Peggy J De Vos Van Steenwijk

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions
    Peggy J De Vos Van Steenwijk
    Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Immunol Immunother 61:1485-92. 2012
  2. pmc Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses
    Marij J P Welters
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:11895-9. 2010
  3. doi request reprint An unexpectedly large polyclonal repertoire of HPV-specific T cells is poised for action in patients with cervical cancer
    Peggy J De Vos Van Steenwijk
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:2707-17. 2010
  4. doi request reprint M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells
    Moniek Heusinkveld
    Department of Clinical Oncology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands
    J Immunol 187:1157-65. 2011
  5. doi request reprint Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response
    Peggy J De Vos Van Steenwijk
    Department of Gynaecology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Cancer Res 14:7188-95. 2008

Collaborators

Detail Information

Publications5

  1. pmc A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions
    Peggy J De Vos Van Steenwijk
    Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Immunol Immunother 61:1485-92. 2012
    ..Thus, vaccination of HSIL patients results in increased HPV16-specific T-cell immunity. Further development of this type of treatment relies on the ability to motivate patients and in the reduction in the side effects...
  2. pmc Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses
    Marij J P Welters
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:11895-9. 2010
    ..Foxp3(+) T cells have been associated previously with impaired immunity in malignancies. Here we demonstrate that the vaccine-prompted level of this population is associated with early treatment failure...
  3. doi request reprint An unexpectedly large polyclonal repertoire of HPV-specific T cells is poised for action in patients with cervical cancer
    Peggy J De Vos Van Steenwijk
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:2707-17. 2010
    ..This vast existing local T-cell population is awaiting proper stimulation and can be exploited for the immunotherapy of cancer...
  4. doi request reprint M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells
    Moniek Heusinkveld
    Department of Clinical Oncology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands
    J Immunol 187:1157-65. 2011
    ....
  5. doi request reprint Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response
    Peggy J De Vos Van Steenwijk
    Department of Gynaecology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Cancer Res 14:7188-95. 2008
    ..To characterize HPV16 E6- and E7-specific T-cell immunity in patients with high-grade squamous intraepithelial lesions (HSIL)...