diseases and general impairments on walking disability in the general oldest-old population...
  26. ncbi request reprint Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age
    Anita H J van den Biggelaar
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Exp Gerontol 42:693-701. 2007
    ..A high innate IL-1ra to IL-1beta production capacity reflects a better ability to neutralize inflammation and may therefore protect against depressive symptoms...
  27. doi request reprint Warts in primary schoolchildren: prevalence and relation with environmental factors
    F M van Haalen
    Department of Public Health and Primary Care, Leiden University Medical Centre, PO Box 9600, Leiden 2300 RC, The Netherlands
    Br J Dermatol 161:148-52. 2009
    ..Warts are very common in primary schoolchildren. However, knowledge on wart epidemiology and causes of wart transmission is scarce...
  28. doi request reprint Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age
    R J Goekoop
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Osteoarthritis Cartilage 18:942-7. 2010
    ..We investigated whether innate differences in cytokine response were associated with the absence of osteoarthritis (OA) in old age...
  29. ncbi request reprint [Cardiovascular prevention in the over-80 age group is not beneficial]
    W de Ruijter
    Leids Universitair Medisch Centrum, afd Public Health en Eerstelijnsgeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 152:27. 2008
    ..However, evidence for the effectiveness of any preventive intervention is lacking. Regarding primary prevention, it is also unknown which elderly are actually at risk of developing new cardiovascular disease...
  30. pmc Time trends in preventive drug treatment after myocardial infarction in older patients
    Wouter de Ruijter
    Leiden University Medical Center, Department of Public Health and Primary Care, Leiden, The Netherlands
    Br J Gen Pract 60:47-9. 2010
    ..Although the greatest relative increase (2.2 times greater) took place in patients aged > or =80 years, these patients consistently had most room for improvement...
  31. pmc Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial
    Sjoerd C Bruggink
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    CMAJ 182:1624-30. 2010
    ..Cryotherapy is widely used for the treatment of cutaneous warts in primary care. However, evidence favours salicylic acid application. We compared the effectiveness of these treatments as well as a wait-and-see approach...
  32. doi request reprint Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Age Ageing 39:331-7. 2010
    ..Muscle strength measurements could be useful as part of a clinical evaluation of oldest old patients to determine who are most at risk of accelerated decline in the near future...
  33. ncbi request reprint High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Mech Ageing Dev 128:517-21. 2007
    ..Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time...
  34. pmc Chronic kidney disease in patients with diabetes mellitus type 2 or hypertension in general practice
    Victor van der Meer
    Department of Public Health and Primary Care, Leiden University Medical Centre and Academic Primary Health Care Centre Stevenshof, Leiden, The Netherlands
    Br J Gen Pract 60:884-90. 2010
    ..The prevalence and severity of chronic kidney disease (CKD) in primary care patients with diabetes or hypertension is unknown...
  35. pmc Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, The Netherlands
    CMAJ 182:1953-8. 2010
    ..We investigated the prognostic value of elevated erythropoietin levels on mortality among very elderly people in the general population...
  36. ncbi request reprint The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study
    Wouter de Ruijter
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 55:872-7. 2007
    ..To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status...
  37. ncbi request reprint Assistive devices and community-based services among 85-year-old community-dwelling elderly in The Netherlands: ownership, use, and need for intervention
    Anton J M de Craen
    Section of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Disabil Rehabil Assist Technol 1:199-203. 2006
    ..To assess the home-situation of the oldest old regarding the ownership, use, and need for intervention of assistive devices and community-based services...
  38. doi request reprint Yield and costs of direct and stepped screening for depressive symptoms in subjects aged 75 years and over in general practice
    Gerda M Van der Weele
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Int J Geriatr Psychiatry 26:229-38. 2011
    ..To examine yield and costs of two screening methods for depressive symptoms in subjects ≥75 years in general practice...
  39. doi request reprint Current choices in the treatment of cutaneous warts: a survey among Dutch GP
    Sjoerd C Bruggink
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Fam Pract 27:549-53. 2010
    ..GPs apply several treatments for patients with cutaneous warts. Available evidence recommends salicylic acid application...
