Ferdinand Breedveld

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Arthritis Res Ther 8:216. 2006
  2. pmc Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 7:R949-58. 2005
  3. ncbi request reprint Osteoarthritis--the impact of a serious disease
    F C Breedveld
    Departments of Rheumatology and Medicine, Leiden University Medical Centre, Leiden, The Netherlands
    Rheumatology (Oxford) 43:i4-8. 2004
  4. pmc Appropriate and effective management of rheumatoid arthritis
    F C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 63:627-33. 2004
  5. pmc Understanding emerging treatment paradigms in rheumatoid arthritis
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Center, C1 39, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:S3. 2011
  6. ncbi request reprint Therapeutic monoclonal antibodies
    F C Breedveld
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Lancet 355:735-40. 2000
  7. pmc Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis
    F C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    Ann Rheum Dis 64:52-5. 2005
  8. ncbi request reprint Multiple faces of rheumatoid arthritis: diagnostic and therapeutic algorithms
    F Breedveld
    University Hospital, Department of Rheumatology, P O Box 9600, 2300 RC Leiden, The Netherlands
    Autoimmun Rev 3:S22. 2004
  9. ncbi request reprint The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4 R Postbox 9600, Leiden 2300 RC, The Netherlands
    Arthritis Rheum 54:26-37. 2006
  10. ncbi request reprint Should rheumatoid arthritis be treated conservatively or aggressively?
    F C Breedveld
    University of Leiden, Leiden, The Netherlands
    Rheumatology (Oxford) 42:ii41-3. 2003

Detail Information

Publications73

  1. pmc Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Arthritis Res Ther 8:216. 2006
    ..These definitions of remission refer to different disease states; therefore, we propose that the term remission is reserved for patients that are not treated with antirheumatic drugs...
  2. pmc Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 7:R949-58. 2005
    ..In conclusion, the phenotype of RA patients with or without anti-CCP antibodies is similar with respect to clinical presentation but differs with respect to disease course...
  3. ncbi request reprint Osteoarthritis--the impact of a serious disease
    F C Breedveld
    Departments of Rheumatology and Medicine, Leiden University Medical Centre, Leiden, The Netherlands
    Rheumatology (Oxford) 43:i4-8. 2004
    ..Furthermore, because this disease is associated with comorbid conditions, patient safety must also be considered when designing new therapies...
  4. pmc Appropriate and effective management of rheumatoid arthritis
    F C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 63:627-33. 2004
    ..The latest strategies and treatments enable remission to be achieved in many more patients than formerly...
  5. pmc Understanding emerging treatment paradigms in rheumatoid arthritis
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Center, C1 39, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:S3. 2011
    ..In the present review, we summarize the salient points of several recently proposed and emerging treatment paradigms with an emphasis on how these strategies may impact future practice...
  6. ncbi request reprint Therapeutic monoclonal antibodies
    F C Breedveld
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Lancet 355:735-40. 2000
    ..The therapeutic use of mAb is now established, and is perhaps the first example of how the "new biology" and the understanding of underlying molecular mechanisms has benefited patients...
  7. pmc Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis
    F C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    Ann Rheum Dis 64:52-5. 2005
    ..To identify factors associated with poor physical function in rheumatoid arthritis and to assess whether baseline joint damage has an impact on improvement in physical function during infliximab treatment...
  8. ncbi request reprint Multiple faces of rheumatoid arthritis: diagnostic and therapeutic algorithms
    F Breedveld
    University Hospital, Department of Rheumatology, P O Box 9600, 2300 RC Leiden, The Netherlands
    Autoimmun Rev 3:S22. 2004
  9. ncbi request reprint The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4 R Postbox 9600, Leiden 2300 RC, The Netherlands
    Arthritis Rheum 54:26-37. 2006
    ..To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive rheumatoid arthritis (RA) who had not previously received MTX treatment...
  10. ncbi request reprint Should rheumatoid arthritis be treated conservatively or aggressively?
    F C Breedveld
    University of Leiden, Leiden, The Netherlands
    Rheumatology (Oxford) 42:ii41-3. 2003
  11. pmc Infliximab in active early rheumatoid arthritis
    F C Breedveld
    Department of Rheumatology, University of Leiden, Leiden, The Netherlands
    Ann Rheum Dis 63:149-55. 2004
    ..To examine the impact of the combination of infliximab plus methotrexate (MTX) on the progression of structural damage in patients with early rheumatoid arthritis (RA)...
