Peter ten Dijke

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
    Songting Shi
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Building 2, Room R 02 022, Postzone S 1 P, PO Box 9600, Einthovenweg 20, 2300 RC, Leiden, The Netherlands
    Cell Mol Life Sci 70:407-23. 2013
  2. pmc Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity
    Anders Sundqvist
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, 75124, Uppsala, Sweden
    Breast Cancer Res 14:204. 2012
  3. ncbi request reprint Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva
    David J J de Gorter
    Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands
    Curr Pharm Des 18:4087-92. 2012
  4. pmc BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression
    Hildegonda P H Naber
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cell Oncol (Dordr) 35:19-28. 2012
  5. doi request reprint TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia
    Peter Ten Dijke
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands
    Sci Signal 5:pt2. 2012
  6. pmc TGF-β signaling in breast cancer cell invasion and bone metastasis
    Yvette Drabsch
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Mammary Gland Biol Neoplasia 16:97-108. 2011
  7. pmc TGF-β in progression of liver disease
    Steven Dooley
    Molecular Hepatology Alcohol Associated Diseases II Medical Clinic Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cell Tissue Res 347:245-56. 2012
  8. pmc Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy
    Dwi U Kemaladewi
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 P, PO Box 9600, Leiden, 2300RC, The Netherlands
    BMC Med Genomics 4:36. 2011
  9. pmc Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells
    Gudrun Valdimarsdottir
    Dept of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    BMC Cell Biol 7:16. 2006
  10. pmc A rapid and sensitive bioassay to measure bone morphogenetic protein activity
    Lior Zilberberg
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    BMC Cell Biol 8:41. 2007

Collaborators

Detail Information

Publications64

  1. pmc Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
    Songting Shi
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Building 2, Room R 02 022, Postzone S 1 P, PO Box 9600, Einthovenweg 20, 2300 RC, Leiden, The Netherlands
    Cell Mol Life Sci 70:407-23. 2013
    ....
  2. pmc Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity
    Anders Sundqvist
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, 75124, Uppsala, Sweden
    Breast Cancer Res 14:204. 2012
    ..In the case of breast cancer, the role of Smads in epithelial plasticity, tumor-stroma interactions, invasion, and metastasis seems of particular importance...
  3. ncbi request reprint Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva
    David J J de Gorter
    Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands
    Curr Pharm Des 18:4087-92. 2012
    ..This discovery has paved the way for further investigations into the molecular basis underlying FOP and has recently pointed towards potential strategies to treat this devastating disease...
  4. pmc BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression
    Hildegonda P H Naber
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cell Oncol (Dordr) 35:19-28. 2012
    ..In breast cancer, high levels of TGF-β are associated with poor outcome, whereas inhibition of TGF-β-signaling reduces metastasis. In contrast, BMP-7 inhibits bone metastasis of breast cancer cells...
  5. doi request reprint TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia
    Peter Ten Dijke
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands
    Sci Signal 5:pt2. 2012
    ..Here, we show that shear stress activates TGF-β-Alk5 signaling in ECs, which is necessary for EndoMT in the cushions. Moreover, we show that the absence of a primary cilium is critically important for this transition process...
  6. pmc TGF-β signaling in breast cancer cell invasion and bone metastasis
    Yvette Drabsch
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Mammary Gland Biol Neoplasia 16:97-108. 2011
    ..The therapeutic strategies to target the TGF-β pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-β in breast cancer invasion and metastasis...
  7. pmc TGF-β in progression of liver disease
    Steven Dooley
    Molecular Hepatology Alcohol Associated Diseases II Medical Clinic Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cell Tissue Res 347:245-56. 2012
    ..We emphasise that, in order to achieve therapeutic effects, we need to target TGF-β signalling in the right cell type at the right time...
