Elizabeth C M de Lange

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain
    Elizabeth C M de Lange
    Division of Pharmacology, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden, The Netherlands
    Clin Pharmacokinet 41:691-703. 2002
  2. pmc Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats
    Joost Westerhout
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    AAPS J 14:543-53. 2012
  3. pmc [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats
    Joost Verbeek
    Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
    EJNMMI Res 2:36. 2012
  4. pmc [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Femke E Froklage
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands
    EJNMMI Res 2:12. 2012
  5. pmc Utility of CSF in translational neuroscience
    Elizabeth C M de Lange
    Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    J Pharmacokinet Pharmacodyn 40:315-26. 2013
  6. pmc The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects
    Elizabeth Cm de Lange
    Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands
    Fluids Barriers CNS 10:12. 2013
  7. ncbi request reprint The physiological characteristics and transcytosis mechanisms of the blood-brain barrier (BBB)
    Elizabeth C M de Lange
    Head Target Site Equilibration Group, LACDR Pharmacology, Leiden University, Leiden, The Netherlands
    Curr Pharm Biotechnol 13:2319-27. 2012
  8. pmc Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease
    Paulien Gm Ravenstijn
    Division of Pharmacology, LACDR Leiden University, Leiden, The Netherlands
    Fluids Barriers CNS 9:4. 2012
  9. pmc (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
    BMC Med Imaging 11:1. 2011
  10. ncbi request reprint BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123
    E C de Lange
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, The Netherlands
    Pharm Res 15:1657-65. 1998

Collaborators

  • Meindert Danhof
  • MICHAEL J O'NEILL
  • Oscar Della Pasqua
  • Margareta Hammarlund-Udenaes
  • G Luurtsema
  • Joost Westerhout
  • Jasper Stevens
  • Stina Syvänen
  • Tamara J van Steeg
  • Rob A Voskuyl
  • Adriaan A Lammertsma
  • Jean Smeets
  • Jonas Eriksson
  • Paulien Gm Ravenstijn
  • Femke E Froklage
  • Dirk Jan van den Berg
  • Joost Verbeek
  • Albert D Windhorst
  • Piet H van der Graaf
  • Bart A Ploeger
  • Marc C Huisman
  • Piet Hein van der Graaf
  • Dorien Groenendaal
  • Jan Freijer
  • Paulien G M Ravenstijn
  • Robin Hartman
  • Marissa Rongen
  • N Harry Hendrikse
  • Jaap C Reijneveld
  • Gunilla Osswald
  • Jan J Heimans
  • Yoshihiko Tagawa
  • Henk Jan Drenth
  • Martinus P J Mooijer
  • Carla Fm Molthoff
  • Bart Ploeger
  • Maaike Labots
  • Carla F M Molthoff
  • Harm A G Niederlander
  • Sanne de Ridder
  • Ernst Suidgeest
  • Kristel van Belle
  • Anne Hersey
  • Hywel Lewis
  • Mark A Ward
  • Andrew D Ayrton
  • Cathy Mottart
  • Gareth Ball
  • Tracey K Murray
  • Thomas Lemarchand
  • Mario Merlini
  • Andrea Rosier
  • Glynis Nicholls
  • Dennis de Mik
  • Christine de Ville de Goyet
  • Marjolijn Hameetman
  • Elke H J Krekels

