R Maarten Egeler

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Abundant expression of CD40 and CD40-ligand (CD154) in paediatric Langerhans cell histiocytosis lesions
    R M Egeler
    Southern Alberta Children s Cancer Program, Alberta Children s Hospital Tom Baker Cancer Centre, Department of Oncology and Pediatrics, University of Calgary, Alberta, Calgary, Canada
    Eur J Cancer 36:2105-10. 2000
  2. ncbi request reprint [Two brothers with familial hemophagocytic lymphohistiocytosis, treated by transplantation of stem cells from a single unrelated donor]
    K C J M Kraal
    Leids Universitair Medisch Centrum, afd Kindergeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:2309-12. 2002
  3. doi request reprint Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage
    R Maarten Egeler
    Department of Pediatric Immunology, Hematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Immunol Rev 234:213-32. 2010
  4. pmc Intact interferon signaling in peripheral blood leukocytes of high-grade osteosarcoma patients
    Emilie P Buddingh
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Immunol Immunother 61:941-7. 2012
  5. doi request reprint Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma
    Jens H W Pahl
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 18:432-41. 2012
  6. pmc Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells
    Emilie P Buddingh
    Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Cancer Immunol Immunother 60:575-86. 2011
  7. doi request reprint Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7
    Claudia M J M Faaij
    Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Pediatr Blood Cancer 55:344-8. 2010
  8. ncbi request reprint A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease
    Claudia M J M Faaij
    Department of Paediatrics, Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Br J Haematol 133:538-49. 2006
  9. doi request reprint No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies
    Cristiana E T da Costa
    Department of Pediatrics, Immunology Laboratory, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 48:239-49. 2009
  10. doi request reprint NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways
    Dirk H J Verhoeven
    Division of Immunology, Hematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Mol Immunol 45:3917-25. 2008

Detail Information

Publications43

  1. ncbi request reprint Abundant expression of CD40 and CD40-ligand (CD154) in paediatric Langerhans cell histiocytosis lesions
    R M Egeler
    Southern Alberta Children s Cancer Program, Alberta Children s Hospital Tom Baker Cancer Centre, Department of Oncology and Pediatrics, University of Calgary, Alberta, Calgary, Canada
    Eur J Cancer 36:2105-10. 2000
    ..Since this interaction is an accessible and realistic target for immunotherapy, these findings prompt speculation on the use of blocking antibodies to CD40 or to CD40L in the treatment of LCH...
  2. ncbi request reprint [Two brothers with familial hemophagocytic lymphohistiocytosis, treated by transplantation of stem cells from a single unrelated donor]
    K C J M Kraal
    Leids Universitair Medisch Centrum, afd Kindergeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:2309-12. 2002
    ..Immune suppression can induce prolonged remission in FHLH, but cure is only achieved after a successful allogeneic stem-cell transplantation. Without transplantation, the prognosis is very poor...
  3. doi request reprint Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage
    R Maarten Egeler
    Department of Pediatric Immunology, Hematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Immunol Rev 234:213-32. 2010
    ..Finally, we discuss recent insights into plasticity of T-helper cell subsets in light of the lesion microenvironment. LCH continues to provide urgent clinical questions thereby inspiring innovative DC lineage research...
  4. pmc Intact interferon signaling in peripheral blood leukocytes of high-grade osteosarcoma patients
    Emilie P Buddingh
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Immunol Immunother 61:941-7. 2012
    ..Since interferon signaling is intact in immune cells of osteosarcoma patients, there is a potential for indirect immunological effects of interferon-α treatment in osteosarcoma...
  5. doi request reprint Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma
    Jens H W Pahl
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 18:432-41. 2012
    ..In this study, we explored whether the cytolytic function of resting NK cells can be augmented and specifically directed toward sarcoma cells by antibody-dependent cellular cytotoxicity (ADCC)...
  6. pmc Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells
    Emilie P Buddingh
    Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Cancer Immunol Immunother 60:575-86. 2011
    ..Our data support the exploitation of NK cells or NK cell-activating agents in patients with high-grade osteosarcoma...
