M D Ferrari

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Current perspectives on effective migraine treatments: are small clinical differences important for patients?
    Michel D Ferrari
    Leiden University Medical Centre, Leiden, The Netherlands
    Drugs Today (Barc) 39:37-41. 2003
  2. ncbi request reprint Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study
    Mark C Kruit
    Department of Radiology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Brain 128:2068-77. 2005
  3. ncbi request reprint Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases
    Irene Favier
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Arch Neurol 64:25-31. 2007
  4. pmc Chronic cluster headache: a review
    Irene Favier
    Department of Neurology, K5 Q Leiden University Medical Centre, 9600, 2300 RC Leiden, The Netherlands
    J Headache Pain 6:3-9. 2005
  5. pmc Epigenetic mechanisms in migraine: a promising avenue?
    Else Eising
    Department of Human Genetics, Leiden University Medical Centre, Einthovenweg 20, Leiden 2333 ZC, The Netherlands
    BMC Med 11:26. 2013
  6. pmc Prophylactic treatment of migraine; the patient's view, a qualitative study
    Frans Dekker
    Leiden University Medical Center, Public Health and Primary Care, Postzone VO P, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Fam Pract 13:13. 2012
  7. pmc Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain
    Asha Nair
    Neurobiology Sector, International School for Advanced Studies SISSA, via Bonomea 265, 34136 Trieste, Italy
    Mol Pain 6:48. 2010
  8. ncbi request reprint Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials
    M D Ferrari
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 22:633-58. 2002
  9. ncbi request reprint Should we advise patients to treat migraine attacks early: methodologic issues
    Michel D Ferrari
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur Neurol 53:17-21. 2005
  10. ncbi request reprint Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials
    M D Ferrari
    Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, Albinusdreef 2, 2333 ZA, Leiden, Netherlands
    Lancet 358:1668-75. 2001

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Current perspectives on effective migraine treatments: are small clinical differences important for patients?
    Michel D Ferrari
    Leiden University Medical Centre, Leiden, The Netherlands
    Drugs Today (Barc) 39:37-41. 2003
    ..At recommended doses, almotriptan 12.5 mg, eletriptan 80 mg and rizatriptan 10 mg provided the highest likelihood of consistent success...
  2. ncbi request reprint Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study
    Mark C Kruit
    Department of Radiology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Brain 128:2068-77. 2005
    ..The results suggest that a combination of (possibly migraine attack-related) hypoperfusion and embolism is the likeliest mechanism for PC infarction in migraine, and not atherosclerosis or small-vessel disease...
  3. ncbi request reprint Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases
    Irene Favier
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Arch Neurol 64:25-31. 2007
    ..We found that even typical TACs can be caused by an underlying lesion. Clinical warning signs and symptoms are relatively rare. We recommend neuroimaging in all patients with a TAC or TAC-like syndrome...
  4. pmc Chronic cluster headache: a review
    Irene Favier
    Department of Neurology, K5 Q Leiden University Medical Centre, 9600, 2300 RC Leiden, The Netherlands
    J Headache Pain 6:3-9. 2005
    ..It is remarkable that little is known about risk factors that make CH chronic...
  5. pmc Epigenetic mechanisms in migraine: a promising avenue?
    Else Eising
    Department of Human Genetics, Leiden University Medical Centre, Einthovenweg 20, Leiden 2333 ZC, The Netherlands
    BMC Med 11:26. 2013
    ..Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine...
  6. pmc Prophylactic treatment of migraine; the patient's view, a qualitative study
    Frans Dekker
    Leiden University Medical Center, Public Health and Primary Care, Postzone VO P, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Fam Pract 13:13. 2012
    ..Patients and physicians appear to have reservations about initiating this treatment option. This paper explores the opinions, motives and expectations of patients regarding prophylactic migraine therapy...
  7. pmc Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain
    Asha Nair
    Neurobiology Sector, International School for Advanced Studies SISSA, via Bonomea 265, 34136 Trieste, Italy
    Mol Pain 6:48. 2010
    ..We investigated whether this gain-of-function mutation changed the structure and function of trigeminal neuron P2X3 receptors that are thought to be important contributors to migraine pain...
