Carine J M Doggen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII
    Carine J M Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 108:4045-51. 2006
  2. ncbi HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women
    C J M Doggen
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    J Thromb Haemost 2:700-1. 2004
  3. ncbi Serum lipid levels and the risk of venous thrombosis
    Carine J M Doggen
    Department of Epidemiology, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 24:1970-5. 2004
  4. ncbi Polymorphisms in the protein C gene as risk factor for venous thrombosis
    Elisabeth R Pomp
    Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 101:62-7. 2009
  5. pmc F9 Malmö, factor IX and deep vein thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, C7 P Leiden University Medical Center, Leiden, The Netherlands
    Haematologica 94:693-9. 2009
  6. ncbi Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations
    Elisabeth R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 139:289-96. 2007
  7. doi Multiple SNP testing improves risk prediction of first venous thrombosis
    Hugoline G de Haan
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 120:656-63. 2012
  8. ncbi Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction
    Rick van Minkelen
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 203:201-5. 2009
  9. doi The effect of flight-related behaviour on the risk of venous thrombosis after air travel
    Anja J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 144:425-9. 2009
  10. ncbi No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 167:497-501. 2007

Collaborators

Detail Information

Publications43

  1. ncbi Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII
    Carine J M Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 108:4045-51. 2006
    ..2 (ORadj, 3.2; 95% CI, 2.0-5.1). Thus, factors XIc and XIIc have opposite and synergistic effects on the risk of myocardial infarction in men; factor VIIIc and factor IXc increase the risk...
  2. ncbi HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women
    C J M Doggen
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    J Thromb Haemost 2:700-1. 2004
  3. ncbi Serum lipid levels and the risk of venous thrombosis
    Carine J M Doggen
    Department of Epidemiology, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 24:1970-5. 2004
    ..Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results...
  4. ncbi Polymorphisms in the protein C gene as risk factor for venous thrombosis
    Elisabeth R Pomp
    Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 101:62-7. 2009
    ..There is no clear synergistic effect of the CC/GG genotype with factor V Leiden or oral contraceptive use on thrombotic risk...
  5. pmc F9 Malmö, factor IX and deep vein thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, C7 P Leiden University Medical Center, Leiden, The Netherlands
    Haematologica 94:693-9. 2009
    ..We recently reported the association between the Malmö sequence variant in F9 (rs6048) and deep vein thrombosis...
  6. ncbi Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations
    Elisabeth R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 139:289-96. 2007
    ..70-13.15); for prothrombin 20210A this was a 6.6-fold increased risk (OR(adj) 6.58, 95% CI 2.31-18.69). Body height, weight and obesity increase the risk of venous thrombosis, especially obesity in women using oral contraceptives...
  7. doi Multiple SNP testing improves risk prediction of first venous thrombosis
    Hugoline G de Haan
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 120:656-63. 2012
    ..82 (95% CI, 0.81-0.83), indicating good diagnostic accuracy. To become clinically useful, subgroups of high-risk persons must be identified in whom genetic profiling will also be cost-effective...
  8. ncbi Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction
    Rick van Minkelen
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 203:201-5. 2009
    ..It is unclear whether variations in IL1RN affect the risk of myocardial infarction...
  9. doi The effect of flight-related behaviour on the risk of venous thrombosis after air travel
    Anja J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 144:425-9. 2009
    ..The effect of behavioural factors during flying on the risk of venous thrombosis after air travel is limited. Current advice on prevention of travel-related thrombosis may have to be reconsidered...
  10. ncbi No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 167:497-501. 2007
    ..The aim of the present study was to evaluate the effect of the MTHFR genotype on the risk of venous thrombosis, overall and in subgroups of known risk factors, in a single large study...
  11. doi Minor injuries as a risk factor for venous thrombosis
    Karlijn J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 168:21-6. 2008
    ..We studied the association of venous thrombosis with common minor injuries, such as minor sural muscle ruptures and ankle sprains...
  12. doi Alcohol consumption is associated with a decreased risk of venous thrombosis
    Elisabeth R Pomp
    Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 99:59-63. 2008
    ..In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels...
  13. pmc Low thrombin activatable fibrinolysis inhibitor activity levels are associated with an increased risk of a first myocardial infarction in men
    Mirjam E Meltzer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Haematologica 94:811-8. 2009
    ..TAFI regulates fibrinolysis, but other roles of this inhibitor, including anti-inflammatory properties, have also been demonstrated...
  14. ncbi Effect of elevated levels of coagulation factors on the risk of venous thrombosis in long-distance travelers
    Saskia Kuipers
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 113:2064-9. 2009
    ..7; 95% CI, 5.4-498). We conclude that increased levels of FII and FVIII increase the risk of venous thrombosis in travelers. Furthermore, the risk is greatly increased if other risk factors are present as well...
  15. ncbi Risk of myocardial infarction attributable to elevated levels of total cholesterol among hypertensives
    Nicole L Glazer
    Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA
    Am J Hypertens 18:759-66. 2005
    ....
  16. doi The value of family history as a risk indicator for venous thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Arch Intern Med 169:610-5. 2009
    ..We studied the contribution of family history to the risk of venous thrombosis in relation to known risk factors...
  17. doi Venous thrombosis of the upper extremity: effect of blood group and coagulation factor levels on risk
    Linda E Flinterman
    Department of Clinical Epidemiology, Leiden University, The Netherlands
    Br J Haematol 149:118-23. 2010
    ..1, 95% CI, 1.3-3.6). The other factors were not associated with an increased risk. Elevated levels of several procoagulant factors are associated with a strongly increased risk of venous thrombosis of the upper extremity...
  18. doi Gene variants associated with deep vein thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 299:1306-14. 2008
    ..The genetic causes of deep vein thrombosis (DVT) are not fully understood...
  19. doi The relationship between exercise and risk of venous thrombosis in elderly people
