Nicole A Datson

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. pmc MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, PO Box 9503, 2300 RA Leiden, The Netherlands
    Nucleic Acids Res 27:1300-7. 1999
  2. pmc Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands
    BMC Genomics 8:190. 2007
  3. ncbi request reprint Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Eur J Neurosci 20:2541-54. 2004
  4. doi request reprint Central corticosteroid actions: Search for gene targets
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands
    Eur J Pharmacol 583:272-89. 2008
  5. ncbi request reprint Scaling down SAGE: from miniSAGE to microSAGE
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University, Leiden, The Netherlands
    Curr Pharm Biotechnol 9:351-61. 2008
  6. ncbi request reprint A molecular blueprint of gene expression in hippocampal subregions CA1, CA3, and DG is conserved in the brain of the common marmoset
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Hippocampus 19:739-52. 2009
  7. doi request reprint The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Hippocampus 22:359-71. 2012
  8. pmc Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR and Leiden University Medical Center, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Psychopharmacology (Berl) 217:525-38. 2011
  9. doi request reprint Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Endocrinology 152:3749-57. 2011
  10. ncbi request reprint Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Eur J Neurosci 14:675-89. 2001

Detail Information

Publications33

  1. pmc MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, PO Box 9503, 2300 RA Leiden, The Netherlands
    Nucleic Acids Res 27:1300-7. 1999
    ....
  2. pmc Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands
    BMC Genomics 8:190. 2007
    ..In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited...
  3. ncbi request reprint Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Eur J Neurosci 20:2541-54. 2004
    ....
  4. doi request reprint Central corticosteroid actions: Search for gene targets
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, The Netherlands
    Eur J Pharmacol 583:272-89. 2008
    ....
  5. ncbi request reprint Scaling down SAGE: from miniSAGE to microSAGE
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University, Leiden, The Netherlands
    Curr Pharm Biotechnol 9:351-61. 2008
    ....
  6. ncbi request reprint A molecular blueprint of gene expression in hippocampal subregions CA1, CA3, and DG is conserved in the brain of the common marmoset
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Hippocampus 19:739-52. 2009
    ....
  7. doi request reprint The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Hippocampus 22:359-71. 2012
    ....
  8. pmc Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR and Leiden University Medical Center, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Psychopharmacology (Berl) 217:525-38. 2011
    ..We hypothesize that the same genes and pathways underlying behavioral sensitization in mice are also involved in the vulnerability to psychosis...
  9. doi request reprint Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Endocrinology 152:3749-57. 2011
    ..GC-binding transcription factors therefore may be unique partners for DNA-bound GR and may in part explain cell-specific transcriptional regulation by glucocorticoids in the context of the hippocampus...
  10. ncbi request reprint Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Eur J Neurosci 14:675-89. 2001
    ....
  11. ncbi request reprint Expression profile of 30,000 genes in rat hippocampus using SAGE
    N A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Hippocampus 11:430-44. 2001
    ..This is the first extensive inventory of gene expression in the hippocampus and serves as a reference for future studies aimed at elucidating hippocampal transcriptional responses under various conditions...
  12. ncbi request reprint The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates
    Dorine E M Feldker
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, PO Box 9502, 2300 RA Leiden, The Netherlands
    Brain Res 1089:10-20. 2006
    ..Together, we hypothesize that reduced NFkappaB signaling and diminished protein biosynthesis form part of the molecular mechanisms by which a chronic psychosocial stressor induces structural alterations in hippocampus of LAL mice...
  13. pmc Previous history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus
    Nicole A Datson
    Division of Medical Pharmacology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
    Endocrinology 154:3261-72. 2013
    ..We propose that this altered transcriptional potential forms part of the molecular mechanism underlying the enhanced vulnerability for stress-related disorders like depression caused by chronic stress. ..
  14. doi request reprint Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome
    J Annelies E Polman
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Endocrinology 154:1832-44. 2013
    ..In conclusion, our results highlight the existence of 2 populations of GBS in the rat hippocampal genome...
  15. pmc A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes
    Joost B Vos
    Dept of Pulmonology, Leiden University Medical Center, Leiden, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Genomics 7:9. 2006
    ..These data sets were used to elucidate a common denominator in epithelial host defense...
  16. ncbi request reprint GeneChip analysis of hippocampal gene expression profiles of short- and long-attack-latency mice: technical and biological implications
    Dorine E M Feldker
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosci Res 74:701-16. 2003
    ..As gas5 does not encode a protein but several small nuclear RNAs, our data suggest that small RNAs may contribute to the molecular mechanisms underlying the extreme behavioral differences between LAL and SAL mice...
  17. ncbi request reprint Large-scale gene expression profiling of discrete brain regions: potential, limitations, and application in genetics of aggressive behavior
    Dorine E M Feldker
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Centre, Leiden, The Netherlands
    Behav Genet 33:537-48. 2003
    ..In this special issue, we focus on the principles of SAGE and DNA microarrays, as well as their advantages and disadvantages and application to analysis in brain tissue in order to identify aggression-related genes...
