Susana M Chuva de Sousa Lopes


Affiliation: Leiden University Medical Center
Country: The Netherlands


  1. Vértesy Á, Arindrarto W, Roost M, Reinius B, Torrens Juaneda V, Bialecka M, et al. Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells. Nat Commun. 2018;9:1873 pubmed publisher
    ..Altogether, we uncover the complexity and cell-to-cell heterogeneity of transcriptional and epigenetic remodeling in female human germ cells. ..
  2. de Sousa Lopes S, Roelen B. An overview on the diversity of cellular organelles during the germ cell cycle. Histol Histopathol. 2010;25:267-76 pubmed publisher
  3. Roost M, van Iperen L, Ariyurek Y, Buermans H, Arindrarto W, Devalla H, et al. KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas. Stem Cell Reports. 2015;4:1112-24 pubmed publisher
    ..We thus provide a flexible and expandable platform to monitor and evaluate the efficiency of differentiation in vitro. ..
  4. Heeren A, van Iperen L, Klootwijk D, De Melo Bernardo A, Roost M, Gomes Fernandes M, et al. Development of the follicular basement membrane during human gametogenesis and early folliculogenesis. BMC Dev Biol. 2015;15:4 pubmed publisher
    ..This knowledge may contribute to improve methods to recreate the environment needed for successful folliculogenesis in vitro and that would benefit a large number of infertility patients. ..
  5. Gomes Fernandes M, Dries R, Roost M, Semrau S, De Melo Bernardo A, Davis R, et al. BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells. Stem Cell Reports. 2016;6:85-94 pubmed publisher
    ..We showed that BMP-SMAD signaling modulates lineage priming in mESCs, by transiently regulating the enzymatic machinery responsible for DNA methylation. ..
  6. Heeren A, He N, de Souza A, Goercharn Ramlal A, van Iperen L, Roost M, et al. On the development of extragonadal and gonadal human germ cells. Biol Open. 2016;5:185-94 pubmed publisher
    ..Our findings highlight species-specific differences in early gametogenesis between mice and humans. We report the presence of a population of ectopic germ cells in the human adrenals during development. ..
  7. Locher H, Frijns J, van Iperen L, de Groot J, Huisman M, Chuva de Sousa Lopes S. Neurosensory development and cell fate determination in the human cochlea. Neural Dev. 2013;8:20 pubmed publisher
    ..In this study, we investigated the onset of hair cell differentiation and innervation in the human fetal cochlea at various stages of development...
  8. Roost M, Slieker R, Bialecka M, van Iperen L, Gomes Fernandes M, He N, et al. DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells. Nat Commun. 2017;8:908 pubmed publisher
    ..Here, the authors generated transcriptional and DNA methylation data from 21 organs during human development and 6 isogenic induced pluripotent stem cell lines. ..