Tom Deboer

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Sleep 36:127-36. 2013
  2. ncbi request reprint Short light-dark cycles affect sleep in mice
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Neurosci 26:3518-23. 2007
  3. ncbi request reprint Long term effects of sleep deprivation on the mammalian circadian pacemaker
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center Leiden, The Netherlands
    Sleep 30:257-62. 2007
  4. ncbi request reprint Sleep regulation in the Djungarian hamster: comparison of the dynamics leading to the slow-wave activity increase after sleep deprivation and daily torpor
    Tom Deboer
    Department of Neurophysiology, LUMC, Leiden, The Netherlands
    Sleep 26:567-72. 2003
  5. ncbi request reprint Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
    Tom Deboer
    Institute of Pharmacology and Toxicology, CH 8057, Switzerland
    J Neurophysiol 88:839-46. 2002
  6. doi request reprint Sleep and sleep homeostasis in constant darkness in the rat
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Sleep Res 18:357-64. 2009
  7. ncbi request reprint Electroencephalogram theta frequency changes in parallel with euthermic brain temperature
    Tom Deboer
    Department of Physiology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Brain Res 930:212-5. 2002
  8. pmc Technologies of sleep research
    T Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Mol Life Sci 64:1227-35. 2007
  9. doi request reprint Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock
    Sahar Farajnia
    Department of Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurosci 32:5891-9. 2012
  10. pmc Circadian regulation of sleep and the sleep EEG under constant sleep pressure in the rat
    Roman Yasenkov
    Laboratory for Neurophysiology, Department of Molecular Cell Biology Leiden University Medical Center, Leiden, The Netherlands
    Sleep 33:631-41. 2010

