Research Topics
| George Kk LauSummaryAffiliation: The Chinese University of Hong Kong Publications
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Detail Information
Publications
Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapyGeorge K K Lau
Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China
Gastroenterology 125:1742-9. 2003....
Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis BGeorge K K Lau
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
N Engl J Med 352:2682-95. 2005....
Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized studyGeorge K K Lau
Clinical Trial Center, LKS Faculty of Medicine, The University of Hong Kong, Alice Ho Miu Ling Nethersole Hospital, Hong Kong SAR, China
Korean J Hepatol 16:315-20. 2010..In a previous pivotal phase III clinical study, 24 weeks treatment with clevudine 30 mg has been shown to profoundly suppress HBV replication and normalize serum alanine aminotransferase level...
Treatment of Hepatitis B e Antigen-negative PatientsChee Kin Hui
George K Lau, MD, FRCP Department of Medicine, Room 1838, Block K, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
Curr Treat Options Gastroenterol 10:474-82. 2007..However, this latter approach can lead to development of viral resistance and long-term safety concerns...
HBeAg-positive chronic hepatitis B: why do I treat my patients with pegylated interferonGeorge K K Lau
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
Liver Int 29:125-9. 2009..Recently, based on long-term follow-up study, the better durability of sustained response further enhances the confidence in the use of PEG-IFN-alpha in chronic HBeAg-positive patients...
Hepatitis B reactivation after chemotherapy: two decades of clinical researchGeorge K K Lau
Department of Medicine, The University of Hong Kong, Room 1838, Block K, Queen Mary Hospital, 102 Pokfulum Road, Hong Kong, Hong Kong SAR China
Hepatol Int 2:152-62. 2008..Careful epidemiological study will be needed to clarify the impact of occult hepatitis B infection in patients treated with cytotoxic or immunosuppressive therapy...
Thymosin-alpha1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phaseG K K Lau
Departments of Medicine and Pathology, Queen Mary Hospital Clinical Trials Centre, The Institute of Molecular Biology, The University of Hong Kong, Hong Kong SAR, China
J Viral Hepat 9:280-7. 2002..Hence combination therapy with immunomodulatory agents and nucleoside analogues should be explored...
Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantationGeorge K K Lau
Division of Gastroenterology and Hepatology, University of Hong Kong, Hong Kong Special Administrative Region, China
Hepatology 36:702-9. 2002..09; P =.021). In conclusion, preemptive lamivudine reduced HBV exacerbation. The use of lamivudine with other immunosuppressive regimens to prevent exacerbation of HBV should be further explored...
Chronic hepatitis B: a global health problem requiring coherent worldwide treatment strategiesGeorge Lau
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
Hepatol Int 1:316-25. 2007..This article reviews the current treatments available and suggests a framework for a rational approach to managing the disease...
Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversionGeorge K K Lau
Clinical Trial Center, LKS Faculty of Medicine, The University of Hong Kong, Humanity and Health GI and Liver Clinic, Hong Kong, SAR
Liver Int 30:512-20. 2010..The mechanisms for enhanced HBeAg seroconversion rates with new-generation NAs are also discussed...
96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis BChee Kin Hui
Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
J Hepatol 48:714-20. 2008..To determine the efficacy of adefovir dipivoxil (ADV) plus emtricitabine (FTC) combination therapy in chronic HBV infection...
Changes in liver histology as a "surrogate" end point of antiviral therapy for chronic HBV can predict progression to liver complicationsChee Kin Hui
Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
J Clin Gastroenterol 42:533-8. 2008..Improvement in modified HAI after antiviral therapy has usually been defined as a 2-point reduction in modified HAI score...
High hepatitis B virus (HBV) DNA viral load as the most important risk factor for HBV reactivation in patients positive for HBV surface antigen undergoing autologous hematopoietic cell transplantationGeorge K K Lau
Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, People's Republic of China
Blood 99:2324-30. 2002..A high HBV DNA level (>10(5) copies/mL) was the most important risk factor for HBV reactivation, and its lowering by administration of nucleoside analogues before transplantation should be considered...
Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donorsChee-Kin Hui
Division of Gastroenterology and Hepatology, The University of Hong Kong, China
Am J Transplant 5:1437-45. 2005..01, adjusted hazards ratio 7.27, 95%CI 1.62-32.58). Our data support the use of prophylactic therapy in preventing HBV-related hepatitis after allogeneic HSCT from HBsAg-positive donor...
Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantationChee-Kin Hui
Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR, China
J Clin Virol 32:173-8. 2005..CONCLUSION: Our findings suggested that sexual precautions should be taken in these patients after HCT. Alternatively, or even additionally, active vaccination should be delivered to these patients once they have lost their HBV immunity...
Hepatitis B reactivation in patients positive for hepatitis B surface antigen undergoing autologous hematopoietic cell transplantationShing-Yan Ma
Division of Hematology, University Department of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
Leuk Lymphoma 44:1281-5. 2003..However, the latter approach would need the patient's hepatitis B viral load be monitored at a very close interval and might not be cost-effective...