  8. ncbi request reprint Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials
    M D Ferrari
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 22:633-58. 2002
    ..5 mg provide the highest likelihood of consistent success. Sumatriptan features the longest clinical experience and the widest range of formulations. All triptans are contra-indicated in the presence of cardiovascular disease...
  9. ncbi request reprint Should we advise patients to treat migraine attacks early: methodologic issues
    Michel D Ferrari
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur Neurol 53:17-21. 2005
    ..At present, there is no scientific support to advise patient to treat early. Patients should be advised to take their medication as soon as they are sure they are developing a migraine headache, but not during the aura phase...
  10. ncbi request reprint Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials
    M D Ferrari
    Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, Albinusdreef 2, 2333 ZA, Leiden, Netherlands
    Lancet 358:1668-75. 2001
    ..Triptan trials have similar designs, facilitating meta-analysis; this will provide a foundation for using triptans in clinical practice...
  11. ncbi request reprint The use of multiattribute decision models in evaluating triptan treatment options in migraine
    M D Ferrari
    Dept of Neurology, Leiden University Medical Centre, 9600, 2300 RC Leiden, The Netherlands
    J Neurol 252:1026-32. 2005
    ..These differ, to greater or lesser degrees, on a range of clinical attributes important for treatment selection...
  12. ncbi request reprint No involvement of the calcium channel gene (CACNA1A) in a family with cluster headache
    J Haan
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 21:959-62. 2001
    ..Haplotype analysis did not reveal an obvious disease haplotype, and SSCP analysis of all 47 exons of the CACNA1A gene did not reveal a causative mutation. CH in this family is not caused by mutations in the CACNA1A gene...
  13. ncbi request reprint Characterization of acetylcholine release and the compensatory contribution of non-Ca(v)2.1 channels at motor nerve terminals of leaner Ca(v)2.1-mutant mice
    S Kaja
    Department of Neurology, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Neuroscience 144:1278-87. 2007
    ..2 channels, and hampers that of Ca(v)2.3 channels. This is the first report directly showing at single synapses the deficits and plasticity in transmitter release resulting from the Ln mutation of Cacna1a...
  14. ncbi request reprint Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine
    B de Vries
    Departments of Human Genetics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 69:2170-6. 2007
    ..It will also facilitate the often difficult differential diagnosis from other causes of transient hemiparesis...
  15. pmc Shared genetic factors in migraine and depression: evidence from a genetic isolate
    A H Stam
    Department of Neurology, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands G
    Neurology 74:288-94. 2010
    ..To investigate the co-occurrence of migraine and depression and assess whether shared genetic factors may underlie both diseases...
  16. doi request reprint MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study
    M K Liem
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Neurology 72:143-8. 2009
    ..In this 7-year follow-up study, we aimed to determine whether there are associations between the different radiologic hallmarks in CADASIL and decline in specific cognitive domains...
  17. ncbi request reprint Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine
    E E Kors
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Ann Neurol 49:753-60. 2001
    ..This finding may have important implications for the understanding and treatment of this dramatic syndrome...
  18. ncbi request reprint Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness
    S Kaja
    Department of Neurology and Clinical Neurophysiology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Neuroscience 135:81-95. 2005
    ..1 channels and show that the resulting altered neurotransmitter release is not associated with morphological changes at the NMJ or muscle weakness, not even in the longer term...
  19. pmc Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study
    M C Kruit
    Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 30:129-36. 2010
    ..Longitudinal studies are needed to assess whether these lesions are progressive and have relevant (long-term) functional correlates...
  20. doi request reprint CACNA1A mutation linking hemiplegic migraine and alternating hemiplegia of childhood
    B de Vries
    Department of Human Genetics, Leiden University Medical Centre, Leiden, Germany
    Cephalalgia 28:887-91. 2008
    ..These results also suggest that CACNA1A mutation scanning is indicated in patients with a severe neurological phenotype that includes paroxysmal (alternating) hemiplegia...
