S M Arend

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Infect Immun 70:2544-8. 2002
  2. ncbi request reprint Cavitating pneumonia after treatment with infliximab and prednisone
    S M Arend
    Department of Infectious Diseases C5P 39, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 23:638-41. 2004
  3. pmc T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals
    Valerie Martinez
    Laboratoire d Immunologie Cellulaire, INSERM U543, Hopital Pitie Salpetriere, Paris Cedex 13, France
    BMC Infect Dis 7:83. 2007
  4. ncbi request reprint ESAT-6 and CFP-10 in clinical versus environmental isolates of Mycobacterium kansasii
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 191:1301-10. 2005
  5. ncbi request reprint TNF-alpha blockade and tuberculosis: better look before you leap
    S M Arend
    Department of Infectious Diseases C5P, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neth J Med 61:111-9. 2003
  6. ncbi request reprint Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 186:1797-807. 2002
  7. ncbi request reprint A patient with de novo tuberculosis during anti-tumor necrosis factor-alpha therapy illustrating diagnostic pitfalls and paradoxical response to treatment
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 45:1470-5. 2007
  8. ncbi request reprint Double-blind randomized Phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection
    Sandra M Arend
    Department of Infectious Diseases, C5P, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC Leiden, The Netherlands
    Tuberculosis (Edinb) 88:249-61. 2008
  9. doi request reprint Diagnosis and treatment of lung infection with nontuberculous mycobacteria
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Pulm Med 15:201-8. 2009
  10. ncbi request reprint Repeatedly negative tuberculin skin tests followed by active tuberculosis in an immunocompetent individual
    S M Arend
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Neth J Med 58:76-81. 2001