  12. pmc Current and future management approaches for rheumatoid arthritis
    Ferdinand C Breedveld
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res 4:S16-21. 2002
    ..These new biologic agents and future nonbiologic agents that target proteins in signaling cascades are likely to change the landscape of RA treatments...
  13. doi request reprint The value of early intervention in RA--a window of opportunity
    Ferdinand Breedveld
    Department of Rheumatology, Leiden University Medical Center, C4R, PO Box 9600, 2300RC Leiden, The Netherlands
    Clin Rheumatol 30:S33-9. 2011
    ..It is important to assess the benefits of any intervention not just to healthcare costs but to society as a whole, and physicians should be advocates for optimal access to effective therapies for their patients...
  14. ncbi request reprint Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial
    Henrike van Dongen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1424-32. 2007
    ..To determine whether patients with undifferentiated arthritis (UA; inflammatory, nontraumatic arthritis that cannot be diagnosed using current classification criteria) benefit from treatment with methotrexate (MTX)...
  15. ncbi request reprint Rituximab pharmacokinetics in patients with rheumatoid arthritis: B-cell levels do not correlate with clinical response
    Ferdinand Breedveld
    Leiden University Medical Center, Rheumatology, PO Box 9600, Leiden, 2300 RC, The Netherlands
    J Clin Pharmacol 47:1119-28. 2007
    ....
  16. ncbi request reprint Linker for activation of T cells: sensing redox imbalance
    Sonja I Gringhuis
    Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Methods Enzymol 352:248-57. 2002
  17. ncbi request reprint A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:433-40. 2007
    ..However, 40-50% of patients with UA experience spontaneous remission. Thus, adequate decision-making regarding treatment of patients with early UA requires identification of those patients in whom RA will develop...
  18. doi request reprint Brain involvement in rheumatoid arthritis: a magnetic resonance spectroscopy study
    Bart J Emmer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:3190-5. 2009
    ..The purpose of this study was to examine by proton magnetic resonance spectroscopy ((1)H-MRS) the influence of inflammation on cerebral metabolism in patients with rheumatoid arthritis (RA)...
  19. doi request reprint Cost-utility analysis of treatment strategies in patients with recent-onset rheumatoid arthritis
    Wilbert B Van Den Hout
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:291-9. 2009
    ..To evaluate societal costs and quality-adjusted life years (QALYs) of treatment strategies for patients with recent-onset active rheumatoid arthritis (RA)...
  20. pmc An open-label pilot study of the effectiveness of adalimumab in patients with rheumatoid arthritis and previous infliximab treatment: relationship to reasons for failure and anti-infliximab antibody status
    Arie E van der Bijl
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Clin Rheumatol 27:1021-8. 2008
    ..Adalimumab was effective and well-tolerated in patients with RA who previously failed IFX therapy, irrespective of reason for discontinuation and of HACA status...
  21. ncbi request reprint Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes
    Ingrid Meulenbelt
    Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The Netherlands
    Eur J Hum Genet 14:1280-7. 2006
    ..3 for FOA. Candidate gene analysis suggested a possible association of a PTHR2 variant with generalized radiographic OA; it is, however, unlikely the major disease gene for the observed linkage to the FOA phenotype...
  22. ncbi request reprint The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 54:1117-21. 2006
    ..We therefore determined the influence of the SE alleles and anti-CCP antibodies on the progression from recent-onset undifferentiated arthritis (UA) to RA...
  23. ncbi request reprint Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes
    Judith A M Wessels
    Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 54:1087-95. 2006
    ..To determine associations of methotrexate (MTX) efficacy and toxicity with single-nucleotide polymorphisms (SNPs) in genes coding for folate pathway enzymes in patients with early rheumatoid arthritis (RA)...
  24. pmc Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper
    Margreet Kloppenburg
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 66:1157-61. 2007
    ..Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of addressing key issues and facilitating research into hand osteoarthritis...
  25. ncbi request reprint Biologics in early rheumatoid arthritis
    Jeska K de Vries-Bouwstra
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Rheum Dis Clin North Am 31:745-62. 2005
    ..The exact role of these agents in the treatment of early-stage RA is unknown...