  40. pmc The additional value of routine electrocardiograms in cardiovascular risk management of older people
    Wouter de Ruijter
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Scand J Prim Health Care 26:147-53. 2008
    ..To evaluate whether routinely performed ECGs in older people from the general population have added value for cardiovascular risk management beyond the information that is already available from their medical records...
  41. pmc Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study
    Thomas van Bemmel
    Departments of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Geriatr 10:17. 2010
    ..Nested within the Leiden 85-plus study, a population based follow-up study of the oldest old, a sample of 81 nonagenarians was recruited...
  42. doi request reprint Co-occurrence of depression and anxiety in elderly subjects aged 90 years and its relationship with functional status, quality of life and mortality
    Gerda M Van der Weele
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Int J Geriatr Psychiatry 24:595-601. 2009
    ..To examine the prevalence of concurrent depression and anxiety and its relationship with functional status, quality of life and mortality in individuals at age 90...
  43. pmc Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study
    Wouter de Ruijter
    Leiden University Medical Center, Department of Public Health and Primary Care V0 P, PO Box 9600, 2300 RC Leiden, Netherlands
    BMJ 338:a3083. 2009
    ..To investigate the performance of classic risk factors, and of some new biomarkers, in predicting cardiovascular mortality in very old people from the general population with no history of cardiovascular disease...
  44. pmc Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    BMC Geriatr 10:42. 2010
    ..The aim of this systematic review was to evaluate the association between subnormal vitamin B12 concentrations and anaemia in older people...
  45. pmc Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    CMAJ 181:151-7. 2009
    ..There is limited insight into the attributable effect of anemia and comorbidity on functional status and mortality in old age...
  46. pmc Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study
    Carolina H Y Ling
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    CMAJ 182:429-35. 2010
    ..However, the oldest old population (i.e., over 85 years) is underrepresented in such studies. Our objective was to assess the association between muscular strength and mortality in the oldest old population...
  47. ncbi request reprint [Disciplinary proceedings on screening and preventive diagnostics]
    Yvonne M Drewes
    Leids Universitair Medisch Centrum, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 153:A233. 2009
    ..To gain insight into the disciplinary verdicts on screening and preventive diagnostics and their contribution to the professional standard...
  48. doi request reprint Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Post Zone V 0 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arch Intern Med 168:2238-44. 2008
    ..However, the effects of vitamin B(12) and folate deficiency on the development of anemia in old age have not yet been established...
  49. ncbi request reprint Prospective study of the effect of blood pressure on renal function in old age: the Leiden 85-Plus Study
    Thomas van Bemmel
    Department of Gerontology and Geriatrics, C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 17:2561-6. 2006
    ..08]; P < 0.001). In the oldest individual, high BP is not associated with renal function. In contrast, low DBP is associated with an accelerated decline of renal function. The clinical implications of these findings have to be studied...
  50. ncbi request reprint Markers of autonomic tone on a standard ECG are predictive of mortality in old age
    Thomas van Bemmel
    Section of Gerontology and Geriatrics, Department of Internal Medicine, C1 R, Leiden University Medical Center, Leiden, The Netherlands
    Int J Cardiol 107:36-41. 2006
    ..To investigate markers of autonomic tone on a standard electrocardiogram in relation to mortality in old age...
  51. ncbi request reprint Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia
    Anton J M de Craen
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Am J Epidemiol 161:114-20. 2005
    ....
  52. ncbi request reprint Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 173:6719-26. 2004
    ..Together, our data indicate that KIR-expressing CD4 T cells are predominantly HLA class II-restricted effector memory Th1 cells, and that a significant, previously unrecognized fraction of effector memory Th1 cells expresses KIR...
  53. ncbi request reprint Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study
    Anita H J van den Biggelaar
    Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2 R, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Exp Gerontol 39:1407-14. 2004
    ..We conclude that a malfunctioning innate immune response predicts frailty in old age and is under specific (immuno-) genetic control...
  54. ncbi request reprint Does depression in old age increase only cardiovascular mortality? The Leiden 85-plus Study
    David J Vinkers
    Department of General Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Int J Geriatr Psychiatry 19:852-7. 2004
    ..Depression in old age is associated with an increased mortality risk of cardiovascular disease but the mortality risk from non-cardiovascular causes is disputed...
