Research Topics
| Ralph W KupkaSummaryCountry: The Netherlands Publications
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Detail Information
Publications
Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatientsRalph W Kupka
Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
Am J Psychiatry 162:1273-80. 2005..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...- Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorderRalph W Kupka
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 9:531-5. 2007..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder... - Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studiesRalph W Kupka
Altrecht Institute for Mental Health Care and University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Psychiatry 64:1483-94. 2003..Several risk factors have been suggested to be associated with rapid cycling. The purpose of this meta-analysis was to compare clinical studies for the evidence of discriminating factors between rapid and non-rapid cycling... - Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar NetworkWillem A Nolen
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Am J Psychiatry 161:1447-54. 2004..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder... 
Comorbidity of anxiety and depressive disorders: a comparative population study in Western and non-Western inhabitants in the NetherlandsAgnes C Schrier
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Int J Soc Psychiatry 58:186-94. 2012..Overlap of depressive and anxiety symptoms is supposedly more common in non-Western populations. This can lead to diagnostic uncertainity and undertreatment...- Similarity in depressive symptom profile in a population-based study of migrants in the NetherlandsAgnes C Schrier
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Soc Psychiatry Psychiatr Epidemiol 45:941-51. 2010..Our second aim was to study ethnic differences in the association of depressive symptoms and general functioning... - Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trialSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:617-24. 2005..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002... - An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatmentEsther M Knijff
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Bipolar Disord 9:743-53. 2007..To study the ex vivo interleukin (IL)-1beta and IL-6 production of monocytes in bipolar disorder (BD) patients in the absence/presence of lithium... - Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenonTrisha Suppes
Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
Arch Gen Psychiatry 62:1089-96. 2005..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved... - Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
J Clin Psychiatry 67:1551-60. 2006..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder... - Are bipolar mood symptoms affected by the phase of the menstrual cycle?Geetha Shivakumar
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
J Womens Health (Larchmt) 17:473-8. 2008..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue... - A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytesRoos C Padmos
Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
Arch Gen Psychiatry 65:395-407. 2008..Mood disturbances are associated with an activated inflammatory response system... - Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment NetworkTrisha Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
Int Clin Psychopharmacol 22:376-81. 2007..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted... - The poor prognosis of childhood-onset bipolar disorderGabriele S Leverich
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Pediatr 150:485-90. 2007..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness... - A relative resistance of T cells to dexamethasone in bipolar disorderEsther M Knijff
Department of Immunology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
Bipolar Disord 8:740-50. 2006..In this study, we investigated the in vitro responsiveness of T cells to dexamethasone (DEX) of patients with bipolar disorder (BD)... - Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizersGabriele S Leverich
Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
Am J Psychiatry 163:232-9. 2006..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression... - Monocyte-derived dendritic cells in bipolar disorderEsther M Knijff
Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
Biol Psychiatry 59:317-26. 2006..Dendritic cells (DC) are key regulators of the immune system, which is compromised in patients with bipolar disorder. We sought to study monocyte-derived DC in bipolar disorder... - Evidence that the immunopathogenic mechanism of lithium-induced psoriasis differs from that of regular psoriasisEsther M Knijff
Bipolar Disord 7:388-9. 2005 - A high prevalence of organ-specific autoimmunity in patients with bipolar disorderRoos C Padmos
Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
Biol Psychiatry 56:476-82. 2004..The level of TPOA was negatively correlated with the serum level of sIL-2R, a measure of T cell activation. CONCLUSION: Bipolar disorder is associated with organ-specific autoimmunity to the antigens TPO, H/K ATPase, and GAD65... - A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar NetworkRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:396-406. 2003..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations... - High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorderM Nadine Breunis
Department of Immunology, Erasmus University Rotterdam (MNB, HAD, Rotterdam, The Netherlands
Biol Psychiatry 53:157-65. 2003..CONCLUSION: The T cell system was found to be activated in both symptomatic and euthymic patients with bipolar disorder. The pathophysiological significance of these findings remains to be explored... - High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposureRalph W Kupka
Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
Biol Psychiatry 51:305-11. 2002..These variables appear to be independent risk factors for the development of hypothyroidism, especially in women with bipolar disorder...