Fibrosis progression in chronic hepatitis C patients with occult hepatitis B co-infectionChee Kin Hui
Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Clin Virol 35:185-92. 2006..946). In conclusion, chronic HCV patients with occult HBV co-infection does not seem to progress more than patients without occult HBV infection. However, more large-scale studies are needed before a definite conclusion can be obtained...
Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapyChee Kin Hui
Centre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, China
Gastroenterology 131:59-68. 2006..De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy...
A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantationChee-Kin Hui
Division of Gastroenterology and Hepatology, The University of Hong Kong, SAR, China
Blood 106:464-9. 2005..Our study showed that long-term hepatic complications occur in a significant proportion of HBsAg+ patients after HSCT and the incidence of liver cirrhosis is reduced in those with sustained serologic clearance of HBsAg after HSCT...
Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis BGeorge K K Lau
Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
Antivir Ther 12:705-18. 2007..The patterns of hepatitis B viral dynamics during different antiviral therapies and the associated changes in HBV-specific T-cell reactivity are not well defined...
Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patientsChee Kin Hui
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region SAR, China
Hepatology 46:690-8. 2007..51 fibrosis units/year, range 0 to +2.03 fibrosis units/year, P = 0.02). CONCLUSION: Spontaneous sustained remission of disease is associated not only with little progression of fibrosis but also with regression of fibrosis...
Immune system and hepatitis B virus infectionChee-Kin Hui
Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Clin Virol 34:S44-8. 2005..Therapeutic strategies aimed at correcting this defective T cell reactivity could represent a complementary approach to the cure of chronic HBV infection...
Current issues and future directions in treatmentChee-Kin Hui
Center for the Study of Liver Diseases, The University of Hong Kong, SAR, China
Semin Liver Dis 26:192-7. 2006..Further improvement in CHB therapy is limited by a lack of understanding of the host immune characteristics associated with sustained disease remission...
Comparison of real-time PCR assays for monitoring serum hepatitis B virus DNA levels during antiviral therapyChee-Kin Hui
Department of Medicine, University of Hong Kong, Hong Kong, SAR, China
J Clin Microbiol 44:2983-7. 2006..The results of the RealART and Digene Hybrid assays were related (r = 0.94; P < 0.001) and diverged by 2 orders of magnitude. The RealART assay can be used to effectively monitor serum hepatitis B virus DNA levels...
Peginterferon-alpha2a (40 kDa) (Pegasys) for hepatitis BChee Kin Hui
Department of Medicine, Center for the Study of Liver Diseases, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
Expert Rev Anti Infect Ther 3:495-504. 2005....
Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic areaChee-Kin Hui
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China
J Hepatol 42:813-9. 2005..45). CONCLUSIONS: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection...
Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation: clinicopathologic features and prognostic implicationShing Y Ma
Department of Medicine, Queen Mary Hospital, Hong Kong, China
Transplantation 77:1252-9. 2004..CONCLUSIONS: Hepatitic and classic liver GVHD differed biochemically and pathologically, but these differences showed no obvious impact on outcome. The distinction of hepatitic GVHD from other hepatitis is mandatory...
Current issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far EastVincent C C Cheng
Department of Microbiology, Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong SAR, China
Semin Liver Dis 23:239-50. 2003..The mechanisms by which transfer of immunity occurs and its potential relationship with grafts from living related donors should be further explored...
Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infectionHai Ying Zhang
Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
Liver Int 25:571-9. 2005..Macrophage migration inhibitory factor (MIF) has emerged to be a pivotal cytokine in immune-mediated diseases...
Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis BChee Kin Hui
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
J Hepatol 47:191-202. 2007..We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts...
Management of chronic hepatitis B in treatment-experienced patientsChee-Kin Hui
Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, 103 Pokfulam Road, Hong Kong SAR, China
Gastroenterol Clin North Am 33:601-16, x. 2004....
Silver nanoparticles inhibit hepatitis B virus replicationLei Lu
Department of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Antivir Ther 13:253-62. 2008..The aim of the present study was to investigate the effects of silver nanoparticles on hepatitis B virus (HBV)...
Treatment of immunosuppressed chronic hepatitis B patientsGeorge K K Lau
Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
Med J Malaysia 60:57-62. 2005
Clevudine for the treatment of chronic hepatitis B virus infectionChee-Kin Hui
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
Expert Opin Investig Drugs 14:1277-84. 2005..Based on the early results of clevudine, more large-scale human studies with clevudine monotherapy or combination therapy is eagerly awaited...
Role of liver biopsy in the management of liver dysfunction after hematopoietic stem-cell transplantation in a hepatitis B virus-prevalent patient populationShing-Yan Ma
University Department of Medicine, Queen Mary Hospital, Hong Kong
Transplantation 76:169-76. 2003..CONCLUSIONS: Clinical diagnoses of LFT derangements post-HSCT might be adequate for initiation of treatment, but liver biopsies in HBV-HCV carriers were needed, as this might impact on management...