  18. pmc A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells
    J Annelies E Polman
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, 2333 CC, The Netherlands
    BMC Neurosci 13:118. 2012
    ..The objective of the present study was to identify genome-wide glucocorticoid receptor binding sites in neuronal PC12 cells using Chromatin ImmunoPrecipitation combined with next generation sequencing (ChIP-Seq)...
  19. ncbi request reprint Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time
    M C Morsink
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    J Neuroendocrinol 18:239-52. 2006
    ..Furthermore, we identified a number of interesting candidate genes which may underlie the glucocorticoid-mediated effects on hippocampal cell function...
  20. pmc Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-JUN in a neuronal context
    Niels Speksnijder
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University Medical Center, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Mol Neurosci 48:209-18. 2012
    ..At the same time, GR influences MEF2 activity and DNA binding. These results give novel insight into the molecular interplay of GR and MEF2 in the control of genes important for neuronal plasticity...
  21. ncbi request reprint Exploring host-pathogen interactions at the epithelial surface: application of transcriptomics in lung biology
    Joost B Vos
    Department of Pulmonology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L367-77. 2007
    ..In particular, the interactions between epithelial cells in the human lungs and clinically relevant microorganisms are the central focus of this review...
  22. ncbi request reprint The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells
    M C Morsink
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Amsterdam, The Netherlands
    J Neurochem 99:1282-98. 2006
    ..Finally, we identified a number of interesting genes, such as SWI/SNF, synaptosomal-associated protein 25 and certain Rab proteins which may play a role in the effects of glucocorticoids on catecholaminergic neuronal functioning...
  23. pmc Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator
    Ioannis Zalachoras
    Department of Endocrinology and Metabolism and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 110:7910-5. 2013
    ..Thus, C108297 represents a class of ligands that has the potential to more selectively abrogate pathogenic GR-dependent processes in the brain, while retaining beneficial aspects of GR signaling...
  24. ncbi request reprint Brain region-specific transcriptomic markers of serotonin-1A receptor agonist action mediating sexual rejection and aggression in female marmoset monkeys
    Yves Aubert
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    J Sex Med 10:1461-75. 2013
    ....
  25. doi request reprint Glucocorticoids modulate the mTOR pathway in the hippocampus: differential effects depending on stress history
    J Annelies E Polman
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
    Endocrinology 153:4317-27. 2012
    ..Based on these findings, we propose that direct regulation of the mTOR pathway by GC represents an important mechanism regulating neuronal plasticity in the rat DG, which changes after exposure to chronic stress...
  26. ncbi request reprint Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense
    Joost B Vos
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Physiol Genomics 21:324-36. 2005
    ..aeruginosa is characterized by expression of genes involved in epithelial barrier formation and host defense...
  27. ncbi request reprint Genetic dissection of corticosterone receptor function in the rat hippocampus
    E Vreugdenhil
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, P O Box 9503, 2300 RA, The Netherlands
    Eur Neuropsychopharmacol 11:423-30. 2001
    ..These findings suggest a novel mode of operation of the CaMK pathway in control of Ca2+ homeostasis relevant for CORT-related brain disorders...
  28. ncbi request reprint Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes
    M C Morsink
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University Medical Center LUMC, P O Box 9502, 2300 RA, Leiden, The Netherlands
    Brain Res 1150:14-20. 2007
    ..The results are important for understanding the role of GR in pleiotropic control of hippocampal neurotransmission and plasticity, which is characterized by recovery of function transiently raised by excitatory input...
  29. doi request reprint Glucocorticoid signaling and stress-related limbic susceptibility pathway: about receptors, transcription machinery and microRNA
    E R de Kloet
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Brain Res 1293:129-41. 2009
    ..We focus on the question how the action of CORT can change from protective to harmful...
  30. ncbi request reprint Serial analysis of gene expression predicts structural differences in hippocampus of long attack latency and short attack latency mice
    Dorine E M Feldker
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Centre, PO Box 9502, 2300 RA Leiden, The Netherlands
    Eur J Neurosci 17:379-87. 2003
    ....
  31. ncbi request reprint Identification of differentially regulated genes in mildly hyperlipidemic ApoE3-Leiden mice by use of serial analysis of gene expression
    A J Kreeft
    Department of Human and Clinical Genetics, Leiden University Medical Centre, University of Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 21:1984-90. 2001
    ..This inventory of differentially expressed genes will provide a unique basis for detailed studies to gain more insight into their role in lipoprotein homeostasis and atherosclerosis...
  32. pmc Antisense-mediated isoform switching of steroid receptor coactivator-1 in the central nucleus of the amygdala of the mouse brain
    Ioannis Zalachoras
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Leiden University Medical Center, Leiden, The Netherlands
    BMC Neurosci 14:5. 2013
    ..This nuclear receptor coregulator exists in two splice variants (SRC-1a and SRC-1e) which display differential distribution and opposing activities in the brain, and whose mRNAs differ in a single SRC-1e specific exon...
  33. ncbi request reprint Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression
    Simon J Evans
    Mental Health Research Institute, 205 Zina Pitcher Place, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Eur J Neurosci 16:409-13. 2002
    ..This report provides the first broad evaluation of Affymetrix Gene Chip sensitivity relevant to studying the brain...