  8. pmc Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy
    Dwi U Kemaladewi
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 P, PO Box 9600, Leiden, 2300RC, The Netherlands
    BMC Med Genomics 4:36. 2011
    ..In this study, we aim to knockdown myostatin by means of exon skipping, a technique which has been successfully applied to reframe the genetic defect of dystrophin gene in DMD patients...
  9. pmc Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells
    Gudrun Valdimarsdottir
    Dept of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    BMC Cell Biol 7:16. 2006
    ..Besides differential receptor binding, the duration of TGF-beta signaling is an important specificity determinant for signaling responses. TGF-beta/ALK1-induced Smad1/5 phosphorylation in ECs occurs transiently...
  10. pmc A rapid and sensitive bioassay to measure bone morphogenetic protein activity
    Lior Zilberberg
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    BMC Cell Biol 8:41. 2007
    ..In this paper, we describe a highly sensitive, rapid, and specific cell-based assay for the quantification of BMP activity...
  11. pmc Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts
    Carola Krause
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
    Fibrogenesis Tissue Repair 4:14. 2011
    ..abstract:..
  12. doi request reprint Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling
    Peter Ten Dijke
    Department of Molecular Cell Biology, Building 2, Room R 02 022, Leiden University Medical Center, Postzone S 1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Bone Joint Surg Am 90:31-5. 2008
    ..Thus, high bone mass in sclerosteosis and Van Buchem disease may result from increased Wnt signaling due to the absence of or insensitivity to sclerostin...
  13. doi request reprint Endoglin in angiogenesis and vascular diseases
    Peter Ten Dijke
    Department of Molecular Cell Biology, Leiden University Medical Center, Building 2, Room R 02 022, Postzone S 1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Angiogenesis 11:79-89. 2008
    ..These exciting advances provide opportunities for the development of new therapies for diseases with vascular abnormalities...
  14. ncbi request reprint Bone morphogenetic protein signal transduction in bone
    P ten Dijke
    Department of Molecular and Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Curr Med Res Opin 22:S7-11. 2006
    ..Extracellular antagonists, such as noggin, inhibit binding to BMP receptors. BMP-2 and BMP-7 have demonstrated clinical utility for bone regeneration, and are commercially available through the use of recombinant DNA technology...
  15. ncbi request reprint Extracellular control of TGFbeta signalling in vascular development and disease
    Peter Ten Dijke
    Molecular Cell Biology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Mol Cell Biol 8:857-69. 2007
    ..Together, these extracellular interactions determine the final bioavailability of TGFbeta to vascular cells, and dysregulation is associated with an increasing number of vascular pathologies...
  16. doi request reprint Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis
    M Petersen
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden, The Netherlands
    Oncogene 29:1351-61. 2010
    ..Thus, Smad2 and Smad3 differentially affect breast cancer bone metastasis formation in vivo...
  17. ncbi request reprint BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    Marion Scharpfenecker
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Sci 120:964-72. 2007
    ..Taken together, these results suggest that BMP-9 is a physiological ALK1 ligand that plays an important role in the regulation of angiogenesis...
  18. ncbi request reprint Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways
    Valeria V Orlova
    Department of Molecular Cell Biology, and Centre for Biomedical Genetics, Leiden University Medical Center, RC Leiden, The Netherlands
    Histol Histopathol 26:1219-30. 2011
    ..In this review, we discuss our current understanding of the TGF-β signaling pathway and its regulation of endothelial and vascular smooth muscle cell function...
  19. doi request reprint Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma
    E Pardali
    Department of Molecular Cell Biology, Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Oncogene 30:334-45. 2011
    ..The present study delineates an important role of endoglin in tumor cell plasticity and progression of aggressive tumors...
  20. doi request reprint Shear induced collateral artery growth modulated by endoglin but not by ALK1
    Leonard Seghers
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 16:2440-50. 2012
    ..Importantly, endoglin contributes to both shear induced collateral artery growth and to ischaemia induced angiogenesis, whereas ALK1 is only involved in ischaemia induced angiogenesis...