  21. doi request reprint CACNA1A R1347Q: a frequent recurrent mutation in hemiplegic migraine
    A H Stam
    Department of Neurology and Clinical Genetic, Erasmus Medical Centre, Leiden, The Netherlands
    Clin Genet 74:481-5. 2008
    ..This study clearly demonstrates that the availability of multiple families better reflects the full clinical spectrum associated with FHM1 mutations...
  22. ncbi request reprint Alternating hemiplegia of childhood: no mutations in the glutamate transporter EAAT1
    B de Vries
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Neuropediatrics 37:302-4. 2006
    ..No mutations were found. The SLC1A3 EAAT1 glutamate transporter gene does not seem to be involved in the pathogenesis of AHC...
  23. ncbi request reprint The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine
    J J Hottenga
    Department of Human Genetics, Leiden University Medical Centre, Leiden, and Department of Neurology, Rijnland Hospital, Leiderdorp, The Netherlands
    Cephalalgia 25:1168-72. 2005
    ..Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine...
  24. ncbi request reprint Chronic frequent headache in the general population: comorbidity and quality of life
    N J Wiendels
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 26:1443-50. 2006
    ..Many CFH patients have a comorbid chronic condition requiring daily medication. Both high headache frequency and comorbidity contribute to the low quality of life in these patients...
  25. doi request reprint Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation
    A H Stam
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1125-9. 2009
    ....
  26. ncbi request reprint Mutant P/Q-type calcium channel electrophysiology and migraine
    J J Plomp
    Department of Neurology, Department of Physiology and Medical Pharmacology, Leiden University Medical Center, POB 9600, 2300 RC, Leiden, The Netherlands
    Curr Opin Investig Drugs 2:1250-60. 2001
    ..We will review these studies and discuss the possible implications for the understanding of migraine pathophysiology...
  27. ncbi request reprint Single-fiber EMG in familial hemiplegic migraine
    G M Terwindt
    Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Neurology 63:1942-3. 2004
    ..Mean jitter did not differ significantly between patients and control subjects or among patients. No blocking was found. The results suggest that neuromuscular function is normal in FHM...
  28. ncbi request reprint Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering alpha(1A) Ca(2+) channel mutation
    J J Plomp
    Department of Physiology, Leiden University Medical Centre, Leiden, The Netherlands
    Brain 123:463-71. 2000
    ..This study shows that functional consequences of alpha(1A) mutations causing cerebral disorders can be characterized at the NMJ...
  29. doi request reprint A review of the genetic relation between migraine and epilepsy
    J Haan
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 28:105-13. 2008
    ..Most attention will be paid to the genetic relationship between these two paroxysmal disorders...
  30. pmc Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3
    R A Ophoff
    Departments of Human and Clinical Genetics and Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 69:447-53. 2001
    ..Our study shows that three autosomal dominant vasculopathy syndromes with prominent cerebroretinal manifestations map to the same 3-cM interval on 3p21, suggesting a common locus...
  31. ncbi request reprint Alternating hemiplegia of childhood: no mutations in the second familial hemiplegic migraine gene ATP1A2
    E E Kors
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Neuropediatrics 35:293-6. 2004
    ..We performed a mutation analysis of the ATP1A2 gene in six patients, using direct sequencing, but found no mutations in any of the 23 exons. Other cerebral ion channel genes remain candidate genes for AHC...
  32. doi request reprint Migraine headache is not associated with cerebral or meningeal vasodilatation--a 3T magnetic resonance angiography study
    G G Schoonman
    Department of Neurology K5 Q, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Brain 131:2192-200. 2008
    ..In contrast to widespread belief, migraine attacks are not associated with vasodilatation of cerebral or meningeal blood vessels. Future anti-migraine drugs may not require vasoconstrictor action...
  33. ncbi request reprint Typical cluster headache caused by granulomatous pituitary involvement
    I Favier
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 27:173-6. 2007
    ..This case reinforces the growing evidence that even in typical cases of cluster headache, neuroimaging is mandatory to exclude structural lesions...
