Marjolijn Duijvestein

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Gut 59:1662-9. 2010
  2. doi Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Stem Cells 29:1549-58. 2011
  3. doi Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University, Medical Center, Leiden, The Netherlands
    Cytotherapy 13:1066-73. 2011
  4. doi Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro
    Anne Christine W Vos
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Inflamm Bowel Dis 18:401-8. 2012
  5. doi Miltefosine suppresses inflammation in a mouse model of inflammatory bowel disease
    Auke P Verhaar
    Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Inflamm Bowel Dis 19:1974-82. 2013
  6. doi Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions
    Caterina Strisciuglio
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Crohns Colitis 7:534-41. 2013
  7. doi Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2
    Auke P Verhaar
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    J Immunol 190:6589-95. 2013
  8. doi Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
    Manon E Wildenberg
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 142:1493-503.e6. 2012
  9. doi Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner
    Anne Christine W Vos
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 140:221-30. 2011
  10. doi Quality of web-based information on inflammatory bowel diseases
    Sander van der Marel
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Inflamm Bowel Dis 15:1891-6. 2009

Collaborators

Detail Information

Publications14

  1. doi Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Gut 59:1662-9. 2010
    ..Our objective was to determine the safety and feasibility of autologous bone marrow derived MSC therapy in patients with refractory Crohn's disease...
  2. doi Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Stem Cells 29:1549-58. 2011
    ..These data demonstrate that IFN-γ activation of MSCs increases their immunosuppresive capacities and importantly, their therapeutic efficacy in vivo...
  3. doi Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University, Medical Center, Leiden, The Netherlands
    Cytotherapy 13:1066-73. 2011
    ..However, little is known about MSC interactions with these immunosuppressive drugs. To address this issue we studied the combined effect of MSC and IBD drugs in in vitro functionality assays...
  4. doi Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro
    Anne Christine W Vos
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Inflamm Bowel Dis 18:401-8. 2012
    ..In addition, we studied the effect of infliximab/azathioprine combination treatment on the differentiation and function of regulatory macrophages...
  5. doi Miltefosine suppresses inflammation in a mouse model of inflammatory bowel disease
    Auke P Verhaar
    Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Inflamm Bowel Dis 19:1974-82. 2013
    ..Although the exact mechanism of action of miltefosine has yet to be elucidated, the drug has previously been shown to inhibit phospholipases and protein kinase C, both key components of proproliferative signal transduction in T cells...
  6. doi Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions
    Caterina Strisciuglio
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Crohns Colitis 7:534-41. 2013
    ..In this study we aimed to determine whether autophagy also regulates DC-epithelial cell interactions and whether this influences the ensuing immune response...
  7. doi Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2
    Auke P Verhaar
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    J Immunol 190:6589-95. 2013
    ..In conclusion, we find that effects of glucocorticoids on TCR-induced T cell proliferation are mainly nongenomic and can be bypassed by the activation of an Lck-independent signaling pathway...
  8. doi Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
    Manon E Wildenberg
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 142:1493-503.e6. 2012
    ..We investigated the involvement of the immunologic synapse-the site of contact between dendritic cells (DCs) and T cells, which contains molecules involved in antigen recognition and regulates immune response...
  9. doi Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner
    Anne Christine W Vos
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 140:221-30. 2011
    ..We examined the immunosuppressive effects of different anti-TNFα reagents on activated T cells...
  10. doi Quality of web-based information on inflammatory bowel diseases
    Sander van der Marel
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Inflamm Bowel Dis 15:1891-6. 2009
    ..As information is largely unregulated, our objective was to evaluate the quality, readability, accuracy, and accessibility of the information concerning IBD available on the World Wide Web...
  11. pmc Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Negl Trop Dis 2:e227. 2008
    ..We have characterized the innate immune responses, at the molecular level, in children according to their helminth infection status and their atopic reactivity to allergens...
  12. pmc Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease
    Ilse Molendijk
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Allergy (Cairo) 2012:187408. 2012
    ....
  13. doi Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease
    Daniel W Hommes
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Crohns Colitis 5:543-9. 2011
    ..Recently, several cases have been reported of successful remission induction in Crohn's disease patients by means of hematopoietic stem cell transplantation (HSCT). Here we report our long-term (4 to 6 years) outcome in three patients...
  14. doi In vivo biodistribution of stem cells using molecular nuclear medicine imaging
    Mick M Welling
    Department of Radiology, Molecular Imaging Laboratories Leiden, Section Nuclear Medicine, Leiden University Medical Center, Leiden, Netherlands
    J Cell Physiol 226:1444-52. 2011
    ..In addition, we evaluate current problems and directions related to stem cell tracking using radiolabels, including a possible role for their clinical implementation...