  21. ncbi request reprint Role of TGF-beta in the tumor stroma
    H P H Naber
    Department of Molecular Cell Biology, Leiden University Medical Centre, Postbus 9600, 2300 RC Leiden, The Netherlands
    Curr Cancer Drug Targets 8:466-72. 2008
    ..TGF-beta can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-beta influences different stromal compartments...
  22. ncbi request reprint Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis
    M Petersen
    Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
    Kidney Int 73:705-15. 2008
    ..Our study shows that GW788388 is a potent and selective inhibitor of TGF-beta signalling in vitro and renal fibrosis in vivo...
  23. ncbi request reprint Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix
    A Olofsson
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 270:31294-7. 1995
    ..These results suggest that the different splice forms of LTBP-1 mediate different localization patterns of the latent TGF-beta complexes in vivo...
  24. ncbi request reprint Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation
    Y Ishidou
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    J Bone Miner Res 10:1651-9. 1995
    ..The present data suggest that expression of BMP type I receptors is up-regulated during bone formation, and that they may play important roles in bone morphogenesis...
  25. pmc Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160
    A Olofsson
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 751 24 Uppsala, Sweden
    Biochem J 324:427-34. 1997
    ....
  26. ncbi request reprint Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta
    H Yamashita
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:1995-2001. 1994
    ..These results revealed that endoglin is a phosphorylated protein which forms a heteromeric complex with signaling receptors for TGF-beta...
  27. pmc Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours
    N Yamada
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Br J Cancer 73:624-9. 1996
    ..These results suggest the presence of BMP receptors and a functional role for BMPs in malignant glioma...
  28. ncbi request reprint Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis
    L Erlacher
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 13:383-92. 1998
    ..Our data show that distinct members of the BMP family differentially regulate the progression in the osteogenic lineage, and this may be due to their selective affinity for specific receptor complexes...
  29. ncbi request reprint Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats
    T Onishi
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    Bone 22:605-12. 1998
    ..Thus, these findings suggested that BMPs acting through their BMP receptors may play major roles in modulating the sequential events leading to bone formation...
  30. ncbi request reprint TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
    Nature 390:465-71. 1997
    ..Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs...
  31. pmc Cloning and characterization of a human type II receptor for bone morphogenetic proteins
    B L Rosenzweig
    Synergen, Inc, Boulder, CO 80301 2546, USA
    Proc Natl Acad Sci U S A 92:7632-6. 1995
    ..Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by BMPR-II in the presence of type I receptors after stimulation by OP-1/BMP-7...
  32. ncbi request reprint Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members
    M Afrakhte
    Unit of Pathology, University Hospital, Uppsala, S 751 85, Sweden
    Biochem Biophys Res Commun 249:505-11. 1998
    ..Thus, expression of inhibitory Smads is induced by multiple stimuli, including the various TGF-beta family members, whose action they antagonize...
  33. ncbi request reprint Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway
    A Nakao
    Ludwig Institute for Cancer Research, Box 595, S 751 24 Uppsala, Sweden
    J Biol Chem 272:2896-900. 1997
    ..Smad2 is closely linked to DPC4 on chromosome 18q21.1, a region often deleted in human cancers. Cells that lack Smad2 may escape from TGF-beta-mediated growth inhibition and promote cancer progression...
  34. pmc Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses
    S Souchelnytskyi
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    EMBO J 15:6231-40. 1996
    ..Mutations of Ser165 changed the phosphorylation pattern of TbetaR-I. These observations suggest that TGF-beta receptor signaling specificity is modulated by phosphorylation of Ser165 of TbetaR-I...
  35. ncbi request reprint Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
    A Nakao
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Nature 389:631-5. 1997
    ..TGF-beta rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGF-beta responses...
  36. ncbi request reprint Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
    P Franzen
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Cell 75:681-92. 1993
    ..These results suggest that signal transduction by TGF beta involves the formation of a heteromeric complex of two different serine/threonine kinase receptors...