  34. doi request reprint Triptan overuse in the Dutch general population: a nationwide pharmaco-epidemiology database analysis in 6.7 million people
    F Dekker
    Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    Cephalalgia 31:943-52. 2011
    ....
  35. ncbi request reprint Severe episodic neurological deficits and permanent mental retardation in a child with a novel FHM2 ATP1A2 mutation
    K R J Vanmolkot
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Neurol 59:310-4. 2006
    ..Her family members suffered from hemiplegic and confusional migraine attacks...
  36. doi request reprint Migraine and genetic and acquired vasculopathies
    A H Stam
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 29:1006-17. 2009
    ..This review focuses on genetic and acquired vasculopathies associated with migraine. We speculate how genetic and acquired vascular mechanisms might be involved in migraine...
  37. ncbi request reprint Cardiovascular autonomic function tests in cluster headache
    J A van Vliet
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 26:329-31. 2006
    ..3 (SD 12.2) vs. 74.8 (SD 9.0), P = 0.04]. Autonomic dysfunction during a cluster period, but outside an attack, does not include systemic cardiovascular control...
  38. ncbi request reprint Cerebral microbleeds in CADASIL
    S A Lesnik Oberstein
    Department of Clinical Genetics, Leiden University Medical Center, Rijnland Hospital, Leiden, The Netherlands
    Neurology 57:1066-70. 2001
    ..However, the presence of cerebral microbleeds, which often remain undetected on conventional MRI, has not been determined in CADASIL...
  39. ncbi request reprint The prevalence of premonitory symptoms in migraine: a questionnaire study in 461 patients
    G G Schoonman
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 26:1209-13. 2006
    ..In conclusion, premonitory symptoms are frequently reported by migraine patients. Sensitivity and specificity of premonitory symptoms for migraine need to be assessed using prospective methods...
  40. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: structural MR imaging changes and apolipoprotein E genotype
    R van den Boom
    Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
    AJNR Am J Neuroradiol 27:359-62. 2006
    ..We investigated the correlation between the apoE genotype and radiologic data in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
  41. ncbi request reprint Evaluating the IHS criteria for cluster headache--a comparison between patients meeting all criteria and patients failing one criterion
    J A van Vliet
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 26:241-5. 2006
    ..These patients may therefore be diagnosed with CH. Attack frequency may not be a useful criterion for the diagnosis of CH. The upper limit of 3 h should be increased in future diagnostic criteria...
  42. doi request reprint An early 18th-century case description of cluster headache
    E B Arkink
    Department of Radiology, Leiden University Medical Centre, The Netherlands
    Cephalalgia 30:1392-5. 2010
    ..We will also give a short overview of other descriptions of cluster and cluster-like headache in historical literature...
  43. doi request reprint Space headache: a new secondary headache
    A A Vein
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 29:683-6. 2009
    ..We propose to classify space headache as a separate entity among the secondary headaches attributed to disorders of homeostasis...
  44. ncbi request reprint Is stress a trigger factor for migraine?
    G G Schoonman
    Department of Neurology K5 Q, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Psychoneuroendocrinology 32:532-8. 2007
    ..Although mental stress is commonly considered to be an important trigger factor for migraine, experimental evidence for this belief is yet lacking...
  45. ncbi request reprint Reproducibility and feasibility of neurophysiological assessment of the sensory trigeminal system for future application to paroxysmal headaches
    J A van Vliet
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 22:474-81. 2002
    ..Duration, amplitude and area parameters of the BR responses were less appropriate for longitudinal studies...
  46. ncbi request reprint Syncope in migraine: the population-based CAMERA study
    R D Thijs
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Neurology 66:1034-7. 2006
    ..To examine the association between migraine and syncope-related autonomic nervous system (ANS) symptoms...
  47. ncbi request reprint [Migraine and cardiovascular risk]
    G M Terwindt
    Leids Universitair Medisch Centrum, afd Neurologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 151:2029-31. 2007
    ..Further research will have to show whether migraine is an independent risk factor for cardiovascular disease and whether prophylactic treatment of migraine attacks will lower this increased risk for cardiovascular disease...