Detail Information

Publications26

  1. ncbi request reprint Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain
    Elizabeth C M de Lange
    Division of Pharmacology, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden, The Netherlands
    Clin Pharmacokinet 41:691-703. 2002
    ..As non-invasive alternative techniques, positron emission tomography or magnetic resonance spectroscopy may be of added value...
  2. pmc Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats
    Joost Westerhout
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    AAPS J 14:543-53. 2012
    ..The physiologically based pharmacokinetic modeling approach is important, as it allowed the prediction of human brain ECF exposure on the basis of human CSF concentrations...
  3. pmc [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats
    Joost Verbeek
    Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
    EJNMMI Res 2:36. 2012
    ..abstract:..
  4. pmc [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Femke E Froklage
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands
    EJNMMI Res 2:12. 2012
    ..abstract:..
  5. pmc Utility of CSF in translational neuroscience
    Elizabeth C M de Lange
    Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    J Pharmacokinet Pharmacodyn 40:315-26. 2013
    ..Finally the model should include measures of target site engagement and CNS effects, to ultimately learn about concentrations that best predict particular target site concentrations, via human CSF concentrations...
  6. pmc The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects
    Elizabeth Cm de Lange
    Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands
    Fluids Barriers CNS 10:12. 2013
    ..On the basis of a few advanced preclinical microdialysis based investigations it will be shown that the "Mastermind approach" has a high potential for the prediction of human CNS drug effects...
  7. ncbi request reprint The physiological characteristics and transcytosis mechanisms of the blood-brain barrier (BBB)
    Elizabeth C M de Lange
    Head Target Site Equilibration Group, LACDR Pharmacology, Leiden University, Leiden, The Netherlands
    Curr Pharm Biotechnol 13:2319-27. 2012
    ..Specific and detailed information on drug delivery approaches aiming at transcytosis into the brain will be dealt with in other parts of this special issue...
  8. pmc Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease
    Paulien Gm Ravenstijn
    Division of Pharmacology, LACDR Leiden University, Leiden, The Netherlands
    Fluids Barriers CNS 9:4. 2012
    ..abstract:..
  9. pmc (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
    BMC Med Imaging 11:1. 2011
    ..The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate...
  10. ncbi request reprint BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123
    E C de Lange
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, The Netherlands
    Pharm Res 15:1657-65. 1998
    ..The effect of P-glycoprotein (Pgp) on brain distribution using mdr1a (-/-) mice was investigated...
  11. ncbi request reprint Potential role of ABC transporters as a detoxification system at the blood-CSF barrier
    Elizabeth C M de Lange
    Division of Pharmacology, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratoria, Leiden University, PO Box 9502, 2300RA Leiden, The Netherlands
    Adv Drug Deliv Rev 56:1793-809. 2004
    ..A concerted action of P-gp and MRP1 at the choroid plexus might contribute to the maintenance of the role of the BCSFB in brain homeostasis...
  12. pmc Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling
    Elizabeth C M de Lange
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, 2300 RA, Leiden University, Leiden, The Netherlands
    AAPS J 7:E532-43. 2005
    ....
  13. doi request reprint The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid
    Joost Westerhout
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    J Pharmacokinet Pharmacodyn 40:327-42. 2013
    ..Therefore, information on functionality of P-gp is required for the prediction of human brain target site concentrations of P-gp substrates on the basis of human CSF concentrations...
  14. doi request reprint Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans
    Jasper Stevens
    Division of Pharmacology, Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    J Pharmacokinet Pharmacodyn 39:463-77. 2012
    ..The PK-PD model successfully predicted the system prolactin response in humans, indicating that positive feedback on prolactin synthesis and allometric scaling thereof could be a new feature in describing complex homeostatic mechanisms...
  15. doi request reprint Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics
    Dorien Groenendaal
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, PO Box 9502, 2300 RA Leiden, The Netherlands
    Eur J Pharm Sci 34:149-63. 2008
    ....
  16. doi request reprint Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration
    Jasper Stevens
    Division of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Drug Metab Dispos 39:2275-82. 2011
    ..Describing remoxipride pharmacokinetics at the target site (brain ECF) in a semiphysiology-based manner would allow for better prediction of pharmacodynamic effects...
  17. ncbi request reprint The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments
    Paulien G M Ravenstijn
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, Leiden, The Netherlands
    J Pharmacol Toxicol Methods 57:114-30. 2008
    ....
  18. ncbi request reprint Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model
    Tamara J van Steeg
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Pharmacol Exp Ther 324:1234-42. 2008
    ..In conclusion, a meaningful estimate of in vivo affinity for S(-)-atenolol could be obtained using a mechanism-based pharmacodynamic modeling approach...
  19. doi request reprint Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research
    Meindert Danhof
    Leiden University, Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Einsteinweg 55, PO Box 9503, 2300 RA Leiden, The Netherlands
    Trends Pharmacol Sci 29:186-91. 2008
    ..In this review, the principles of mechanism-based PK-PD modeling are described and illustrated by recent applications...
  20. doi request reprint Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting
    Joost Westerhout
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Pharm Sci 100:3577-93. 2011
    ..g., inhibition of an efflux transporter or induction of pathological state). With the use of advanced mathematical modeling procedures, we may dissect contributions of individual mechanisms in animals as links to the human situation...
  21. ncbi request reprint Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis
    Meindert Danhof
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, 2300 RA Leiden, The Netherlands
    Annu Rev Pharmacol Toxicol 47:357-400. 2007
    ..This has yielded models with much-improved properties for extrapolation and prediction. These models constitute a theoretical basis for rational drug discovery and development...
  22. doi request reprint Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples
    Jasper Stevens
    Division of Pharmacology, LACDR Leiden University, Leiden, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 878:969-75. 2010
    ..Considering the small sample volumes, the high sensitivity and good reproducibility, the analytical methods are suitable for analyzing small sample volumes with low remoxipride concentrations...
  23. ncbi request reprint Prediction of methotrexate CNS distribution in different species - influence of disease conditions
    Joost Westerhout
    Department of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands
    Eur J Pharm Sci 57:11-24. 2014
    ....
  24. ncbi request reprint Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats
    Tamara J van Steeg
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, Leiden, The Netherlands
    J Pharmacol Toxicol Methods 56:72-8. 2007
    ..Here we present an experimental approach to modify serum protein levels and binding in the rat, in a robust, reproducible, and time-dependent manner...
  25. pmc A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs
    Jasper Stevens
    Division of Pharmacology, LACDR Leiden University, Leiden, The Netherlands
    Pharm Res 26:1911-7. 2009
    ..To develop a new minimal-stress model for intranasal administration in freely moving rats and to evaluate in this model the brain distribution of acetaminophen following intranasal versus intravenous administration...
  26. ncbi request reprint Transport across the blood-brain barrier: stereoselectivity and PET-tracers
    Gert Luurtsema
    PET Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Mol Imaging Biol 6:306-18. 2004
    ..Given the differences in transport and binding, it is concluded that quantitative PET studies can only be performed using pure enantiomers...