Marieke CH de Visser

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis
    M C de Visser
    Dept of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 83:577-82. 2000
  2. ncbi request reprint Factor X levels, polymorphisms in the promoter region of factor X, and the risk of venous thrombosis
    M C de Visser
    Hemostasis and Thrombosis Research Center, Dept of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 85:1011-7. 2001
  3. ncbi request reprint The effect of plasma caeruloplasmin levels on the sensitivity for activated protein C
    Marieke C H de Visser
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, The Netherlands
    Br J Haematol 118:843-6. 2002
  4. ncbi request reprint Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci
    M C H De Visser
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:1771-6. 2003
  5. pmc Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association
    Rachid El Galta
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Genet 8:63. 2007

Collaborators

Detail Information

Publications5

  1. ncbi request reprint The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis
    M C de Visser
    Dept of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 83:577-82. 2000
    ..However, the HR2 haplotype is associated with a reduced sensitivity for APC in carriers of FVL and with reduced factor V antigen levels...
  2. ncbi request reprint Factor X levels, polymorphisms in the promoter region of factor X, and the risk of venous thrombosis
    M C de Visser
    Hemostasis and Thrombosis Research Center, Dept of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 85:1011-7. 2001
    ..We conclude that high FX levels predict risk of thrombosis, but are not a risk factor for venous thrombosis when the levels of other vitamin K-dependent proteins are taken into account...
  3. ncbi request reprint The effect of plasma caeruloplasmin levels on the sensitivity for activated protein C
    Marieke C H de Visser
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, The Netherlands
    Br J Haematol 118:843-6. 2002
    ..19 x 10-2; 95% CI: -0.34 x 10-2 to -0.05 x 10-2). After additional adjustment for factor VIII levels, which are known to influence the assay, the effect of caeruloplasmin on APC sensitivity completely disappeared...
  4. ncbi request reprint Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci
    M C H De Visser
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:1771-6. 2003
    ..70 (P = 0.04) and non-parametric Z-score = 1.92 (P = 0.03)]. About 20% of the total variation in VWF levels may be attributed to this VWF locus...
  5. pmc Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association
    Rachid El Galta
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Genet 8:63. 2007
    ..As an alternative to the likelihood ratio statistic, we derive a score statistic, which has a tractable expression. For haplotype analysis, we assume that phase is known...