  48. ncbi request reprint Impairment of trigeminal sensory pathways in cluster headache
    J A van Vliet
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 23:414-9. 2003
    ..This seems primarily due of changes within the higher cerebral regions of the system...
  49. ncbi request reprint Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study
    J A van Vliet
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Neurology 60:630-3. 2003
    ..Intranasal sumatriptan is a new formulation with better tolerability than the subcutaneous route. Two open-label studies suggested efficacy of intranasal sumatriptan in cluster headache...
  50. pmc Cluster headache in women: relation with menstruation, use of oral contraceptives, pregnancy, and menopause
    J A van Vliet
    Department of Neurology, Medical Centre Haaglanden, The Hague, Netherlands
    J Neurol Neurosurg Psychiatry 77:690-2. 2006
    ..Cluster headache can, however, have a large impact on individual women, for example to refrain from having children...
  51. ncbi request reprint Sumatriptan-nonresponders: a survey in 366 migraine patients
    W H Visser
    Department of Neurology, Leiden (The Netherlands) University Hospital, The Netherlands
    Headache 36:471-5. 1996
    ..In conclusion, we found few, if any, clinically relevant risk factors for nonresponse to sumatriptan. Administration of sumatriptan too early was the strongest indicator and should be avoided...
  52. ncbi request reprint Meta-analysis of rizatriptan efficacy in randomized controlled clinical trials
    M D Ferrari
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Cephalalgia 21:129-36. 2001
    ..The benefit was maintained over 24 h; 38% of patients on rizatriptan 10 mg had sustained pain relief vs. 32% for rizatriptan 5 mg (P = 0.001)...
  53. pmc Features involved in the diagnostic delay of cluster headache
    J A van Vliet
    Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
    J Neurol Neurosurg Psychiatry 74:1123-5. 2003
    ..Besides, while adequate and evidence based treatment is available in diagnosed cases, CH seems to be poorly managed. The authors performed a nationwide survey among CH patients, and looked for factors involved in the diagnostic delay...
  54. ncbi request reprint Migraine genetics: an update
    J Haan
    Department of Neurology, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands E mail
    Curr Pain Headache Rep 9:213-20. 2005
    ....
  55. doi request reprint Cerebrovascular reactivity is a main determinant of white matter hyperintensity progression in CADASIL
    M K Liem
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    AJNR Am J Neuroradiol 30:1244-7. 2009
    ..The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL...
  56. ncbi request reprint Vascular reactivity during migraine attacks: a transcranial Doppler study
    C P Zwetsloot
    University Hospital, Department of Clinical Neurophysiology, Leiden, The Netherlands
    Headache 31:593-5. 1991
    ..We conclude that the vasomotor reactivity is normal during migraine attacks without aura...
  57. pmc Iron accumulation in deep brain nuclei in migraine: a population-based magnetic resonance imaging study
    M C Kruit
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Cephalalgia 29:351-9. 2009
    ..It remains unclear whether iron accumulation in the antinociceptive network has a causative role in the development of (chronic) migraine headache...
  58. ncbi request reprint Episodic ataxia type 2. Three novel truncating mutations and one novel missense mutation in the CACNA1A gene
    A M J M van den Maagdenberg
    MGC Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol 249:1515-9. 2002
    ..Of the twenty two EA-2 mutations identified thus far, including those of the present study, seventeen are truncating mutations and five are missense mutations, all resulting in an EA-2 clinical phenotype...
  59. pmc Postdural puncture headache in migraineurs and nonheadache subjects: a prospective study
    W P J van Oosterhout
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Neurology 80:941-8. 2013
    ....
  60. doi request reprint Aortic root pathology in Marfan syndrome increases the risk of migraine with aura
    H Koppen
    Leiden University Medical Centre, The Netherlands
    Cephalalgia 32:467-72. 2012
    ..To assess the lifetime prevalence of migraine in patients with Marfan syndrome (MFS) and to investigate a history of aortic root replacement (AR) as a possible risk factor...
