Marian Beekman

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Heritabilities of apolipoprotein and lipid levels in three countries
    Marian Beekman
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Center, Leiden, The Netherlands
    Twin Res 5:87-97. 2002
  2. pmc Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
    Marian Beekman
    Molecular Epidemiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:18046-9. 2010
  3. pmc Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study
    Martinette T Streppel
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Nutr J 12:75. 2013
  4. pmc Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study
    Marian Beekman
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, ZC, 2333, The Netherlands
    Aging Cell 12:184-93. 2013
  5. ncbi request reprint Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Twin Res 6:322-4. 2003
  6. ncbi request reprint Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 11:845-50. 2003
  7. ncbi request reprint Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies
    Marian Beekman
    Section of Molecular Epidemiology, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:355-62. 2006
  8. ncbi request reprint Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
  9. doi request reprint Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
  10. pmc Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 10:686-98. 2011

Detail Information

Publications38

  1. ncbi request reprint Heritabilities of apolipoprotein and lipid levels in three countries
    Marian Beekman
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Center, Leiden, The Netherlands
    Twin Res 5:87-97. 2002
    ..Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries...
  2. pmc Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
    Marian Beekman
    Molecular Epidemiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:18046-9. 2010
    ..Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease...
  3. pmc Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study
    Martinette T Streppel
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Nutr J 12:75. 2013
    ..This study was conducted to examine the relative validity of the food frequency questionnaire (FFQ) used to assess dietary intake in the Leiden Longevity Study...
  4. pmc Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study
    Marian Beekman
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, ZC, 2333, The Netherlands
    Aging Cell 12:184-93. 2013
    ..2, 17q12-q22, and 19p13.3-p13.11. As the latter linkage results are not explained by common variants, we suggest that rare variants play an important role in human familial longevity...
  5. ncbi request reprint Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Twin Res 6:322-4. 2003
    ..Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs...
  6. ncbi request reprint Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 11:845-50. 2003
    ..Our study provides strong evidence for the presence of a QTL on chromosome 19 with a major effect on LDL-C plasma levels in outbred Caucasian populations...
  7. ncbi request reprint Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies
    Marian Beekman
    Section of Molecular Epidemiology, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:355-62. 2006
    ..Meta-analyses of all previous studies implied that the association in U.S. Caucasians may have its source in admixture of the U.S. control population rather than in the genetic effect of the locus on exceptional longevity...
  8. ncbi request reprint Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
    ..In conclusion, application of a new meta-analysis approach maximised the power to detect QTLs for lipid levels and improved the precision of their location estimate...
  9. doi request reprint Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    ....
  10. pmc Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 10:686-98. 2011
    ..005). In conclusion, the major locus determining familial longevity up to high age as detected by GWAS was marked by rs2075650, which tags the deleterious effects of the ApoE ε4 allele. No other major longevity locus was found...
  11. pmc Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, The Netherlands
    Aging (Albany NY) 3:55-62. 2011
    ..523). The better glucose tolerance of the "offspring" is not explained by a lower burden of type 2 diabetes risk alleles, suggesting that specific mechanisms determining longevity exist...
  12. doi request reprint Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health
    L Renee Ruhaak
    Department of Parasitology, Biomolecular Mass Spectrometry Unit, Leiden University Medical Center, Leiden, The Netherlands
    J Proteome Res 10:1667-74. 2011
    ..In conclusion, we describe two glycan features, of which increased levels mark familial longevity and decreased levels of one of these features mark the presence of cardiovascular disease...
  13. ncbi request reprint Combined association and linkage analysis applied to the APOE locus
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Genet Epidemiol 26:328-37. 2004
    ....
  14. doi request reprint Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study
    Maarten P Rozing
    Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Am Geriatr Soc 58:564-9. 2010
    ..To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity...
  15. pmc Lipid metabolism in long-lived families: the Leiden Longevity Study
    Anika A M Vaarhorst
    Molecular Epidemiology Section, Department Medical Statistics and Bioinformatics, Leiden University Medical Centre, RC, Leiden, The Netherlands
    Age (Dordr) 33:219-27. 2011
    ..Due to the analysis of a comprehensive lipid profile, we confirmed an important role of lipid metabolism in human longevity, with LDL size and triglyceride levels as major predicting factors...
  16. pmc C-reactive protein and glucose regulation in familial longevity
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Age (Dordr) 33:623-30. 2011
    ..To test this hypothesis, our future research will be focused on assessing the robustness of insulin sensitivity in response to various challenges in offspring from long-lived families and controls...
  17. pmc Human insulin/IGF-1 and familial longevity at middle age
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Aging (Albany NY) 1:714-22. 2009
    ....
  18. doi request reprint Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles
    Steffan Daniël Bos
    Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 72:1669-74. 2013
    ..We investigated hand OA and these putative OA biomarker characteristics at different ages in individuals with a propensity for healthy ageing, in controls, and in patients with OA...