  55. ncbi request reprint Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming
    Anita H J van den Biggelaar
    Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2 R, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    FASEB J 18:1022-4. 2004
    ..77; 95% CI: 0.68-0.88), while a positive association with IL-10 was found (RR = 1.22; 95% CI: 1.05-1.41). We suggest that cardiovascular mortality is a late consequence of evolutionary programming for a pro-inflammatory response...
  56. ncbi request reprint The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus Study
    David J Vinkers
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Int J Geriatr Psychiatry 19:80-4. 2004
    ..The 15-item Geriatric Depression Scale (GDS-15) is a widely used screening instrument for depressive symptoms in the elderly, but its ability to detect alterations in depressive symptoms over time has not been established...
  57. ncbi request reprint Accuracy of the 15-item geriatric depression scale (GDS-15) in a community sample of the oldest old
    Anton J M de Craen
    Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Int J Geriatr Psychiatry 18:63-6. 2003
    ..This might influence the sensitivity and specificity of the 15-item Geriatric Depression Scale (GDS-15). Few studies, however, have included subjects older than 85 years to evaluate the GDS-15 as a screening instrument for depression...
  58. ncbi request reprint Association between high-density lipoprotein and cognitive impairment in the oldest old
    Eric van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Ann Neurol 51:716-21. 2002
    ..At least part of the association between high-density lipoprotein cholesterol and cognitive function is independent of atherosclerotic disease...
  59. ncbi request reprint In an observational study elderly patients had an increased risk of falling due to home hazards
    Thomas van Bemmel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, C1 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 58:63-7. 2005
    ..The objective of this study was to explore the relationship between home hazards and the incidence of falls in the oldest old population...
  60. ncbi request reprint Seasonal mood variation in the elderly: the Leiden 85-plus study
    Anton J M de Craen
    Department of General Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Int J Geriatr Psychiatry 20:269-73. 2005
    ..The influence of seasonal changes on mood and behaviour is called seasonality. The prevalence of seasonality in elderly subjects is unknown...
  61. ncbi request reprint Late-onset dementia: structural brain damage and total cerebral blood flow
    Aart Spilt
    Department of Radiology, General Internal Medicine and Neurology, Leiden University Medical Center, Albinusdreef, C2 S, 2333 ZA Leiden, The Netherlands
    Radiology 236:990-5. 2005
    ..To prospectively compare indicators of structural brain damage and total cerebral blood flow in patients with late-onset dementia, subjects of the same age with optimal cognitive function, and young subjects...
  62. ncbi request reprint In a population-based prospective study, no association between high blood pressure and mortality after age 85 years
    Thomas van Bemmel
    Department of Gerontology and Geriatrics, C2 R, Leiden University Medical Centre, Leiden, The Netherlands
    J Hypertens 24:287-92. 2006
    ..To study the impact of a history of hypertension and current blood pressure on mortality in the oldest old...
  63. ncbi request reprint Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age
    Bastiaan T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Am J Med Genet 107:201-8. 2002
    ..Furthermore, they emphasize that variation at the APOE locus has a higher impact on the risk of dementia than on the risk of cardiovascular disease in old age...
  64. pmc How usual is usual care in pragmatic intervention studies in primary care? An overview of recent trials
    Antonia F H Smelt
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Br J Gen Pract 60:e305-18. 2010
    ..The behaviour of caregivers and patients in this control group should be influenced by the actions of researchers as little as possible. Guidelines for describing the composition and management of a usual care control group are lacking...
  65. ncbi request reprint Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus Study
    Annetje Bootsma-van der Wiel
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Eur J Public Health 15:494-7. 2005
    ..Disability in activities of daily living (ADL) might be more prevalent among elderly with low income due to higher prevalence of chronic diseases and impairments, as well as stronger associations of these factors with ADL-disability...
  66. pmc Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study
    J W Blom
    Department of Public Health and Primary Care, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands
    Age (Dordr) 35:431-8. 2013
    ..These findings need to be considered with recently reported beneficial effects of antihypertensive treatment in this age group...
  67. ncbi request reprint Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study
    Eric van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Diabetes 51:1088-92. 2002
    ..These findings showed that low IL-10 production capacity (i.e., a pro-inflammatory response) is associated with the metabolic syndrome and type 2 diabetes...
