Miranda Van Eck

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 17:3117-26. 1997
  2. ncbi request reprint Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
    Miranda Van Eck
    Divison of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Lipid Res 49:136-46. 2008
  3. ncbi request reprint Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2413-9. 2007
  4. ncbi request reprint Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Circ Res 100:678-85. 2007
  5. ncbi request reprint Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:929-34. 2006
  6. ncbi request reprint Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Atherosclerosis 183:230-7. 2005
  7. ncbi request reprint Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Curr Opin Lipidol 16:307-15. 2005
  8. pmc Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Am J Pathol 165:785-94. 2004
  9. pmc Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
  10. ncbi request reprint Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA, Leiden, The Netherlands
    Atherosclerosis 154:103-12. 2001

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 17:3117-26. 1997
    ....
  2. ncbi request reprint Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
    Miranda Van Eck
    Divison of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Lipid Res 49:136-46. 2008
    ..In conclusion, SR-BI plays an important physiological role in the metabolism of VLDL (remnants)...
  3. ncbi request reprint Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2413-9. 2007
    ..In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated...
  4. ncbi request reprint Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Circ Res 100:678-85. 2007
    ..Most importantly, we show for the first time that bone marrow-derived CETP is an important contributor to total serum CETP activity and mass...
  5. ncbi request reprint Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:929-34. 2006
    ..However, the possibly beneficial effects of specific upregulation of macrophage ABCA1 on atherogenesis are still unknown...
  6. ncbi request reprint Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Atherosclerosis 183:230-7. 2005
    ..The very-low-density lipoprotein receptor (VLDLr) is highly expressed in macrophage-rich areas of atherosclerotic lesions. The exact role of the macrophage VLDLr in atherosclerotic lesion development, however, is presently unclear...
  7. ncbi request reprint Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Curr Opin Lipidol 16:307-15. 2005
    ..This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development...
  8. pmc Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Am J Pathol 165:785-94. 2004
    ..It thus appears that, depending on the stage of atherosclerotic lesion development, SR-BI in bone marrow-derived cells is either pro-atherogenic or anti-atherogenic, indicating a unique dual role in the pathogenesis of atherosclerosis...
  9. pmc Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
    ..Our results provide evidence that leukocyte ABCA1 plays a critical role in the protection against atherosclerosis, and we identify ABCA1 as a leukocyte factor that controls the recruitment of inflammatory cells...
  10. ncbi request reprint Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA, Leiden, The Netherlands
    Atherosclerosis 154:103-12. 2001
    ....
  11. ncbi request reprint Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Sylvius Laboratories, Leiden University The Netherlands
    Arterioscler Thromb Vasc Biol 20:2600-6. 2000
    ....
  12. ncbi request reprint Role of macrophage-derived lipoprotein lipase in lipoprotein metabolism and atherosclerosis
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 20:E53-62. 2000
    ....
  13. ncbi request reprint Accelerated atherosclerosis in C57Bl/6 mice transplanted with ApoE-deficient bone marrow
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA, Leiden, The Netherlands
    Atherosclerosis 150:71-80. 2000
    ..We anticipate that pharmacological approaches to increase apoE synthesis and/or secretion by macrophages might be beneficial for the treatment of atherosclerosis...
  14. ncbi request reprint Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158-->Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice
    M Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
    Arterioscler Thromb Vasc Biol 20:119-27. 2000
    ....
  15. doi request reprint Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet
    Ying Zhao
    Division of Biopharmaceutics, University Medical Center Groningen, The Netherlands
    Circ Res 107:e20-31. 2010
    ....