Miranda Van Eck


Affiliation: Leiden University
Country: The Netherlands


  1. van der Stoep M, Korporaal S, Van Eck M. High-density lipoprotein as a modulator of platelet and coagulation responses. Cardiovasc Res. 2014;103:362-71 pubmed publisher
    ..Thus, HDL's antithrombotic actions are multiple and therefore, raising HDL may be an important therapeutic strategy to reduce the risk of arterial and venous thrombosis. ..
  2. van der Geest R, Ouweneel A, van der Sluis R, Groen A, Van Eck M, Hoekstra M. Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice. Toxicol Appl Pharmacol. 2016;306:1-7 pubmed publisher
    ..In conclusion, we have shown that endogenous glucocorticoids exacerbate the liver injury and hypercholesterolemia associated with acute cholestasis in mice. ..
  3. Louwe M, Lammers B, Frias M, Foks A, de Leeuw L, Hildebrand R, et al. Abca1 deficiency protects the heart against myocardial infarction-induced injury. Atherosclerosis. 2016;251:159-163 pubmed publisher
    ..12), suggesting a detrimental role for hematopoietic Abca1 after MI. Although Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after MI. ..
  4. request reprint
    Van Eck M, de Winther M, Herijgers N, Havekes L, Hofker M, Groot P, et al. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2000;20:2600-6 pubmed
  5. request reprint
    Eck M, Oost J, Goudriaan J, Hoekstra M, Hildebrand R, Bos I, et al. Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development. Atherosclerosis. 2005;183:230-7 pubmed
    ..7-fold increase (P<0.05) in the mean atherosclerotic lesion area to 32+/-3 x 10(3)microm(2). The macrophage VLDLr facilitates atherosclerotic lesion development, probably by mediating the accumulation of atherogenic lipoproteins. ..
  6. request reprint
    Van Eck M, Singaraja R, Ye D, Hildebrand R, James E, Hayden M, et al. Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2006;26:929-34 pubmed
    ..However, the possibly beneficial effects of specific upregulation of macrophage ABCA1 on atherogenesis are still unknown...
  7. request reprint
    Van Eck M, Ye D, Hildebrand R, Kar Kruijt J, de Haan W, Hoekstra M, et al. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. Circ Res. 2007;100:678-85 pubmed
    ..Most importantly, we show for the first time that bone marrow-derived CETP is an important contributor to total serum CETP activity and mass. ..
  8. request reprint
    Van Eck M, Hoekstra M, Out R, Bos I, Kruijt J, Hildebrand R, et al. Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo. J Lipid Res. 2008;49:136-46 pubmed
    ..In conclusion, SR-BI plays an important physiological role in the metabolism of VLDL (remnants). ..
  9. request reprint
    Van Eck M, Herijgers N, van Dijk K, Havekes L, Hofker M, Groot P, et al. Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158-->Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2000;20:119-27 pubmed

More Information


  1. request reprint
    Van Eck M, Zimmermann R, Groot P, Zechner R, van Berkel T. Role of macrophage-derived lipoprotein lipase in lipoprotein metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20:E53-62 pubmed
  2. Van Eck M, Bos I, Kaminski W, Orso E, Rothe G, Twisk J, et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A. 2002;99:6298-303 pubmed
    ..Our results provide evidence that leukocyte ABCA1 plays a critical role in the protection against atherosclerosis, and we identify ABCA1 as a leukocyte factor that controls the recruitment of inflammatory cells...
  3. Van Eck M, Bos I, Hildebrand R, Van Rij B, Van Berkel T. Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am J Pathol. 2004;165:785-94 pubmed
    ..It thus appears that, depending on the stage of atherosclerotic lesion development, SR-BI in bone marrow-derived cells is either pro-atherogenic or anti-atherogenic, indicating a unique dual role in the pathogenesis of atherosclerosis. ..
  4. request reprint
    Van Eck M, Pennings M, Hoekstra M, Out R, Van Berkel T. Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis. Curr Opin Lipidol. 2005;16:307-15 pubmed
    ..This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development...
  5. request reprint
    Van Eck M, Hoekstra M, Hildebrand R, Yaong Y, Stengel D, Kruijt J, et al. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL. Arterioscler Thromb Vasc Biol. 2007;27:2413-9 pubmed
    ..SR-BI deficiency results in a reduced activity of the antioxidant enzyme PON1 and a significant increase in oxidative stress, potentially contributing to the proatherogenic effect of SR-BI deficiency. ..