  61. ncbi request reprint Migraine in the elderly: a review
    J Haan
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 27:97-106. 2007
    ..The review will focus on treatment choices in elderly migraine patients. These must be based on knowledge of mechanisms of physiological and pathological ageing...
  62. ncbi request reprint Methionine-enkephalin in migraine and tension headache. Differences between classic migraine, common migraine and tension headache, and changes during attacks
    M D Ferrari
    Department of Neurology, University Hospital, Leiden, The Netherlands
    Headache 30:160-4. 1990
    ..We suggest that determination of MET levels in platelets and plasma may be a useful marker to discriminate between TH and common migraine. The rise in MET during attacks may be directed against the ictal increase of serotonin...
  63. ncbi request reprint Chronic frequent headache in the general population: prevalence and associated factors
    N J Wiendels
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 26:1434-42. 2006
    ..CFH is common and associated with overuse of analgesics, psychopathology, smoking, sleeping problems, a history of head/neck trauma and low educational level. Female sex is a risk factor for headache, not for chronification of headache...
  64. ncbi request reprint SUNCT syndrome resolving after contralateral hemispheric ischaemic stroke
    J A van Vliet
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 23:235-7. 2003
  65. ncbi request reprint Expanding the phenotypic spectrum of the CACNA1A gene T666M mutation: a description of 5 families with familial hemiplegic migraine
    E E Kors
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Arch Neurol 60:684-8. 2003
    ..The clinical features of T666M families have been reported, but the course is unknown...
  66. ncbi request reprint Partial cosegregation of familial hemiplegic migraine and a benign familial infantile epileptic syndrome
    G M Terwindt
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Epilepsia 38:915-21. 1997
    ..2 and 8q, and benign infantile familial convulsions (BIFC), as yet unlinked...
  67. ncbi request reprint Transmitter release deficits at the neuromuscular synapse of mice with mutations in the Cav2.1 (alpha1A) subunit of the P/Q-type Ca2+ channel
    J J Plomp
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:29-32. 2003
  68. ncbi request reprint MRI findings in migraine
    M C Kruit
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Rev Neurol (Paris) 161:661-5. 2005
    ..Due to various methodological problems no definite conclusion could be drawn from these studies...
  69. ncbi request reprint Gammahydroxybutyrate and narcolepsy: a double-blind placebo-controlled study
    G J Lammers
    Department of Neurology, Leiden University Hospital, The Netherlands
    Sleep 16:216-20. 1993
    ..007) and the number of awakenings out of REM sleep (p = 0.016), and tended to increase slow wave sleep (p = 0.053). Adverse events were few and mild. We conclude that GHB is an effective and well-tolerated treatment for narcolepsy...
  70. ncbi request reprint Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation
    E E Kors
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Neurology 63:1136-7. 2004
  71. ncbi request reprint Normobaric hypoxia and nitroglycerin as trigger factors for migraine
    G G Schoonman
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Cephalalgia 26:816-9. 2006
    ..The median time to attacks was 5 h. In conclusion, the (remarkably) low response rate to NTG is surprising in view of previous data. Further studies are required to establish fully the potency of hypoxia in triggering migraine attacks...
  72. ncbi request reprint Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura
    G M Terwindt
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Neurology 56:1028-32. 2001
    ..To assess the involvement of the 19p13 familial hemiplegic migraine (FHM) locus in migraine with and without aura...
  73. ncbi request reprint Familial cyclic vomiting syndrome
    J Haan
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Cephalalgia 22:552-4. 2002
    ..We conclude that 'pure' CVS may also be a hereditary disorder. Its relation to migraine will be discussed...
  74. doi request reprint Predictors of migraine headache recurrence: a pooled analysis from the eletriptan database
    David W Dodick
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Headache 48:184-93. 2008
    ....
  75. ncbi request reprint Migraine as a risk factor for subclinical brain lesions
    Mark C Kruit
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 291:427-34. 2004
    ..Clinical series have suggested an increased prevalence of cerebral infarction and white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are prevalent in the general migraine population...
