Research Topics
Genomes and GenesSpecies | Carine J M DoggenSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Publications
Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XIICarine J M Doggen
Department of Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Blood 108:4045-51. 2006..2 (ORadj, 3.2; 95% CI, 2.0-5.1). Thus, factors XIc and XIIc have opposite and synergistic effects on the risk of myocardial infarction in men; factor VIIIc and factor IXc increase the risk...- HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal womenC J M Doggen
Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
J Thromb Haemost 2:700-1. 2004 - Serum lipid levels and the risk of venous thrombosisCarine J M Doggen
Department of Epidemiology, University of Washington, Seattle, USA
Arterioscler Thromb Vasc Biol 24:1970-5. 2004..Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results... - Polymorphisms in the protein C gene as risk factor for venous thrombosisElisabeth R Pomp
Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Thromb Haemost 101:62-7. 2009..There is no clear synergistic effect of the CC/GG genotype with factor V Leiden or oral contraceptive use on thrombotic risk... 
F9 Malmö, factor IX and deep vein thrombosisIrene D Bezemer
Department of Clinical Epidemiology, C7 P Leiden University Medical Center, Leiden, The Netherlands
Haematologica 94:693-9. 2009..We recently reported the association between the Malmö sequence variant in F9 (rs6048) and deep vein thrombosis...- Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutationsElisabeth R Pomp
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Br J Haematol 139:289-96. 2007..70-13.15); for prothrombin 20210A this was a 6.6-fold increased risk (OR(adj) 6.58, 95% CI 2.31-18.69). Body height, weight and obesity increase the risk of venous thrombosis, especially obesity in women using oral contraceptives... 
Multiple SNP testing improves risk prediction of first venous thrombosisHugoline G de Haan
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Blood 120:656-63. 2012..82 (95% CI, 0.81-0.83), indicating good diagnostic accuracy. To become clinically useful, subgroups of high-risk persons must be identified in whom genetic profiling will also be cost-effective...- Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarctionRick van Minkelen
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Atherosclerosis 203:201-5. 2009..It is unclear whether variations in IL1RN affect the risk of myocardial infarction... - The effect of flight-related behaviour on the risk of venous thrombosis after air travelAnja J M Schreijer
Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
Br J Haematol 144:425-9. 2009..The effect of behavioural factors during flying on the risk of venous thrombosis after air travel is limited. Current advice on prevention of travel-related thrombosis may have to be reconsidered... - No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA studyIrene D Bezemer
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Arch Intern Med 167:497-501. 2007..The aim of the present study was to evaluate the effect of the MTHFR genotype on the risk of venous thrombosis, overall and in subgroups of known risk factors, in a single large study... - Minor injuries as a risk factor for venous thrombosisKarlijn J van Stralen
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Arch Intern Med 168:21-6. 2008..We studied the association of venous thrombosis with common minor injuries, such as minor sural muscle ruptures and ankle sprains... - Alcohol consumption is associated with a decreased risk of venous thrombosisElisabeth R Pomp
Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, Leiden, The Netherlands
Thromb Haemost 99:59-63. 2008..In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels... - Low thrombin activatable fibrinolysis inhibitor activity levels are associated with an increased risk of a first myocardial infarction in menMirjam E Meltzer
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Haematologica 94:811-8. 2009..TAFI regulates fibrinolysis, but other roles of this inhibitor, including anti-inflammatory properties, have also been demonstrated... - Effect of elevated levels of coagulation factors on the risk of venous thrombosis in long-distance travelersSaskia Kuipers
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Blood 113:2064-9. 2009..7; 95% CI, 5.4-498). We conclude that increased levels of FII and FVIII increase the risk of venous thrombosis in travelers. Furthermore, the risk is greatly increased if other risk factors are present as well... - Risk of myocardial infarction attributable to elevated levels of total cholesterol among hypertensivesNicole L Glazer
Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA
Am J Hypertens 18:759-66. 2005.... - The value of family history as a risk indicator for venous thrombosisIrene D Bezemer
Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
Arch Intern Med 169:610-5. 2009..We studied the contribution of family history to the risk of venous thrombosis in relation to known risk factors... - Venous thrombosis of the upper extremity: effect of blood group and coagulation factor levels on riskLinda E Flinterman
Department of Clinical Epidemiology, Leiden University, The Netherlands
Br J Haematol 149:118-23. 2010..1, 95% CI, 1.3-3.6). The other factors were not associated with an increased risk. Elevated levels of several procoagulant factors are associated with a strongly increased risk of venous thrombosis of the upper extremity... - Gene variants associated with deep vein thrombosisIrene D Bezemer
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
JAMA 299:1306-14. 2008..The genetic causes of deep vein thrombosis (DVT) are not fully understood... - The relationship between exercise and risk of venous thrombosis in elderly peopleKarlijn J van Stralen
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Am Geriatr Soc 56:517-22. 2008..To study whether exercise is associated with the risk of venous thrombosis in elderly people... - Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive useElisabeth R Pomp
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Am J Hematol 83:97-102. 2008..0-fold increased risk. In conclusion, smoking appears to be a risk factor for venous thrombosis with the greatest relative effect among young women using oral contraceptives... - Haplotypes encoding the factor VIII 1241 Glu variation, factor VIII levels and the risk of venous thrombosisA Yaël Nossent
Department of Haematology, C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Thromb Haemost 95:942-8. 2006..However, FVIII gene variations do contribute to both levels of FVIII and the risk of thrombosis... - Malignancies, prothrombotic mutations, and the risk of venous thrombosisJeanet W Blom
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
JAMA 293:715-22. 2005..Carriers of the factor V Leiden and prothrombin 20210A mutations appear to have an even higher risk... 