Collaborators

Detail Information

Publications32

  1. pmc Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Sleep 36:127-36. 2013
    ..1 channels that are less susceptible to inhibition by G-proteins. We hypothesized that Cacna1a R192Q mice could show reduced susceptibility to adenosine, which may result in a sleep phenotype characterized by decreased sleep...
  2. ncbi request reprint Short light-dark cycles affect sleep in mice
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Neurosci 26:3518-23. 2007
    ..The results demonstrate that pigmented animals can show REM sleep induction after dark onset and indicate that light has significant effects on the regulation of sleep...
  3. ncbi request reprint Long term effects of sleep deprivation on the mammalian circadian pacemaker
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center Leiden, The Netherlands
    Sleep 30:257-62. 2007
    ..We questioned therefore whether sleep deprivation may have long-term effects on the circadian pacemaker, which may explain altered sleep patterns following sleep deprivation...
  4. ncbi request reprint Sleep regulation in the Djungarian hamster: comparison of the dynamics leading to the slow-wave activity increase after sleep deprivation and daily torpor
    Tom Deboer
    Department of Neurophysiology, LUMC, Leiden, The Netherlands
    Sleep 26:567-72. 2003
    ..We have analyzed in more detail the timecourse of the process that is common for waking and daily torpor and that could account for the subsequent increase in slow-wave activity...
  5. ncbi request reprint Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
    Tom Deboer
    Institute of Pharmacology and Toxicology, CH 8057, Switzerland
    J Neurophysiol 88:839-46. 2002
    ..Our data suggest that in Ligand KO the SWA increase is caused by an increase in excitatory input to the cortex, whereas in R1KO this input seems to be almost absent...
  6. doi request reprint Sleep and sleep homeostasis in constant darkness in the rat
    Tom Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Sleep Res 18:357-64. 2009
    ....
  7. ncbi request reprint Electroencephalogram theta frequency changes in parallel with euthermic brain temperature
    Tom Deboer
    Department of Physiology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Brain Res 930:212-5. 2002
    ..The results support the hypothesis that moderate changes in brain temperature can influence EEG power density spectra...
  8. pmc Technologies of sleep research
    T Deboer
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Mol Life Sci 64:1227-35. 2007
    ..Gene manipulation holds great promise for the future since it is possible not only to investigate the functions of different genes under normal conditions, but also to mimic human pathology in much greater detail...
  9. doi request reprint Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock
    Sahar Farajnia
    Department of Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurosci 32:5891-9. 2012
    ..We propose that aberrant SCN rhythmicity in old animals--with electrophysiological arrhythmia at the single-cell level and phase desynchronization at the network level--can account for defective circadian function with aging...
  10. pmc Circadian regulation of sleep and the sleep EEG under constant sleep pressure in the rat
    Roman Yasenkov
    Laboratory for Neurophysiology, Department of Molecular Cell Biology Leiden University Medical Center, Leiden, The Netherlands
    Sleep 33:631-41. 2010
    ..Activity of faster EEG frequencies (10-25 Hz) is thought to be under influence of circadian factors. The relative contribution of both processes to the distribution of sleep and wakefulness and EEG activity in rodents remains uncertain...
  11. ncbi request reprint Sleep states alter activity of suprachiasmatic nucleus neurons
    Tom Deboer
    Department of Neurophysiology, Leiden University Medical Center, Box 9604, 2300 RC Leiden, Netherlands
    Nat Neurosci 6:1086-90. 2003
    ..Our results indicate that the 24-hour pattern in electrical activity that is controlled by the molecular machinery of the SCN is substantially modified by afferent information from the central nervous system...
  12. doi request reprint Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice
    Floor van Oosterhout
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Neurol 64:315-24. 2008
    ..1 calcium channels, causing increased presynaptic calcium influx and neurotransmitter release. We investigated whether these mice have an abnormal adjustment to phase advance shifts...
  13. pmc Seasonal aspects of sleep in the Djungarian hamster
    Svitlana Palchykova
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    BMC Neurosci 4:9. 2003
    ..The second recording was performed when they had returned to summer physiology, despite the maintenance of the 'winter' conditions...
  14. ncbi request reprint Seasonal encoding by the circadian pacemaker of the SCN
    Henk Tjebbe VanderLeest
    Department of Molecular Cell Biology, Lab for Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Curr Biol 17:468-73. 2007
    ..48 and 3.85 hr, respectively). The data indicate that coding for day length involves plasticity within SCN neuronal networks in which the phase distribution of oscillating neurons carries information on the photoperiod's duration...
  15. doi request reprint Correlation with behavioral activity and rest implies circadian regulation by SCN neuronal activity levels
    Thijs Houben
    Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands
    J Biol Rhythms 24:477-87. 2009
    ....
  16. ncbi request reprint Running wheel accessibility affects the regional electroencephalogram during sleep in mice
    Vladyslav V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Cereb Cortex 16:328-36. 2006
    ..25-4.0 Hz) was unrelated to waking. The data suggest that in mice EEG power in the lower frequency, corresponding to the slow oscillations described in cats and humans, is related to local sleep homeostasis...