    Karlijn J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 56:517-22. 2008
    ..To study whether exercise is associated with the risk of venous thrombosis in elderly people...
  20. ncbi Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use
    Elisabeth R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hematol 83:97-102. 2008
    ..0-fold increased risk. In conclusion, smoking appears to be a risk factor for venous thrombosis with the greatest relative effect among young women using oral contraceptives...
  21. ncbi Haplotypes encoding the factor VIII 1241 Glu variation, factor VIII levels and the risk of venous thrombosis
    A Yaël Nossent
    Department of Haematology, C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 95:942-8. 2006
    ..However, FVIII gene variations do contribute to both levels of FVIII and the risk of thrombosis...
  22. ncbi Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    Jeanet W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:715-22. 2005
    ..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
  23. pmc Travel-related venous thrombosis: results from a large population-based case control study (MEGA study)
    Suzanne C Cannegieter
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e307. 2006
    ..Recent studies have indicated an increased risk of venous thrombosis after air travel. Nevertheless, questions on the magnitude of risk, the underlying mechanism, and modifying factors remain unanswered...
  24. ncbi Venous thrombosis in the elderly
    F R Rosendaal
    Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:310-7. 2007
    ..In addition to a review of the literature, new data are presented from the MEGA-study. Thrombosis in the elderly should be a focus of future studies...
  25. doi HMG-CoA reductase inhibitors, other lipid-lowering medication, antiplatelet therapy, and the risk of venous thrombosis
    A S Ramcharan
    Department of Clinical Epidemiology, Leiden University Medical Centre, The Netherlands
    J Thromb Haemost 7:514-20. 2009
    ..We have studied the risk of venous thrombosis with use of statins, other lipid-lowering medication, and antiplatelet therapy...
  26. pmc Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factors
    E R Pomp
    Department of Clinical Epidemiology, C7 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Epidemiol 25:459-66. 2010
    ..Our experience with the intricacies of dealing with two control groups may be useful to others when thinking about an optimal research design or the best statistical approach...
  27. ncbi Old and new risk factors for upper extremity deep venous thrombosis
    J W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 3:2471-8. 2005
    ....
  28. doi Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study
    E R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:632-7. 2008
    ..Objective: In the MEGA study, we evaluated pregnancy and the postpartum period as risk factors for venous thrombosis in 285 patients and 857 control subjects...
  29. ncbi Regular sports activities decrease the risk of venous thrombosis
    K J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:2186-92. 2007
    ..Stasis of the blood has been postulated as a major cause of venous thrombosis. However, little is known about the effect of stimulating the blood flow in order to prevent venous thrombosis through, for example, sports activities...
  30. doi Mechanisms of the factor V Leiden paradox
    K J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1872-7. 2008
    ..So far few studies have investigated possible mechanisms for this so-called FVL paradox...
  31. ncbi Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens
    Huib A A M van Vliet
    Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:563-8. 2005
    ..Our objective was to test the usefulness of sex hormone-binding globulin (SHBG) as a marker for the thrombotic risk of an oral contraceptive...
  32. doi The -589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals
    E Paffen
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:1633-8. 2008
    ....
  33. doi Recurrent thrombosis and survival after a first venous thrombosis of the upper extremity
    L E Flinterman
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 118:1366-72. 2008
    ..Little is known about the consequences of a first venous thrombosis in the upper extremity. We studied the incidence of, survival, and risk factors for recurrence in a follow-up study...
  34. doi Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction
    M D van der Krabben
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:720-5. 2008
    ..The aim of this study was to examine whether genetic predisposition to high levels of coagulation factors influences the risk of developing fatal and non-fatal arterial cardiovascular events in men with a first myocardial infarction (MI)...
  35. ncbi Current perspective of venous thrombosis in the upper extremity
    L E Flinterman
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:1262-6. 2008
    ..In this review an overview of the different risk factors, possible treatments and the complications for patients with a venous thrombosis of the upper extremity is given...
  36. pmc The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
    BMJ 339:b2921. 2009
    ..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
  37. ncbi Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:802-6. 2005
    ..This may manifest itself as a reduced time to pregnancy (increased fecundity) and fewer miscarriages in the first trimester...
  38. pmc The tortuous history of the implementation of early ambulation after delivery
    K J van Stralen
    Department of Clinical Epidemiology, Division of Reproductive Medicine, Leiden University Medical Centre, The Netherlands
    J R Soc Med 100:90-6. 2007
  39. pmc Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS Med 5:e97. 2008
    ..Here, we investigated the combined effect of hypofibrinolysis with established risk factors associated with hypercoagulability...
  40. ncbi Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trial
    Iwan C C van der Horst
    Department of Cardiology, Isala Klinieken, Hospital De Weezenlanden, Zwolle, The Netherlands
    J Am Coll Cardiol 42:784-91. 2003
    ..In this study we considered the question of whether adjunction of glucose-insulin-potassium (GIK) infusion to primary coronary transluminal angioplasty (PTCA) is effective in patients with an acute myocardial infarction (MI)...
  41. ncbi ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
    Chan K N K Chion
    Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    Blood 109:1998-2000. 2007
    ..5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13...
  42. ncbi Fibrinolysis and the risk of venous and arterial thrombosis
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Hematol 14:242-8. 2007
    ..In this review, we evaluated studies that investigated the association between fibrinolysis and thrombosis...
  43. ncbi High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells
    Stephanie Bezzina Wettinger
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 105:2000-6. 2005
    ..These data support the hypothesis that an inflammatory response involving leucocytes plays a role in the pathogenesis of myocardial infarction...