G B Bleeker

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Circulation 116:1440-8. 2007
  2. pmc Assessing right ventricular function: the role of echocardiography and complementary technologies
    G B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 92:i19-26. 2006
  3. ncbi request reprint Relative merits of M-mode echocardiography and tissue Doppler imaging for prediction of response to cardiac resynchronization therapy in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 99:68-74. 2007
  4. pmc Optimal use of echocardiography in cardiac resynchronisation therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 93:1339-50. 2007
  5. pmc Acquired right ventricular dysfunction
    G B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 92:i14-8. 2006
  6. doi request reprint Short-term overt hypothyroidism induces discrete diastolic dysfunction in patients treated for differentiated thyroid carcinoma
    H C Hoftijzer
    Leiden University Medical Center, Leiden, The Netherlands
    Eur J Clin Invest 39:204-10. 2009
  7. ncbi request reprint Uncontrolled acromegaly is associated with progressive mitral valvular regurgitation
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Growth Horm IGF Res 16:101-7. 2006
  8. ncbi request reprint Triplane tissue Doppler imaging: a novel three-dimensional imaging modality that predicts reverse left ventricular remodelling after cardiac resynchronisation therapy
    N R Van de Veire
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 94:e9. 2008
  9. ncbi request reprint Acceleration-dependent left bundle branch block with severe left ventricular dyssynchrony results in acute heart failure: are there more patients who benefit from cardiac resynchronization therapy?
    Katja Zeppenfeld
    Leiden University Medical Center, Department of Cardiology, Leiden, The Netherlands
    J Cardiovasc Electrophysiol 17:101-3. 2006
  10. ncbi request reprint Cardiac resynchronization therapy in patients with systolic left ventricular dysfunction and symptoms of mild heart failure secondary to ischemic or nonischemic cardiomyopathy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 98:230-5. 2006

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Circulation 116:1440-8. 2007
    ..The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown...
  2. pmc Assessing right ventricular function: the role of echocardiography and complementary technologies
    G B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 92:i19-26. 2006
  3. ncbi request reprint Relative merits of M-mode echocardiography and tissue Doppler imaging for prediction of response to cardiac resynchronization therapy in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 99:68-74. 2007
    ..05) when color-coded TDI was used. Color-coded TDI was superior to M-mode echocardiography for prediction of response to CRT...
  4. pmc Optimal use of echocardiography in cardiac resynchronisation therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 93:1339-50. 2007
    ..Echocardiography is also useful to evaluate long-term benefit from CRT. Finally, echocardiography is important in optimisation of pacemaker settings, including AV and VV optimisation...
  5. pmc Acquired right ventricular dysfunction
    G B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 92:i14-8. 2006
  6. doi request reprint Short-term overt hypothyroidism induces discrete diastolic dysfunction in patients treated for differentiated thyroid carcinoma
    H C Hoftijzer
    Leiden University Medical Center, Leiden, The Netherlands
    Eur J Clin Invest 39:204-10. 2009
    ..Our objective was to investigate the effects of acute hypothyroidism on cardiac function in patients with iatrogenically induced subclinical hyperthyroidism after treatment for differentiated thyroid carcinoma...
  7. ncbi request reprint Uncontrolled acromegaly is associated with progressive mitral valvular regurgitation
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Growth Horm IGF Res 16:101-7. 2006
    ..The aim of this study was to evaluate the change in prevalence of valvular heart disease in relation to the clinical activity, because the natural history of valvular changes in acromegaly is unknown...
  8. ncbi request reprint Triplane tissue Doppler imaging: a novel three-dimensional imaging modality that predicts reverse left ventricular remodelling after cardiac resynchronisation therapy
    N R Van de Veire
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 94:e9. 2008
    ..Recently a 3-D probe allowing simultaneous acquisition of TDI data in three imaging planes became available...
  9. ncbi request reprint Acceleration-dependent left bundle branch block with severe left ventricular dyssynchrony results in acute heart failure: are there more patients who benefit from cardiac resynchronization therapy?
    Katja Zeppenfeld
    Leiden University Medical Center, Department of Cardiology, Leiden, The Netherlands
    J Cardiovasc Electrophysiol 17:101-3. 2006
    ..CRT prevented these adverse reactions. Accordingly, optimal evaluation for CRT may include testing for LV dyssynchrony during exercise...
  10. ncbi request reprint Cardiac resynchronization therapy in patients with systolic left ventricular dysfunction and symptoms of mild heart failure secondary to ischemic or nonischemic cardiomyopathy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 98:230-5. 2006
    ..In conclusion, CRT had comparable effects in patients in NYHA class II and in NYHA classes III to IV heart failure in terms of LV resynchronization, improvement in LV ejection fraction, and LV reverse remodeling...