  76. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: MR imaging findings at different ages--3rd-6th decades
    Rivka van den Boom
    Departments of Radiology, Clinical Genetics, and Neurology, Leiden University Medical Center, C2S, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Radiology 229:683-90. 2003
    ....
  77. ncbi request reprint Priorities for triptan treatment attributes and the implications for selecting an oral triptan for acute migraine: a study of US primary care physicians (the TRIPSTAR Project)
    F Michael Cutrer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Ther 26:1533-45. 2004
    ..Physicians treating patients with migraine can now choose from among 7 triptans, which differ on a range of attributes that may be important for treatment selection...
  78. ncbi request reprint Migraine: new treatment options from molecular biology
    Anine H Stam
    Department of Neurology, Leiden University Medical Centre, Leiden, 2300 RC Leiden, The Netherlands
    Expert Rev Neurother 5:653-61. 2005
    ..Molecular biologic research will increasingly become important in understanding the pathophysiology of migraine and in identifying potential molecular targets for novel treatments...
  79. ncbi request reprint Incipient CADASIL
    Saskia A J Lesnik Oberstein
    Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arch Neurol 60:707-12. 2003
    ..Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Knowledge of disease expression in young adult NOTCH3 mutation carriers (MCs) is limited...
  80. ncbi request reprint Brain stem and cerebellar hyperintense lesions in migraine
    Mark C Kruit
    Department of Radiology, Leiden University Medical Center, PO Box 9600, The Netherlands
    Stroke 37:1109-12. 2006
    ..Migraineurs are at increased risk of cerebellar infarcts and supratentorial white matter lesions. The prevalence, frequency, and distribution of infratentorial hyperintense lesions in migraine are unknown...
  81. ncbi request reprint Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, Leiden University Medical Center, The Netherlands
    Medicine (Baltimore) 82:251-6. 2003
    ..To our knowledge, this is the first study showing that NOTCH3 mutation carriers may be at increased risk of early acute myocardial infarction, expanding CADASIL disease expression beyond the central nervous system to include the heart...
  82. ncbi request reprint Cerebral hemodynamics and white matter hyperintensities in CADASIL
    Rivka van den Boom
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cereb Blood Flow Metab 23:599-604. 2003
    ..This study suggests that a decrease in baseline TCBF in NOTCH3 mutation carriers precedes the development of white matter hyperintensities...
  83. ncbi request reprint Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo
    Umesh A Badrising
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Ann Neurol 51:369-72. 2002
    ..Serum creatine kinase activity decreased significantly in the methotrexate group. We conclude that oral methotrexate did not slow down progression of muscle weakness but decreased serum creatine kinase activity...
  84. ncbi request reprint Tripstar: a comprehensive patient-based approach to compare triptans
    Michel D Ferrari
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Headache 42:18-25. 2002
    ..5 mg is most similar to the ideal, principally because of its good tolerability. Further tests of the Tripstar model are planned that will gauge the relative importance of a broader range of attributes...
  85. ncbi request reprint Subcortical lacunar lesions: an MR imaging finding in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Rivka van den Boom
    Department of Radiology, Leiden University Medical Center, Albinusdreef 2, C2S, The Netherlands
    Radiology 224:791-6. 2002
    ....
  86. ncbi request reprint Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL
    Michael K Liem
    Department of Radiology, Leiden University Medical Center, C2S, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Stroke 38:923-8. 2007
    ..The objective of this study was to determine to what extent lacunar infarcts and microbleeds on MRI contribute to cognitive decline in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy...
  87. ncbi request reprint Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 106:107-11. 2003
    ..Confirmation by DNA analysis is requisite for positive results, and when there exists high clinical suspicion, also for negative results...
  88. ncbi request reprint George W. Bruyn, born Delft, 14 December 1928, died La Salvetat, 23 June 2002
    Michel D Ferrari
    Leiden University Medical Centre, Leiden, The Netherlands
    Cephalalgia 22:767-8. 2002
  89. ncbi request reprint Migraine--current understanding and treatment
    Peter J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    N Engl J Med 346:257-70. 2002
  90. ncbi request reprint Therapeutic gain or therapeutic ratio?
