B R Bloem

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi Clinimetrics of postural instability in Parkinson's disease
    B R Bloem
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    J Neurol 245:669-73. 1998
  2. ncbi Are automatic postural responses in patients with Parkinson's disease abnormal due to their stooped posture?
    B R Bloem
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, The Netherlands
    Exp Brain Res 124:481-8. 1999
  3. doi First trial reactions and habituation rates over successive balance perturbations in Parkinson's disease
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 217:123-9. 2012
  4. doi Split-belt locomotion in Parkinson's disease with and without freezing of gait
    W Nanhoe-Mahabier
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, The Netherlands
    Neuroscience 236:110-6. 2013
  5. doi Dynamic posturography in Parkinson's disease: diagnostic utility of the "first trial effect"
    J E Visser
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 168:387-94. 2010
  6. doi Balance control in patients with distal versus proximal muscle weakness
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Neuroscience 164:1876-86. 2009
  7. doi The effects of vibrotactile biofeedback training on trunk sway in Parkinson's disease patients
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 18:1017-21. 2012
  8. ncbi The multiple tasks test. Strategies in Parkinson's disease
    B R Bloem
    Department of Neurology, University Hospital St Radboud, Nijmegen, The Netherlands
    Exp Brain Res 137:478-86. 2001
  9. doi Effect of subthalamic nucleus deep brain stimulation on axial motor control and protective arm responses in Parkinson's disease
    J E Visser
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 157:798-812. 2008
  10. doi Epidemiology and pathophysiology of falls in facioscapulohumeral disease
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1357-63. 2009