  11. ncbi request reprint Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy
    Nico R Van de Veire
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 100:476-82. 2007
    ..LV dyssynchrony parameters, derived from the triplane TDI dataset, were highly predictive for acute volumetric response to CRT...
  12. doi request reprint Effects of interruption of long-term cardiac resynchronization therapy on left ventricular function and dyssynchrony
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 102:718-21. 2008
    ..In conclusion, despite the presence of LV reverse remodeling, interruption of CRT resulted in worsening of LV function and desynchronization. Therefore, continuous long-term pacing is warranted to maintain the beneficial effects...
  13. ncbi request reprint Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Electrophysiol 15:544-9. 2004
    ..Lack of left ventricular dyssynchrony may explain the nonresponse. Accordingly, we evaluated the presence of left ventricular dyssynchrony using tissue Doppler imaging (TDI) in 90 consecutive patients with heart failure...
  14. doi request reprint Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy
    Nina Ajmone Marsan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart Rhythm 5:1257-64. 2008
    ..Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony...
  15. ncbi request reprint Tissue Doppler imaging to assess left ventricular dyssynchrony and resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Echocardiogr 6:382-4. 2005
    ..We describe the use of tissue Doppler imaging to assess left ventricular dyssynchrony and subsequent resynchronization in a patient with end-stage heart failure undergoing cardiac resynchronization therapy...
  16. ncbi request reprint Postero-lateral scar tissue resulting in non-response to cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Electrophysiol 17:899-901. 2006
    ..In patients with ischemic cardiomyopathy and history of previous infarction, assessment of scar tissue should be considered before CRT implantation...
  17. ncbi request reprint Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 113:969-76. 2006
    ..In the present study, the relationship between transmural posterolateral scar tissue and response to CRT was evaluated...
  18. ncbi request reprint Does left ventricular dyssynchrony immediately after acute myocardial infarction result in left ventricular dilatation?
    Sjoerd A Mollema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart Rhythm 4:1144-8. 2007
    ..Substantial LV dyssynchrony seems mandatory for echocardiographic response to CRT. Conversely, LV dyssynchrony early after acute myocardial infarction may result in LV dilatation during follow-up...
  19. pmc Limited effects of growth hormone replacement in patients with GH deficiency during long-term cure of acromegaly
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Pituitary 12:339-46. 2009
    ..005 and P = 0.021, respectively), paralleled by a small, but significant decrease in BMD of the hip. The beneficial effects of rhGH replacement in patients with GHD during cure from acromegaly are limited in this study...
  20. ncbi request reprint Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur Heart J 28:33-41. 2007
    ..response to CRT was evaluated. In addition, the presence of scar tissue in the left ventricular (LV) lead position was specifically related to response to CRT...
  21. ncbi request reprint Usefulness of QRS duration to predict response to cardiac resynchronization therapy in patients with end-stage heart failure
    Sjoerd A Mollema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 100:1665-70. 2007
    ..In conclusion, baseline QRS duration is not predictive for clinical and echocardiographic responses to CRT at 6-month follow-up. Better predictors for CRT response are needed...
  22. ncbi request reprint Comparison of response to cardiac resynchronization therapy in patients with sinus rhythm versus chronic atrial fibrillation
    Sander G Molhoek
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 94:1506-9. 2004
    ..Nevertheless, the long-term survival rate was comparable between patients who had sinus rhythm and those who had AF. Patients who had AF demonstrated comparable benefit from CRT as those who had sinus rhythm...
  23. ncbi request reprint Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT?
    Maureen M Henneman
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Nucl Med 48:1104-11. 2007
    ..The aim of the present study was to investigate whether the degree of left ventricular (LV) dyssynchrony, as assessed with phase analysis from gated myocardial perfusion SPECT (GMPS), can predict which patients will respond to CRT...
  24. ncbi request reprint Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy
    Jeroen J Bax
    Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 44:1834-40. 2004
    ..This study was designed to predict the response and prognosis after cardiac resynchronization therapy (CRT) in patients with end-stage heart failure (HF)...
  25. ncbi request reprint Effect of total scar burden on contrast-enhanced magnetic resonance imaging on response to cardiac resynchronization therapy
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 99:657-60. 2007
    ..In conclusion, total scar burden, assessed using contrast-enhanced magnetic resonance imaging, is an important factor influencing response to CRT and may be included in the selection process for CRT candidates...
  26. ncbi request reprint Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling
    Sjoerd A Mollema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 50:1532-40. 2007
    ..We sought to identify predictors of left ventricular (LV) remodeling after acute myocardial infarction...
