Jeroen T Buijs

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Osteotropic cancers: from primary tumor to bone
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Lett 273:177-93. 2009
  2. ncbi request reprint Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 67:8742-51. 2007
  3. doi request reprint Inhibition of bone resorption and growth of breast cancer in the bone microenvironment
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, C4 R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Bone 44:380-6. 2009
  4. pmc BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, J3 100, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 171:1047-57. 2007
  5. doi request reprint High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:5163-73. 2010
  6. ncbi request reprint Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo
    Gabri van der Pluijm
    Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands
    Cancer Res 65:7682-90. 2005
  7. pmc Integrin αv expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Pathol 179:2559-68. 2011
  8. ncbi request reprint Advances in optical imaging and novel model systems for cancer metastasis research
    Nico V Henriquez
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Clin Exp Metastasis 24:699-705. 2007
  9. pmc The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, The Netherlands
    Clin Exp Metastasis 28:615-25. 2011
  10. ncbi request reprint TGF-beta and BMP7 interactions in tumour progression and bone metastasis
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Metastasis 24:609-17. 2007

Collaborators

Detail Information

Publications15

  1. doi request reprint Osteotropic cancers: from primary tumor to bone
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Lett 273:177-93. 2009
    ..For this reason, this review uses the 'seed and soil' hypothesis as a template to discuss novel insight and developments in the bone metastasis field...
  2. ncbi request reprint Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 67:8742-51. 2007
    ..Because exogenous BMP7 can still counteract the breast cancer growth at the primary site and in bone, BMP7 may represent a novel therapeutic molecule for repression of local and bone metastatic growth of breast cancer...
  3. doi request reprint Inhibition of bone resorption and growth of breast cancer in the bone microenvironment
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, C4 R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Bone 44:380-6. 2009
    ..However, interference with the bone micro-environmental growth support could still be of therapeutic relevance when given to patients early in the course of bone metastatic disease...
  4. pmc BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, J3 100, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 171:1047-57. 2007
    ..Thus, BMP7 can still counteract the epithelial-to-mesenchymal transition process in the metastatic tumor, positioning BMP7 as a novel therapeutic molecule for treatment of metastatic bone disease...
  5. doi request reprint High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:5163-73. 2010
    ..Our findings suggest that ALDH-based viable cell sorting can be used to identify and characterize tumor-initiating and, more importantly perhaps, metastasis-initiating cells in human prostate cancer...
  6. ncbi request reprint Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo
    Gabri van der Pluijm
    Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands
    Cancer Res 65:7682-90. 2005
    ..Inhibition of bone turnover may represent a useful adjuvant therapy especially for cancer patients at risk to develop bone metastasis...
  7. pmc Integrin αv expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Pathol 179:2559-68. 2011
    ....
  8. ncbi request reprint Advances in optical imaging and novel model systems for cancer metastasis research
    Nico V Henriquez
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Clin Exp Metastasis 24:699-705. 2007
    ....
  9. pmc The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, The Netherlands
    Clin Exp Metastasis 28:615-25. 2011
    ..Our findings show, for the first time, that the ALDH7A1 enzyme is functionally involved in the formation of bone metastases and that the effect appeared dependent on the microenvironment, i.e., bone versus prostate...
  10. ncbi request reprint TGF-beta and BMP7 interactions in tumour progression and bone metastasis
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Metastasis 24:609-17. 2007
    ..For instance, the tumour-stroma interactions occurring in the tissue of cancer origin, including epithelium-to-mesenchyme transition (EMT), bear similarities with the role of bone matrix-derived TGF-beta in skeletal metastasis formation...
  11. pmc Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer
    Geertje van der Horst
    Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Neoplasia 13:516-25. 2011
    ....
  12. ncbi request reprint Bone morphogenetic proteins and its receptors; therapeutic targets in cancer progression and bone metastasis?
    Jeroen T Buijs
    Dept of Urology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Curr Pharm Des 16:1291-300. 2010
    ..Especially in the last decade, studies have focused on the role of several BMPs in osteotropic cancers. In this review, the role of BMPs, particularly that of BMP7, in breast and prostate cancer will be discussed...
  13. ncbi request reprint Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis
    Irene C Notting
    Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 46:1581-7. 2005
    ..Therefore, the development of novel anticancer strategies is urgent, and more sensitive and less invasive methods of detecting and monitoring in vivo tumor growth and metastatic disease in cancer models are needed...
  14. doi request reprint Multimodal imaging and treatment of bone metastasis
    Eric L Kaijzel
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Clin Exp Metastasis 26:371-9. 2009
    ..In this paper, we discuss the use of optical imaging strategies--either alone or in combination with CT--to study intrabone tumor growth, tumor progression and to monitor efficacy of therapeutic agents in metastatic bone disease...
  15. ncbi request reprint Prognostic significance of periodic acid-Schiff-positive patterns in primary breast cancer and its lymph node metastases
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Breast Cancer Res Treat 84:117-30. 2004
    ..In conclusion, the presence of PAS+ networks in lymph node metastases is a new, reliable and convenient indicator for prognosis of breast cancer patients...