  17. ncbi request reprint Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle
    Mariska J Vansteensel
    Department of Neurophysiology, Leiden University Medical Center, Wassenaarseweg 62, P O Box 9604, 2300 RC, Leiden, The Netherlands
    Curr Biol 13:1538-42. 2003
    ..Our study indicates that hierarchical levels of organization within the circadian timing system influence SCN output and suggests a strong and unforeseen role of extra-SCN areas in regulating pacemaker function...
  18. ncbi request reprint Selective sleep deprivation after daily torpor in the Djungarian hamster
    Svitlana Palchykova
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Sleep Res 11:313-9. 2002
    ..The frontal predominance of slow waves encountered both after torpor and SD indicates that waking and torpor induce similar regional changes in EEG SWA...
  19. ncbi request reprint Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2
    Vladyslav V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Brain Res 947:204-11. 2002
    ..v.3.2 channels may be involved in the generation of EEG oscillations in the high delta and low theta range in sleep. They support the notion that GABA-mediated synchronization of cortical activity contributes to the electroencephalogram...
  20. ncbi request reprint Sleep deprivation in prion protein deficient mice sleep deprivation in prion protein deficient mice and control mice: genotype dependent regional rebound
    Reto Huber
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Neuroreport 13:1-4. 2002
    ..Our findings may reflect differences between the genotypes in the need for recovery in this particular brain region...
  21. doi request reprint Enhanced phase resetting in the synchronized suprachiasmatic nucleus network
    Ashna Ramkisoensing
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Rhythms 29:4-15. 2014
    ..On the basis of the phase shifts observed in vitro, we conclude that highly synchronized SCN networks with high-amplitude rhythms show a larger phase-shifting capacity than desynchronized networks of low amplitude. ..
  22. doi request reprint Aging of the suprachiasmatic clock
    Sahar Farajnia
    1Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Neuroscientist 20:44-55. 2014
    ..Understanding the mechanisms underlying age-related deficits in circadian clock function will therefore not only benefit rhythm disorders but also alleviate age-associated diseases aggravated by clock dysfunction. ..
  23. ncbi request reprint Differential responses of circadian activity onset and offset following GABA-ergic and opioid receptor activation
    Mariska J Vansteensel
    Department of Neurophysiology, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    J Biol Rhythms 18:297-306. 2003
    ..The data implicate that the early subjective day is an interesting phase for analysis of molecular and biochemical processes involved in nonphotic phase shifting...
  24. doi request reprint Circadian modulation of sleep in rodents
    Roman Yasenkov
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Prog Brain Res 199:203-18. 2012
    ..Knowledge about the interaction between sleep and the circadian clock and the circadian modulation of sleep in other species than humans is important to better understand the underlying regulatory mechanisms...
  25. ncbi request reprint [In time for Beijing: influence of the biological clock on athletic performance]
    J H Meijer
    Leids Universitair Medisch Centrum, Laboratorium voor Neurofysiologie, afd Moleculaire Celbiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 152:1809-12. 2008
    ..We give some advice for athletes who must cross multiple time zones shortly before a competition...
  26. ncbi request reprint Sleep in the blind mole rat Spalax ehrenbergi
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Sleep 24:147-54. 2001
    ..A prominent adaptation is their blindness, which is due to an atrophy of the eyes...
  27. pmc Methylphenidate modifies the motion of the circadian clock
    Michael C Antle
    Department of Psychology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Neuropsychopharmacology 37:2446-55. 2012
    ..These observations suggest that methylphenidate alters the underlying circadian clock. The observed changes are consistent with clock alterations that would promote sleep-onset insomnia...
  28. pmc Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:6464-9. 2001
    ..Because alpha1 GABA(A) receptors mediate the sedative action of Dz, our results provide evidence that the hypnotic effect of Dz and its EEG "fingerprint" can be dissociated from its sedative action...
  29. ncbi request reprint Convergence of circadian and sleep regulatory mechanisms on hypocretin-1
    T Deboer
    Department of Neurophysiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neuroscience 129:727-32. 2004
    ..Our data indicate that the circadian pacemaker of the SCN and sleep homeostatic mechanisms converge on one single sleep regulatory substance...
  30. ncbi request reprint Running wheel size influences circadian rhythm period and its phase shift in mice
    T Deboer
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    J Comp Physiol A 186:969-73. 2000
    ..It can be concluded that technical features of the running wheel can influence the circadian period of wheel running...
  31. ncbi request reprint Investigating sleep homeostasis using an unusual instability
    Tom Deboer
    Am J Physiol Regul Integr Comp Physiol 287:R8-9. 2004
  32. ncbi request reprint Development of the 24-h rest-activity pattern in human infants
    Oskar G Jenni
    Growth and Development Center, University Children s Hospital Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Infant Behav Dev 29:143-52. 2006
    ..Miniaturized actigraphs are ideal tools for long-term longitudinal monitoring of rest-activity behavior in infants...