  68. ncbi request reprint Is depression in old age fatal only when people feel lonely?
    Max L Stek
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Am J Psychiatry 162:178-80. 2005
    ..The authors studied the relationship between the presence of depressive symptoms and all-cause mortality in old age, especially the potential distorting effect of perceived loneliness...
  69. ncbi request reprint Walking and talking as predictors of falls in the general population: the Leiden 85-Plus Study
    Annetje Bootsma-van der Wiel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    J Am Geriatr Soc 51:1466-71. 2003
    ..To compare the value of dual tasking in predicting falling in the general population of oldest old with that of easy-to-administer single tasks...
  70. ncbi request reprint Natural history of depression in the oldest old: population-based prospective study
    Max L Stek
    Leiden University Medical Centre, Section of Gerontology and Geriatrics, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Psychiatry 188:65-9. 2006
    ..Despite its negative consequences, little is known about the natural history of depression in the oldest old...
  71. ncbi request reprint [The guideline 'Cardiovascular risk management' is too simplified for elderly care]
    Wouter de Ruijter
    Leids Universitair Medisch Centrum, afd Public Health en Eerstelijnsgeneeskunde, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 156:A5197. 2012
    ..Alternative approaches are conveyed: the use of age-dependent thresholds for different risk categories, the use of relative risk charts, and the search for better risk markers in (very) old age...
  72. doi request reprint Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals
    W P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands
    Aliment Pharmacol Ther 27:491-7. 2008
    ..Some studies have shown that short-term use of proton pump inhibitors decreases the absorption of vitamin B12, but the results of studies into long-term proton pump inhibitor use and vitamin B12 deficiency are inconsistent...
  73. ncbi request reprint High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age
    Annelies W E Weverling-Rijnsburger
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 163:1549-54. 2003
    ..The aim of this study was to evaluate the relationships between low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol levels and mortality from specific causes among people in the oldest age categories...
  74. pmc Temporal relation between depression and cognitive impairment in old age: prospective population based study
    David J Vinkers
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    BMJ 329:881. 2004
    ..To examine the temporal relation between depression and cognitive impairment in old age...
  75. doi request reprint Diabetic retinopathy screening in patients with diabetes mellitus in primary care: Incentives and barriers to screening attendance
    K N D van Eijk
    Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Res Clin Pract 96:10-6. 2012
    ..Because attendance rates and reasons for non-attendance in an unselected diabetes population are unknown, this study examines incentives and barriers to attend DR-screening...
  76. ncbi request reprint Evaluation of continuous summary physical performance scores (CSPPS) in an elderly cohort
    Jeri W Nieves
    Clinical Research Center, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Aging Clin Exp Res 17:193-200. 2005
    ..The aim of this study was to examine the validity and reliability of the Continuous Summary Physical Performance Score (CSPPS) and its relationship to the Quartile Summary Physical Performance Score (QSPPS)...
  77. ncbi request reprint Benzodiazepine use and risk of mortality in individuals aged 85 years or older
    David J Vinkers
    JAMA 290:2942-3. 2003
  78. ncbi request reprint Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study
    Carmen M Martin-Ruiz
    Henry Wellcome Biogerontology Research Laboratory, University of Newcastle, Newcastle upon Tyne, UK
    Aging Cell 4:287-90. 2005
    ..We conclude that blood monocyte telomere length is not a predictive indicator for age-related morbidity and mortality at ages over 85 years, possibly because of a high degree of telomere length instability in this group...
  79. ncbi request reprint Does depression specifically increase cardiovascular mortality?
    David J Vinkers
    Arch Intern Med 165:119; author reply 119-20. 2005
  80. ncbi request reprint Leisure activities and the risk of dementia
    David J Vinkers
    N Engl J Med 349:1290-2; author reply 1290-2. 2003
  81. ncbi request reprint The clinically meaningful change in physical performance scores in an elderly cohort
    Jeri W Nieves
    Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Aging Clin Exp Res 19:484-91. 2007
    ....
  82. ncbi request reprint Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality
    Nicolas Ochs
    University of Lausanne, Lausanne, Switzerland
    Ann Intern Med 148:832-45. 2008
    ..Data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD) and mortality are conflicting...