Collaborators

Detail Information

Publications34

  1. ncbi Clinimetrics of postural instability in Parkinson's disease
    B R Bloem
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    J Neurol 245:669-73. 1998
    ..43; P = 0.11). These results cast doubt on the use of the retropulsion test as a measure of postural instability in Parkinson's disease...
  2. ncbi Are automatic postural responses in patients with Parkinson's disease abnormal due to their stooped posture?
    B R Bloem
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, The Netherlands
    Exp Brain Res 124:481-8. 1999
    ..Other postural abnormalities (most notably the increased ML responses and insufficient voluntary responses) did not appear in stooped controls and may contribute to balance impairment in Parkinson's disease...
  3. doi First trial reactions and habituation rates over successive balance perturbations in Parkinson's disease
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 217:123-9. 2012
    ..We studied balance reactions in Parkinson's disease using posturography, specifically focusing on the responses to the first, fully unpractised balance disturbance, and on the subsequent habituation rates...
  4. doi Split-belt locomotion in Parkinson's disease with and without freezing of gait
    W Nanhoe-Mahabier
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, The Netherlands
    Neuroscience 236:110-6. 2013
    ..We examined if stride time variability and deficits in interlimb coordination between the upper and lower limbs would increase during split-belt locomotion in PD, and particularly so in patients with FOG...
  5. doi Dynamic posturography in Parkinson's disease: diagnostic utility of the "first trial effect"
    J E Visser
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 168:387-94. 2010
    ..Early masseter activity warrants further studies to evaluate a potential startle component in the pathophysiology of balance disorders...
  6. doi Balance control in patients with distal versus proximal muscle weakness
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Neuroscience 164:1876-86. 2009
    ..This observation, together with the retained ability of patients to use compensatory arm movements, provides targets that may be amenable to improvement with therapeutic intervention...
  7. doi The effects of vibrotactile biofeedback training on trunk sway in Parkinson's disease patients
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 18:1017-21. 2012
    ..Specifically, we investigated the effect of artificial vibrotactile biofeedback on trunk sway in PD...
  8. ncbi The multiple tasks test. Strategies in Parkinson's disease
    B R Bloem
    Department of Neurology, University Hospital St Radboud, Nijmegen, The Netherlands
    Exp Brain Res 137:478-86. 2001
    ..In addition, impaired motor learning may partially explain the higher error rate in PD. Future studies must determine if impaired MTT performance can predict actual falls in daily life...
  9. doi Effect of subthalamic nucleus deep brain stimulation on axial motor control and protective arm responses in Parkinson's disease
    J E Visser
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 157:798-812. 2008
    ..In contrast, protective arm movements did appear to be levodopa-responsive. Future studies should focus on identifying subgroups of optimal responders, particularly patients with levodopa-induced dyskinesias...
  10. doi Epidemiology and pathophysiology of falls in facioscapulohumeral disease
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1357-63. 2009
    ..Here falls in patients with facioscapulohumeral disease (FSHD) who suffered from lower limb muscle weakness were examined. This study provides insights into the prevalence, relevance and pathophysiology of falls in FSHD...
  11. doi Sleep matters in Parkinson's disease: use of a priority list to assess the presence of sleep disturbances
    M Louter
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Neurol 20:259-65. 2013
    ..Furthermore, we determined whether relevance as perceived by patients correlated with the subjective presence of sleep disruption scored with a rating scale...
  12. doi CSF α-synuclein does not differentiate between parkinsonian disorders
    M B Aerts
    Department of Neurology, Parkinson Center Nijmegen ParC, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurobiol Aging 33:430.e1-3. 2012
    ..Adjustment for age, disease severity or presence of erythrocytes or blood pigments in CSF did not alter these results. Our results imply that CSF α-synuclein is currently unsuitable as biomarker to differentiate between PD and AP...
  13. doi Walking patterns in Parkinson's disease with and without freezing of gait
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 182:217-24. 2011
    ....
  14. ncbi Evaluation of a Patient-Specific Index as an outcome measure for physiotherapy in Parkinson's disease
    M J Nijkrake
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Phys Rehabil Med 45:507-12. 2009
    ..The aim of this paper was to develop and evaluate a patient-specific index for physiotherapy in Parkinson's disease (PSI-PD)...
  15. ncbi Is lower leg proprioception essential for triggering human automatic postural responses?
    B R Bloem
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Exp Brain Res 130:375-91. 2000
    ..Considering these body segment displacements, any automatic postural response with an onset within the first 200 ms could well be triggered by receptors located at the knee, hip or trunk. (ABSTRACT TRUNCATED)..
  16. doi Side of symptom onset affects motor dysfunction in Parkinson's disease
    C A Haaxma
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 170:1282-5. 2010
    ..We conclude that the side of symptom onset affects motor dysfunction in PD, and suggest that the non-dominant right hemisphere may be more susceptible to dopaminergic denervation than the dominant left hemisphere...
  17. pmc Improving community healthcare for patients with Parkinson's disease: the dutch model