A new and sensitive method for the quantification of HBV cccDNA by real-time PCRMing Liang He
The Institute of Molecular Biology and Open Laboratory of the Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong, China
Biochem Biophys Res Commun 295:1102-7. 2002..Not only is this method rapid, economical, highly sensitive, it can be used to monitor HBV cccDNA in infected human liver biopsies and to guide patients undergoing long-term anti-HBV therapy...
Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinomaQing Yu He
Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Hong Kong, China
J Cell Biochem 103:740-52. 2008..Given the fact that SAA is not a specific biomarker, further attempt is being made to identify the other two most discriminatory peaks to realize the possibility of using the predictive model for HCC surveillance and prediction...
Serum biomarkers of hepatitis B virus infected liver inflammation: a proteomic studyQing Yu He
Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
Proteomics 3:666-74. 2003..These unique phenomena appear specific to HBV infection. A combination simultaneously considering the quantities and isoforms of these proteins could be a useful serum biomarker (or index) for HBV diagnosis and therapy...
Therapeutic efficacy of Traditional Chinese Medicine 319 recipe on hepatic fibrosis induced by carbon tetrachloride in ratsK F Cheung
Department of Medicine, The University of Hong Kong, HKSAR, China
J Ethnopharmacol 124:142-50. 2009..TCM 319 recipe is a Chinese Medicine formula which consists of six Chinese herbs. In this study, we investigated the anti-fibrotic efficacy and mechanisms of TCM 319 recipe...
Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin useKam Chuen Lai
Departments of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
N Engl J Med 346:2033-8. 2002..The role of gastric acid suppression in preventing the recurrence of ulcer complications after the eradication of Helicobacter pylori infection in patients taking long-term low-dose aspirin is uncertain...
Prophylactic lamivudine therapy for hepatitis B patients undergoing immunosuppressive therapyGeorge K K Lau
Blood 100:3054. 2002
Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis BZheng Zhang
Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
Gastroenterology 134:1938-49, 1949.e1-3. 2008....
Comparing the safety, tolerability and quality of life in patients with chronic hepatitis B vs chronic hepatitis C treated with peginterferon alpha-2aPatrick Marcellin
Service d hépatologie and INSERM CRB3, University of Paris, Hopital Beaujon, Clichy, France
Liver Int 28:477-85. 2008..Pooled data from five studies of peginterferon alpha-2a in patients with chronic HCV infection (CHC) were compared with two studies of the drug in patients with chronic HBV infection (CHB)...
HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis BMichael W Fried
University of North Carolina, Chapel Hill, NC 27599 7584, USA
Hepatology 47:428-34. 2008....
Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotherapyChee-Kin Hui
Blood 105:2616-7. 2005
Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigenGeorge K K Lau
Institute of Hepatology, University College London, London, England
Gastroenterology 122:614-24. 2002..Therapeutic immunization with HBV core gene or protein deserves further investigation in patients with chronic hepatitis B...
Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: a randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudinePierre Vandepapeliere
GlaxoSmithKline Biologicals, 1330 Rixensart, Belgium
Vaccine 25:8585-97. 2007....
Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis BPatrick Marcellin
Service d Hepatologie, INSERM Unité 481 and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
N Engl J Med 351:1206-17. 2004..As a result, nucleoside and nucleotide analogues are typically continued indefinitely, a strategy associated with the risk of resistance and unknown long-term safety implications...
Genetic characteristics of hepatitis B virus genotypes as a factor for interferon-induced HBeAg clearanceJinlin Hou
Institute of Hepatology, University College London, London WC1E 6HX, UK
J Med Virol 79:1055-63. 2007..The optimal duration of interferon-based therapies in chronic hepatitis B may vary between different HBV genotypes...
Chronic hepatitis B: HBeAg seroconversion after pegylated interferon and nucleos(t)ide analogsHarry L A Janssen
Hepatology 42:1459; author reply 1459-60. 2005
A phase II dose-escalating trial of clevudine in patients with chronic hepatitis BPatrick Marcellin
Service d Hepatologie, Hopital Beaujon, Clichy, France
Hepatology 40:140-8. 2004..The pharmacokinetic profile of clevudine was proportional to the dose. In conclusion, these results demonstrate the tolerability and potent activity of clevudine in HBV-infected patients and support further clinical study...
Asian-Pacific consensus statement on the management of chronic hepatitis B: an updateYun-Fan Liaw
Liver Research Unit, Chang Gung University, Taipei, Taiwan
J Gastroenterol Hepatol 18:239-45. 2003
Does treatment with interferon-based therapy improve the natural history of chronic hepatitis B infection?George K K Lau
J Hepatol 46:6-8. 2007
Late-onset pure red blood cell aplasia owing to delayed lymphoid engraftment complicating ABO-mismatched hematopoietic stem cell transplantationWing Y Au
Transfusion 44:946-7. 2004
Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 updateYun Fan Liaw
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
Liver Int 25:472-89. 2005..A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update...