  27. ncbi request reprint Left ventricular dyssynchrony predicts benefit of cardiac resynchronization therapy in patients with end-stage heart failure before pacemaker implantation
    Jeroen J Bax
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 92:1238-40. 2003
    ..The presence of left ventricular dyssynchrony is needed to result in improvement after cardiac resynchronization therapy...
  28. doi request reprint Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy
    Nina Ajmone Marsan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Electrophysiol 19:392-9. 2008
    ..To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT)...
  29. doi request reprint Increased aortic root diameters in patients with acromegaly
    Agatha A van der Klaauw
    Departments of Endocrinology, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 159:97-103. 2008
    ..At present, it is unknown whether acromegaly also affects the aortic root...
  30. pmc Real-time three-dimensional echocardiography as a novel approach to quantify left ventricular dyssynchrony: a comparison study with phase analysis of gated myocardial perfusion single photon emission computed tomography
    Nina Ajmone Marsan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Echocardiogr 21:801-7. 2008
    ..Gated myocardial perfusion single photon emission computed tomography (GMPS) with phase analysis is a reliable technique to quantify LV dyssynchrony and predict response to cardiac resynchronization therapy...
  31. doi request reprint Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomography and noninvasive assessment of left ventricular dyssynchrony by 3-dimensional tissue synchronization imaging in patients with heart failure scheduled for cardiac re
    Nico R Van de Veire
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 101:1023-9. 2008
    ..Optimal LV lead positioning in a vein draining the area of latest mechanical activation (determined from tri-plane TSI) resulted in acute improvement of LV dyssynchrony and systolic function after CRT implantation...
  32. doi request reprint Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy
    Victoria Delgado
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 51:1944-52. 2008
    ..Furthermore, changes in extent of LV dyssynchrony for each type of strain were evaluated during follow-up...
  33. ncbi request reprint Hemodynamic effects of long-term cardiac resynchronization therapy: analysis by pressure-volume loops
    Paul Steendijk
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 113:1295-304. 2006
    ..Acute hemodynamic effects of cardiac resynchronization therapy (CRT) were reported previously, but detailed invasive studies showing hemodynamic consequences of long-term CRT are not available...
  34. doi request reprint Cardiac manifestations of GH deficiency after treatment for acromegaly: a comparison to patients with biochemical remission and controls
    Agatha A van der Klaauw
    Department of Endocrinology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 159:705-12. 2008
    ..Both GH excess and GH deficiency (GHD) lead to specific cardiac pathology. The aim of this study was to evaluate cardiac morphology and function in patients with GHD after treatment for acromegaly...
  35. doi request reprint Optimal left ventricular lead position predicts reverse remodeling and survival after cardiac resynchronization therapy
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 52:1402-9. 2008
    ....
  36. ncbi request reprint Left ventricular dyssynchrony in patients with heart failure: pathophysiology, diagnosis and treatment
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Nat Clin Pract Cardiovasc Med 3:213-9. 2006
    ..In this review, we discuss the pathophysiology, diagnosis and treatment of LV dyssynchrony in patients with heart failure...
  37. doi request reprint Magnetic resonance imaging and computed tomography in assessing cardiac veins and scar tissue
    Nico R Van de Veire
    Department of Cardiology, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
    Europace 10:iii110-3. 2008
    ....
  38. ncbi request reprint Assessment of left ventricular dyssynchrony in patients with conduction delay and idiopathic dilated cardiomyopathy: head-to-head comparison between tissue doppler imaging and velocity-encoded magnetic resonance imaging
    Jos J M Westenberg
    Division of Image Processing, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 47:2042-8. 2006
    ..This study sought to compare tissue Doppler imaging (TDI) with velocity-encoded (VE) magnetic resonance imaging (MRI) for left ventricular (LV) dyssynchrony assessment...
  39. ncbi request reprint Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing
    Laurens F Tops
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 50:1180-8. 2007
    ..Speckle-tracking strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall strain and left ventricular (LV) dyssynchrony...
  40. pmc Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left atrial size and reversal to sinus rhythm
    P Kies
    Department of Cardiology, Leiden University Medical Centre, The Netherlands
    Heart 92:490-4. 2006
    ..To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal to sinus rhythm (SR) in patients with heart failure with atrial fibrillation (AF)...
  41. ncbi request reprint Reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study
    J W A Smit
    Leiden University Medical Center, Department of Endocrinology, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Endocrinol Metab 90:6041-7. 2005
    ..Subclinical hyperthyroidism has been reported to affect systolic and diastolic cardiac function. However, the reversibility of these effects is not well established...