Collaborators

Detail Information

Publications43

  1. pmc Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Infect Immun 70:2544-8. 2002
    ..Moreover, our results suggest that there is significant cross-reactivity between T-ESAT-6 and L-ESAT-6, which has implications for the use of ESAT-6 as tool for diagnosis of leprosy and TB in areas where both diseases are endemic...
  2. ncbi request reprint Cavitating pneumonia after treatment with infliximab and prednisone
    S M Arend
    Department of Infectious Diseases C5P 39, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 23:638-41. 2004
    ..The patient responded well to fluconazole. The risk of infection after treatment with TNF-alpha antagonists and the possible causative microorganisms are discussed...
  3. pmc T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals
    Valerie Martinez
    Laboratoire d Immunologie Cellulaire, INSERM U543, Hopital Pitie Salpetriere, Paris Cedex 13, France
    BMC Infect Dis 7:83. 2007
    ..Cellular and humoral immune responses to Erp (Exported repetitive protein)--a recently identified M. tuberculosis protein--have not yet been investigated in humans and may contribute to this aim...
  4. ncbi request reprint ESAT-6 and CFP-10 in clinical versus environmental isolates of Mycobacterium kansasii
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 191:1301-10. 2005
    ..In vitro, clinical and environmental genotypes of M. kansasii expressed CFP-10 and ESAT-6. Thus, virulence of M. kansasii is not directly related to esat-6 and cfp-10 genes or gene expression...
  5. ncbi request reprint TNF-alpha blockade and tuberculosis: better look before you leap
    S M Arend
    Department of Infectious Diseases C5P, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neth J Med 61:111-9. 2003
    ..Awaiting further consensus protocols, a provisional flow chart is presented that is based on dinical parameters to provide a logical framework to reduce and minimise the risk of tuberculosis during TNF blockade...
  6. ncbi request reprint Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 186:1797-807. 2002
    ..ELISA and ELISPOT yielded comparable results, as did whole antigen and peptides (P<.0001). These results may be relevant for the development of novel assays for diagnosis of tuberculosis...
  7. ncbi request reprint A patient with de novo tuberculosis during anti-tumor necrosis factor-alpha therapy illustrating diagnostic pitfalls and paradoxical response to treatment
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 45:1470-5. 2007
    ....
  8. ncbi request reprint Double-blind randomized Phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection
    Sandra M Arend
    Department of Infectious Diseases, C5P, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC Leiden, The Netherlands
    Tuberculosis (Edinb) 88:249-61. 2008
    ..1 microg. Further studies are needed to evaluate sensitization after repeated doses and to study the effect of additional CFP-10 on the sensitivity of a TB-specific skin test...
  9. doi request reprint Diagnosis and treatment of lung infection with nontuberculous mycobacteria
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Pulm Med 15:201-8. 2009
    ..This review summarizes recent literature regarding epidemiological, clinical, diagnostic and therapeutic aspects of NTM lung infections...
  10. ncbi request reprint Repeatedly negative tuberculin skin tests followed by active tuberculosis in an immunocompetent individual
    S M Arend
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Neth J Med 58:76-81. 2001
    ..The causes of false-negative and false-positive PPD skin test results are reviewed...
  11. ncbi request reprint Pneumonia caused by Mycobacterium kansasii in a series of patients without recognised immune defect
    S M Arend
    Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin Microbiol Infect 10:738-48. 2004
    ..kansasii infections. The identical fingerprint patterns of the isolates suggested the existence of a virulent strain of M. kansasii...
  12. ncbi request reprint Uncommon presentations of tuberculosis: the potential value of a novel diagnostic assay based on the Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10
    S M Arend
    Department of Infectious Diseases, Leiden University Medical Center, The Netherlands
    Int J Tuberc Lung Dis 5:680-6. 2001
    ..Leiden University Medical Center, Leiden, the Netherlands...
  13. pmc Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact
    S M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Diagn Lab Immunol 8:1089-96. 2001
    ..The specificity of the TST or in vitro responses to PPD will be even less when the proportion of BCG-vaccinated persons among TB contacts evaluated for LTBI increases...
  14. pmc Antigenic equivalence of human T-cell responses to Mycobacterium tuberculosis-specific RD1-encoded protein antigens ESAT-6 and culture filtrate protein 10 and to mixtures of synthetic peptides
    S M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Infect Immun 68:3314-21. 2000
    ..tuberculosis, and peptides have the advantage of faster production at lower cost...
  15. ncbi request reprint Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10
    S M Arend
    Dept of Infectious Diseases, C5P, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Infect Dis 181:1850-4. 2000
    ..These data indicate that ESAT-6 and CFP-10 are promising antigens for highly specific immunodiagnosis of TB, even in BCG-vaccinated individuals...
  16. ncbi request reprint Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-gamma assay
    E M S Leyten
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur Respir J 29:1212-6. 2007
    ....
  17. ncbi request reprint Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis
    A Geluk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Scand J Immunol 59:66-70. 2004
    ..tuberculosis at the T-cell level. This crossreactivity has implications for the use of CFP-10 of these mycobacterial species as diagnostic tool in areas endemic for both the diseases...
  18. doi request reprint Grading of a positive sputum smear and the risk of Mycobacterium tuberculosis transmission
    E M Lohmann
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Tuberc Lung Dis 16:1477-84. 2012
    ..Limited data are available on the effect of the degree of acid-fast positivity, of a polymerase chain reaction (PCR) result or of bronchoalveolar lavage (BAL) fluid results on the risk of transmission...
  19. pmc Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria
    May Young Lin
    Department of Infectious Diseases, Leiden University Medical Centre, C5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Infect Immun 77:5071-9. 2009
    ..tuberculosis antigens to which cross-reactive immunity is induced by NTM infection/exposure. The high conservation of M. tuberculosis DosR regulon-encoded antigens most likely enables them to induce cross-reactive T-cell responses...
  20. ncbi request reprint Interferon-gamma release assays during follow-up of tuberculin skin test-positive contacts
    W P J Franken
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Tuberc Lung Dis 12:1286-94. 2008
    ..Following a large-scale contact investigation, individuals with a positive tuberculin skin test (TST) result were offered preventive tuberculosis treatment...
  21. ncbi request reprint Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis
    Eliane M S Leyten