  26. pmc Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score
    Sjoerd M van der Kooij
    Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 66:1356-62. 2007
    ..To determine the efficacy of subsequent disease modifying antirheumatic drug (DMARD) therapies after initial methotrexate (MTX) failure in patients with recent onset rheumatoid arthritis (RA), treated according to the DAS for 2 years...
  27. ncbi request reprint Effectiveness of the introduction of an International Classification of Functioning, Disability and Health-based rehabilitation tool in multidisciplinary team care in patients with rheumatoid arthritis
    John Verhoef
    Department of Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 57:240-8. 2007
    ....
  28. ncbi request reprint Treatment of recent-onset rheumatoid arthritis: lessons from the BeSt study
    Cornelia F Allaart
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Rheumatol Suppl 80:25-33. 2007
    ..To determine the efficacy, toxicity, utilities, and costs of 4 treatment strategies for patients with recent-onset rheumatoid arthritis (RA)...
  29. ncbi request reprint The usage of functional wrist orthoses in patients with rheumatoid arthritis
    Ingeborg G de Boer
    Department of Rheumatology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Disabil Rehabil 30:286-95. 2008
    ..To describe the usage of functional wrist orthoses and to identify factors contributing to usage in patients with rheumatoid arthritis (RA)...
  30. ncbi request reprint Are patients with rheumatoid arthritis less physically active than the general population?
    Machteld H van den Berg
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Rheumatol 13:181-6. 2007
    ..In particular, the literature investigating how these PA levels are in proportion to the levels among the general population is scarce...
  31. pmc Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells
    Jacob M van Laar
    B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Pathol 171:917-27. 2007
    ..Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion...
  32. ncbi request reprint Most people with rheumatoid arthritis undertake leisure-time physical activity in the Netherlands: an observational study
    Marleen H van den Berg
    Leiden University Medical Centre, Leiden, 2300 RC, The Netherlands
    Aust J Physiother 53:113-8. 2007
    ..by people with rheumatoid arthritis? What type of physical activity or exercise do they prefer? What is their attitude towards physical activity or exercise? What are the perceived barriers to undertaking physical activity or exercise?..
  33. ncbi request reprint Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study
    Stella A Botha-Scheepers
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 57:626-32. 2007
    ....
  34. pmc Patient preferences for treatment: report from a randomised comparison of treatment strategies in early rheumatoid arthritis (BeSt trial)
    Yvonne P M Goekoop-Ruiterman
    Leiden University Medical Center, Department of Rheumatology C1 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 66:1227-32. 2007
    ..To determine treatment preferences among patients with recent onset rheumatoid arthritis participating in a randomised controlled trial comparing four therapeutic strategies...
  35. doi request reprint Innovative treatment strategies for patients with rheumatoid arthritis
    Sjoerd M van der Kooij
    Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 20:287-94. 2008
    ..The present review provides an update on novel treatment strategies striving for remission in patients with recent onset of rheumatoid arthritis...
  36. ncbi request reprint Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial
    Yvonne P M Goekoop-Ruiterman
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 146:406-15. 2007
    ..In patients with early rheumatoid arthritis, initial combination therapies provide earlier clinical improvement and less progression of joint damage after 1 year compared with initial monotherapies (as demonstrated in the BeSt study)...
  37. doi request reprint Changes in outcome measures for impairment, activity limitation, and participation restriction over two years in osteoarthritis of the lower extremities
    Stella Botha-Scheepers
    Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
    Arthritis Rheum 59:1750-5. 2008
    ....
  38. ncbi request reprint Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    Tom W J Huizinga
    Department of Rheumatology C4R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 52:3433-8. 2005
    ..We undertook this study to make the first comparison of SE allele frequencies in the healthy population with those in RA patients who do or do not harbor anti-CCP antibodies...
  39. pmc Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways
    Sonja I Gringhuis
    Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 22:400-11. 2002
    ..Conclusively, the data suggest a role for LAT as a crucial intermediate in the sensitivity of TCR signaling and hence T lymphocytes toward chronic oxidative stress...
  40. ncbi request reprint A randomized comparison of care provided by a clinical nurse specialist, an inpatient team, and a day patient team in rheumatoid arthritis
    Gerhardus J Tijhuis
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 47:525-31. 2002
    ....
  41. ncbi request reprint Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis? Results of a randomized controlled trial
    Zuzana de Jong
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:2415-24. 2003
    ....