  7. doi request reprint Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7
    Claudia M J M Faaij
    Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Pediatr Blood Cancer 55:344-8. 2010
    ..These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin...
  8. ncbi request reprint A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease
    Claudia M J M Faaij
    Department of Paediatrics, Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Br J Haematol 133:538-49. 2006
    ..These findings support the involvement of CCL27/CTACK-CCR10 interaction in recruiting CD4+ T cells to the skin, thus contributing to the pathogenesis of acute GvHD...
  9. doi request reprint No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies
    Cristiana E T da Costa
    Department of Pediatrics, Immunology Laboratory, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 48:239-49. 2009
    ..c) 2008 Wiley-Liss, Inc...
  10. doi request reprint NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways
    Dirk H J Verhoeven
    Division of Immunology, Hematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Mol Immunol 45:3917-25. 2008
    ..To explore the feasibility of natural killer (NK) cell mediated immunotherapy and to identify molecular mechanisms involved, the susceptibility of EWS to NK cells was investigated...
  11. doi request reprint In situ detection of HY-specific T cells in acute graft-versus-host disease-affected male skin after sex-mismatched stem cell transplantation
    Yeung Hyen Kim
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biol Blood Marrow Transplant 18:381-7. 2012
    ....
  12. pmc Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis
    Dagmar Berghuis
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Sarcoma Res 2:8. 2012
    ..abstract:..
  13. ncbi request reprint Langerhans cell histiocytosis: a pathologic combination of oncogenesis and immune dysregulation
    R Maarten Egeler
    Department of Pediatric Immunology, Hematology, Oncology, Bone Marrow Transplantation, and Autoimmune Diseases, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Pediatr Blood Cancer 42:401-3. 2004
  14. doi request reprint Psychometric qualities of the Dutch version of the Pediatric Inventory for Parents (PIP): a multi-center study
    C M Jantien Vrijmoet-Wiersma
    Pediatric Department, Leiden University Medical Center, Leiden, The Netherlands
    Psychooncology 19:368-75. 2010
    ..For that reason, the Pediatric Inventory for Parents (PIP), a disease-related measure, was translated into Dutch and its psychometric qualities were determined to prove its value...
  15. doi request reprint Prognostic factors in pulmonary metastasized high-grade osteosarcoma
    Emilie P Buddingh
    Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Blood Cancer 54:216-21. 2010
    ..Resection of pulmonary metastases has previously been reported to improve outcome in high-grade osteosarcoma (OS) patients. Factors influencing survival in OS patients with pulmonary metastases are important for clinical decision making...
  16. doi request reprint Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8(+) T-lymphocyte infiltration and affect tumour progression
    Dagmar Berghuis
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Pathol 223:347-57. 2011
    ..Recognition of the merits and exploitation/induction of an inflammatory microenvironment may improve the efficacy of natural immune responses against, and (adoptive) immunotherapeutic approaches for, Ewing sarcoma...
  17. doi request reprint Atypical varicella zoster infection associated with hemophagocytic lymphohistiocytosis
    Jutte E van der Werff ten Bosch
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Blood Cancer 53:226-8. 2009
    ..These two cases demonstrate the difficulties in recognizing VZV reactivation, and in order to start adequate and timely treatment, the need to consider VZV as a possible cause of HLH in severely immunocompromised patients...
  18. ncbi request reprint Management of Epstein-Barr virus (EBV) reactivation after allogeneic stem cell transplantation by simultaneous analysis of EBV DNA load and EBV-specific T cell reconstitution
    Nicola E Annels
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 42:1743-8. 2006
    ..Quantification of EBV DNA load in asymptomatic individuals who are at risk is a useful (although not entirely predictive) indicator of progression to EBV-LPD and guide for preemptive treatment with CD20 antibodies...
  19. doi request reprint Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition
    Dagmar Berghuis
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Pathol 218:222-31. 2009
    ..The majority of EWS tumours, particularly if advanced-stage, exhibit complete or partial absence of both classes of HLA. This knowledge will be instrumental in the design of cellular immunotherapeutic strategies for advanced-stage EWS...