  42. ncbi request reprint Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am Heart J 154:1160-5. 2007
    ..We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT)...
  43. doi request reprint Comparison of time course of response to cardiac resynchronization therapy in patients with ischemic versus nonischemic cardiomyopathy
    Nina Ajmone Marsan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 103:690-4. 2009
    ..An acute decrease in LVESV can predict response to CRT at 6-month follow-up. Nonischemic patients show significantly greater LV reverse remodeling compared with ischemic patients...
  44. ncbi request reprint Nuclear imaging in cardiac resynchronization therapy
    Maureen M Henneman
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Nucl Med 48:2001-10. 2007
    ..In the current review, a comprehensive summary is provided on the potential role of nuclear imaging in the selection of heart failure patients for CRT. The value of other imaging techniques is also addressed...
  45. ncbi request reprint Clinical versus echocardiographic parameters to assess response to cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 97:260-3. 2006
    ..To better understand and define response to CRT, the relation between improvement in clinical and echocardiographic parameters was evaluated in 144 patients...
  46. ncbi request reprint Benefit of combined resynchronization and defibrillator therapy in heart failure patients with and without ventricular arrhythmias
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 48:464-70. 2006
    ..We attempted to assess the efficacy of combined cardiac resynchronization therapy-implantable cardioverter-defibrillator (CRT-ICD) in heart failure patients with and without ventricular arrhythmias...
  47. ncbi request reprint Cardiac resynchronization therapy in patients with a narrow QRS complex
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 48:2243-50. 2006
    ....
  48. ncbi request reprint Left ventricular dyssynchrony predicts right ventricular remodeling after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 46:2264-9. 2005
    ..The purpose of this research was to evaluate right ventricular (RV) remodeling after six months of cardiac resynchronization therapy (CRT)...
  49. pmc Tissue synchronisation imaging accurately measures left ventricular dyssynchrony and predicts response to cardiac resynchronisation therapy
    Nico R Van de Veire
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 93:1034-9. 2007
    ..Tissue synchronisation imaging (TSI) is a new technique to assess left ventricular (LV) dyssynchrony...
  50. ncbi request reprint Comparison of effectiveness of cardiac resynchronization therapy in patients <70 versus > or =70 years of age
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 96:420-2. 2005
    ..Survival was evaluated up to 2 years. The effects of CRT in elderly patients (age > or =70 years) were compared with those in younger patients (age <70 years)...
  51. ncbi request reprint Effect of cardiac resynchronization therapy on inducibility of ventricular tachyarrhythmias in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy
    Philippine Kies
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 95:1111-4. 2005
    ..Clinical, electrophysiologic, and echocardiographic data of 18 patients were obtained before and after 6 months of cardiac resynchronization...
  52. doi request reprint Noninvasive imaging in cardiac resynchronization therapy--Part 2: Follow-up and optimization of settings
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Pacing Clin Electrophysiol 31:1628-39. 2008
    ..Furthermore, optimization of CRT settings, in particular atrioventricular and interventricular delay, will be discussed using echocardiography and other (device-based) techniques...
  53. doi request reprint Long-term prognosis after cardiac resynchronization therapy is related to the extent of left ventricular reverse remodeling at midterm follow-up
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 53:483-90. 2009
    ....
  54. ncbi request reprint Phase analysis of gated myocardial perfusion single-photon emission computed tomography compared with tissue Doppler imaging for the assessment of left ventricular dyssynchrony
    Maureen M Henneman
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 49:1708-14. 2007
    ..The purpose of this study was to compare left ventricular (LV) dyssynchrony assessment by gated myocardial perfusion single-photon emission computed tomography (SPECT) (GMPS) and tissue Doppler imaging (TDI)...
  55. ncbi request reprint Frequency of left ventricular dyssynchrony in patients with heart failure and a narrow QRS complex
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 95:140-2. 2005
    ..In the present study, the incidence of LV dyssynchrony was prospectively evaluated in 64 patients with heart failure and narrow QRS complexes using tissue Doppler imaging...
  56. ncbi request reprint Dispersion of repolarization in cardiac resynchronization therapy
    Bart Hooft Van Huysduynen
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Heart Rhythm 2:1286-93. 2005
    ..The possibility of identifying these patients by ECG repolarization indices has been suggested...
  57. ncbi request reprint Does a gender difference in response to cardiac resynchronization therapy exist?
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Pacing Clin Electrophysiol 28:1271-5. 2005
    ..The aim of the current study was to evaluate whether a gender difference exists in response to CRT...