  37. ncbi request reprint Regulation of Smad signaling by protein kinase C
    I Yakymovych
    Ludwig Institute for Cancer Research, Box 595, Uppsala, Sweden
    FASEB J 15:553-5. 2001
    ..Thus, PKC-dependent phosphorylation of Smad3 leads to down-regulation of the growth inhibitory and apoptotic action of TGF-b...
  38. ncbi request reprint Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
    P ten Dijke
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Oncogene 8:2879-87. 1993
    ..These results suggest that each ALK may have different in vivo functions...
  39. ncbi request reprint Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads
    A Kumar
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:656-61. 2001
    ..We also show here that the extracellular cripto protein is required for nodal signaling, making it distinct from activin or TGF-beta signaling...
  40. ncbi request reprint Characterization of type I receptors for transforming growth factor-beta and activin
    P ten Dijke
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Science 264:101-4. 1994
    ....
  41. ncbi request reprint Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
    P ten Dijke
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:16985-8. 1994
    ..These results suggest that ALK-3 and ALK-6 are type I receptors for OP-1 and BMP-4; in addition, ALK-2 is a type I receptor shared by activin and OP-1, but not by BMP-4...
  42. ncbi request reprint Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein
    A Moren
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:32469-78. 1994
    ..The LTBP-2 gene was assigned to chromosome 14q24. These results indicate that different forms of latent TGF-beta complexes occur and suggest that the different associated proteins may function to target the complexes to specific sites...
  43. ncbi request reprint Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
    N Dewulf
    Laboratory of Molecular Biology Celgen, University of Leuven, Belgium
    Endocrinology 136:2652-63. 1995
    ..In addition, the expression of these genes in many soft tissues suggests broader functions for BMPs in embryogenesis...
  44. ncbi request reprint Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization
    E Roijer
    Laboratory of Cancer Genetics, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Cytogenet Cell Genet 81:189-90. 1998
  45. ncbi request reprint Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway
    S J Wicks
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem Soc Trans 34:761-3. 2006
    ..Studies are currently under way using activity-based HA (haemagglutinin)-tagged ubiquitin probes to identify the full spectrum of DUBs that impact on Smad/TGF-beta signalling activity...
  46. ncbi request reprint Transforming growth factor beta1 induces nuclear export of inhibitory Smad7
    S Itoh
    Ludwig Institute for Cancer Research, Biomedical Center Box 595, S 751 24 Uppsala, Sweden
    J Biol Chem 273:29195-201. 1998
    ..This suggests that an intact Mad homology 2 domain is important for nuclear localization of Smad7. The nuclear localization of Smad7 suggests a functional role distinct from its antagonistic effect in receptor-mediated Smad activation...
  47. ncbi request reprint Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases
    S Souchelnytskyi
    Biomedical Center, Ludwig Institute for Cancer Research, Uppsala, Sweden
    Methods Mol Biol 124:107-20. 2001
  48. ncbi request reprint The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line
    H Jornvall
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    J Biol Chem 276:5140-6. 2001
    ..These results indicate that ALK7 may participate in the control of proliferation of neuronal precursors and morphological differentiation of postmitotic neurons...
  49. pmc The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling
    S Itoh
    The Netherlands Cancer Institute, Division of Cellular Biochemistry, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nucleic Acids Res 28:4291-8. 2000
    ..Our results indicate a direct physical and functional interplay between two negative regulators of cell proliferation, Smad3 and P/CAF...
  50. ncbi request reprint Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis
    A Zwijsen
    Department of Cell Growth, Differentiation, and Development VIB07, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Dev Dyn 218:663-70. 2000
    ..This confirms earlier conclusions of similar, but complementary, experiments using a dominant negative type II TGF beta receptor demonstrating that TGF beta signalling is required for normal preimplantation development...