  20. ncbi request reprint Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways
    Alfons S K de Hooge
    Department of Pediatrics, Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 13:206-14. 2007
    ..Here, we have studied their in vitro and in vivo expression in Ewing sarcoma and the implications for susceptibility to cytotoxicity...
  21. ncbi request reprint Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL
    Nicola E Annels
    Department of Paediatrics, Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Center, The Netherlands
    Blood 103:2806-8. 2004
    ..These findings suggest that the original expression of CCR9 and CD103 on the leukemic cells contributed to the relapse location in the gut of this patient...
  22. pmc Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis
    Nicola E Annels
    Leiden University Medical Center, Department of Pediatrics, Division of Immunology, Hematology, Oncology, BMT and Autoimmune Diseases, PO Box 9600, 2300 RC Leiden, Netherlands
    J Exp Med 197:1385-90. 2003
    ..We postulate that the lesional LCs themselves control the persistence and progression of LCH...
  23. doi request reprint Health-related quality of life, cognitive functioning and behaviour problems in children with Langerhans cell histiocytosis
    C M Jantien Vrijmoet-Wiersma
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Blood Cancer 52:116-22. 2009
    ..Furthermore, we investigated which medical determinants and social demographic factors were predictive for HRQoL, cognitive functioning and behavioural problems...
  24. ncbi request reprint Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
    Lynne M Ball
    Department of Pediatric Stem Cell Transplantation, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 110:2764-7. 2007
    ..These data suggest that MSCs, possibly thanks to their potent immunosuppressive effect on alloreactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure in haploidentical HSC transplant recipients...
  25. ncbi request reprint Once-daily intravenous busulfan in children prior to stem cell transplantation: study of pharmacokinetics and early clinical outcomes
    Juliette Zwaveling
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    Anticancer Drugs 17:1099-105. 2006
    ..Future investigations should be aimed at further optimizing the target area under the curve of intravenous busulfan for specific patient groups...
  26. ncbi request reprint ABO incompatible stem cell transplantation in children does not influence outcome
    A M Helming
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Blood Cancer 49:313-7. 2007
    ....
  27. ncbi request reprint Intravenous busulfan in children prior to stem cell transplantation: study of pharmacokinetics in association with early clinical outcome and toxicity
    J Zwaveling
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Bone Marrow Transplant 35:17-23. 2005
    ..We concluded that, in accordance with previous data, within the observed AUCs no clear relationship was observed between Bu AUC and outcome with respect to toxicity, engraftment and relapse...
  28. ncbi request reprint Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcomas
    J K Anninga
    Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Leiden University Medical Center, J6S, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 40:963-70. 2004
    ..Our results suggest that the monoclonal antibody trastuzumab (Herceptin(R)), directed against the HER2-receptor, is not likely to be an effective therapeutic agent in OS...
  29. pmc Significance of amplified fragment length polymorphism in identification and epidemiological examination of Candida species colonization in children undergoing allogeneic stem cell transplantation
    L M Ball
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1673-9. 2004
    ..albicans by a rapid enzyme test. AFLP analysis of surveillance cultures allowed more accurate and informative epidemiological evaluations of pathogenic yeasts in children during transplantation...
  30. ncbi request reprint Paediatric allogeneic bone marrow transplantation for homozygous beta-thalassaemia, the Dutch experience
    L M Ball
    The Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Bone Marrow Transplant 31:1081-7. 2003
    ..Our results emphasise the importance of the conditioning regimen and post-transplant chimerism surveillance predictive of rejection or long-term stable engraftment...
  31. ncbi request reprint Allogeneic bone marrow transplantation for juvenile myelomonocytic leukemia: a single center experience of 23 patients
    E T Korthof
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 35:455-61. 2005
    ..9). Together with a trend towards less relapse in patients with graft-versus-host-disease and in patients transplanted with matched unrelated donors, this suggests a graft-versus-leukemia effect of allogeneic BMT in JMML...
  32. ncbi request reprint How to improve the search for an unrelated haematopoietic stem cell donor. Faster is better than more!
    M B A Heemskerk
    Europdonor Foundation, Leiden, The Netherlands
    Bone Marrow Transplant 35:645-52. 2005
    ..It may be more effective to optimize the chance on transplantation by making the search process more efficient...
