Research Topics
Species | Roel H DeRijkSummaryAffiliation: Leiden University Country: The Netherlands Publications
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Publications
Single nucleotide polymorphisms related to HPA axis reactivityRoel H DeRijk
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
Neuroimmunomodulation 16:340-52. 2009..We propose that these genetic variants which modulate HPA axis reactivity are part of the genetic makeup that determines individual stress responsivity and coping style, affecting vulnerability to disease...- Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental healthRoel H DeRijk
Department of Psychiatry, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
Eur J Pharmacol 585:492-501. 2008..Furthermore, mineralocorticoid- and glucocorticoid receptors are drug targets, thereby aiming at the underlying mechanisms of stress-related disorders... - Corticosteroid receptor polymorphisms: determinants of vulnerability and resilienceRoel H DeRijk
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
Eur J Pharmacol 583:303-11. 2008.... 
A common polymorphism in the mineralocorticoid receptor modulates stress responsivenessRoel H DeRijk
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
J Clin Endocrinol Metab 91:5083-9. 2006..Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes...- Mineralocorticoid receptor gene variants as determinants of HPA axis regulation and behaviorRoel H DeRijk
Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, Leiden, The Netherlands
Endocr Dev 20:137-48. 2011.... - Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort studySophie A Vreeburg
Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
Arch Gen Psychiatry 66:617-26. 2009..There is a central belief that depression is associated with hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in higher cortisol levels. However, results are inconsistent... - Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disordersGerthe Veen
Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Metabolism 58:821-7. 2009..These data lend support to the hypothesis that the relationship between affective disorders and cardiovascular disease is partly mediated by HPA-axis perturbations... - Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasoneNienke van Leeuwen
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
Psychoneuroendocrinology 35:339-49. 2010..The association of the CAR with functional MR gene variants only in dexamethasone treated subjects suggests the involvement of MR in dexamethasone induced suppression of morning cortisol... - Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIsMelanie D Klok
Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Einsteinweg 55, 2333 CC Leiden, The Netherlands
Psychoneuroendocrinology 36:484-94. 2011..In this study we examined the effect of common functional MR gene variants on the cortisol awakening response (CAR), which is often disturbed in stress-related disorders like depression... - Basal cortisol levels in relation to dimensions and DSM-IV categories of depression and anxietyGerthe Veen
Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Psychiatry Res 185:121-8. 2011..The present study shows that linear and nonlinear associations with salivary cortisol are detected when using phenotypic dimensions and may be complementary to phenotypic DSM-IV categories when doing neuroendocrine research... - Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress responseNienke van Leeuwen
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
Psychoneuroendocrinology 36:699-709. 2011..Moreover, these haplotypes may contribute to individual differences in perceived chronic stress as well as neuroendocrine and cardiovascular stress responses... - C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjectsGerthe Veen
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
Stress 14:128-35. 2011..Hence, genetic variants in the CRP gene that are associated with lifetime plasma CRP levels were also associated with salivary cortisol levels after awakening, in basal, non-inflammatory conditions... - The functional c.-2G>C variant of the mineralocorticoid receptor modulates blood pressure, renin, and aldosterone levelsNienke van Leeuwen
Division of Medical Pharmacology Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
Hypertension 56:995-1002. 2010..2G>C in the MR gene associates with increased activation of the renin-angiotensin-aldosterone axis and with increased blood pressure, probably related to decreased MR expression... - Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?E Ronald de Kloet
Department of Medical Pharmacology, Leiden University Medical Center and the Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
Nat Clin Pract Endocrinol Metab 3:168-79. 2007.... - Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorderMelanie D Klok
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
J Psychiatr Res 45:871-8. 2011..A decreased expression of corticosteroid receptors in specific brain regions of MDD patients could underlie HPA hyperactivity, mood and cognitive disturbances often observed in patients suffering from stress-related psychopathologies... - The influence of psychiatric comorbidity on the dexamethasone/CRH test in major depressionGerthe Veen
Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Eur Neuropsychopharmacol 19:409-15. 2009..The present study investigated whether comorbidity of anxiety or somatoform disorders might be an explaining factor for this finding... - Associations between sociodemographic, sampling and health factors and various salivary cortisol indicators in a large sample without psychopathologySophie A Vreeburg
Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
Psychoneuroendocrinology 34:1109-20. 2009..Sociodemographic, health and sampling-related determinants of salivary cortisol levels were examined in a sample without potential disturbances because of psychopathology... - Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistryRoel H DeRijk
Division of Medical Pharmacology, Leiden University, 2300 RA Leiden, The Netherlands
Brain Res Mol Brain Res 116:17-26. 2003..A functionally relevant role for the GRbeta in control of the human hippocampus is therefore not very likely. Whether this is altered in disease conditions awaits further research... - Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuseThomas Rinne
GGZ Buitenamstel, Department of Psychiatry, Free University Amsterdam, The Netherlands
Biol Psychiatry 52:1102-12. 2002..Sustained childhood abuse rather than BPD, MDD, or PTSD pathology accounts for this effect. Possibly due to an enhanced efficacy of HPA suppression by dexamethasone, PTSD attenuates the ACTH response to DEX/CRH...