    S H J Keus
    Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Parkinsons Dis 2012:543426. 2012
    ..This comprehensive approach is likely to be feasible for other countries as well, so we currently collaborate in a European collaboration to improve community care for persons with Parkinson's disease...
  18. ncbi Quality indicators for physiotherapy in Parkinson's disease
    M J Nijkrake
    Donders Center for Brain, Cognition and Behavior, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Phys Rehabil Med 45:239-45. 2009
    ..The aim of this study was to develop quality indicators for physiotherapy in Parkinson's disease (PD) according to international criteria...
  19. doi Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome
    M B Aerts
    Department of Neurology, Parkinson Center Nijmegen ParC, Radboud University Nijmegen Medical Centre, The Netherlands
    Mov Disord 26:169-73. 2011
    ..2% and specificity of 66.7% in discriminating PSP and CBS. In conclusion, our results suggest that CSF parameters are of additional value in the diagnostic differentiation of CBS and PD...
  20. doi Trunk sway analysis to quantify the warm-up phenomenon in myotonia congenita patients
    C G C Horlings
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    J Neurol Neurosurg Psychiatry 80:207-12. 2009
    ..A new approach is presented to quantify this warm-up phenomenon under clinically relevant gait and balance tasks...
  21. ncbi Allied health care interventions and complementary therapies in Parkinson's disease
    M J Nijkrake
    Parkinson Center Nijmegen ParC, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 13:S488-94. 2007
    ..Finally, we discuss the need for an improved organization of allied health care, and identify topics for future research to further underpin the pros and cons of allied health care and complementary therapies in PD...
  22. ncbi CSF hypocretin-1 levels are normal in multiple-system atrophy
    W F Abdo
    Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P O Box 9101, 6500 Nijmegan, HB, The Netherlands
    Parkinsonism Relat Disord 14:342-4. 2008
    ..We did not observe any differences from control values...
  23. ncbi Falls in the elderly. I. Identification of risk factors
    B R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Wien Klin Wochenschr 113:352-62. 2001
    ..The identified risk factors can serve as a template for the design of prevention strategies, which are discussed in the companion article...
  24. ncbi CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia
    W F Abdo
    Department of Neurology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurology 67:474-9. 2006
    ..Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease..
  25. ncbi The Multiple Tasks Test: development and normal strategies
    B R Bloem
    Department of Neurology, Radboud Oost, University Medical Centre, St Radboud, 6500 H13 Nijmegen, The Netherlands
    Gait Posture 14:191-202. 2001
    ..Motor learning influenced performance among subjects who received the MTT in order of increasing difficulty. Further studies must determine whether the MTT can be used to evaluate balance disorders...
  26. doi Clinimetric analyses of the Modified Parkinson Activity Scale
    S H J Keus
    Parkinson Centre Nijmegen, Department of Neurology, 935, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Parkinsonism Relat Disord 15:263-9. 2009
    ....
  27. ncbi An uncommon cause of stroke in young adults
    M J van Putten
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Arch Neurol 56:1018-20. 1999
    ..Underlying vessel wall disorders of the aorta, such as Erdheim Gsell cystic medionecrosis, should be considered in young patients with spontaneous arterial dissection...
  28. doi The ParkinsonNet trial: design and baseline characteristics
    Samyra H J Keus
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Mov Disord 25:830-7. 2010
    ..Baseline characteristics of participants in the ParkinsonNet and control clusters were comparable. With 699 participating patients, this is the largest allied health study in PD to date...
  29. doi Imaging the impact of genes on Parkinson's disease
    J P M van der Vegt
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 164:191-204. 2009
    ..We also discuss how functional and structural neuroimaging can be used to better characterize these genotype-phenotype correlations...
  30. ncbi Why old people fall (and how to stop them)
    N C Voermans
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Pract Neurol 7:158-71. 2007
  31. pmc Ten steps to identify atypical parkinsonism
    W F Abdo
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 77:1367-9. 2006
    ..Balance impairment is a frequently encountered problem in patients with Parkinson's disease. A profound balance disorder, however, is an atypical feature...
  32. ncbi Hemispheric asymmetry and somatotopy of afferent inhibition in healthy humans
    R C G Helmich
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Exp Brain Res 167:211-9. 2005
    ..This suggests that SAI induced by electrical D2 stimulation is not focal and somatotopically specific, but a more widespread inhibitory phenomenon...
  33. ncbi Falls in the elderly. II. Strategies for prevention
    I Boers
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Wien Klin Wochenschr 113:398-407. 2001
    ..In addition, prevention is important for health policy makers who aim to reduce falls in the general population by reducing or eliminating commonly present risk factors (even if they are only weakly associated with falls)...
  34. doi Weight loss in neurodegenerative disorders
    N A Aziz
    Department of Neurology, Leiden University Medical Centre, Albinusdreef 2, Leiden, The Netherlands
    J Neurol 255:1872-80. 2008
    ..Moreover, there are indications for defects in the systemic energy homeostasis and gastrointestinal function, which may also serve as therapeutic targets. However, the clinical merits of such interventions have yet to be demonstrated...