  33. ncbi request reprint [Favorable current prognosis after HLA-identical bone marrow transplantation for children with required severe aplastic anemia; evaluation of 30 years of bone marrow transplantation at the Leiden University Medical Center]
    M van Steekelenburg
    Willem Alexander Kinder en Jeugdcentrum, sectie Immunologie, Hematologie, Oncologie, Beenmergtransplantatie en Auto immuunziekten IHOBA, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:1542-6. 2002
    ..To evaluate the results of 30 years of allogeneic HLA-identical bone marrow transplantation (BMT) as the treatment for children with acquired severe aplastic anaemia...
  34. ncbi request reprint Allogeneic stem cell transplantation in X-linked lymphoproliferative disease: two cases in one family and review of the literature
    A C Lankester
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 36:99-105. 2005
    ..Based on these results and in order to improve the final outcome, we conclude that alloSCT should be recommended in both symptomatic and asymptomatic XLP patients...
  35. ncbi request reprint Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases working party of the European Group for Blood and Marrow Transplantation
    M Miano
    Department of Paediatric Haematology and Oncology, IRCSS Giannina Gaslini, Genova, Italy
    Bone Marrow Transplant 39:89-99. 2007
    ..0001) had higher TRM. Indications for paediatric HSCT have changed considerably during the last seven years. These changes provide tools for decision making in health-care planning and counselling...
  36. ncbi request reprint HLA-identical haematopoietic stem cell transplantation for acute leukaemia in children: less relapse with higher biologically effective dose of TBI
    A J Willemze
    Division of Immunology, Hematology, Oncology and Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Bone Marrow Transplant 40:319-27. 2007
    ..034) and increased overall survival. AML patients with acute GVHD got no relapse (P=0.02); this was not the case in ALL patients. Fractionated TBI regimens with higher BED should be evaluated in prospective studies...
  37. ncbi request reprint Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity
    M J D van Tol
    Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Bone Marrow Transplant 35:S73-6. 2005
    ..The feasibility of several approaches for the manipulation of immunity in the immunocompromised host to prevent a fatal course of the infection is discussed...
  38. doi request reprint Acute GvHD: pathogenesis and classification
    L M Ball
    Department of Paediatric Immunology, Hematology, Oncology, Bone Marrow Transplantation, and Auto immune Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 41:S58-64. 2008
    ..The authors concentrate on the most recent knowledge of the pathogenesis as well as the classification of aGvHD...
  39. ncbi request reprint Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation
    L M Ball
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 35:S35-8. 2005
    ..We are investigating new strategies to improve the outcome of haplo-identical PBSCT, which may allow us to offer this form of treatment to more children requiring urgent HSCT...
  40. ncbi request reprint Survey on haematopoietic stem cell transplantation for children in Europe
    M Miano
    Department of Paediatric Haematology and Oncology, IRCCS G Gaslini, Genova, Italy
    Bone Marrow Transplant 35:S3-8. 2005
    ..It demonstrates the compliance of most major paediatric institutions and confirms the important role of cooperation between National Registries and EBMT Registries...
  41. ncbi request reprint Early marrow transplantation in a pre-symptomatic neonate with late infantile metachromatic leukodystrophy does not halt disease progression
    R G M Bredius
    Bone Marrow Transplant 39:309-10. 2007
  42. ncbi request reprint The importance of identifying a back-up donor for unrelated stem cell transplantation
    S M van Walraven
    Europdonor Foundation, Leiden, The Netherlands
    Bone Marrow Transplant 35:437-40. 2005
    ..We strongly encourage implementing a search for at least one back-up donor in the primary search. Identifying a back-up donor can save precious time and complicated logistic rescheduling...
  43. ncbi request reprint Causes of death--other than progressive leukemia--in childhood acute lymphoblastic (ALL) and myeloid leukemia (AML): the Dutch Childhood Oncology Group experience
    A M Slats
    Department of Pediatric Hematology Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Leukemia 19:537-44. 2005
    ..We conclude that mortality dropped favorably in ALL, but not in AML. Especially for AML, effective but less toxic therapy and better supportive care guidelines need to be developed...