  19. doi request reprint Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:365-8. 2010
    ..In human populations, an association was observed between low thyroid function and longevity at old age, but the beneficial effects of low thyroid hormone metabolism at middle age remain elusive...
  20. pmc Lipoprotein particle profiles mark familial and sporadic human longevity
    Bastiaan T Heijmans
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 3:e495. 2006
    ..Here, we investigate whether this observation can be confirmed for familial longevity in an outbred European population and whether it can be extended to sporadic longevity in the general population...
  21. ncbi request reprint Reduced insulin/IGF-1 signalling and human longevity
    Diana van Heemst
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 4:79-85. 2005
    ..This effect was stronger for the GH1 SNP than for variation in the conserved IIS genes that were found to affect longevity in model organisms...
  22. doi request reprint Gene expression analysis of mTOR pathway: association with human longevity
    Willemijn M Passtoors
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Aging Cell 12:24-31. 2013
    ..Thus, the mTOR pathway not only plays a role in the regulation of disease and aging in animal models, but also in human health and longevity...
  23. pmc A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels
    Steffan D Bos
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 18:953-9. 2010
    ..A novel gene involved in the innate immune response of TNFalpha is identified. Genetic variation in this gene may have a role in diseases and disorders in which TNFalpha is closely involved...
  24. pmc Lipidomics of familial longevity
    Vanessa Gonzalez-Covarrubias
    Netherlands Metabolomics Centre, Leiden, The Netherlands
    Aging Cell 12:426-34. 2013
    ..This sex-specific lipid signature marks familial longevity and may suggest a plasma lipidome with a better antioxidant capacity, lower lipid peroxidation and inflammatory precursors, and an efficient beta-oxidation function...
  25. pmc Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Age (Dordr) 35:235-49. 2013
    ..In conclusion, this study shows that genetic variation in genes involved in the IIS and TM pathways is associated with human longevity...
  26. pmc Homocysteine and familial longevity: the Leiden Longevity Study
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e17543. 2011
    ..63). The results suggest that homocysteine metabolism is not likely to predict familial longevity...
  27. pmc Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Bioessays 35:386-96. 2013
    ..Hence, these studies may assist in obtaining a more holistic perspective on the role of the genome in aging and lifespan regulation...
  28. pmc Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R
    Willemijn M Passtoors
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e27759. 2012
    ....
  29. doi request reprint Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs
    Kai Ye
    Molecular Epidemiology, Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Twin Res Hum Genet 16:1026-32. 2013
    ..The low number of somatic variants observed by using two NGS platforms might provide a framework for detecting disease-related somatic variants in phenotypically discordant MZ twins. ..
  30. pmc How to deal with the early GWAS data when imputing and combining different arrays is necessary
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 20:572-6. 2012
    ..To avoid false positive results, we recommend that more stringent QCs should be applied. We also advocate reporting the imputation quality measure (R(T)(2)) for the post-imputation QCs in publications...
  31. pmc Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity
    L Renee Ruhaak
    Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e12566. 2010
    ..It has been shown previously that the N-glycosylation pattern of human immunoglobulin G (IgG) is age-dependent. Here we investigate whether N-linked glycans reflect early features of human longevity...
  32. ncbi request reprint Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study
    Manja Schoenmaker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 14:79-84. 2006
    ..We conclude that our sample is genetically enriched for extreme survival...
  33. doi request reprint Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging
    Erik B van den Akker
    Department of Molecular Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands The Delft Bioinformatics Lab, Delft University of Technology, PO Box 5031, 2600 GA, Delft, The Netherlands
    Aging Cell 13:216-25. 2014
    ..The hereby-detected age-associated and consistently coexpressed PPI modules therefore may provide a molecular basis for future research into mechanisms underlying human aging. ..
  34. ncbi request reprint Variation in the SHC1 gene and longevity in humans
    Simon P Mooijaart
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9503, RC Leiden 2300, The Netherlands
    Exp Gerontol 39:263-8. 2004
    ..Low valine allele frequency resulted, however, in low power to detect statistical significance. These data suggest that an association between the Met(410)Val polymorphism and longevity in humans may exist...
  35. ncbi request reprint Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?
    Bernd W Brandt
    Section of Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
    Bioessays 27:339-46. 2005
    ..Here, the vitellogenin family emerges as a potential key connection between lipid metabolism and the insulin/IGF-1 signalling pathway...
  36. pmc Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
    Linda Broer
    1 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands 2 Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 21:1163-8. 2013
    ..20; P-value=3.24 × 10(-10)). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age...
  37. ncbi request reprint Copulas in QTL mapping
    Bojan Basrak
    Department of Mathematics, University of Zagreb, EURANDOM, Bijenicka 30, 10000 Zagreb, Croatia
    Behav Genet 34:161-71. 2004
    ..The new method can be extended to more general pedigrees and multivariate phenotypes in a similar way as the original variance components method...
  38. ncbi request reprint Variation in the human TP53 gene affects old age survival and cancer mortality
    Diana van Heemst
    Exp Gerontol 40:11-5. 2005
    ..032) despite a 2.54 fold increased (p = 0.007) proportional mortality from cancer. It is suggested that human p53 protect against cancer but at a cost of longevity...