Travel-related venous thrombosis: results from a large population-based case control study (MEGA study)Suzanne C Cannegieter
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
PLoS Med 3:e307. 2006..9; 95% CI 0.9-25.6) as well. CONCLUSIONS: The risk of venous thrombosis after travel is moderately increased for all modes of travel. Subgroups exist in which the risk is highly increased...- Venous thrombosis in the elderlyF R Rosendaal
Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 5:310-7. 2007..In addition to a review of the literature, new data are presented from the MEGA-study. Thrombosis in the elderly should be a focus of future studies... - HMG-CoA reductase inhibitors, other lipid-lowering medication, antiplatelet therapy, and the risk of venous thrombosisA S Ramcharan
Department of Clinical Epidemiology, Leiden University Medical Centre, The Netherlands
J Thromb Haemost 7:514-20. 2009..We have studied the risk of venous thrombosis with use of statins, other lipid-lowering medication, and antiplatelet therapy... - Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factorsE R Pomp
Department of Clinical Epidemiology, C7 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Eur J Epidemiol 25:459-66. 2010..Our experience with the intricacies of dealing with two control groups may be useful to others when thinking about an optimal research design or the best statistical approach... - Old and new risk factors for upper extremity deep venous thrombosisJ W Blom
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 3:2471-8. 2005..CONCLUSION: A CVC is a very strong risk factor for arm thrombosis. Most risk factors for thrombosis in the leg are also risk factors for arm thrombosis... - Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA studyE R Pomp
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 6:632-7. 2008..Objective: In the MEGA study, we evaluated pregnancy and the postpartum period as risk factors for venous thrombosis in 285 patients and 857 control subjects... - Regular sports activities decrease the risk of venous thrombosisK J van Stralen
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 5:2186-92. 2007..Stasis of the blood has been postulated as a major cause of venous thrombosis. However, little is known about the effect of stimulating the blood flow in order to prevent venous thrombosis through, for example, sports activities... - Mechanisms of the factor V Leiden paradoxK J van Stralen
Department of Clinical Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 28:1872-7. 2008..So far few studies have investigated possible mechanisms for this so-called FVL paradox... - Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogensHuib A A M van Vliet
Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Hum Reprod 20:563-8. 2005..SHBG levels were positively associated with the increased APC resistance. CONCLUSIONS: Our findings support the hypothesis that the effect of an oral contraceptive on SHBG levels might be a marker for the thrombotic risk... - The -589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individualsE Paffen
Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 6:1633-8. 2008.... - Recurrent thrombosis and survival after a first venous thrombosis of the upper extremityL E Flinterman
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Circulation 118:1366-72. 2008..Little is known about the consequences of a first venous thrombosis in the upper extremity. We studied the incidence of, survival, and risk factors for recurrence in a follow-up study... - Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarctionM D van der Krabben
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 6:720-5. 2008..The aim of this study was to examine whether genetic predisposition to high levels of coagulation factors influences the risk of developing fatal and non-fatal arterial cardiovascular events in men with a first myocardial infarction (MI)... - Current perspective of venous thrombosis in the upper extremityL E Flinterman
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 6:1262-6. 2008..In this review an overview of the different risk factors, possible treatments and the complications for patients with a venous thrombosis of the upper extremity is given... - The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control studyA Van Hylckama Vlieg
Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
BMJ 339:b2921. 2009..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands... - Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosisF M van Dunne
Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Hum Reprod 20:802-6. 2005..This may manifest itself as a reduced time to pregnancy (increased fecundity) and fewer miscarriages in the first trimester... - The tortuous history of the implementation of early ambulation after deliveryK J van Stralen
Department of Clinical Epidemiology, Division of Reproductive Medicine, Leiden University Medical Centre, The Netherlands
J R Soc Med 100:90-6. 2007 - Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosisMirjam E Meltzer
Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS Med 5:e97. 2008..Here, we investigated the combined effect of hypofibrinolysis with established risk factors associated with hypercoagulability... - Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trialIwan C C van der Horst
Department of Cardiology, Isala Klinieken, Hospital De Weezenlanden, Zwolle, The Netherlands
J Am Coll Cardiol 42:784-91. 2003..In the subgroup of 856 patients without signs of HF, a significant reduction was seen. The effect of GIK infusion in patients with signs of HF (Killip class > or =2) at admission is uncertain... - ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in menChan K N K Chion
Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
Blood 109:1998-2000. 2007..5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13... - Fibrinolysis and the risk of venous and arterial thrombosisMirjam E Meltzer
Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
Curr Opin Hematol 14:242-8. 2007..In this review, we evaluated studies that investigated the association between fibrinolysis and thrombosis... - High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cellsStephanie Bezzina Wettinger
Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Blood 105:2000-6. 2005..These data support the hypothesis that an inflammatory response involving leucocytes plays a role in the pathogenesis of myocardial infarction...