  58. ncbi request reprint Effect of left ventricular remodeling after cardiac resynchronization therapy on frequency of ventricular arrhythmias
    Philippine Kies
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 94:130-2. 2004
    ..Clinical, echocardiographic, and implantable cardioverter-defibrillator (ICD) data of 17 patients with ICDs were obtained before and after they had received an upgrade to an ICD-cardiac resynchronization therapy device...
  59. ncbi request reprint Reverse ventricular remodelling after cardiac resynchronization therapy is associated with a reduction in serum tenascin-C and plasma matrix metalloproteinase-9 levels
    Marleen H M Hessel
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Heart Fail 9:1058-63. 2007
    ..In heart failure patients, cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling...
  60. doi request reprint Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur Heart J 29:757-65. 2008
    ..The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT)...
  61. ncbi request reprint Extent of viability to predict response to cardiac resynchronization therapy in ischemic heart failure patients
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Nucl Med 47:1565-70. 2006
    ..Preliminary data suggest that the presence of myocardial viability may be important for response to CRT. The aim of this study was to evaluate whether the extent of viability could predict response to CRT after 6 mo...
  62. ncbi request reprint Beneficial hemodynamic and clinical effects of surgical ventricular restoration in patients with ischemic dilated cardiomyopathy
    Sven A F Tulner
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Thorac Surg 82:1721-7. 2006
    ..However, a comprehensive midterm analysis of this approach on left ventricular (LV) and right ventricular function is not yet available. We investigated biventricular function and clinical status at 6-month follow-up...
  63. pmc Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging
    Nina Ajmone Marsan
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands
    Eur J Nucl Med Mol Imaging 35:166-73. 2008
    ..Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal count changes throughout the cardiac cycle...
  64. ncbi request reprint What is the value of QRS duration for the prediction of response to cardiac resynchronization therapy?
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am Heart Hosp J 5:110-3. 2007
  65. doi request reprint Noninvasive imaging in cardiac resynchronization therapy--part 1: selection of patients
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Pacing Clin Electrophysiol 31:1475-99. 2008
    ..Furthermore, other information derived from MRI, nuclear imaging, and computed tomography useful for the selection of potential candidates for CRT will be discussed...
  66. ncbi request reprint Long-term follow-up of cardiac resynchronization therapy in patients with end-stage heart failure
    Sander G Molhoek
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    J Cardiovasc Electrophysiol 16:701-7. 2005
    ..Long-term follow-up of cardiac resynchronization therapy...
  67. ncbi request reprint Acute effects of initiation and withdrawal of cardiac resynchronization therapy on papillary muscle dyssynchrony and mitral regurgitation
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 50:2071-7. 2007
    ..The effect of interruption of CRT at 6 months' follow-up on dyssynchrony and MR was also evaluated...
  68. doi request reprint Myocardial collagen metabolism in failing hearts before and during cardiac resynchronization therapy
    Soban Umar
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Heart Fail 10:878-83. 2008
    ..In patients with heart failure cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling...
  69. doi request reprint Cardiac resynchronization therapy in patients with ischemic versus non-ischemic heart failure: Differential effect of optimizing interventricular pacing interval
    Nina Ajmone Marsan
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Am Heart J 158:769-76. 2009
    ..The purpose of this study was to evaluate the acute effect of interventricular pacing interval (V-V) optimization on left ventricular (LV) systolic performance and dyssynchrony in ischemic versus non-ischemic patients...
  70. ncbi request reprint Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Circulation 112:1580-6. 2005
    ..However, it is unknown whether LV reverse remodeling translates into a better long-term prognosis and what extent of reverse remodeling is clinically relevant, which were investigated in this study...
  71. ncbi request reprint Importance of left ventricular lead position in cardiac resynchronization therapy
    Gabe B Bleeker
    Eur Heart J 28:1182-3. 2007
  72. ncbi request reprint Usefulness of tissue Doppler velocity and strain dyssynchrony for predicting left ventricular reverse remodeling response after cardiac resynchronization therapy
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Am J Cardiol 100:1263-70. 2007
    ..In conclusion, parameters of tissue Doppler longitudinal velocity, but not longitudinal strain, predicted LV reverse remodeling after CRT...
  73. ncbi request reprint Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy
    John Gorcsan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Am Coll Cardiol 50:1476-83. 2007
    ....
  74. ncbi request reprint Biventricular pacing and transmural dispersion of the repolarization
    Cees A Swenne
    Europace 9:48-9; author reply 61. 2007
  75. ncbi request reprint Comparison of effectiveness of cardiac resynchronization therapy in patients with versus without diabetes mellitus
    Philippine Kies
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 96:108-11. 2005
    ..Clinical parameters were obtained before and after 6 months of CRT. Long-term follow-up was performed <2 years after implantation...