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Microbes Infect 8:2052-60. 2006
    ..Particularly strong IFN-gamma responses to latency antigens were observed in latently infected individuals, suggesting that immune responses against these antigens may contribute to controlling latent M. tuberculosis infection...
  22. pmc Variation in T-SPOT.TB spot interpretation between independent observers from different laboratories
    Willeke P J Franken
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Vaccine Immunol 16:1439-42. 2009
    ..The test result as positive or negative varied between independent raters, mainly due to samples with values around the cutoff. This warrants further study regarding determinants affecting the reading of T-SPOT.TB...
  23. ncbi request reprint Is there evidence for recommending silver-coated urinary catheters in guidelines?
    B S Niël-Weise
    Working Party Infection Prevention, Leiden University Medical Center, Leiden, The Netherlands
    J Hosp Infect 52:81-7. 2002
    ....
  24. ncbi request reprint Interferon-gamma production in response to M. tuberculosis antigens in TB patients in Indonesia
    Yanri W Subronto
    Dept of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 531:249-60. 2003
  25. ncbi request reprint Is the tuberculin skin test an accurate method of detecting tuberculosis in patients with rheumatoid arthritis?
    Tom W J Huizinga
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Nat Clin Pract Rheumatol 2:188-9. 2006
  26. pmc Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results
    Willeke P J Franken
    Department of Infectious Diseases, C5 P 37, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Clin Vaccine Immunol 14:1239-41. 2007
    ..TB assay, during a contact investigation. One year later, 12/29 subjects (41%) had converted to positive TST results in association with negative IGRA results...
  27. pmc Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure
    Eliane M S Leyten
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Microbiol 44:1197-201. 2006
    ..6, and TB7.7 for the diagnosis of latent infection. In particular, positive responses to peptides 2 to 6 of TB37.6 were observed exclusively in recently infected persons...
  28. doi request reprint Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers
    Jaap T van Dissel
    Leiden University Medical Center, Department of Infectious Diseases, Leiden, The Netherlands
    Vaccine 28:3571-81. 2010
    ..These strong responses persisted through 2.5 years of follow-up, indicating the induction of a substantial memory response in the vaccine recipients...
  29. ncbi request reprint Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor
    S M Arend
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands
    Neth J Med 59:140-51. 2001
    ....
  30. pmc Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation
    Eliane M S Leyten
    Department of Infectious Diseases, C5P, Leiden University Medical Center, RC Leiden, The Netherlands
    Clin Vaccine Immunol 14:880-5. 2007
    ....
  31. ncbi request reprint Nontuberculous mycobacterial infection in children: a 2-year prospective surveillance study in the Netherlands
    Margje H Haverkamp
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 39:450-6. 2004
    ..Thirty children underwent surgery, and chemotherapy was the single treatment in 24 (39%) of the cases. The treatment of localized NTM infection in immunocompetent children by antimycobacterial drugs should be evaluated further...
  32. ncbi request reprint Successful treatment of fungus balls due to fluconazole-resistant Candida sake obstructing ureter stents in a renal transplant patient
    S M Arend
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P O Box 9600, 2300RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 25:43-5. 2006
    ..Eradication of the infection was achieved by surgical removal of the ureter with all stents and construction of a cysto-pyelostomy...
  33. ncbi request reprint Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts
    Sandra M Arend
    Leiden University Medical Center, Infectious Diseases, Leiden, The Netherlands
    Am J Respir Crit Care Med 175:618-27. 2007
    ..QuantiFERON-TB Gold (QFT-G) and T-SPOT.TB are based on interferon (IFN)-gamma responses to Mycobacterium tuberculosis-specific antigens. A novel in-tube format of QFT-G (QFT-GIT) offers logistical advantages...
  34. ncbi request reprint Risk factors of acute hepatic failure during antituberculosis treatment: two cases and literature review
    F Smink
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Neth J Med 64:377-84. 2006
    ..An evaluation of chronic viral hepatitis in risk groups before starting ATT could be worthwhile...
  35. ncbi request reprint Prospective controlled study of the diagnostic value of skin biopsy in patients with presumed meningococcal disease
    S M Arend
    Department of Infectious Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 25:643-9. 2006
    ....
  36. pmc Comparison of Mantoux and QuantiFERON TB Gold tests for diagnosis of latent tuberculosis infection in Army personnel
    Willeke P J Franken
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Vaccine Immunol 14:477-80. 2007
    ..Among subjects positive by TST, 44.4% of recruits were positive by QFT-GIT compared with 11.5% subjects tested after missions abroad, suggesting that most TST conversions in the latter group were caused by nontuberculous mycobacteria...
  37. pmc Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family
    Rikke Louise Vinther Skjøt
    Department of TB Immunology, Statens Serum Institute, Copenhagen, Denmark
    Infect Immun 70:5446-53. 2002
    ..4 stimulated the largest responses, but epitopes unique to both TB10.3 and TB12.9 were found. The relevance of the findings for TB vaccine development and as a potential mechanism for immune evasion is discussed...
  38. pmc Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level
    H Martin Vordermeier
    TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Vaccine Immunol 14:1203-9. 2007
    ....
  39. pmc Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection
    Inger Brock
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Clin Microbiol 42:2379-87. 2004
    ..In a validation experiment with new experimental groups, the sensitivities obtained were 57% for the combination of peptides and 90% for the combination of the peptides, ESAT-6, and CFP-10. This combination gave a specificity of 95%...
  40. pmc Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis
    Abebech Demissie
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 13:179-86. 2006
    ....
  41. pmc Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 110:507-12. 2003
    ..In contrast, very limited responses were seen in M. bovis BCG-vaccinated donors. This study therefore emphasizes the diagnostic potential of proteins encoded by the RD1 region...
  42. pmc PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family
    Limei Meng Okkels
    Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Infect Immun 71:6116-23. 2003
    ..The immunodominant epitope (residues 118 to 135) for both TB patients and BCG-vaccinated individuals was found to be highly conserved among a large number of PPE family members...
  43. ncbi request reprint Evidence of endogenous reactivation of tuberculosis after a long period of latency
    Sandra M Arend
    J Infect Dis 186:876-7. 2002