    Peter J Goadsby
    Headache 43:814-5; author reply 815-6. 2003
  91. ncbi request reprint The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online
    Kaate R J Vanmolkot
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Hum Mutat 28:522. 2007
    ..Our findings establish the role of neuronal Na(v)1.1 sodium channels in FHM and reinforce the involvement of ion channel dysfunction in the pathogenesis of this episodic brain disorder...
  92. ncbi request reprint Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice
    Simon Kaja
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurophysiol 95:2698-704. 2006
    ..This is the first report of compensatory expression of non-Cav2.1 channels at NMJs of mice with a single amino acid change in Cav2.1...
  93. ncbi request reprint Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya
    Simon Kaja
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Neurosci 25:2009-20. 2007
    ..Taken together, our studies indicate that the gait abnormality of RN mice is due to a combination of ataxia and muscle weakness and that RN models aspects of the NMJ dysfunction in LEMS...
  94. ncbi request reprint Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction
    Simon Kaja
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Brain Res 1143:92-101. 2007
    ..1 channel function due to alpha(2)delta-2 absence. We conclude that alpha(2)delta-2, beta(4), and gamma(2) accessory subunits are redundant for the transmitter release-mediating function of presynaptic Ca(v)2.1 channels at the mouse NMJ...
  95. ncbi request reprint First case of compound heterozygosity in Na,K-ATPase gene ATP1A2 in familial hemiplegic migraine
    Kaate R J Vanmolkot
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 15:884-8. 2007
    ..Cellular survival assays revealed Na,K-ATPase dysfunction for both ATP1A2 mutants, indicating that both mutations are disease causative. This is the first case of compound heterozygosity for any of the known FHM genes...
  96. ncbi request reprint The phe-124-Cys and A-161T variants of the human 5-HT1B receptor gene are not major determinants of the clinical response to sumatriptan
    Suneet Mehrotra
    Erasmus MC Department of Pharmacology, Rotterdam, The Netherlands
    Headache 47:711-6. 2007
    ..However, some patients do not respond to sumatriptan or experience recurrence of the headache after initial relief. In addition, some patients report chest symptoms after the use of sumatriptan...
  97. ncbi request reprint Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study
    Guus G Schoonman
    Department of Neurology, University Medical Center, Leiden, The Netherlands
    J Cereb Blood Flow Metab 28:198-206. 2008
    ....
  98. ncbi request reprint C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
    Anna Richards
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 39:1068-70. 2007
    ..These data have implications for the maintenance of vascular integrity in the degenerative cerebral microangiopathies leading to stroke and dementias...
  99. ncbi request reprint Epilepsy in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Joost Haan
    Department of Neurology, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cerebrovasc Dis 24:316-7. 2007
  100. ncbi request reprint Prioritizing treatment attributes and their impact on selecting an oral triptan: results from the TRIPSTAR Project
    David W Dodick
    Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA
    Curr Pain Headache Rep 8:435-42. 2004
    ..Using a multiattribute decision model, we combined these data on the importance of treatment attributes with information on the relative performance of the oral triptans derived from a recent meta-analysis of controlled clinical trials...
  101. doi request reprint Frontal lobe structure and executive function in migraine patients
    Nicole Schmitz
    Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Neurosci Lett 440:92-6. 2008
    ..Frontal and parietal lobe abnormalities in migraineurs could be an underlying cause of significantly slower response time during cognitive set-shifting...

Research Grants3

  1. Progression of brain lesions in migraine. The Population-Based CAMERA MRI follow-
    Michel Ferrari; Fiscal Year: 2009
    ..If confirmed, this would call for an earlier and more aggressive prophylactic treatment of migraine to prevent attacks and related brain damage. ..
  2. Progression of brain lesions in migraine. The Population-Based CAMERA MRI follow-
    MARK CHRISTIAN KRUIT; Fiscal Year: 2010
    ..If confirmed, this would call for an earlier and more aggressive prophylactic treatment of migraine to prevent attacks and related brain damage. ..