Jean Pierre Bayley

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Differential HFE allele expression in hemochromatosis heterozygotes
    Jean Pierre Bayley
    Gastroenterology 123:652-3; author reply 653. 2002
  2. pmc Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
    Ana M Cervera
    Department of Regenerative Cardiology, Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain
    Mol Cancer 8:89. 2009
  3. pmc Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma
    Erik F Hensen
    Department of Otolaryngology and Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Fam Cancer 10:355-63. 2011
  4. pmc Low penetrance of a SDHB mutation in a large Dutch paraganglioma family
    Frederik J Hes
    Department of Clinical Genetics, Leiden University Medical Center, POBox 9600, 2300 RC Leiden, The Netherlands
    BMC Med Genet 11:92. 2010
  5. pmc Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7987. 2009
  6. pmc The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 10:34. 2009
  7. doi request reprint SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 11:366-72. 2010
  8. pmc The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, P, O, Box 9503, 2300 RA, Leiden, The Netherlands
    BMC Med Genet 9:20. 2008
  9. pmc Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 7:1. 2006
  10. pmc The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency
    Jean Pierre Bayley
    Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9503, 2300 RA, Leiden, The Netherlands
    BMC Med Genet 6:39. 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Differential HFE allele expression in hemochromatosis heterozygotes
    Jean Pierre Bayley
    Gastroenterology 123:652-3; author reply 653. 2002
  2. pmc Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
    Ana M Cervera
    Department of Regenerative Cardiology, Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain
    Mol Cancer 8:89. 2009
    ..These results support the notion that loss of mitochondrial function alters epigenetic processes and might provide a signature methylation mark for paraganglioma...
  3. pmc Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma
    Erik F Hensen
    Department of Otolaryngology and Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Fam Cancer 10:355-63. 2011
    ..Little is still known of the origins and causes of truly sporadic tumors, and the role of oxygen in the relationships between high-altitude, familial and truly sporadic paragangliomas remains to be elucidated...
  4. pmc Low penetrance of a SDHB mutation in a large Dutch paraganglioma family
    Frederik J Hes
    Department of Clinical Genetics, Leiden University Medical Center, POBox 9600, 2300 RC Leiden, The Netherlands
    BMC Med Genet 11:92. 2010
    ..We evaluate the phenotype and penetrance of a germline SDHB mutation in a large and clinically well-characterized paraganglioma family...
  5. pmc Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7987. 2009
    ..SDHD is remarkable in showing an 'imprinted' tumor suppressor phenotype. Mutations of SDHD show a very high penetrance in man and we postulated that knockout of Sdhd would lead to the development of PGL/PC, probably in aged mice...
  6. pmc The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 10:34. 2009
    ..The majority of variants of the SDH genes are missense and nonsense mutations. To date few large deletions of the SDH genes have been described...
  7. doi request reprint SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 11:366-72. 2010
    ..We aimed to identify SDHAF2 mutation carriers, assess the clinical genetic significance of SDHAF2, and describe the associated clinical phenotype...
  8. pmc The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, P, O, Box 9503, 2300 RA, Leiden, The Netherlands
    BMC Med Genet 9:20. 2008
    ....
  9. pmc Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 7:1. 2006
    ..Succinate dehydrogenase is a heterotetrameric protein complex and a component of both the Krebs cycle and the mitochondrial respiratory chain (succinate:ubiquinone oxidoreductase or complex II)...
  10. pmc The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency
    Jean Pierre Bayley
    Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9503, 2300 RA, Leiden, The Netherlands
    BMC Med Genet 6:39. 2005
    ..The largest subunit, SDHA, is mutated in patients with Leigh syndrome and late-onset optic atrophy, but has not as yet been identified as a factor in hereditary cancer...
  11. ncbi request reprint Association between polymorphisms in the human chemokine receptor genes CCR2 and CX3CR1 and rheumatoid arthritis
    J P Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Tissue Antigens 62:170-4. 2003
    ..We found no evidence for a significant independent role for the CCR2 and CX3CR1 variants in the susceptibility to or severity of rheumatoid arthritis...
  12. doi request reprint Molecular characterization of novel germline deletions affecting SDHD and SDHC in pheochromocytoma and paraganglioma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Endocr Relat Cancer 16:929-37. 2009
    ..Gene deletions of SDHD and SDHC represent a substantial proportion of all mutations, and must be considered in paraganglioma patients shown to be negative for mutations by sequencing...
  13. ncbi request reprint Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  14. pmc The Dutch founder mutation SDHD.D92Y shows a reduced penetrance for the development of paragangliomas in a large multigenerational family
    Erik F Hensen
    Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, Leiden 2300 RC, The Netherlands
    Eur J Hum Genet 18:62-6. 2010
    ..This finding will allow a more accurate genetic counseling and warrants a 'wait and scan' policy for asymptomatic paragangliomas, combined with biochemical screening for catecholamine excess in SDHD-linked patients...
  15. pmc High prevalence of occult paragangliomas in asymptomatic carriers of SDHD and SDHB gene mutations
    Berdine L Heesterman
    Department of Otolaryngology and ENT, LUMC, Leiden, The Netherlands
    Eur J Hum Genet 21:469-70. 2013
    ..SDHB carrier risk is considerably lower, consistent with lower penetrance of SDHB mutations. For both syndromes, the risk of symptomless sympathetic paragangliomas is small...
  16. doi request reprint The role of complex II in disease
    Attje S Hoekstra
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Biochim Biophys Acta 1827:543-51. 2013
    ..This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease...
  17. doi request reprint Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
    Jean Pierre Bayley
    Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Building 2, Leiden, The Netherlands
    Curr Opin Genet Dev 20:324-9. 2010
    ..Here we discuss these diverse hypotheses and highlight very recent findings on the possible effects of IDH gene mutations...
  18. ncbi request reprint Is there a future for TNF promoter polymorphisms?
    J P Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genes Immun 5:315-29. 2004
    ..Studies of the TNF region are increasingly using extended haplotypes that can better capture the variation of the MHC region...
  19. doi request reprint The Warburg effect in 2012
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Oncol 24:62-7. 2012
    ..A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis...
  20. ncbi request reprint Allele-specific expression of the IL-1 alpha gene in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 171:2349-53. 2003
    ..The finding of monoallelic expression of a cytokine gene in human CD4+ T cell clones provides evidence for allele-specific silencing/activation as another layer of regulation of IL-1alpha gene expression...
  21. doi request reprint Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus
    Rogier A Oldenburg
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 47:947-56. 2008
    ..001). Five candidate genes were selected from the region around D9S167 and their coding regions subjected to direct sequence analysis in 16 probands. No clear pathogenic mutations were found in any of these genes...
  22. ncbi request reprint Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis
    J P Bayley
    Department of Rheumatology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Rheumatology (Oxford) 42:969-71. 2003
    ..To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients...