Genomes and Genes
Diederik Pc De Rooy
Affiliation: Leiden University Medical Center
Country: The Netherlands
- Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritisDiederik P C de Rooy
Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
Ann Rheum Dis 72:769-75. 2013..Dickkopf-1 (Dkk-1) and sclerostin (Sost) are negative regulators and lipoprotein receptor-related protein-5 (LRP-5) and Kremen-1 are transmembrane receptors involved in this pathway...
- Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic?Diederik P C de Rooy
Department of Rheumatology, Leiden University Medical Center, C1 46, PO Box 9600, 2300 RC, Leiden, The Netherlands
Rheumatology (Oxford) 50:93-100. 2011..In early undifferentiated arthritis (UA), prediction of the development of RA is crucial, and in case of RA predicting the severity of the disease course may guide individualized treatment decisions...
- Loss of metacarpal bone density predicts RA development in recent-onset arthritisDiederik P C de Rooy
Department of Rheumatology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Rheumatology (Oxford) 51:1037-41. 2012..We determined the ability of radiographic BMD loss to predict RA development and arthritis persistency in patients with early undifferentiated arthritis (UA)...
- Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?Diederik P C de Rooy
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Res Ther 13:R180. 2011..We aimed to evaluate the validity of this notion and explored whether clinical subphenotypes can be discerned within anti-CCP-negative RA...