  51. ncbi request reprint Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
    K Pardali
    Ludwig Institute for Cancer Research, Box 595, SE 751 24 Uppsala, Sweden
    J Biol Chem 275:29244-56. 2000
    ..In conclusion, Smad proteins play important roles in regulation of the p21 gene by TGF-beta, and the functional cooperation of Smad proteins with Sp1 involves the physical interaction of these two types of transcription factors...
  52. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  53. ncbi request reprint Chromosomal localization of three human genes encoding bone morphogenetic protein receptors
    A K Aström
    Laboratory of Cancer Genetics, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Mamm Genome 10:299-302. 1999
    ..Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped to 6q23...
  54. ncbi request reprint SMAD3 represses androgen receptor-mediated transcription
    S A Hayes
    Department of Surgery, Stanford University School of Medicine, California 94303, USA
    Cancer Res 61:2112-8. 2001
    ..These results provide fresh insight for understanding the mechanism by which TGF-beta regulates the androgen-signaling pathway in prostate cancer cells...
  55. pmc Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice
    J Larsson
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine and Department of Medicine, Lund University Hospital, Lund, Sweden
    EMBO J 20:1663-73. 2001
    ....
  56. ncbi request reprint Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors
    S Souchelnytskyi
    Ludwig Institute for Cancer Research, Biomedical Center, S 751 24 Uppsala, Sweden
    J Biol Chem 273:25364-70. 1998
    ..Our results are consistent with the possibility that the C-domain of antagonistic Smads is an effector domain whereas the N-domain may confer specificity for distinct signaling pathways...
  57. ncbi request reprint ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells
    D Noda
    Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Oncogene 25:5591-600. 2006
    ..Furthermore, activation of the p21 CDK inhibitor promoter by TGF-beta is potentiated by ELAC2. Taken together our data indicate an important transcriptional scaffold function for ELAC2 in TGF-beta/Smad signaling mediated growth arrest...
  58. ncbi request reprint Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs
    H Tanimoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Mol Cell 5:59-71. 2000
    ..We suggest that regulation of tkv by HH is a key part of the mechanism that controls the level and distribution of DPP...
  59. ncbi request reprint Bone morphogenetic protein signalling in NGF-stimulated PC12 cells
    S Althini
    Department of Neuroscience, Uppsala University, Biomedical Centre, Box 587, SE 751 23, Uppsala, Sweden
    Biochem Biophys Res Commun 307:632-9. 2003
    ..Hence, NGF and BMP signals are likely to interact further downstream at the transcriptional level in neuronal differentiation of the PC12 cells...
  60. ncbi request reprint Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2
    C Meno
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
    Dev Cell 1:127-38. 2001
    ..These results suggest that Nodal is a long-range signaling molecule but that its range of action is normally limited by the feedback inhibitor Lefty2...
  61. pmc Apoptosis in podocytes induced by TGF-beta and Smad7
    M Schiffer
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:807-16. 2001
    ..Our results suggest a novel functional role for Smad7 as amplifier of TGF-beta-induced apoptosis in podocytes and a new pathomechanism for podocyte depletion in progressive glomerulosclerosis...
  62. ncbi request reprint Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity
    N Olsson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, S-751 85, Uppsala, Sweden
    Cell Signal 13:483-90. 2001
    ..These results indicate that different signalling pathways mediate TGF-beta1-induced migration and growth inhibition in HMC-1 cells, where the migration involves MEK activity...
  63. pmc Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
    F Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    EMBO J 20:4132-42. 2001
    ..The data strongly suggest that the molecular mechanism by which AMSH exerts its action is by inhibiting the binding of Smad6 to activated type I receptors or activated R-Smads...
  64. ncbi request reprint Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes
    E Pardali
    Division of Tumor Biology, Department of Cell and Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Biol Chem 275:3552-60. 2000
    ..Considering the wide range of biological phenomena that AMLs and Smads regulate, the physical/functional interplay between them has implications that extend beyond the regulation of class switching to IgA...