Danielle L Champagne

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. doi request reprint Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research
    Danielle L Champagne
    Institute of Biology, Department of Integrative Zoology, Leiden University, Leiden, The Netherlands
    Behav Brain Res 214:332-42. 2010
  2. ncbi request reprint Maternal care influences neuronal survival in the hippocampus of the rat
    Timothy W Bredy
    Developmental Neuroendocrinology Laboratory and McGill Program for the Study of Behaviour, Genes and Environment, Douglas Hospital Research Centre, 6875 Boul LaSalle Blvd, Montreal, Canada, H4H 1R3
    Eur J Neurosci 18:2903-9. 2003
  3. doi request reprint Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
  4. doi request reprint Fundamental aspects of the impact of glucocorticoids on the (immature) brain
    Danielle L Champagne
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratory, Leiden, The Netherlands
    Semin Fetal Neonatal Med 14:136-42. 2009
  5. doi request reprint Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus
    Rosemary C Bagot
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neurobiol Learn Mem 92:292-300. 2009
  6. doi request reprint Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Physiol Behav 106:707-21. 2012
  7. doi request reprint The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Gorlaeus Laboratories, The Netherlands
    Horm Behav 60:165-76. 2011
  8. doi request reprint Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy
    Sanne E F Claessens
    Department of Medical Pharmacology, LACDR LUMC, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Brain Res 1482:1-12. 2012
  9. doi request reprint Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds
    Shaukat Ali
    Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, Leiden, The Netherlands
    Behav Brain Res 228:272-83. 2012
  10. pmc Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring
    Laura A Smit-Rigter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e5167. 2009