  42. ncbi request reprint Exercise therapy in patients with rheumatoid arthritis
    Theodora P M Vilet Vlieland
    Leiden University Medical Center, Department of Rheumatology, C4 R, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Curr Rheumatol Rep 4:369-70. 2002
  43. ncbi request reprint Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:395-9. 2004
    ..The relevance of this model for human disease remains a subject of controversy. We set out to determine whether GPI autoantibodies occur in patients with rheumatoid arthritis (RA) and, if so, at what stage of the RA...
  44. ncbi request reprint High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: a review
    R obert J Verburg
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 63:627-37. 2002
    ..In this review we discuss background, clinical results, protocols, and future prospects of high dose chemotherapy and autologous SCT for RA...
  45. ncbi request reprint Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis
    Wilbert B Van Den Hout
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 53:39-47. 2005
    ..To estimate the cost utility and cost effectiveness of long-term, high-intensity exercise classes compared with usual care in rheumatoid arthritis (RA) patients...
  46. ncbi request reprint Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo
    Umesh A Badrising
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Ann Neurol 51:369-72. 2002
    ..Serum creatine kinase activity decreased significantly in the methotrexate group. We conclude that oral methotrexate did not slow down progression of muscle weakness but decreased serum creatine kinase activity...
  47. ncbi request reprint An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Arthritis Rheum 52:2637-44. 2005
    ....
  48. ncbi request reprint Rheumatoid vasculitis treated with infliximab
    A Egon van der Bijl
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    J Rheumatol 32:1607-9. 2005
    ..TNF-a antagonists should be considered as treatment in systemic RV, especially in patients who do not respond to immunosuppressive drugs or who have contraindication for such treatment...
  49. ncbi request reprint Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis
    Kirsten N Verpoort
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 52:3058-62. 2005
    ..We undertook this study to investigate whether anti-CCP-negative RA is associated with other HLA-DRB1 alleles...
  50. ncbi request reprint Randomized comparison of a multidisciplinary job-retention vocational rehabilitation program with usual outpatient care in patients with chronic arthritis at risk for job loss
    Petronella D M de Buck
    Leiden University Medical Center, The Netherlands
    Arthritis Rheum 53:682-90. 2005
    ..We conducted a randomized controlled trial to investigate the effectiveness of a multidisciplinary job-retention vocational rehabilitation (VR) program in patients with a rheumatic condition who were at risk for job loss...
  51. ncbi request reprint Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2113-21. 2004
    ..We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides (anti-CCP antibodies)...
  52. ncbi request reprint Two-year follow-up of a randomized controlled trial of a clinical nurse specialist intervention, inpatient, and day patient team care in rheumatoid arthritis
    Gerhardus J Tijhuis
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    J Adv Nurs 41:34-43. 2003
    ..However, long-term controlled studies showing how the effectiveness of CNSs compares with that of other forms of co-ordinated care, such as multidisciplinary team care, are lacking...
  53. ncbi request reprint Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis
    Tanja C A Tolboom
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 52:1999-2002. 2005
    ..This study was undertaken to investigate the association of these in vitro characteristics with disease characteristics in patients with RA...
  54. ncbi request reprint Pulmonary fibrosis in a patient with rheumatoid arthritis treated with adalimumab
    Abraham Schoe
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Rheum 55:157-9. 2006
  55. ncbi request reprint Leflunomide: a manageable safety profile
    Peit L C M Van Riel
    Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Rheumatol Suppl 71:21-4. 2004
    ..Other patient management recommendations in this review reflect the views of the majority of participants as expressed in the meeting...
  56. ncbi request reprint How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis
    Henk Visser
    Department of Rheumatology, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 46:357-65. 2002
    ..To develop a clinical model for the prediction, at the first visit, of 3 forms of arthritis outcome: self-limiting, persistent nonerosive, and persistent erosive arthritis...
  57. ncbi request reprint Slowing of bone loss in patients with rheumatoid arthritis by long-term high-intensity exercise: results of a randomized, controlled trial
    Zuzana de Jong
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:1066-76. 2004
    ....
  58. ncbi request reprint Using predicted disease outcome to provide differentiated treatment of early rheumatoid arthritis
    Jeska de Vries-Bouwstra
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Rheumatol 33:1747-53. 2006
    ..To determine the usefulness of a prediction model for making treatment decisions in early rheumatoid arthritis (RA)...
