Roel H DeRijk

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. doi request reprint Single nucleotide polymorphisms related to HPA axis reactivity
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Neuroimmunomodulation 16:340-52. 2009
  2. doi request reprint Mineralocorticoid receptor gene variants as determinants of HPA axis regulation and behavior
    Roel H DeRijk
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, Leiden, The Netherlands
    Endocr Dev 20:137-48. 2011
  3. ncbi request reprint A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Clin Endocrinol Metab 91:5083-9. 2006
  4. doi request reprint Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Eur J Pharmacol 583:303-11. 2008
  5. doi request reprint Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health
    Roel H DeRijk
    Department of Psychiatry, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Eur J Pharmacol 585:492-501. 2008
  6. doi request reprint Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study
    Sophie A Vreeburg
    Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:617-26. 2009
  7. doi request reprint Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone
    Nienke van Leeuwen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Psychoneuroendocrinology 35:339-49. 2010
  8. doi request reprint Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disorders
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Metabolism 58:821-7. 2009
  9. doi request reprint Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs
    Melanie D Klok
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Psychoneuroendocrinology 36:484-94. 2011
  10. doi request reprint Basal cortisol levels in relation to dimensions and DSM-IV categories of depression and anxiety
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Psychiatry Res 185:121-8. 2011

Detail Information

Publications20

  1. doi request reprint Single nucleotide polymorphisms related to HPA axis reactivity
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Neuroimmunomodulation 16:340-52. 2009
    ..We propose that these genetic variants which modulate HPA axis reactivity are part of the genetic makeup that determines individual stress responsivity and coping style, affecting vulnerability to disease...
  2. doi request reprint Mineralocorticoid receptor gene variants as determinants of HPA axis regulation and behavior
    Roel H DeRijk
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, Leiden, The Netherlands
    Endocr Dev 20:137-48. 2011
    ....
  3. ncbi request reprint A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Clin Endocrinol Metab 91:5083-9. 2006
    ..Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes...
  4. doi request reprint Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Eur J Pharmacol 583:303-11. 2008
    ....
  5. doi request reprint Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health
    Roel H DeRijk
    Department of Psychiatry, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Eur J Pharmacol 585:492-501. 2008
    ..Furthermore, mineralocorticoid- and glucocorticoid receptors are drug targets, thereby aiming at the underlying mechanisms of stress-related disorders...
  6. doi request reprint Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study
    Sophie A Vreeburg
    Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:617-26. 2009
    ..There is a central belief that depression is associated with hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in higher cortisol levels. However, results are inconsistent...
  7. doi request reprint Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone
    Nienke van Leeuwen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Psychoneuroendocrinology 35:339-49. 2010
    ..The association of the CAR with functional MR gene variants only in dexamethasone treated subjects suggests the involvement of MR in dexamethasone induced suppression of morning cortisol...
  8. doi request reprint Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disorders
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Metabolism 58:821-7. 2009
    ..These data lend support to the hypothesis that the relationship between affective disorders and cardiovascular disease is partly mediated by HPA-axis perturbations...
  9. doi request reprint Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs
    Melanie D Klok
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    Psychoneuroendocrinology 36:484-94. 2011
    ..In this study we examined the effect of common functional MR gene variants on the cortisol awakening response (CAR), which is often disturbed in stress-related disorders like depression...
  10. doi request reprint Basal cortisol levels in relation to dimensions and DSM-IV categories of depression and anxiety
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Psychiatry Res 185:121-8. 2011
    ..The present study shows that linear and nonlinear associations with salivary cortisol are detected when using phenotypic dimensions and may be complementary to phenotypic DSM-IV categories when doing neuroendocrine research...
  11. doi request reprint Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response
    Nienke van Leeuwen
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Psychoneuroendocrinology 36:699-709. 2011
    ..Moreover, these haplotypes may contribute to individual differences in perceived chronic stress as well as neuroendocrine and cardiovascular stress responses...
  12. doi request reprint C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Stress 14:128-35. 2011
    ..Hence, genetic variants in the CRP gene that are associated with lifetime plasma CRP levels were also associated with salivary cortisol levels after awakening, in basal, non-inflammatory conditions...
  13. ncbi request reprint Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?
    E Ronald de Kloet
    Department of Medical Pharmacology, Leiden University Medical Center and the Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Nat Clin Pract Endocrinol Metab 3:168-79. 2007
    ....
  14. doi request reprint The functional c.-2G>C variant of the mineralocorticoid receptor modulates blood pressure, renin, and aldosterone levels
    Nienke van Leeuwen
    Division of Medical Pharmacology Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Hypertension 56:995-1002. 2010
    ..2G>C in the MR gene associates with increased activation of the renin-angiotensin-aldosterone axis and with increased blood pressure, probably related to decreased MR expression...
  15. doi request reprint Salivary cortisol levels and the 2-year course of depressive and anxiety disorders
    Sophie A Vreeburg
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Psychoneuroendocrinology 38:1494-502. 2013
    ..Whether cortisol level predicts the course of these disorders has not been examined in detail. We examined whether salivary cortisol indicators predict the 2-year course of depression and anxiety disorders...
  16. doi request reprint Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder
    Melanie D Klok
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    J Psychiatr Res 45:871-8. 2011
    ..A decreased expression of corticosteroid receptors in specific brain regions of MDD patients could underlie HPA hyperactivity, mood and cognitive disturbances often observed in patients suffering from stress-related psychopathologies...
  17. doi request reprint The influence of psychiatric comorbidity on the dexamethasone/CRH test in major depression
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Neuropsychopharmacol 19:409-15. 2009
    ..The present study investigated whether comorbidity of anxiety or somatoform disorders might be an explaining factor for this finding...
  18. doi request reprint Associations between sociodemographic, sampling and health factors and various salivary cortisol indicators in a large sample without psychopathology
    Sophie A Vreeburg
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Psychoneuroendocrinology 34:1109-20. 2009
    ..Sociodemographic, health and sampling-related determinants of salivary cortisol levels were examined in a sample without potential disturbances because of psychopathology...
  19. ncbi request reprint Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse
    Thomas Rinne
    GGZ Buitenamstel, Department of Psychiatry, Free University Amsterdam, The Netherlands
    Biol Psychiatry 52:1102-12. 2002
    ..In humans, PTSD and MDD are associated with decreased and increased resistance to glucocorticoid feedback, respectively, which might reflect persistent changes in neuroendocrine sequelae following childhood abuse...
  20. ncbi request reprint Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden University, 2300 RA Leiden, The Netherlands
    Brain Res Mol Brain Res 116:17-26. 2003
    ..A functionally relevant role for the GRbeta in control of the human hippocampus is therefore not very likely. Whether this is altered in disease conditions awaits further research...