Collaborators

Detail Information

Publications19

  1. doi request reprint Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research
    Danielle L Champagne
    Institute of Biology, Department of Integrative Zoology, Leiden University, Leiden, The Netherlands
    Behav Brain Res 214:332-42. 2010
    ..These findings are consistent with previous findings in rodents and support the usefulness of such behavioral paradigms in zebrafish...
  2. ncbi request reprint Maternal care influences neuronal survival in the hippocampus of the rat
    Timothy W Bredy
    Developmental Neuroendocrinology Laboratory and McGill Program for the Study of Behaviour, Genes and Environment, Douglas Hospital Research Centre, 6875 Boul LaSalle Blvd, Montreal, Canada, H4H 1R3
    Eur J Neurosci 18:2903-9. 2003
    ..These findings emphasize the importance of early maternal care for hippocampal development...
  3. doi request reprint Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  4. doi request reprint Fundamental aspects of the impact of glucocorticoids on the (immature) brain
    Danielle L Champagne
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Gorlaeus Laboratory, Leiden, The Netherlands
    Semin Fetal Neonatal Med 14:136-42. 2009
    ..This concept has led to the hypothesis that a 'mismatch' between early and later life conditions can enhance vulnerability to disease...
  5. doi request reprint Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus
    Rosemary C Bagot
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neurobiol Learn Mem 92:292-300. 2009
    ..We suggest that decreased pup LG during postnatal life may be adaptive in high-threat environments, potentially enhancing hippocampal function in the offspring under conditions of adversity...
  6. doi request reprint Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Physiol Behav 106:707-21. 2012
    ..For this purpose the combined effects of early-life adversity and later-life stress exposure on behavioral markers of psychosis susceptibility were studied in male Wistar rats...
  7. doi request reprint The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Gorlaeus Laboratories, The Netherlands
    Horm Behav 60:165-76. 2011
    ..In conclusion, separation environment, maternal care and genotype do not affect adrenal desensitization to repeated 8 h-MS itself, but may modulate the adrenal stress-responsiveness of separated pups...
  8. doi request reprint Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy
    Sanne E F Claessens
    Department of Medical Pharmacology, LACDR LUMC, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Brain Res 1482:1-12. 2012
    ..These acute alterations in the neonate brain might underlie later functional impairments reported in DEX-treated animals and humans and further illustrate the impact of early GR activation on brain development...
  9. doi request reprint Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds
    Shaukat Ali
    Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, Leiden, The Netherlands
    Behav Brain Res 228:272-83. 2012
    ..We conclude that behavioral assays with zebrafish embryos could be useful for pharmaceutical efficacy and toxicity screening. The precise phenotypic outcome obtained with behavioral assay varies with compound class...
  10. pmc Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring
    Laura A Smit-Rigter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e5167. 2009
    ....
  11. doi request reprint The use of the zebrafish model in stress research
    Peter J Steenbergen
    Institute of Biology, Department of Integrative Zoology, Leiden University, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 35:1432-51. 2011
    ..We also present novel methodologies associated with the development of the zebrafish stress model and discuss how such methodologies can contribute to remove the main bottleneck in the field of drug discovery...
  12. doi request reprint Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Academic Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden University, Leiden, The Netherlands Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA Mental Health Care Center, PTSD Clinical Research Program and Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J Peters Veterans Affairs Medical Center, Bronx, USA Electronic address
    Psychoneuroendocrinology 39:39-57. 2014
    ..In conclusion, programming of an adult fearful phenotype linked to amygdala priming develops if pups are repeatedly isolated from peers in a novel-environment, while away from the dam for a prolonged period of time...
  13. doi request reprint Zebrafish embryos and larvae: a new generation of disease models and drug screens
    Shaukat Ali
    Institute of Biology, Leiden University, Sylvius Laboratory, The Netherlands
    Birth Defects Res C Embryo Today 93:115-33. 2011
    ..Finally, the zebrafish poses no challenge to the position of rodent models: it is complementary to them, especially in early stages of drug research...
  14. doi request reprint MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain
    Erno Vreugdenhil
    Leiden Amsterdam Center for Drug Research Medical Pharmacology Department, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Endocrinology 150:2220-8. 2009
    ..Ultimately, our results may provide a better understanding of the etiology of stress-related diseases as well as the efficacy of GC therapy...
  15. doi request reprint Brain development under stress: hypotheses of glucocorticoid actions revisited
    Melly S Oitzl
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research LACDR Leiden University Medical Centre LUMC, University of Leiden, Einsteinweg 55, P O Box 9502, 2300 RA Leiden, The Netherlands
    Neurosci Biobehav Rev 34:853-66. 2010
    ..The Predictive Adaptation Hypothesis therefore presents a conceptual framework to examine the role of glucocorticoids in understanding individual phenotypic differences in stress-related behaviours over the lifespan...
  16. doi request reprint Patterns of avoidance behaviours in the light/dark preference test in young juvenile zebrafish: a pharmacological study
    Peter J Steenbergen
    Institute of Biology, Department of Integrative Zoology, Leiden University, The Netherlands
    Behav Brain Res 222:15-25. 2011
    ..This behavioural-based assay is also versatile and can accommodate drug screening of both anxiolytic and anxiogenic compounds while eventually amenable to automation and high-throughput capacity in a near future...
  17. pmc Large-scale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience
    Shaukat Ali
    Institute of Biology, Leiden University, Sylvius Laboratory, Leiden, The Netherlands
    PLoS ONE 6:e20037. 2011
    ..We have therefore conducted the first large-scale (>1500 embryos) analysis of acute, stage-specific drug effects on zebrafish development, with a large panel of readouts...
  18. pmc Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences
    Sanne E F Claessens
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    Psychopharmacology (Berl) 214:141-54. 2011
    ..The interplay between genes and environment underlies this phenomenon...
  19. ncbi request reprint Zebrafish development and regeneration: new tools for biomedical research
    Sebastiaan A Brittijn
    Institute of Biology, Dept Integrative Zoology, University of Leiden, The Netherlands
    Int J Dev Biol 53:835-50. 2009
    ..Zebrafish cannot replace mammalian models in the drug development pipeline. Nevertheless, they can provide a cost-effective bridge between cell-based assays and mammalian whole-organism models...