  59. ncbi request reprint Criteria for early rheumatoid arthritis: from Bayes' law revisited to new thoughts on pathogenesis
    Tom W J Huizinga
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 46:1155-9. 2002
  60. ncbi request reprint Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation
    Naghmeh Riyazi
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 52:1443-50. 2005
    ....
  61. doi request reprint Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial
    Paul Emery
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds Teaching Hospitals Trust, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, United Kingdom, UK
    Lancet 372:375-82. 2008
    ....
  62. ncbi request reprint Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging
    Richard J Reece
    Leeds Teaching Hospitals, University of Leeds, 36 Clarendon Road, LS2 9NZ Leeds, UK
    Arthritis Rheum 46:366-72. 2002
    ..Therefore, this investigation was undertaken to evaluate DEMRI as an efficacy assessment tool for differentiating treatment effect in a randomized, active-controlled trial comparing leflunomide and methotrexate...
  63. ncbi request reprint Methotrexate treatment and mortality in rheumatoid arthritis
    Robert B M Landewe
    Lancet 360:1095-6; author reply 1097-8. 2002
  64. ncbi request reprint Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism
    René J Berckmans
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 46:2857-66. 2002
    ..To determine the cellular origin of synovial microparticles, their procoagulant properties, and their relationship to local hypercoagulation...
  65. ncbi request reprint A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis
    Jasper J Haringman
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:2387-92. 2006
    ..The objective of this study was to evaluate the effects of human anti-CCL2/MCP-1 monoclonal antibody (ABN912) treatment in patients with rheumatoid arthritis (RA)...
  66. ncbi request reprint Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes
    Philip H J Remans
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:920-31. 2004
    ..Introduction of dominant-negative Ras into synovial fluid T cells restored redox balance, providing evidence that deregulated Ras and Rap1 signaling underlies oxidative stress and consequent altered T cell function observed in RA...
  67. ncbi request reprint Lefunomide in combination therapy
    Joachim R Kalden
    Department of Internal Medicine III, Universitaet Erlangen Nuremberg, Erlangen, Germany
    J Rheumatol Suppl 71:25-30. 2004
    ..The Expert Panel concluded that combination therapy with leflunomide has a place in the treatment of RA. Caution is advised, however, when using combination treatments and, therefore, the patient's safety should be carefully monitored...
  68. ncbi request reprint The efficacy of leflunomide monotherapy in rheumatoid arthritis: towards the goals of disease modifying antirheumatic drug therapy
    Josef S Smolen
    Division of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
    J Rheumatol Suppl 71:13-20. 2004
    ..Moreover, to ensure good tolerability and compliance in patients receiving a loading dose, information and adequate support should be provided throughout treatment...
  69. ncbi request reprint Controversies in COX-2 selective inhibition
    Lee S Simon
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Rheumatol 29:1501-10. 2002
  70. ncbi request reprint Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues
    Tineke C T M van der Pouw Kraan
    Department of Molecular Cell Biology, VU Medical Center, van der Boechorst straat 7, 1081 BT Amsterdam, The Netherlands
    Arthritis Rheum 48:2132-45. 2003
    ..To generate a molecular description of synovial tissue from rheumatoid arthritis (RA) patients that would allow us to unravel novel aspects of pathogenesis and to identify different forms of disease...
  71. ncbi request reprint InforMatrix: treatment of rheumatoid arthritis using biologicals
    Bart J F van den Bemt
    Sint Maartenskliniek, Herngstdalseweg 3, 6522JV Nijmegen, The Netherlands
    Expert Opin Pharmacother 7:1769-89. 2006
    ..Using this interactive matrix technique makes rational consideration of the treatment options for rheumatoid arthritis possible...
  72. ncbi request reprint The need for new classification criteria for rheumatoid arthritis
    Daniel Aletaha
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna General Hospital, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Arthritis Rheum 52:3333-6. 2005
  73. ncbi request reprint A comparison of the OARSI response criteria with patient's global assessment in patients with osteoarthritis of the hip treated with a non-pharmacological intervention
    Hugo L Hoeksma
    Department of Physical Therapy, Leyenburg Hospital, The Hague, The Netherlands
    Osteoarthritis Cartilage 14:77-81. 2006
    ..e., manual therapy or exercise therapy...